SH2D5 (SH2 domain containing 5)

Gene

• Entrez ID: 400745
• Gene name: SH2 domain containing 5
• Gene symbol: SH2D5
• Synonyms (NCBI Gene): -
• Chromosome: 1
• Chromosome location: 1p36.12

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT717237	hsa-miR-4750-3p	HITS-CLIP	19536157
MIRT717236	hsa-miR-93-3p	HITS-CLIP	19536157
MIRT717235	hsa-miR-3692-5p	HITS-CLIP	19536157
MIRT717234	hsa-miR-6859-3p	HITS-CLIP	19536157
MIRT717233	hsa-miR-6846-3p	HITS-CLIP	19536157
MIRT717232	hsa-miR-4513	HITS-CLIP	19536157
MIRT717231	hsa-miR-6855-3p	HITS-CLIP	19536157
MIRT717230	hsa-miR-6857-3p	HITS-CLIP	19536157
MIRT717229	hsa-miR-134-5p	HITS-CLIP	19536157
MIRT717228	hsa-miR-3118	HITS-CLIP	19536157
MIRT717227	hsa-miR-3164	HITS-CLIP	19536157
MIRT717226	hsa-miR-6820-3p	HITS-CLIP	19536157
MIRT717225	hsa-miR-7977	HITS-CLIP	19536157
MIRT717224	hsa-miR-6071	HITS-CLIP	19536157
MIRT717223	hsa-miR-3136-5p	HITS-CLIP	19536157
MIRT717222	hsa-miR-4439	HITS-CLIP	19536157
MIRT717237	hsa-miR-4750-3p	HITS-CLIP	19536157
MIRT717236	hsa-miR-93-3p	HITS-CLIP	19536157
MIRT717235	hsa-miR-3692-5p	HITS-CLIP	19536157
MIRT717234	hsa-miR-6859-3p	HITS-CLIP	19536157
MIRT717233	hsa-miR-6846-3p	HITS-CLIP	19536157
MIRT717232	hsa-miR-4513	HITS-CLIP	19536157
MIRT717231	hsa-miR-6855-3p	HITS-CLIP	19536157
MIRT717230	hsa-miR-6857-3p	HITS-CLIP	19536157
MIRT717229	hsa-miR-134-5p	HITS-CLIP	19536157
MIRT717228	hsa-miR-3118	HITS-CLIP	19536157
MIRT717227	hsa-miR-3164	HITS-CLIP	19536157
MIRT717226	hsa-miR-6820-3p	HITS-CLIP	19536157
MIRT717225	hsa-miR-7977	HITS-CLIP	19536157
MIRT717224	hsa-miR-6071	HITS-CLIP	19536157
MIRT717223	hsa-miR-3136-5p	HITS-CLIP	19536157
MIRT717222	hsa-miR-4439	HITS-CLIP	19536157
MIRT1344332	hsa-miR-1297	CLIP-seq
MIRT1344333	hsa-miR-140-5p	CLIP-seq
MIRT1344334	hsa-miR-198	CLIP-seq
MIRT1344335	hsa-miR-2355-3p	CLIP-seq
MIRT1344336	hsa-miR-26a	CLIP-seq
MIRT1344337	hsa-miR-26b	CLIP-seq
MIRT1344338	hsa-miR-3120-3p	CLIP-seq
MIRT1344339	hsa-miR-3155	CLIP-seq
MIRT1344340	hsa-miR-3155b	CLIP-seq
MIRT1344341	hsa-miR-3976	CLIP-seq
MIRT1344342	hsa-miR-4465	CLIP-seq
MIRT1344343	hsa-miR-4645-5p	CLIP-seq
MIRT1344344	hsa-miR-4646-3p	CLIP-seq
MIRT1344345	hsa-miR-4673	CLIP-seq
MIRT1344346	hsa-miR-4786-5p	CLIP-seq
MIRT1344347	hsa-miR-484	CLIP-seq
MIRT1344348	hsa-miR-498	CLIP-seq
MIRT1344349	hsa-miR-1289	CLIP-seq
MIRT1344350	hsa-miR-134	CLIP-seq
MIRT1344351	hsa-miR-1908	CLIP-seq
MIRT1344352	hsa-miR-2276	CLIP-seq
MIRT1344353	hsa-miR-2861	CLIP-seq
MIRT1344354	hsa-miR-302a	CLIP-seq
MIRT1344355	hsa-miR-302b	CLIP-seq
MIRT1344356	hsa-miR-302c	CLIP-seq
MIRT1344357	hsa-miR-302d	CLIP-seq
MIRT1344358	hsa-miR-302e	CLIP-seq
MIRT1344359	hsa-miR-3197	CLIP-seq
MIRT1344360	hsa-miR-3198	CLIP-seq
MIRT1344361	hsa-miR-371b-3p	CLIP-seq
MIRT1344362	hsa-miR-372	CLIP-seq
MIRT1344363	hsa-miR-373	CLIP-seq
MIRT1344364	hsa-miR-376a	CLIP-seq
MIRT1344365	hsa-miR-376b	CLIP-seq
MIRT1344366	hsa-miR-3926	CLIP-seq
MIRT1344367	hsa-miR-4294	CLIP-seq
MIRT1344368	hsa-miR-4309	CLIP-seq
MIRT1344369	hsa-miR-4316	CLIP-seq
MIRT1344370	hsa-miR-4641	CLIP-seq
MIRT1344371	hsa-miR-4710	CLIP-seq
MIRT1344372	hsa-miR-4772-3p	CLIP-seq
MIRT1344373	hsa-miR-4778-3p	CLIP-seq
MIRT1344374	hsa-miR-519a	CLIP-seq
MIRT1344375	hsa-miR-519b-3p	CLIP-seq
MIRT1344376	hsa-miR-519c-3p	CLIP-seq
MIRT1344377	hsa-miR-520a-3p	CLIP-seq
MIRT1344378	hsa-miR-520b	CLIP-seq
MIRT1344379	hsa-miR-520c-3p	CLIP-seq
MIRT1344380	hsa-miR-520d-3p	CLIP-seq
MIRT1344381	hsa-miR-520e	CLIP-seq
MIRT1344382	hsa-miR-548ac	CLIP-seq
MIRT1344383	hsa-miR-548d-3p	CLIP-seq
MIRT1344384	hsa-miR-548z	CLIP-seq
MIRT1344385	hsa-miR-663	CLIP-seq
MIRT1344386	hsa-miR-744	CLIP-seq
MIRT1344387	hsa-miR-767-3p	CLIP-seq
MIRT2101791	hsa-miR-2110	CLIP-seq
MIRT2101792	hsa-miR-296-3p	CLIP-seq
MIRT2101793	hsa-miR-3151	CLIP-seq
MIRT2101794	hsa-miR-3689d	CLIP-seq
MIRT2101795	hsa-miR-4271	CLIP-seq
MIRT2101796	hsa-miR-4283	CLIP-seq
MIRT2101797	hsa-miR-4443	CLIP-seq
MIRT2101798	hsa-miR-4489	CLIP-seq
MIRT2101799	hsa-miR-4492	CLIP-seq
MIRT2101800	hsa-miR-4498	CLIP-seq
MIRT2101801	hsa-miR-4725-3p	CLIP-seq
MIRT2101802	hsa-miR-491-5p	CLIP-seq
MIRT2101803	hsa-miR-762	CLIP-seq
MIRT1344348	hsa-miR-498	CLIP-seq
MIRT2459276	hsa-miR-2355-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25331951
GO:0014069	Component	Postsynaptic density	IBA
GO:0014069	Component	Postsynaptic density	IEA
GO:0014069	Component	Postsynaptic density	ISS
GO:0045202	Component	Synapse	IEA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q6ZV89
• Protein name: SH2 domain-containing protein 5
• Protein function: May be involved in synaptic plasticity regulation through the control of Rac-GTP levels.
• Sequence:

  MQKAGAGGRRASDCGLAPHRPRCITKFAQYVGSFPVDDLDTQESVWLVQQQLWALKDCPR
  RRAVILKFSLQGLKIYSGEGEVLLMAHALRRILYSTWCPADCQFAFMARNPRSPASKLFC
  HLFVGSQPGEVQILHLLLCRSFQLAYLLQHPEERAQPEPCPGPTGEVPLKPLSSSGGLVR
  EPFGRDQLSQNVHALVSFRRLPAEGLVGSGKELPESEGRARHARLGNPYCSPTLVRKKAI
  RSKVIRSGAYRGCTYETQLQLSAREAFPAAWEAWPRGPGGHSCLVESEGSLTENIWAFAG
  ISRPCALALLRRDVLGAFLLWPELGASGQWCLSVRTQCGVVPHQVFRNHLGRYCLEHLPA
  EFPSLEALVENHAVTERSLFCPLDMGRLNPTYEEQDCGPPGRPPRTLRPLSHAKSEAELQ
  GLG

• Sequence length: 423

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
STOMACH DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	30659097	Stimulate	★☆☆☆☆ Found in Text Mining only
Hepatitis B	Hepatitis b	Pubtator	30659097	Stimulate	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	30659097		★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	30659097		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	37187527	Associate	★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	25331951		★☆☆☆☆ Found in Text Mining only