Gene Gene information from NCBI Gene database.
Entrez ID 399665
Gene name Estrogen-induced osteoclastogenesis regulator 1
Gene symbol EEIG1
Synonyms (NCBI Gene)
C9orf132FAM102ASYM-3AbA203J24.7
Chromosome 9
Chromosome location 9q34.11
miRNA miRNA information provided by mirtarbase database.
801
miRTarBase ID miRNA Experiments Reference
MIRT017176 hsa-miR-335-5p Microarray 18185580
MIRT023269 hsa-miR-122-5p Microarray 17612493
MIRT023615 hsa-miR-1-3p Microarray 18668037
MIRT044659 hsa-miR-320a CLASH 23622248
MIRT038379 hsa-miR-296-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10
GO ID Ontology Definition Evidence Reference
GO:0005515 Function Protein binding IPI 25416956, 31515488, 32296183
GO:0005634 Component Nucleus IEA
GO:0005634 Component Nucleus ISS
GO:0005737 Component Cytoplasm IEA
GO:0005737 Component Cytoplasm ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
610891 31419 ENSG00000167106
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q5T9C2
Protein name Early estrogen-induced gene 1 protein (EEIG1)
Protein function Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions (By similarity). Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TN
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF10358 NT-C2 6 152 N-terminal C2 in EEIG1 and EHBP1 proteins Domain
Sequence
MAFLMKKKKFKFQTTFTLEELTAVPFVNGVLFCKVRLLDGGDFVSLSSREEVQENCVRWR
KRFTFVCKMSANPATGLLDPCVFRVSVRKELKGGKAYSKLGFADLNLAEFAGSGSTVRCC
LLEGYDTKNTRQDNSILKVTIGMFLLSGDPCF
KTPPSTAKSISIPGQDSSLQLTCKGGGT
SSGGSSTNSLTGSRPPKARPTILSSGLPEEPDQNLSSPEEVFHSGHSRNSSYASQQSKIS
GYSTEHSRSSSLSDLTHRRNTSTSSSASGGLGMTVEGPEGSEREHRPPEKPPRPPRPLHL
SDRSFRRKKDSVESHPTWVDDTRIDADAIVEKIVQSQDFTDGSNTEDSNLRLFVSRDGSA
TLSGIQLATRVSSGVYEPVVIESH
Sequence length 384
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
3
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
GLAUCOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
GOUT GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PRIMARY ANGLE CLOSURE GLAUCOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Angle Closure Glaucoma Angle Closure Glaucoma BEFREE 31377279
★☆☆☆☆
Found in Text Mining only
Glioblastoma Glioblastoma Pubtator 35996545 Associate
★☆☆☆☆
Found in Text Mining only
Primary angle-closure glaucoma Angle closure glaucoma BEFREE 31377279
★☆☆☆☆
Found in Text Mining only