PATE4 (prostate and testis expressed 4)

Gene

• Entrez ID: 399968
• Gene name: Prostate and testis expressed 4
• Gene symbol: PATE4
• Synonyms (NCBI Gene): PATE-B
• Chromosome: 11
• Chromosome location: 11q24.2

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1215028	hsa-miR-103a	CLIP-seq
MIRT1215029	hsa-miR-107	CLIP-seq
MIRT1215030	hsa-miR-1260	CLIP-seq
MIRT1215031	hsa-miR-1260b	CLIP-seq
MIRT1215032	hsa-miR-137	CLIP-seq
MIRT1215033	hsa-miR-15a	CLIP-seq
MIRT1215034	hsa-miR-15b	CLIP-seq
MIRT1215035	hsa-miR-16	CLIP-seq
MIRT1215036	hsa-miR-188-3p	CLIP-seq
MIRT1215037	hsa-miR-190	CLIP-seq
MIRT1215038	hsa-miR-190b	CLIP-seq
MIRT1215039	hsa-miR-195	CLIP-seq
MIRT1215040	hsa-miR-2115	CLIP-seq
MIRT1215041	hsa-miR-214	CLIP-seq
MIRT1215042	hsa-miR-216b	CLIP-seq
MIRT1215043	hsa-miR-2355-5p	CLIP-seq
MIRT1215044	hsa-miR-25	CLIP-seq
MIRT1215045	hsa-miR-2681	CLIP-seq
MIRT1215046	hsa-miR-3156-3p	CLIP-seq
MIRT1215047	hsa-miR-32	CLIP-seq
MIRT1215048	hsa-miR-361-5p	CLIP-seq
MIRT1215049	hsa-miR-3619-5p	CLIP-seq
MIRT1215050	hsa-miR-363	CLIP-seq
MIRT1215051	hsa-miR-3657	CLIP-seq
MIRT1215052	hsa-miR-367	CLIP-seq
MIRT1215053	hsa-miR-3677-3p	CLIP-seq
MIRT1215054	hsa-miR-3677-5p	CLIP-seq
MIRT1215055	hsa-miR-3689a-3p	CLIP-seq
MIRT1215056	hsa-miR-3689c	CLIP-seq
MIRT1215057	hsa-miR-424	CLIP-seq
MIRT1215058	hsa-miR-4286	CLIP-seq
MIRT1215059	hsa-miR-4291	CLIP-seq
MIRT1215060	hsa-miR-4440	CLIP-seq
MIRT1215061	hsa-miR-4460	CLIP-seq
MIRT1215062	hsa-miR-4501	CLIP-seq
MIRT1215063	hsa-miR-4669	CLIP-seq
MIRT1215064	hsa-miR-4687-3p	CLIP-seq
MIRT1215065	hsa-miR-4691-3p	CLIP-seq
MIRT1215066	hsa-miR-4724-3p	CLIP-seq
MIRT1215067	hsa-miR-4727-3p	CLIP-seq
MIRT1215068	hsa-miR-4728-5p	CLIP-seq
MIRT1215069	hsa-miR-497	CLIP-seq
MIRT1215070	hsa-miR-513a-3p	CLIP-seq
MIRT1215071	hsa-miR-516a-3p	CLIP-seq
MIRT1215072	hsa-miR-518a-5p	CLIP-seq
MIRT1215073	hsa-miR-527	CLIP-seq
MIRT1215074	hsa-miR-532-5p	CLIP-seq
MIRT1215075	hsa-miR-570	CLIP-seq
MIRT1215076	hsa-miR-584	CLIP-seq
MIRT1215077	hsa-miR-647	CLIP-seq
MIRT1215078	hsa-miR-668	CLIP-seq
MIRT1215079	hsa-miR-761	CLIP-seq
MIRT1215080	hsa-miR-885-5p	CLIP-seq
MIRT1215081	hsa-miR-922	CLIP-seq
MIRT1215082	hsa-miR-92a	CLIP-seq
MIRT1215083	hsa-miR-92b	CLIP-seq
MIRT1215084	hsa-miR-944	CLIP-seq
MIRT1215028	hsa-miR-103a	CLIP-seq
MIRT1215029	hsa-miR-107	CLIP-seq
MIRT2061906	hsa-miR-1238	CLIP-seq
MIRT2061907	hsa-miR-1264	CLIP-seq
MIRT2061908	hsa-miR-1283	CLIP-seq
MIRT2061909	hsa-miR-1294	CLIP-seq
MIRT2061910	hsa-miR-146a	CLIP-seq
MIRT2061911	hsa-miR-146b-5p	CLIP-seq
MIRT1215037	hsa-miR-190	CLIP-seq
MIRT1215038	hsa-miR-190b	CLIP-seq
MIRT1215042	hsa-miR-216b	CLIP-seq
MIRT2061912	hsa-miR-219-5p	CLIP-seq
MIRT1215043	hsa-miR-2355-5p	CLIP-seq
MIRT2061913	hsa-miR-2467-5p	CLIP-seq
MIRT2061914	hsa-miR-3074-5p	CLIP-seq
MIRT2061915	hsa-miR-3156-5p	CLIP-seq
MIRT2061916	hsa-miR-3188	CLIP-seq
MIRT2061917	hsa-miR-342-3p	CLIP-seq
MIRT1215051	hsa-miR-3657	CLIP-seq
MIRT2061918	hsa-miR-3919	CLIP-seq
MIRT2061919	hsa-miR-3975	CLIP-seq
MIRT1215058	hsa-miR-4286	CLIP-seq
MIRT2061920	hsa-miR-4316	CLIP-seq
MIRT2061921	hsa-miR-4445	CLIP-seq
MIRT2061922	hsa-miR-4457	CLIP-seq
MIRT2061923	hsa-miR-4502	CLIP-seq
MIRT1215063	hsa-miR-4669	CLIP-seq
MIRT1215064	hsa-miR-4687-3p	CLIP-seq
MIRT1215065	hsa-miR-4691-3p	CLIP-seq
MIRT2061924	hsa-miR-4756-3p	CLIP-seq
MIRT2061925	hsa-miR-4782-3p	CLIP-seq
MIRT2061926	hsa-miR-485-5p	CLIP-seq
MIRT2061927	hsa-miR-508-3p	CLIP-seq
MIRT2061928	hsa-miR-513b	CLIP-seq
MIRT1215076	hsa-miR-584	CLIP-seq
MIRT1215077	hsa-miR-647	CLIP-seq
MIRT1215080	hsa-miR-885-5p	CLIP-seq
MIRT1215028	hsa-miR-103a	CLIP-seq
MIRT1215029	hsa-miR-107	CLIP-seq
MIRT2290285	hsa-miR-1237	CLIP-seq
MIRT2061907	hsa-miR-1264	CLIP-seq
MIRT2061909	hsa-miR-1294	CLIP-seq
MIRT2290286	hsa-miR-1299	CLIP-seq
MIRT1215033	hsa-miR-15a	CLIP-seq
MIRT1215034	hsa-miR-15b	CLIP-seq
MIRT1215035	hsa-miR-16	CLIP-seq
MIRT1215037	hsa-miR-190	CLIP-seq
MIRT1215038	hsa-miR-190b	CLIP-seq
MIRT1215039	hsa-miR-195	CLIP-seq
MIRT2290287	hsa-miR-204	CLIP-seq
MIRT2290288	hsa-miR-211	CLIP-seq
MIRT1215041	hsa-miR-214	CLIP-seq
MIRT2061912	hsa-miR-219-5p	CLIP-seq
MIRT2061913	hsa-miR-2467-5p	CLIP-seq
MIRT2290289	hsa-miR-300	CLIP-seq
MIRT2061915	hsa-miR-3156-5p	CLIP-seq
MIRT2061916	hsa-miR-3188	CLIP-seq
MIRT2290290	hsa-miR-3199	CLIP-seq
MIRT2061917	hsa-miR-342-3p	CLIP-seq
MIRT2290291	hsa-miR-3612	CLIP-seq
MIRT1215048	hsa-miR-361-5p	CLIP-seq
MIRT1215049	hsa-miR-3619-5p	CLIP-seq
MIRT1215051	hsa-miR-3657	CLIP-seq
MIRT2290292	hsa-miR-374c	CLIP-seq
MIRT2290293	hsa-miR-381	CLIP-seq
MIRT2061919	hsa-miR-3975	CLIP-seq
MIRT1215057	hsa-miR-424	CLIP-seq
MIRT1215058	hsa-miR-4286	CLIP-seq
MIRT2290294	hsa-miR-4287	CLIP-seq
MIRT1215059	hsa-miR-4291	CLIP-seq
MIRT2061920	hsa-miR-4316	CLIP-seq
MIRT2290295	hsa-miR-4443	CLIP-seq
MIRT2061921	hsa-miR-4445	CLIP-seq
MIRT2061922	hsa-miR-4457	CLIP-seq
MIRT2290296	hsa-miR-4469	CLIP-seq
MIRT2061923	hsa-miR-4502	CLIP-seq
MIRT2290297	hsa-miR-4648	CLIP-seq
MIRT2290298	hsa-miR-4652-5p	CLIP-seq
MIRT2290299	hsa-miR-4654	CLIP-seq
MIRT2290300	hsa-miR-4659a-5p	CLIP-seq
MIRT2290301	hsa-miR-4659b-5p	CLIP-seq
MIRT1215063	hsa-miR-4669	CLIP-seq
MIRT2290302	hsa-miR-4685-3p	CLIP-seq
MIRT1215064	hsa-miR-4687-3p	CLIP-seq
MIRT1215066	hsa-miR-4724-3p	CLIP-seq
MIRT2290303	hsa-miR-4727-5p	CLIP-seq
MIRT2290304	hsa-miR-4740-5p	CLIP-seq
MIRT2290305	hsa-miR-4769-3p	CLIP-seq
MIRT2290306	hsa-miR-4769-5p	CLIP-seq
MIRT2061925	hsa-miR-4782-3p	CLIP-seq
MIRT2290307	hsa-miR-4782-5p	CLIP-seq
MIRT2061926	hsa-miR-485-5p	CLIP-seq
MIRT1215069	hsa-miR-497	CLIP-seq
MIRT2061927	hsa-miR-508-3p	CLIP-seq
MIRT1215070	hsa-miR-513a-3p	CLIP-seq
MIRT2061928	hsa-miR-513b	CLIP-seq
MIRT2290308	hsa-miR-516b	CLIP-seq
MIRT1215075	hsa-miR-570	CLIP-seq
MIRT1215076	hsa-miR-584	CLIP-seq
MIRT2290309	hsa-miR-624	CLIP-seq
MIRT1215077	hsa-miR-647	CLIP-seq
MIRT2290310	hsa-miR-650	CLIP-seq
MIRT2290311	hsa-miR-655	CLIP-seq
MIRT1215079	hsa-miR-761	CLIP-seq
MIRT1215081	hsa-miR-922	CLIP-seq
MIRT1215055	hsa-miR-3689a-3p	CLIP-seq
MIRT1215056	hsa-miR-3689c	CLIP-seq
MIRT1215068	hsa-miR-4728-5p	CLIP-seq
MIRT1215037	hsa-miR-190	CLIP-seq
MIRT1215038	hsa-miR-190b	CLIP-seq
MIRT1215051	hsa-miR-3657	CLIP-seq
MIRT1215058	hsa-miR-4286	CLIP-seq
MIRT1215063	hsa-miR-4669	CLIP-seq
MIRT1215064	hsa-miR-4687-3p	CLIP-seq
MIRT1215076	hsa-miR-584	CLIP-seq
MIRT1215077	hsa-miR-647	CLIP-seq
MIRT1215037	hsa-miR-190	CLIP-seq
MIRT1215038	hsa-miR-190b	CLIP-seq
MIRT1215051	hsa-miR-3657	CLIP-seq
MIRT1215058	hsa-miR-4286	CLIP-seq
MIRT1215063	hsa-miR-4669	CLIP-seq
MIRT1215064	hsa-miR-4687-3p	CLIP-seq
MIRT1215076	hsa-miR-584	CLIP-seq
MIRT1215077	hsa-miR-647	CLIP-seq
MIRT1215037	hsa-miR-190	CLIP-seq
MIRT1215038	hsa-miR-190b	CLIP-seq
MIRT1215051	hsa-miR-3657	CLIP-seq
MIRT1215058	hsa-miR-4286	CLIP-seq
MIRT1215063	hsa-miR-4669	CLIP-seq
MIRT1215064	hsa-miR-4687-3p	CLIP-seq
MIRT1215070	hsa-miR-513a-3p	CLIP-seq
MIRT1215076	hsa-miR-584	CLIP-seq
MIRT1215077	hsa-miR-647	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001669	Component	Acrosomal vesicle	IDA	18387948
GO:0001669	Component	Acrosomal vesicle	IEA
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IDA	18387948
GO:0030548	Function	Acetylcholine receptor regulator activity	IDA	18387948
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0099601	Process	Regulation of neurotransmitter receptor activity	IDA	18387948

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: P0C8F1
• Protein name: Prostate and testis expressed protein 4 (PATE-like protein B) (PATE-B)
• Protein function: May modulate the function of nicotinic acetylcholine receptors. May enhance sperm motility.
• Tissue specificity: TISSUE SPECIFICITY: Specifically expressed in prostate, testis and spinal cord. Present in the acrosomal region of sperm cells. Present in apical epithelial cells of prostatic duct. {ECO:0000269|PubMed:18387948}.
• Sequence:

  MRKMNTLLLVSLSFLYLKEVMGLKCNTCIYTEGWKCMAGRGTCIAKENELCSTTAYFRGD
  KHMYSTHMCKYKCREEESSKRGLLRVTLCCDRNFCNVF

• Sequence length: 98

Pathways

KEGG:

Neuroactive ligand-receptor interaction

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ASTROCYTOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Aniridia	Aniridia	Pubtator	21423868	Associate	★☆☆☆☆ Found in Text Mining only