Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	400954
Gene name	EMAP like 6
Gene symbol	EML6
Synonyms (NCBI Gene)	-
Chromosome	2
Chromosome location	2p16.1

Show/Hide all (88)

miRTarBase ID	miRNA	Experiments	Reference
MIRT446357	hsa-miR-548a-3p	PAR-CLIP	22100165
MIRT446356	hsa-miR-548ar-3p	PAR-CLIP	22100165
MIRT446355	hsa-miR-548az-3p	PAR-CLIP	22100165
MIRT446354	hsa-miR-548e-3p	PAR-CLIP	22100165
MIRT446353	hsa-miR-548f-3p	PAR-CLIP	22100165
MIRT446352	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT446351	hsa-miR-543	PAR-CLIP	22100165
MIRT446350	hsa-miR-302b-5p	PAR-CLIP	22100165
MIRT446349	hsa-miR-302d-5p	PAR-CLIP	22100165
MIRT446348	hsa-miR-6759-3p	PAR-CLIP	22100165
MIRT446346	hsa-miR-3143	PAR-CLIP	22100165
MIRT446347	hsa-miR-192-5p	PAR-CLIP	22100165
MIRT446345	hsa-miR-215-5p	PAR-CLIP	22100165
MIRT446344	hsa-miR-302c-5p	PAR-CLIP	22100165
MIRT446357	hsa-miR-548a-3p	PAR-CLIP	22100165
MIRT446356	hsa-miR-548ar-3p	PAR-CLIP	22100165
MIRT446355	hsa-miR-548az-3p	PAR-CLIP	22100165
MIRT446354	hsa-miR-548e-3p	PAR-CLIP	22100165
MIRT446353	hsa-miR-548f-3p	PAR-CLIP	22100165
MIRT446352	hsa-miR-5582-3p	PAR-CLIP	22100165
MIRT446351	hsa-miR-543	PAR-CLIP	22100165
MIRT446350	hsa-miR-302b-5p	PAR-CLIP	22100165
MIRT446349	hsa-miR-302d-5p	PAR-CLIP	22100165
MIRT446348	hsa-miR-6759-3p	PAR-CLIP	22100165
MIRT446346	hsa-miR-3143	PAR-CLIP	22100165
MIRT446347	hsa-miR-192-5p	PAR-CLIP	22100165
MIRT446345	hsa-miR-215-5p	PAR-CLIP	22100165
MIRT446344	hsa-miR-302c-5p	PAR-CLIP	22100165
MIRT962212	hsa-miR-135a	CLIP-seq
MIRT962213	hsa-miR-135b	CLIP-seq
MIRT962214	hsa-miR-15a	CLIP-seq
MIRT962215	hsa-miR-15b	CLIP-seq
MIRT962216	hsa-miR-16	CLIP-seq
MIRT962217	hsa-miR-195	CLIP-seq
MIRT962218	hsa-miR-219-5p	CLIP-seq
MIRT962219	hsa-miR-3184	CLIP-seq
MIRT962220	hsa-miR-3942-5p	CLIP-seq
MIRT962221	hsa-miR-423-5p	CLIP-seq
MIRT962222	hsa-miR-424	CLIP-seq
MIRT962223	hsa-miR-4436a	CLIP-seq
MIRT962224	hsa-miR-4490	CLIP-seq
MIRT962225	hsa-miR-4524	CLIP-seq
MIRT962226	hsa-miR-4639-5p	CLIP-seq
MIRT962227	hsa-miR-4686	CLIP-seq
MIRT962228	hsa-miR-4703-5p	CLIP-seq
MIRT962229	hsa-miR-4774-5p	CLIP-seq
MIRT962230	hsa-miR-4782-3p	CLIP-seq
MIRT962231	hsa-miR-4788	CLIP-seq
MIRT962232	hsa-miR-4803	CLIP-seq
MIRT962233	hsa-miR-497	CLIP-seq
MIRT962234	hsa-miR-503	CLIP-seq
MIRT962235	hsa-miR-603	CLIP-seq
MIRT962236	hsa-miR-642b	CLIP-seq
MIRT962237	hsa-miR-646	CLIP-seq
MIRT1985195	hsa-miR-103a	CLIP-seq
MIRT1985196	hsa-miR-107	CLIP-seq
MIRT1985197	hsa-miR-4274	CLIP-seq
MIRT1985198	hsa-miR-486-3p	CLIP-seq
MIRT962214	hsa-miR-15a	CLIP-seq
MIRT962215	hsa-miR-15b	CLIP-seq
MIRT962216	hsa-miR-16	CLIP-seq
MIRT962217	hsa-miR-195	CLIP-seq
MIRT2219884	hsa-miR-3182	CLIP-seq
MIRT2219885	hsa-miR-3652	CLIP-seq
MIRT2219886	hsa-miR-3663-3p	CLIP-seq
MIRT962220	hsa-miR-3942-5p	CLIP-seq
MIRT962222	hsa-miR-424	CLIP-seq
MIRT2219887	hsa-miR-4276	CLIP-seq
MIRT2219888	hsa-miR-4428	CLIP-seq
MIRT2219889	hsa-miR-4430	CLIP-seq
MIRT2219890	hsa-miR-4434	CLIP-seq
MIRT2219891	hsa-miR-4505	CLIP-seq
MIRT2219892	hsa-miR-4516	CLIP-seq
MIRT962225	hsa-miR-4524	CLIP-seq
MIRT2219893	hsa-miR-4531	CLIP-seq
MIRT2219894	hsa-miR-4536	CLIP-seq
MIRT962228	hsa-miR-4703-5p	CLIP-seq
MIRT2219895	hsa-miR-4802-5p	CLIP-seq
MIRT962233	hsa-miR-497	CLIP-seq
MIRT962234	hsa-miR-503	CLIP-seq
MIRT2219896	hsa-miR-539	CLIP-seq
MIRT962237	hsa-miR-646	CLIP-seq
MIRT962214	hsa-miR-15a	CLIP-seq
MIRT962215	hsa-miR-15b	CLIP-seq
MIRT962216	hsa-miR-16	CLIP-seq
MIRT962217	hsa-miR-195	CLIP-seq
MIRT962222	hsa-miR-424	CLIP-seq
MIRT962233	hsa-miR-497	CLIP-seq

Show/Hide all (4)

GO ID	Ontology	Definition	Evidence
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0008017	Function	Microtubule binding	IBA

MIM	HGNC	e!Ensembl
621084	35412	ENSG00000214595

Q6ZMW3

Protein name

Echinoderm microtubule-associated protein-like 6 (EMAP-6) (Echinoderm microtubule-associated protein-like 5-like)

Protein function

May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03451	HELP	1 → 49	HELP motif	Family
PF00400	WD40	51 → 91	WD domain, G-beta repeat	Repeat
PF00400	WD40	96 → 136	WD domain, G-beta repeat	Repeat
PF00400	WD40	314 → 353	WD domain, G-beta repeat	Repeat
PF12894	ANAPC4_WD40	372 → 462	Anaphase-promoting complex subunit 4 WD40 domain	Repeat
PF00400	WD40	553 → 592	WD domain, G-beta repeat	Repeat
PF03451	HELP	652 → 715	HELP motif	Family
PF00400	WD40	715 → 757	WD domain, G-beta repeat	Repeat
PF00400	WD40	988 → 1026	WD domain, G-beta repeat	Repeat
PF00400	WD40	1229 → 1267	WD domain, G-beta repeat	Repeat
PF03451	HELP	1330 → 1402	HELP motif	Family
PF00400	WD40	1678 → 1715	WD domain, G-beta repeat	Repeat
PF12894	ANAPC4_WD40	1734 → 1867	Anaphase-promoting complex subunit 4 WD40 domain	Repeat
PF00400	WD40	1917 → 1956	WD domain, G-beta repeat	Repeat

Sequence

MADRTAPRCQLRLEWVYGYRGHQCRNNLYYTAGKEVVYFVAGVGVVYNTREHSQKFFLGH
NDDIISLALHPDKTLVATGQVGKEPYICIWDSYNVQTVSLLKDVHTHGVACLAFDSDGQR
LASVGLDAKNTVCIWDWRKGKLLASATGHSDRIFDISWDPYQPNRVVSCGVKHIKFWTLC
GNALTAKRGIFGKTGDLQTILCLACAKEDITYSGALNGDIYVWKGLNLVRTIQGAHSAGI
FSMYACEEGFATGGRDGCIRLWDTDFKPITKIDLRETEQGYKGLSIRSVCWKADRLLAGT
QDSEIFEVIVRERDKPMLILQGHCEGELWALALHPKKPLAVTGSDDRSVRLWSLADHALI
ARCNMEEAVRSVAFSPDGSQLALGMKDGSFIVLRVRDMTEVVHIKDRKEVIHEMKFSPDG
SYLAVGSNDGPVDVYAVAQRYKKIGECSKSLSFITHIDWSLDSKYLQTNDGAGERLFYRM
PSGKPLTSKEEIKGIPWASWTCVKGPEVSGIWPKYTEVTDINSVDANYNSSVLVSGDDFG
LVKLFKFPCLKRGAKFRKYVGHSAHVTNVRWSHDFQWVLSTGGADHSVFQWRFIPEGVSN
GMLETAPQEGGADSYSEESDSDLSDVPELDSDIEQEAQINYDRQVYKEDLPQLKQQSKEK
NHAVPFLKREKAPEDSLKLQFIHGYRGYDCRNNLFYTQAGEVVYHIAAVAVVYNRQQHSQ
RLYLGHDDDILSLTIHPVKDYVATGQVGRDAAIHVWDTQTLKCLSLLKGQHQRGVCALDF
SADGKCLVSVGLDDFHSIVFWDWKKGEKIATTRGHKDKIFVVKCNPHHVDKLVTVGIKHI
KFWQQAGGGFTSKRGTFGSVGKLETMMCVSYGRMEDLVFSGAATGDIFIWKDILLLKTVK
AHDGPVFAMYALDKGFVTGGKDGIVELWDDMFERCLKTYAIKRSALSTSSKGLLLEDNPS
IRAITLGHGHILVGTKNGEILEIDKSGPMTLLVQGHMEGEVWGLAAHPLLPICATVSDDK
TLRIWELSAQHRMLAVRKLKKGGRCCAFSPDGKALAVGLNDGSFLVVNADTVEDMVSFHH
RKEMISDIKFSKDTGKYLAVASHDNFVDIYNVLTSKRVGICKGASSYITHIDWDSRGKLL
QVNSGAREQLFFEAPRGKRHIIRPSEIEKIEWDTWTCVLGPTCEGIWPAHSDITDVNAAS
LTKDCSLLATGDDFGFVKLFSYPVKGQHARFKKYVGHSAHVTNVRWLHNDSVLLTVGGAD
TALMIWTREFVGTQESKLVDSEESDTDVEEDGGYDSDVAREKAIDYTTKIYAVSIREMEG
TKPHQQLKEVSVEERPPVSRAAPQPEKLQKNNITKKKKLVEELALDHVFGYRGFDCRNNL
HYLNDGADIIFHTAAAGIVQNLSTGSQSFYLEHTDDILCLTVNQHPKYRNVVATSQIGTT
PSIHIWDAMTKHTLSMLRCFHSKGVNYINFSATGKLLVSVGVDPEHTITVWRWQEGAKVA
SRGGHLERIFVVEFRPDSDTQFVSVGVKHMKFWTLAGSALLYKKGVIGSLGAAKMQTMLS
VAFGANNLTFTGAINGDVYVWKDHFLIRLVAKAHTGPVFTMYTTLRDGLIVTGGKERPTK
EGGAVKLWDQEMKRCRAFQLETGQLVECVRSVCRGKGKILVGTKDGEIIEVGEKNAASNI
LIDGHMEGEIWGLATHPSKDLFISASNDGTARIWDLADKKLLNKVSLGHAARCAAYSPDG
EMVAIGMKNGEFVILLVNSLKVWGKKRDRKSAIQDIRISPDNRFLAVGSSEHTVDFYDLT
QGTNLNRIGYCKDIPSFVIQMDFSADGKYIQVSTGAYKRQVHEVPLGKQVTEAVVIEKIT
WASWTSVLGDEVIGIWPRNADKADVNCACVTHAGLNIVTGDDFGLVKLFDFPCTEKFAKH
KRYFGHSAHVTNIRFSYDDKYVVSTGGDDCSVFVWRCL

Sequence length

1958

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (14)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ANDROGENETIC ALOPECIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEARING LOSS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Keratoconus	Uncertain significance	ClinVar Disgenet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
OBESITY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PRIMARY ALDOSTERONISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SENSORINEURAL HEARING LOSS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEVERE MYOPIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (6)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Hypertension	Hypertension	Pubtator	32854392	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hypertensive disease	Hypertension	GWASCAT_DG	30487518		★★★★★ ★☆☆☆☆ Found in Text Mining only
Keratoconus	Keratoconus	Pubtator	33729517, 39238827	Associate	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Leukemia, Myelocytic, Acute	Leukemia	GWASCAT_DG	27903959		★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	GWASCAT_DG	19553259		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Obesity	Obesity	GWASDB_DG	19553259		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

EML6 (EMAP like 6)