Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	400569
Gene name	Mediator complex subunit 11
Gene symbol	MED11
Synonyms (NCBI Gene)	HSPC296NDDRSB
Chromosome	17
Chromosome location	17p13.2
Summary	MED11 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]).[supplied by OMIM, Oct 2008]

Show/Hide all (65)

miRTarBase ID	miRNA	Experiments	Reference
MIRT052666	hsa-miR-3157-5p	CLASH	23622248
MIRT727223	hsa-miR-15a-5p	HITS-CLIP	22473208
MIRT727222	hsa-miR-15b-5p	HITS-CLIP	22473208
MIRT727221	hsa-miR-16-5p	HITS-CLIP	22473208
MIRT727220	hsa-miR-195-5p	HITS-CLIP	22473208
MIRT2039741	hsa-miR-103a	CLIP-seq
MIRT2039742	hsa-miR-107	CLIP-seq
MIRT2039743	hsa-miR-15a	CLIP-seq
MIRT2039744	hsa-miR-15b	CLIP-seq
MIRT2039745	hsa-miR-16	CLIP-seq
MIRT2039746	hsa-miR-195	CLIP-seq
MIRT2039747	hsa-miR-223	CLIP-seq
MIRT2039748	hsa-miR-3183	CLIP-seq
MIRT2039749	hsa-miR-3616-5p	CLIP-seq
MIRT2039750	hsa-miR-3647-5p	CLIP-seq
MIRT2039751	hsa-miR-3921	CLIP-seq
MIRT2039752	hsa-miR-424	CLIP-seq
MIRT2039753	hsa-miR-4279	CLIP-seq
MIRT2039754	hsa-miR-4303	CLIP-seq
MIRT2039755	hsa-miR-4328	CLIP-seq
MIRT2039756	hsa-miR-4653-5p	CLIP-seq
MIRT2039757	hsa-miR-4697-3p	CLIP-seq
MIRT2039758	hsa-miR-4723-3p	CLIP-seq
MIRT2039759	hsa-miR-4795-5p	CLIP-seq
MIRT2039760	hsa-miR-486-3p	CLIP-seq
MIRT2039761	hsa-miR-497	CLIP-seq
MIRT2039762	hsa-miR-573	CLIP-seq
MIRT2039763	hsa-miR-587	CLIP-seq
MIRT2039741	hsa-miR-103a	CLIP-seq
MIRT2039742	hsa-miR-107	CLIP-seq
MIRT2269526	hsa-miR-1295	CLIP-seq
MIRT2039743	hsa-miR-15a	CLIP-seq
MIRT2039744	hsa-miR-15b	CLIP-seq
MIRT2039745	hsa-miR-16	CLIP-seq
MIRT2039746	hsa-miR-195	CLIP-seq
MIRT2039749	hsa-miR-3616-5p	CLIP-seq
MIRT2039750	hsa-miR-3647-5p	CLIP-seq
MIRT2269527	hsa-miR-3691-3p	CLIP-seq
MIRT2039752	hsa-miR-424	CLIP-seq
MIRT2269528	hsa-miR-4480	CLIP-seq
MIRT2269529	hsa-miR-4505	CLIP-seq
MIRT2269530	hsa-miR-4717-5p	CLIP-seq
MIRT2269531	hsa-miR-4731-5p	CLIP-seq
MIRT2269532	hsa-miR-4734	CLIP-seq
MIRT2269533	hsa-miR-4747-5p	CLIP-seq
MIRT2039759	hsa-miR-4795-5p	CLIP-seq
MIRT2039760	hsa-miR-486-3p	CLIP-seq
MIRT2039761	hsa-miR-497	CLIP-seq
MIRT2039762	hsa-miR-573	CLIP-seq
MIRT2568842	hsa-miR-125a-3p	CLIP-seq
MIRT2568843	hsa-miR-326	CLIP-seq
MIRT2568844	hsa-miR-330-5p	CLIP-seq
MIRT2568845	hsa-miR-4287	CLIP-seq
MIRT2568846	hsa-miR-4469	CLIP-seq
MIRT2568847	hsa-miR-4685-3p	CLIP-seq
MIRT2568848	hsa-miR-552	CLIP-seq
MIRT2568849	hsa-miR-642a	CLIP-seq
MIRT2568842	hsa-miR-125a-3p	CLIP-seq
MIRT2568843	hsa-miR-326	CLIP-seq
MIRT2568844	hsa-miR-330-5p	CLIP-seq
MIRT2568845	hsa-miR-4287	CLIP-seq
MIRT2568846	hsa-miR-4469	CLIP-seq
MIRT2568847	hsa-miR-4685-3p	CLIP-seq
MIRT2568848	hsa-miR-552	CLIP-seq
MIRT2568849	hsa-miR-642a	CLIP-seq

Show/Hide all (16)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000151	Component	Ubiquitin ligase complex	IEA
GO:0003712	Function	Transcription coregulator activity	IEA
GO:0005515	Function	Protein binding	IPI	12584197, 30021884, 32296183, 33961781, 35271311
GO:0005634	Component	Nucleus	IDA	24882805
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016592	Component	Mediator complex	IBA
GO:0016592	Component	Mediator complex	IDA	14638676
GO:0016592	Component	Mediator complex	IEA
GO:0032968	Process	Positive regulation of transcription elongation by RNA polymerase II	NAS	11559591
GO:0051123	Process	RNA polymerase II preinitiation complex assembly	NAS	11559591
GO:0060261	Process	Positive regulation of transcription initiation by RNA polymerase II	NAS	11559591
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0070847	Component	Core mediator complex	IPI	24882805

MIM	HGNC	e!Ensembl
612383	32687	ENSG00000161920

Q9P086

Protein name

Mediator of RNA polymerase II transcription subunit 11 (Mediator complex subunit 11)

Protein function

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RN

PDB

7EMF , 7ENA , 7ENC , 7ENJ , 7LBM , 7NVR , 8GXQ , 8GXS , 8T9D , 8TQW , 8TRH

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF10280	Med11	8 → 116	Mediator complex protein	Family

Sequence

MATYSLANERLRALEDIEREIGAILQNAGTVILELSKEKTNERLLDRQAAAFTASVQHVE
AELSAQIRYLTQVATGQPHEGSSYSSRKDCQMALKRVDYARLKLSDVARTCEQMLEN

Sequence length

117

Interactions

View interactions

	Reactome
			PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Neurodegeneration with developmental delay, early respiratory failure, myoclonic seizures, and brain abnormalities	Pathogenic	rs770295047	RCV003223378	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

MED11 (mediator complex subunit 11)