LGALS9 (galectin 9)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Entrez ID 3965
Gene name Galectin 9
Gene symbol LGALS9
Synonyms (NCBI Gene)
HUATLGALS9A
Chromosome 17
Chromosome location 17q11.2
Summary The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. The protein encoded by this gene is an S-type lectin. It is overexpressed in Hodgkin`s disease tissue and might participate in
miRNA miRNA information provided by mirtarbase database.
12
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide all (12)
miRTarBase ID miRNA Experiments Reference
MIRT017245 hsa-miR-335-5p Microarray 18185580
MIRT731478 hsa-miR-22-3p FlowLuciferase reporter assayqRT-PCRWestern blot 26239725
MIRT731478 hsa-miR-22-3p FlowLuciferase reporter assayqRT-PCRWestern blot 26239725
MIRT1108316 hsa-miR-3199 CLIP-seq
MIRT1108317 hsa-miR-3675-5p CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
1
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Show/Hide all (1)
Transcription factor Regulation Reference
HDAC3 Unknown 22027828
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
79
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0002376 Process Immune system process IEA
GO:0002519 Process Natural killer cell tolerance induction IMP 25578313
GO:0002826 Process Negative regulation of T-helper 1 type immune response IDA 16286920
GO:0002826 Process Negative regulation of T-helper 1 type immune response IDA 16286920
GO:0005515 Function Protein binding IPI 32296183
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
601879 6570 ENSG00000168961
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O00182
Protein name Galectin-9 (Gal-9) (Ecalectin) (Tumor antigen HOM-HD-21)
Protein function Binds galactosides (PubMed:18005988). Has high affinity for the Forssman pentasaccharide (PubMed:18005988). Ligand for HAVCR2/TIM3 (PubMed:16286920). Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death (PubMed:16286920). Also stimul
PDB 2EAK , 2EAL , 2YY1 , 2ZHK , 2ZHL , 2ZHM , 2ZHN , 3LSD , 3LSE , 3NV1 , 3NV2 , 3NV3 , 3NV4 , 3WLU , 3WV6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00337 Gal-bind_lectin 16 → 147 Galactoside-binding lectin Domain
PF00337 Gal-bind_lectin 226 → 355 Galactoside-binding lectin Domain
Tissue specificity TISSUE SPECIFICITY: Peripheral blood leukocytes and lymphatic tissues. Expressed in lung, liver, breast and kidney with higher levels in tumor endothelial cells than normal endothelium (at protein level) (PubMed:24333696). Expressed in trophoblast cells i
Sequence
Sequence length 355
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
4
Gene miRNA Transcription factors Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (4)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
AUTISM SPECTRUM DISORDERS — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
EPILEPSY — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
SQUAMOUS CELL LUNG CARCINOMA — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (200)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma Of Esophagus Esophageal Cancer BEFREE 28586026
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma, Clear Cell Adenocarcinoma BEFREE 24895689
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult Hodgkin Lymphoma Hodgkin Lymphoma BEFREE 18503581
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult T-Cell Lymphoma/Leukemia T-Cell Lymphoma/Leukemia BEFREE 17278100, 28321034
★★★★★
★☆☆☆☆
Found in Text Mining only
Antiphospholipid Syndrome Antiphospholipid Syndrome BEFREE 30185417
★★★★★
★☆☆☆☆
Found in Text Mining only
Aplastic Anemia Aplastic anemia LHGDN 18485114
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Arthritis BEFREE 29433546, 29481735
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 30150656, 31600237, 33692448 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Arthritis Rheumatoid Rheumatoid arthritis Pubtator 31430907, 37470226 Stimulate
★★★★★
★☆☆☆☆
Found in Text Mining only
Asthma Asthma BEFREE 17541286, 23121677, 24315451, 28990062
★★★★★
★☆☆☆☆
Found in Text Mining only