Gene Gene information from NCBI Gene database.
Entrez ID 3987
Gene name LIM zinc finger domain containing 1
Gene symbol LIMS1
Synonyms (NCBI Gene)
PINCHPINCH-1PINCH1
Chromosome 2
Chromosome location 2q12.3
Summary The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal ad
miRNA miRNA information provided by mirtarbase database.
711
miRTarBase ID miRNA Experiments Reference
MIRT016105 hsa-miR-421 Sequencing 20371350
MIRT016188 hsa-miR-590-3p Sequencing 20371350
MIRT019634 hsa-miR-340-5p Sequencing 20371350
MIRT023868 hsa-miR-1-3p Proteomics;Microarray 18668037
MIRT024188 hsa-miR-221-3p Sequencing 20371350
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
36
GO ID Ontology Definition Evidence Reference
GO:0001837 Process Epithelial to mesenchymal transition IMP 20926685
GO:0003779 Function Actin binding IEA
GO:0005515 Function Protein binding IPI 10574708, 11331308, 12432066, 15721255, 18339839, 19074270, 20926685, 21390327, 23088713, 23414517, 23455922, 23877428, 25416956, 25852190, 28514442, 29892012, 31515488, 32296183, 32707033, 33961781, 35271311
GO:0005737 Component Cytoplasm IBA
GO:0005829 Component Cytosol TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602567 6616 ENSG00000169756
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P48059
Protein name LIM and senescent cell antigen-like-containing domain protein 1 (Particularly interesting new Cys-His protein 1) (PINCH-1) (Renal carcinoma antigen NY-REN-48)
Protein function Within the IPP (ILK-PINCH-PARVIN) complex, binds to F-actin, promoting F-actin bundling, a process required to generate force for actin cytoskeleton reorganization and subsequent dynamic cell adhesion events such as cell spreading and migration.
PDB 1G47 , 1NYP , 1U5S , 2COR , 2D8X , 2KBX , 3F6Q , 4HI8 , 4HI9 , 6MIF , 7D2S , 7D2T , 7D2U , 7LT9
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00412 LIM 10 67 LIM domain Domain
PF00412 LIM 71 126 LIM domain Domain
PF00412 LIM 135 188 LIM domain Domain
PF00412 LIM 193 248 LIM domain Domain
PF00412 LIM 252 308 LIM domain Domain
Tissue specificity TISSUE SPECIFICITY: Expressed in most tissues except in the brain.
Sequence
Sequence length 325
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  Reactome
    Cell-extracellular matrix interactions
Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
TOOTH AGENESIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma, Clear Cell Adenocarcinoma BEFREE 24895689
★☆☆☆☆
Found in Text Mining only
Alzheimer Disease Alzheimer disease Pubtator 32746944 Associate
★☆☆☆☆
Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA Syndromic microphthalmia BEFREE 30679163
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis Pubtator 35795669 Associate
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 25647720, 29079319, 31801973
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 32751711 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma of larynx Laryngeal carcinoma BEFREE 29755929
★☆☆☆☆
Found in Text Mining only
Central Nervous System Diseases Central nervous system disease Pubtator 32746944 Associate
★☆☆☆☆
Found in Text Mining only
Chronic Disease Chronic disease Pubtator 27838154 Associate
★☆☆☆☆
Found in Text Mining only
Colon Carcinoma Colon Carcinoma BEFREE 25346044
★☆☆☆☆
Found in Text Mining only