Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	3985
Gene name	LIM domain kinase 2
Gene symbol	LIMK2
Synonyms (NCBI Gene)	-
Chromosome	22
Chromosome location	22q12.2
Summary	There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the

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Show/Hide all (331)

miRTarBase ID	miRNA	Experiments
MIRT1109730	hsa-miR-3163	CLIP-seq
MIRT1109731	hsa-miR-548ac	CLIP-seq
MIRT1109732	hsa-miR-548ae	CLIP-seq
MIRT1109733	hsa-miR-548aj	CLIP-seq
MIRT1109734	hsa-miR-548am	CLIP-seq
MIRT1109735	hsa-miR-548d-3p	CLIP-seq
MIRT1109736	hsa-miR-548x	CLIP-seq
MIRT1109737	hsa-miR-548z	CLIP-seq
MIRT1109738	hsa-miR-1290	CLIP-seq
MIRT1109739	hsa-miR-1293	CLIP-seq
MIRT1109740	hsa-miR-1323	CLIP-seq
MIRT1109741	hsa-miR-1343	CLIP-seq
MIRT1109742	hsa-miR-145	CLIP-seq
MIRT1109743	hsa-miR-188-3p	CLIP-seq
MIRT1109744	hsa-miR-194	CLIP-seq
MIRT1109745	hsa-miR-24	CLIP-seq
MIRT1109746	hsa-miR-27a	CLIP-seq
MIRT1109747	hsa-miR-27b	CLIP-seq
MIRT1109748	hsa-miR-3136-3p	CLIP-seq
MIRT1109749	hsa-miR-3165	CLIP-seq
MIRT1109750	hsa-miR-3167	CLIP-seq
MIRT1109751	hsa-miR-3180-5p	CLIP-seq
MIRT1109752	hsa-miR-335	CLIP-seq
MIRT1109753	hsa-miR-412	CLIP-seq
MIRT1109754	hsa-miR-4269	CLIP-seq
MIRT1109755	hsa-miR-4270	CLIP-seq
MIRT1109756	hsa-miR-4284	CLIP-seq
MIRT1109757	hsa-miR-4320	CLIP-seq
MIRT1109758	hsa-miR-4441	CLIP-seq
MIRT1109759	hsa-miR-4444	CLIP-seq
MIRT1109760	hsa-miR-4469	CLIP-seq
MIRT1109761	hsa-miR-4474-3p	CLIP-seq
MIRT1109762	hsa-miR-4483	CLIP-seq
MIRT1109763	hsa-miR-4514	CLIP-seq
MIRT1109764	hsa-miR-451b	CLIP-seq
MIRT1109765	hsa-miR-4659a-3p	CLIP-seq
MIRT1109766	hsa-miR-4659b-3p	CLIP-seq
MIRT1109767	hsa-miR-4691-5p	CLIP-seq
MIRT1109768	hsa-miR-4692	CLIP-seq
MIRT1109769	hsa-miR-4712-5p	CLIP-seq
MIRT1109770	hsa-miR-4714-3p	CLIP-seq
MIRT1109771	hsa-miR-4742-5p	CLIP-seq
MIRT1109772	hsa-miR-4753-5p	CLIP-seq
MIRT1109773	hsa-miR-4755-3p	CLIP-seq
MIRT1109774	hsa-miR-4778-3p	CLIP-seq
MIRT1109775	hsa-miR-513a-5p	CLIP-seq
MIRT1109776	hsa-miR-532-3p	CLIP-seq
MIRT1109777	hsa-miR-548o	CLIP-seq
MIRT1109778	hsa-miR-770-5p	CLIP-seq
MIRT1109779	hsa-miR-802	CLIP-seq
MIRT1109780	hsa-miR-876-5p	CLIP-seq
MIRT1109781	hsa-miR-1236	CLIP-seq
MIRT1109782	hsa-miR-2114	CLIP-seq
MIRT1109783	hsa-miR-214	CLIP-seq
MIRT1109784	hsa-miR-3121-5p	CLIP-seq
MIRT1109785	hsa-miR-361-3p	CLIP-seq
MIRT1109786	hsa-miR-3619-5p	CLIP-seq
MIRT1109787	hsa-miR-4530	CLIP-seq
MIRT1109788	hsa-miR-4722-3p	CLIP-seq
MIRT1109789	hsa-miR-554	CLIP-seq
MIRT1109790	hsa-miR-761	CLIP-seq
MIRT2030548	hsa-miR-1178	CLIP-seq
MIRT1109781	hsa-miR-1236	CLIP-seq
MIRT2030549	hsa-miR-1270	CLIP-seq
MIRT2030550	hsa-miR-1273d	CLIP-seq
MIRT2030551	hsa-miR-1289	CLIP-seq
MIRT2030552	hsa-miR-1291	CLIP-seq
MIRT1109783	hsa-miR-214	CLIP-seq
MIRT2030553	hsa-miR-23a	CLIP-seq
MIRT2030554	hsa-miR-23b	CLIP-seq
MIRT2030555	hsa-miR-23c	CLIP-seq
MIRT1109745	hsa-miR-24	CLIP-seq
MIRT1109746	hsa-miR-27a	CLIP-seq
MIRT1109747	hsa-miR-27b	CLIP-seq
MIRT2030556	hsa-miR-3173-5p	CLIP-seq
MIRT2030557	hsa-miR-338-5p	CLIP-seq
MIRT1109786	hsa-miR-3619-5p	CLIP-seq
MIRT2030558	hsa-miR-3675-5p	CLIP-seq
MIRT2030559	hsa-miR-3909	CLIP-seq
MIRT2030560	hsa-miR-3920	CLIP-seq
MIRT2030561	hsa-miR-3925-3p	CLIP-seq
MIRT2030562	hsa-miR-3940-3p	CLIP-seq
MIRT1109760	hsa-miR-4469	CLIP-seq
MIRT2030563	hsa-miR-4477a	CLIP-seq
MIRT2030564	hsa-miR-4645-3p	CLIP-seq
MIRT2030565	hsa-miR-4676-5p	CLIP-seq
MIRT2030566	hsa-miR-4683	CLIP-seq
MIRT2030567	hsa-miR-4690-3p	CLIP-seq
MIRT1109767	hsa-miR-4691-5p	CLIP-seq
MIRT1109769	hsa-miR-4712-5p	CLIP-seq
MIRT2030568	hsa-miR-4747-3p	CLIP-seq
MIRT2030569	hsa-miR-4762-5p	CLIP-seq
MIRT2030570	hsa-miR-486-3p	CLIP-seq
MIRT1109775	hsa-miR-513a-5p	CLIP-seq
MIRT2030571	hsa-miR-543	CLIP-seq
MIRT2030572	hsa-miR-570	CLIP-seq
MIRT2030573	hsa-miR-575	CLIP-seq
MIRT2030574	hsa-miR-620	CLIP-seq
MIRT2030575	hsa-miR-649	CLIP-seq
MIRT2030576	hsa-miR-671-5p	CLIP-seq
MIRT2030577	hsa-miR-718	CLIP-seq
MIRT1109790	hsa-miR-761	CLIP-seq
MIRT2030578	hsa-miR-766	CLIP-seq
MIRT2030579	hsa-miR-767-3p	CLIP-seq
MIRT1109778	hsa-miR-770-5p	CLIP-seq
MIRT1109779	hsa-miR-802	CLIP-seq
MIRT2261288	hsa-miR-1273g	CLIP-seq
MIRT2030551	hsa-miR-1289	CLIP-seq
MIRT1109738	hsa-miR-1290	CLIP-seq
MIRT1109740	hsa-miR-1323	CLIP-seq
MIRT2261289	hsa-miR-1324	CLIP-seq
MIRT1109741	hsa-miR-1343	CLIP-seq
MIRT2261290	hsa-miR-140-5p	CLIP-seq
MIRT2261291	hsa-miR-143	CLIP-seq
MIRT1109743	hsa-miR-188-3p	CLIP-seq
MIRT1109783	hsa-miR-214	CLIP-seq
MIRT2030553	hsa-miR-23a	CLIP-seq
MIRT2030554	hsa-miR-23b	CLIP-seq
MIRT2030555	hsa-miR-23c	CLIP-seq
MIRT1109746	hsa-miR-27a	CLIP-seq
MIRT1109747	hsa-miR-27b	CLIP-seq
MIRT2261292	hsa-miR-30a	CLIP-seq
MIRT2261293	hsa-miR-30b	CLIP-seq
MIRT2261294	hsa-miR-30c	CLIP-seq
MIRT2261295	hsa-miR-30d	CLIP-seq
MIRT2261296	hsa-miR-30e	CLIP-seq
MIRT2261297	hsa-miR-3120-3p	CLIP-seq
MIRT1109748	hsa-miR-3136-3p	CLIP-seq
MIRT1109750	hsa-miR-3167	CLIP-seq
MIRT2261298	hsa-miR-3179	CLIP-seq
MIRT2261299	hsa-miR-3192	CLIP-seq
MIRT2261300	hsa-miR-323b-3p	CLIP-seq
MIRT2030557	hsa-miR-338-5p	CLIP-seq
MIRT2261301	hsa-miR-33a	CLIP-seq
MIRT2261302	hsa-miR-33b	CLIP-seq
MIRT2261303	hsa-miR-3545-3p	CLIP-seq
MIRT1109786	hsa-miR-3619-5p	CLIP-seq
MIRT2261304	hsa-miR-3663-5p	CLIP-seq
MIRT2261305	hsa-miR-3679-3p	CLIP-seq
MIRT2261306	hsa-miR-374c	CLIP-seq
MIRT2261307	hsa-miR-376a	CLIP-seq
MIRT2261308	hsa-miR-376b	CLIP-seq
MIRT2261309	hsa-miR-377	CLIP-seq
MIRT2261310	hsa-miR-384	CLIP-seq
MIRT2261311	hsa-miR-3913-3p	CLIP-seq
MIRT1109753	hsa-miR-412	CLIP-seq
MIRT2261312	hsa-miR-4256	CLIP-seq
MIRT2261313	hsa-miR-4261	CLIP-seq
MIRT1109754	hsa-miR-4269	CLIP-seq
MIRT2261314	hsa-miR-4281	CLIP-seq
MIRT2261315	hsa-miR-4327	CLIP-seq
MIRT2261316	hsa-miR-4468	CLIP-seq
MIRT1109760	hsa-miR-4469	CLIP-seq
MIRT2030563	hsa-miR-4477a	CLIP-seq
MIRT2261317	hsa-miR-4496	CLIP-seq
MIRT1109763	hsa-miR-4514	CLIP-seq
MIRT2261318	hsa-miR-4519	CLIP-seq
MIRT1109764	hsa-miR-451b	CLIP-seq
MIRT2261319	hsa-miR-4539	CLIP-seq
MIRT2261320	hsa-miR-4639-3p	CLIP-seq
MIRT1109765	hsa-miR-4659a-3p	CLIP-seq
MIRT2261321	hsa-miR-4659a-5p	CLIP-seq
MIRT1109766	hsa-miR-4659b-3p	CLIP-seq
MIRT2261322	hsa-miR-4659b-5p	CLIP-seq
MIRT2261323	hsa-miR-4667-5p	CLIP-seq
MIRT1109767	hsa-miR-4691-5p	CLIP-seq
MIRT1109768	hsa-miR-4692	CLIP-seq
MIRT2261324	hsa-miR-4700-5p	CLIP-seq
MIRT2261325	hsa-miR-4709-3p	CLIP-seq
MIRT1109770	hsa-miR-4714-3p	CLIP-seq
MIRT2261326	hsa-miR-4714-5p	CLIP-seq
MIRT2261327	hsa-miR-4728-3p	CLIP-seq
MIRT2261328	hsa-miR-4731-5p	CLIP-seq
MIRT2261329	hsa-miR-4736	CLIP-seq
MIRT1109771	hsa-miR-4742-5p	CLIP-seq
MIRT1109772	hsa-miR-4753-5p	CLIP-seq
MIRT2261330	hsa-miR-4756-3p	CLIP-seq
MIRT2030569	hsa-miR-4762-5p	CLIP-seq
MIRT2261331	hsa-miR-4770	CLIP-seq
MIRT2261332	hsa-miR-4776-3p	CLIP-seq
MIRT1109774	hsa-miR-4778-3p	CLIP-seq
MIRT2261333	hsa-miR-4786-3p	CLIP-seq
MIRT2261334	hsa-miR-4789-3p	CLIP-seq
MIRT2261335	hsa-miR-4792	CLIP-seq
MIRT2261336	hsa-miR-4796-5p	CLIP-seq
MIRT2261337	hsa-miR-489	CLIP-seq
MIRT1109775	hsa-miR-513a-5p	CLIP-seq
MIRT2261338	hsa-miR-518a-5p	CLIP-seq
MIRT2261339	hsa-miR-527	CLIP-seq
MIRT2030571	hsa-miR-543	CLIP-seq
MIRT1109777	hsa-miR-548o	CLIP-seq
MIRT2261340	hsa-miR-603	CLIP-seq
MIRT2261341	hsa-miR-653	CLIP-seq
MIRT2261342	hsa-miR-655	CLIP-seq
MIRT2261343	hsa-miR-657	CLIP-seq
MIRT2261344	hsa-miR-759	CLIP-seq
MIRT1109790	hsa-miR-761	CLIP-seq
MIRT1109780	hsa-miR-876-5p	CLIP-seq
MIRT2261345	hsa-miR-940	CLIP-seq
MIRT1109783	hsa-miR-214	CLIP-seq
MIRT1109786	hsa-miR-3619-5p	CLIP-seq
MIRT1109790	hsa-miR-761	CLIP-seq
MIRT1109781	hsa-miR-1236	CLIP-seq
MIRT1109743	hsa-miR-188-3p	CLIP-seq
MIRT2261304	hsa-miR-3663-5p	CLIP-seq
MIRT2261311	hsa-miR-3913-3p	CLIP-seq
MIRT2261314	hsa-miR-4281	CLIP-seq
MIRT2030567	hsa-miR-4690-3p	CLIP-seq
MIRT2261337	hsa-miR-489	CLIP-seq
MIRT1109781	hsa-miR-1236	CLIP-seq
MIRT2561286	hsa-miR-1245b-5p	CLIP-seq
MIRT2030549	hsa-miR-1270	CLIP-seq
MIRT2030550	hsa-miR-1273d	CLIP-seq
MIRT2261288	hsa-miR-1273g	CLIP-seq
MIRT1109741	hsa-miR-1343	CLIP-seq
MIRT2261290	hsa-miR-140-5p	CLIP-seq
MIRT1109743	hsa-miR-188-3p	CLIP-seq
MIRT2561287	hsa-miR-1976	CLIP-seq
MIRT2030553	hsa-miR-23a	CLIP-seq
MIRT2030554	hsa-miR-23b	CLIP-seq
MIRT2030555	hsa-miR-23c	CLIP-seq
MIRT2261297	hsa-miR-3120-3p	CLIP-seq
MIRT2561288	hsa-miR-3130-3p	CLIP-seq
MIRT2561289	hsa-miR-3142	CLIP-seq
MIRT2561290	hsa-miR-3150a-3p	CLIP-seq
MIRT2561291	hsa-miR-3152-5p	CLIP-seq
MIRT2561292	hsa-miR-3156-3p	CLIP-seq
MIRT2561293	hsa-miR-3175	CLIP-seq
MIRT2261298	hsa-miR-3179	CLIP-seq
MIRT2030557	hsa-miR-338-5p	CLIP-seq
MIRT2561294	hsa-miR-3616-5p	CLIP-seq
MIRT2561295	hsa-miR-3647-5p	CLIP-seq
MIRT2261304	hsa-miR-3663-5p	CLIP-seq
MIRT2561296	hsa-miR-3907	CLIP-seq
MIRT2030559	hsa-miR-3909	CLIP-seq
MIRT2261311	hsa-miR-3913-3p	CLIP-seq
MIRT2261314	hsa-miR-4281	CLIP-seq
MIRT2561297	hsa-miR-4292	CLIP-seq
MIRT2561298	hsa-miR-4301	CLIP-seq
MIRT2561299	hsa-miR-4307	CLIP-seq
MIRT2561300	hsa-miR-4308	CLIP-seq
MIRT2561301	hsa-miR-4423-3p	CLIP-seq
MIRT2561302	hsa-miR-4446-5p	CLIP-seq
MIRT2261316	hsa-miR-4468	CLIP-seq
MIRT1109760	hsa-miR-4469	CLIP-seq
MIRT2561303	hsa-miR-4494	CLIP-seq
MIRT2561304	hsa-miR-4504	CLIP-seq
MIRT2261318	hsa-miR-4519	CLIP-seq
MIRT2561305	hsa-miR-4635	CLIP-seq
MIRT2261320	hsa-miR-4639-3p	CLIP-seq
MIRT2030564	hsa-miR-4645-3p	CLIP-seq
MIRT2561306	hsa-miR-4645-5p	CLIP-seq
MIRT2261321	hsa-miR-4659a-5p	CLIP-seq
MIRT2261322	hsa-miR-4659b-5p	CLIP-seq
MIRT2561307	hsa-miR-4662a-3p	CLIP-seq
MIRT2261323	hsa-miR-4667-5p	CLIP-seq
MIRT2561308	hsa-miR-4673	CLIP-seq
MIRT2030566	hsa-miR-4683	CLIP-seq
MIRT2030567	hsa-miR-4690-3p	CLIP-seq
MIRT1109767	hsa-miR-4691-5p	CLIP-seq
MIRT2561309	hsa-miR-4698	CLIP-seq
MIRT2261324	hsa-miR-4700-5p	CLIP-seq
MIRT2561310	hsa-miR-4715-3p	CLIP-seq
MIRT2030568	hsa-miR-4747-3p	CLIP-seq
MIRT2561311	hsa-miR-4755-5p	CLIP-seq
MIRT2261332	hsa-miR-4776-3p	CLIP-seq
MIRT2261333	hsa-miR-4786-3p	CLIP-seq
MIRT2261335	hsa-miR-4792	CLIP-seq
MIRT2261337	hsa-miR-489	CLIP-seq
MIRT2561312	hsa-miR-499a-5p	CLIP-seq
MIRT2561313	hsa-miR-542-3p	CLIP-seq
MIRT2561314	hsa-miR-548q	CLIP-seq
MIRT2561315	hsa-miR-573	CLIP-seq
MIRT2561316	hsa-miR-577	CLIP-seq
MIRT2030574	hsa-miR-620	CLIP-seq
MIRT2561317	hsa-miR-645	CLIP-seq
MIRT2030575	hsa-miR-649	CLIP-seq
MIRT2261341	hsa-miR-653	CLIP-seq
MIRT2561318	hsa-miR-670	CLIP-seq
MIRT2561319	hsa-miR-939	CLIP-seq
MIRT1109781	hsa-miR-1236	CLIP-seq
MIRT2561286	hsa-miR-1245b-5p	CLIP-seq
MIRT2030550	hsa-miR-1273d	CLIP-seq
MIRT2261288	hsa-miR-1273g	CLIP-seq
MIRT2261290	hsa-miR-140-5p	CLIP-seq
MIRT1109743	hsa-miR-188-3p	CLIP-seq
MIRT2561287	hsa-miR-1976	CLIP-seq
MIRT2030553	hsa-miR-23a	CLIP-seq
MIRT2030554	hsa-miR-23b	CLIP-seq
MIRT2030555	hsa-miR-23c	CLIP-seq
MIRT2261297	hsa-miR-3120-3p	CLIP-seq
MIRT2561288	hsa-miR-3130-3p	CLIP-seq
MIRT2561289	hsa-miR-3142	CLIP-seq
MIRT2561292	hsa-miR-3156-3p	CLIP-seq
MIRT2261298	hsa-miR-3179	CLIP-seq
MIRT2030557	hsa-miR-338-5p	CLIP-seq
MIRT2561294	hsa-miR-3616-5p	CLIP-seq
MIRT2561295	hsa-miR-3647-5p	CLIP-seq
MIRT2261304	hsa-miR-3663-5p	CLIP-seq
MIRT2030559	hsa-miR-3909	CLIP-seq
MIRT2261311	hsa-miR-3913-3p	CLIP-seq
MIRT2261314	hsa-miR-4281	CLIP-seq
MIRT2561298	hsa-miR-4301	CLIP-seq
MIRT2561299	hsa-miR-4307	CLIP-seq
MIRT2561301	hsa-miR-4423-3p	CLIP-seq
MIRT2261316	hsa-miR-4468	CLIP-seq
MIRT1109760	hsa-miR-4469	CLIP-seq
MIRT2561303	hsa-miR-4494	CLIP-seq
MIRT2561304	hsa-miR-4504	CLIP-seq
MIRT2261318	hsa-miR-4519	CLIP-seq
MIRT2561305	hsa-miR-4635	CLIP-seq
MIRT2261320	hsa-miR-4639-3p	CLIP-seq
MIRT2561306	hsa-miR-4645-5p	CLIP-seq
MIRT2261321	hsa-miR-4659a-5p	CLIP-seq
MIRT2261322	hsa-miR-4659b-5p	CLIP-seq
MIRT2561307	hsa-miR-4662a-3p	CLIP-seq
MIRT2561308	hsa-miR-4673	CLIP-seq
MIRT2030567	hsa-miR-4690-3p	CLIP-seq
MIRT1109767	hsa-miR-4691-5p	CLIP-seq
MIRT2561309	hsa-miR-4698	CLIP-seq
MIRT2561310	hsa-miR-4715-3p	CLIP-seq
MIRT2261332	hsa-miR-4776-3p	CLIP-seq
MIRT2261333	hsa-miR-4786-3p	CLIP-seq
MIRT2261335	hsa-miR-4792	CLIP-seq
MIRT2261337	hsa-miR-489	CLIP-seq
MIRT2561312	hsa-miR-499a-5p	CLIP-seq
MIRT2561313	hsa-miR-542-3p	CLIP-seq
MIRT2561315	hsa-miR-573	CLIP-seq
MIRT2561316	hsa-miR-577	CLIP-seq
MIRT2561317	hsa-miR-645	CLIP-seq
MIRT2261341	hsa-miR-653	CLIP-seq

Show/Hide all (34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	22328514
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	TAS	8537403
GO:0005515	Function	Protein binding	IPI	22328514, 22939624, 25036637, 32707033, 33961781, 35271311, 36931259
GO:0005524	Function	ATP binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	8954941
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	TAS	8537403, 8954941
GO:0005801	Component	Cis-Golgi network	IEA
GO:0005813	Component	Centrosome	IDA	25849865
GO:0005813	Component	Centrosome	IEA
GO:0005819	Component	Spindle	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0006468	Process	Protein phosphorylation	IDA	22328514
GO:0007283	Process	Spermatogenesis	IEA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030036	Process	Actin cytoskeleton organization	IBA
GO:0030953	Process	Astral microtubule organization	IDA	22328514
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0051650	Process	Establishment of vesicle localization	IMP	25849865
GO:0060322	Process	Head development	IEA
GO:0061303	Process	Cornea development in camera-type eye	IEA
GO:0072686	Component	Mitotic spindle	IDA	22328514
GO:0106310	Function	Protein serine kinase activity	IEA
GO:1900182	Process	Positive regulation of protein localization to nucleus	IMP	25849865
GO:1902018	Process	Negative regulation of cilium assembly	IMP	25849865

MIM	HGNC	e!Ensembl
601988	6614	ENSG00000182541

P53671

Protein name

LIM domain kinase 2 (LIMK-2) (EC 2.7.11.1)

Protein function

Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:1101

PDB

1X6A , 4TPT , 5NXD , 7QHG , 8GI4 , 8S3X , 8WSW

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00412	LIM	12 → 68	LIM domain	Domain
PF00412	LIM	72 → 128	LIM domain	Domain
PF00595	PDZ	152 → 236	PDZ domain	Domain
PF07714	PK_Tyr_Ser-Thr	331 → 601	Protein tyrosine and serine/threonine kinase	Domain

Sequence

MSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYC
PKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLY
CGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTV
QVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPV
SQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPK
EPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMK
ELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSM
DPFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNCLIKLDKTVVVADFGLSRLIVEER
KRAPMEKATTKKRTLRKNDRKKRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEII
GQVYADPDCLPRTLDFGLNVKLFWEKFVPTDCPPAFFPLAAICCRLEPESRPAFSKLEDS
FEALSLYLGELGIPLPAELEELDHTVSMQYGLTRDSPP

Sequence length

638

Interactions

View interactions

	KEGG
	Axon guidance Fc gamma R-mediated phagocytosis Regulation of actin cytoskeleton Human immunodeficiency virus 1 infection

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
DIABETIC NEPHROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEUROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIPHERAL NEUROPATHY	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (46)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Alzheimer Disease	Alzheimer disease	Pubtator	40074652	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Behcet Syndrome	Behcet Syndrome	BEFREE	26662719		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	30006972, 31695759		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	28581515		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	27116935	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	30006972, 31695759		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	35273591	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic kidney disease stage 5	Kidney Disease	BEFREE	21150874		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	BEFREE	23585469		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	23585469, 29970879		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	30296500	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cyclic neutropenia	Cyclic Neutropenia	BEFREE	31202856		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	24385048	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	24385048	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathies	Diabetic neuropathy	Pubtator	21150874	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Nephropathy	Diabetic Nephropathy	BEFREE	21150874		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Diabetic Nephropathy	Diabetic Nephropathy	GWASDB_DG	21150874		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Erectile dysfunction	Erectile Dysfunction	BEFREE	30870492		★★★★★ ★☆☆☆☆ Found in Text Mining only
Fibrosarcoma	Fibrosarcoma	BEFREE	15026997		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	25237832	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	31641031		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	31641031		★★★★★ ★☆☆☆☆ Found in Text Mining only
Infertility	Infertility	Pubtator	30365064	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	30594563		★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Diseases	Kidney disease	Pubtator	24551085	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Failure Chronic	Kidney failure	Pubtator	21150874, 24385048	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Failure, Chronic	Kidney Failure	BEFREE	21150874		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	28581515		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	20047470		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	30716360		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	30006972, 31695759		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	22492986, 23585469, 30716360		★★★★★ ★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome X	Metabolic Syndrome	BEFREE	26956845		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	15026997, 19881550, 20047470, 23585469, 30716360		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	19881550		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	Pubtator	23991158	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurofibromatosis 1	Neurofibromatosis	Pubtator	23082153	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurofibromatosis 2	Neurofibromatosis	BEFREE	23934191		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	31072327		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	28938584, 30886151		★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	Pubtator	29751634	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	20047470		★★★★★ ★☆☆☆☆ Found in Text Mining only
Peripheral Nervous System Diseases	Peripheral nervous system disease	Pubtator	36549768	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	30716360		★★★★★ ★☆☆☆☆ Found in Text Mining only
Small Cell Lung Carcinoma	Small cell lung carcinoma	Pubtator	37189142	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	36316865	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

LIMK2 (LIM domain kinase 2)