Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	3954
Gene name	Leucine zipper and EF-hand containing transmembrane protein 1
Gene symbol	LETM1
Synonyms (NCBI Gene)	CONDMIMKHEMdm38SLC55A1
Chromosome	4
Chromosome location	4p16.3
Summary	This gene encodes a protein that is localized to the inner mitochondrial membrane. The protein functions to maintain the mitochondrial tubular shapes and is required for normal mitochondrial morphology and cellular viability. Mutations in this gene cause

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miRTarBase ID	miRNA	Experiments	Reference
MIRT016307	hsa-miR-193b-3p	Proteomics	21512034
MIRT023539	hsa-miR-1-3p	Proteomics	18668040
MIRT028844	hsa-miR-26b-5p	Microarray	19088304
MIRT043486	hsa-miR-331-3p	CLASH	23622248
MIRT041761	hsa-miR-484	CLASH	23622248
MIRT041761	hsa-miR-484	CLASH	23622248
MIRT037046	hsa-miR-877-3p	CLASH	23622248
MIRT551576	hsa-miR-122-3p	PAR-CLIP	21572407
MIRT551575	hsa-miR-508-5p	PAR-CLIP	21572407
MIRT551574	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT551573	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT551572	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT551571	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT551570	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT551569	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT551567	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT551568	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT551566	hsa-miR-3192-5p	PAR-CLIP	21572407
MIRT551565	hsa-miR-4524a-3p	PAR-CLIP	21572407
MIRT551564	hsa-miR-661	PAR-CLIP	21572407
MIRT551562	hsa-miR-6878-5p	PAR-CLIP	21572407
MIRT551563	hsa-miR-6731-5p	PAR-CLIP	21572407
MIRT551561	hsa-miR-8085	PAR-CLIP	21572407
MIRT551560	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT551559	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT551558	hsa-miR-7703	PAR-CLIP	21572407
MIRT551557	hsa-miR-4325	PAR-CLIP	21572407
MIRT551556	hsa-miR-30c-1-3p	PAR-CLIP	21572407
MIRT551555	hsa-miR-30c-2-3p	PAR-CLIP	21572407
MIRT551554	hsa-miR-6788-5p	PAR-CLIP	21572407
MIRT551567	hsa-miR-6849-3p	PAR-CLIP	27292025
MIRT551575	hsa-miR-508-5p	HITS-CLIP	27418678
MIRT551575	hsa-miR-508-5p	HITS-CLIP	27418678
MIRT551560	hsa-miR-6512-3p	HITS-CLIP	27418678
MIRT551560	hsa-miR-6512-3p	HITS-CLIP	27418678
MIRT551564	hsa-miR-661	HITS-CLIP	27418678
MIRT551564	hsa-miR-661	HITS-CLIP	27418678
MIRT551559	hsa-miR-6720-5p	HITS-CLIP	27418678
MIRT551559	hsa-miR-6720-5p	HITS-CLIP	27418678
MIRT551567	hsa-miR-6849-3p	HITS-CLIP	27418678
MIRT551568	hsa-miR-766-3p	HITS-CLIP	27418678
MIRT551568	hsa-miR-766-3p	HITS-CLIP	27418678
MIRT551558	hsa-miR-7703	HITS-CLIP	27418678
MIRT551558	hsa-miR-7703	HITS-CLIP	27418678
MIRT551576	hsa-miR-122-3p	PAR-CLIP	21572407
MIRT551575	hsa-miR-508-5p	PAR-CLIP	21572407
MIRT551574	hsa-miR-25-3p	PAR-CLIP	21572407
MIRT551573	hsa-miR-32-5p	PAR-CLIP	21572407
MIRT551572	hsa-miR-363-3p	PAR-CLIP	21572407
MIRT551571	hsa-miR-367-3p	PAR-CLIP	21572407
MIRT551570	hsa-miR-92a-3p	PAR-CLIP	21572407
MIRT551569	hsa-miR-92b-3p	PAR-CLIP	21572407
MIRT551567	hsa-miR-6849-3p	PAR-CLIP	21572407
MIRT551568	hsa-miR-766-3p	PAR-CLIP	21572407
MIRT551566	hsa-miR-3192-5p	PAR-CLIP	21572407
MIRT551565	hsa-miR-4524a-3p	PAR-CLIP	21572407
MIRT551564	hsa-miR-661	PAR-CLIP	21572407
MIRT551562	hsa-miR-6878-5p	PAR-CLIP	21572407
MIRT551563	hsa-miR-6731-5p	PAR-CLIP	21572407
MIRT551561	hsa-miR-8085	PAR-CLIP	21572407
MIRT551560	hsa-miR-6512-3p	PAR-CLIP	21572407
MIRT551559	hsa-miR-6720-5p	PAR-CLIP	21572407
MIRT551558	hsa-miR-7703	PAR-CLIP	21572407
MIRT551557	hsa-miR-4325	PAR-CLIP	21572407
MIRT551556	hsa-miR-30c-1-3p	PAR-CLIP	21572407
MIRT551555	hsa-miR-30c-2-3p	PAR-CLIP	21572407
MIRT551554	hsa-miR-6788-5p	PAR-CLIP	21572407
MIRT1107887	hsa-miR-1182	CLIP-seq
MIRT1107888	hsa-miR-125a-5p	CLIP-seq
MIRT1107889	hsa-miR-125b	CLIP-seq
MIRT1107890	hsa-miR-1275	CLIP-seq
MIRT1107891	hsa-miR-1276	CLIP-seq
MIRT1107892	hsa-miR-128	CLIP-seq
MIRT1107893	hsa-miR-1285	CLIP-seq
MIRT1107894	hsa-miR-1291	CLIP-seq
MIRT1107895	hsa-miR-1299	CLIP-seq
MIRT1107896	hsa-miR-1324	CLIP-seq
MIRT1107897	hsa-miR-140-3p	CLIP-seq
MIRT1107898	hsa-miR-1972	CLIP-seq
MIRT1107899	hsa-miR-21	CLIP-seq
MIRT1107900	hsa-miR-219-1-3p	CLIP-seq
MIRT1107901	hsa-miR-24	CLIP-seq
MIRT1107902	hsa-miR-25	CLIP-seq
MIRT1107903	hsa-miR-298	CLIP-seq
MIRT1107904	hsa-miR-299-5p	CLIP-seq
MIRT1107905	hsa-miR-3121-3p	CLIP-seq
MIRT1107906	hsa-miR-3123	CLIP-seq
MIRT1107907	hsa-miR-3140-5p	CLIP-seq
MIRT1107908	hsa-miR-3157-5p	CLIP-seq
MIRT1107909	hsa-miR-3165	CLIP-seq
MIRT1107910	hsa-miR-3169	CLIP-seq
MIRT1107911	hsa-miR-3174	CLIP-seq
MIRT1107912	hsa-miR-3176	CLIP-seq
MIRT1107913	hsa-miR-3178	CLIP-seq
MIRT1107914	hsa-miR-3180-5p	CLIP-seq
MIRT1107915	hsa-miR-3187-5p	CLIP-seq
MIRT1107916	hsa-miR-3197	CLIP-seq
MIRT1107917	hsa-miR-32	CLIP-seq
MIRT1107918	hsa-miR-328	CLIP-seq
MIRT1107919	hsa-miR-34a	CLIP-seq
MIRT1107920	hsa-miR-34c-5p	CLIP-seq
MIRT1107921	hsa-miR-3609	CLIP-seq
MIRT1107922	hsa-miR-3612	CLIP-seq
MIRT1107923	hsa-miR-3622a-3p	CLIP-seq
MIRT1107924	hsa-miR-3622b-3p	CLIP-seq
MIRT1107925	hsa-miR-3622b-5p	CLIP-seq
MIRT1107926	hsa-miR-363	CLIP-seq
MIRT1107927	hsa-miR-3653	CLIP-seq
MIRT1107928	hsa-miR-3656	CLIP-seq
MIRT1107929	hsa-miR-3658	CLIP-seq
MIRT1107930	hsa-miR-3664-3p	CLIP-seq
MIRT1107931	hsa-miR-3665	CLIP-seq
MIRT1107932	hsa-miR-367	CLIP-seq
MIRT1107933	hsa-miR-3689d	CLIP-seq
MIRT1107934	hsa-miR-3691-5p	CLIP-seq
MIRT1107935	hsa-miR-376c	CLIP-seq
MIRT1107936	hsa-miR-3911	CLIP-seq
MIRT1107937	hsa-miR-3922-3p	CLIP-seq
MIRT1107938	hsa-miR-3925-5p	CLIP-seq
MIRT1107939	hsa-miR-3929	CLIP-seq
MIRT1107940	hsa-miR-3934	CLIP-seq
MIRT1107941	hsa-miR-3941	CLIP-seq
MIRT1107942	hsa-miR-3945	CLIP-seq
MIRT1107943	hsa-miR-3974	CLIP-seq
MIRT1107944	hsa-miR-3976	CLIP-seq
MIRT1107945	hsa-miR-421	CLIP-seq
MIRT1107946	hsa-miR-4251	CLIP-seq
MIRT1107947	hsa-miR-4252	CLIP-seq
MIRT1107948	hsa-miR-4253	CLIP-seq
MIRT1107949	hsa-miR-4275	CLIP-seq
MIRT1107950	hsa-miR-4284	CLIP-seq
MIRT1107951	hsa-miR-4292	CLIP-seq
MIRT1107952	hsa-miR-4302	CLIP-seq
MIRT1107953	hsa-miR-4319	CLIP-seq
MIRT1107954	hsa-miR-4327	CLIP-seq
MIRT1107955	hsa-miR-4419b	CLIP-seq
MIRT1107956	hsa-miR-4433	CLIP-seq
MIRT1107957	hsa-miR-4436a	CLIP-seq
MIRT1107958	hsa-miR-4443	CLIP-seq
MIRT1107959	hsa-miR-4459	CLIP-seq
MIRT1107960	hsa-miR-4478	CLIP-seq
MIRT1107961	hsa-miR-4487	CLIP-seq
MIRT1107962	hsa-miR-4497	CLIP-seq
MIRT1107963	hsa-miR-449a	CLIP-seq
MIRT1107964	hsa-miR-449b	CLIP-seq
MIRT1107965	hsa-miR-452	CLIP-seq
MIRT1107966	hsa-miR-4525	CLIP-seq
MIRT1107967	hsa-miR-4537	CLIP-seq
MIRT1107968	hsa-miR-4633-3p	CLIP-seq
MIRT1107969	hsa-miR-4649-3p	CLIP-seq
MIRT1107970	hsa-miR-4650-5p	CLIP-seq
MIRT1107971	hsa-miR-466	CLIP-seq
MIRT1107972	hsa-miR-4665-5p	CLIP-seq
MIRT1107973	hsa-miR-4672	CLIP-seq
MIRT1107974	hsa-miR-4676-3p	CLIP-seq
MIRT1107975	hsa-miR-4690-3p	CLIP-seq
MIRT1107976	hsa-miR-4691-3p	CLIP-seq
MIRT1107977	hsa-miR-4695-5p	CLIP-seq
MIRT1107978	hsa-miR-4709-5p	CLIP-seq
MIRT1107979	hsa-miR-4723-5p	CLIP-seq
MIRT1107980	hsa-miR-4731-3p	CLIP-seq
MIRT1107981	hsa-miR-4733-5p	CLIP-seq
MIRT1107982	hsa-miR-4736	CLIP-seq
MIRT1107983	hsa-miR-4752	CLIP-seq
MIRT1107984	hsa-miR-4753-5p	CLIP-seq
MIRT1107985	hsa-miR-4766-5p	CLIP-seq
MIRT1107986	hsa-miR-4768-3p	CLIP-seq
MIRT1107987	hsa-miR-4778-5p	CLIP-seq
MIRT1107988	hsa-miR-4786-3p	CLIP-seq
MIRT1107989	hsa-miR-4786-5p	CLIP-seq
MIRT1107990	hsa-miR-4793-5p	CLIP-seq
MIRT1107991	hsa-miR-4794	CLIP-seq
MIRT1107992	hsa-miR-4801	CLIP-seq
MIRT1107993	hsa-miR-4802-5p	CLIP-seq
MIRT1107994	hsa-miR-485-5p	CLIP-seq
MIRT1107995	hsa-miR-505	CLIP-seq
MIRT1107996	hsa-miR-510	CLIP-seq
MIRT1107997	hsa-miR-512-5p	CLIP-seq
MIRT1107998	hsa-miR-520a-5p	CLIP-seq
MIRT1107999	hsa-miR-520d-5p	CLIP-seq
MIRT1108000	hsa-miR-520f	CLIP-seq
MIRT1108001	hsa-miR-524-5p	CLIP-seq
MIRT1108002	hsa-miR-525-5p	CLIP-seq
MIRT1108003	hsa-miR-544b	CLIP-seq
MIRT1108004	hsa-miR-548ah	CLIP-seq
MIRT1108005	hsa-miR-548t	CLIP-seq
MIRT1108006	hsa-miR-556-3p	CLIP-seq
MIRT1108007	hsa-miR-580	CLIP-seq
MIRT1108008	hsa-miR-590-5p	CLIP-seq
MIRT1108009	hsa-miR-612	CLIP-seq
MIRT1108010	hsa-miR-625	CLIP-seq
MIRT1108011	hsa-miR-637	CLIP-seq
MIRT1108012	hsa-miR-650	CLIP-seq
MIRT1108013	hsa-miR-671-5p	CLIP-seq
MIRT1108014	hsa-miR-766	CLIP-seq
MIRT1108015	hsa-miR-875-3p	CLIP-seq
MIRT1108016	hsa-miR-92a	CLIP-seq
MIRT1108017	hsa-miR-92b	CLIP-seq
MIRT1550726	hsa-miR-3689a-3p	CLIP-seq
MIRT1550727	hsa-miR-3689c	CLIP-seq
MIRT1550728	hsa-miR-4728-5p	CLIP-seq
MIRT2029855	hsa-miR-1184	CLIP-seq
MIRT2029856	hsa-miR-1200	CLIP-seq
MIRT2029857	hsa-miR-1225-3p	CLIP-seq
MIRT2029858	hsa-miR-1227	CLIP-seq
MIRT1107888	hsa-miR-125a-5p	CLIP-seq
MIRT1107889	hsa-miR-125b	CLIP-seq
MIRT1107892	hsa-miR-128	CLIP-seq
MIRT1107893	hsa-miR-1285	CLIP-seq
MIRT2029859	hsa-miR-1286	CLIP-seq
MIRT2029860	hsa-miR-1289	CLIP-seq
MIRT2029861	hsa-miR-147	CLIP-seq
MIRT1107898	hsa-miR-1972	CLIP-seq
MIRT2029862	hsa-miR-1976	CLIP-seq
MIRT2029863	hsa-miR-214	CLIP-seq
MIRT1107900	hsa-miR-219-1-3p	CLIP-seq
MIRT2029864	hsa-miR-2392	CLIP-seq
MIRT1107901	hsa-miR-24	CLIP-seq
MIRT1107903	hsa-miR-298	CLIP-seq
MIRT1107904	hsa-miR-299-5p	CLIP-seq
MIRT2029865	hsa-miR-3064-3p	CLIP-seq
MIRT2029866	hsa-miR-3117-5p	CLIP-seq
MIRT2029867	hsa-miR-3122	CLIP-seq
MIRT1107907	hsa-miR-3140-5p	CLIP-seq
MIRT2029868	hsa-miR-3150b-3p	CLIP-seq
MIRT1107908	hsa-miR-3157-5p	CLIP-seq
MIRT2029869	hsa-miR-3158-5p	CLIP-seq
MIRT1107909	hsa-miR-3165	CLIP-seq
MIRT1107913	hsa-miR-3178	CLIP-seq
MIRT1107915	hsa-miR-3187-5p	CLIP-seq
MIRT2029870	hsa-miR-3193	CLIP-seq
MIRT1107916	hsa-miR-3197	CLIP-seq
MIRT2029871	hsa-miR-337-3p	CLIP-seq
MIRT2029872	hsa-miR-3605-5p	CLIP-seq
MIRT1107922	hsa-miR-3612	CLIP-seq
MIRT2029873	hsa-miR-3619-5p	CLIP-seq
MIRT1107923	hsa-miR-3622a-3p	CLIP-seq
MIRT1107924	hsa-miR-3622b-3p	CLIP-seq
MIRT1107928	hsa-miR-3656	CLIP-seq
MIRT1550726	hsa-miR-3689a-3p	CLIP-seq
MIRT1550727	hsa-miR-3689c	CLIP-seq
MIRT1107933	hsa-miR-3689d	CLIP-seq
MIRT1107936	hsa-miR-3911	CLIP-seq
MIRT2029874	hsa-miR-3913-5p	CLIP-seq
MIRT2029875	hsa-miR-3920	CLIP-seq
MIRT1107939	hsa-miR-3929	CLIP-seq
MIRT2029876	hsa-miR-3943	CLIP-seq
MIRT2029877	hsa-miR-3944-5p	CLIP-seq
MIRT2029878	hsa-miR-4265	CLIP-seq
MIRT2029879	hsa-miR-4267	CLIP-seq
MIRT1107950	hsa-miR-4284	CLIP-seq
MIRT2029880	hsa-miR-4294	CLIP-seq
MIRT2029881	hsa-miR-4296	CLIP-seq
MIRT1107953	hsa-miR-4319	CLIP-seq
MIRT2029882	hsa-miR-4322	CLIP-seq
MIRT2029883	hsa-miR-4323	CLIP-seq
MIRT2029884	hsa-miR-4326	CLIP-seq
MIRT1107954	hsa-miR-4327	CLIP-seq
MIRT2029885	hsa-miR-4417	CLIP-seq
MIRT2029886	hsa-miR-4418	CLIP-seq
MIRT1107955	hsa-miR-4419b	CLIP-seq
MIRT1107956	hsa-miR-4433	CLIP-seq
MIRT1107957	hsa-miR-4436a	CLIP-seq
MIRT1107958	hsa-miR-4443	CLIP-seq
MIRT1107959	hsa-miR-4459	CLIP-seq
MIRT2029887	hsa-miR-4461	CLIP-seq
MIRT1107960	hsa-miR-4478	CLIP-seq
MIRT2029888	hsa-miR-4505	CLIP-seq
MIRT2029889	hsa-miR-4534	CLIP-seq
MIRT1107967	hsa-miR-4537	CLIP-seq
MIRT2029890	hsa-miR-4540	CLIP-seq
MIRT1107968	hsa-miR-4633-3p	CLIP-seq
MIRT1107969	hsa-miR-4649-3p	CLIP-seq
MIRT1107970	hsa-miR-4650-5p	CLIP-seq
MIRT2029891	hsa-miR-4689	CLIP-seq
MIRT1107975	hsa-miR-4690-3p	CLIP-seq
MIRT1107977	hsa-miR-4695-5p	CLIP-seq
MIRT2029892	hsa-miR-4700-3p	CLIP-seq
MIRT2029893	hsa-miR-4711-3p	CLIP-seq
MIRT1550728	hsa-miR-4728-5p	CLIP-seq
MIRT2029894	hsa-miR-4755-3p	CLIP-seq
MIRT2029895	hsa-miR-4758-3p	CLIP-seq
MIRT2029896	hsa-miR-4761-5p	CLIP-seq
MIRT1107985	hsa-miR-4766-5p	CLIP-seq
MIRT1107986	hsa-miR-4768-3p	CLIP-seq
MIRT2029897	hsa-miR-4784	CLIP-seq
MIRT1107991	hsa-miR-4794	CLIP-seq
MIRT1107993	hsa-miR-4802-5p	CLIP-seq
MIRT1107994	hsa-miR-485-5p	CLIP-seq
MIRT2029898	hsa-miR-509-3-5p	CLIP-seq
MIRT2029899	hsa-miR-509-5p	CLIP-seq
MIRT2029900	hsa-miR-516b	CLIP-seq
MIRT2029901	hsa-miR-539	CLIP-seq
MIRT1108003	hsa-miR-544b	CLIP-seq
MIRT1108007	hsa-miR-580	CLIP-seq
MIRT2029902	hsa-miR-595	CLIP-seq
MIRT1108009	hsa-miR-612	CLIP-seq
MIRT2029903	hsa-miR-642b	CLIP-seq
MIRT2029904	hsa-miR-644	CLIP-seq
MIRT2029905	hsa-miR-648	CLIP-seq
MIRT1108012	hsa-miR-650	CLIP-seq
MIRT2029906	hsa-miR-7	CLIP-seq
MIRT2029907	hsa-miR-761	CLIP-seq
MIRT1108014	hsa-miR-766	CLIP-seq
MIRT2260720	hsa-miR-1197	CLIP-seq
MIRT2029858	hsa-miR-1227	CLIP-seq
MIRT2260721	hsa-miR-1231	CLIP-seq
MIRT2260722	hsa-miR-1245b-3p	CLIP-seq
MIRT2260723	hsa-miR-1256	CLIP-seq
MIRT1107893	hsa-miR-1285	CLIP-seq
MIRT2029859	hsa-miR-1286	CLIP-seq
MIRT2029860	hsa-miR-1289	CLIP-seq
MIRT1107895	hsa-miR-1299	CLIP-seq
MIRT2260724	hsa-miR-141	CLIP-seq
MIRT2260725	hsa-miR-1587	CLIP-seq
MIRT2260726	hsa-miR-1912	CLIP-seq
MIRT1107898	hsa-miR-1972	CLIP-seq
MIRT2260727	hsa-miR-200a	CLIP-seq
MIRT1107900	hsa-miR-219-1-3p	CLIP-seq
MIRT2260728	hsa-miR-2276	CLIP-seq
MIRT2029864	hsa-miR-2392	CLIP-seq
MIRT1107901	hsa-miR-24	CLIP-seq
MIRT2260729	hsa-miR-2467-3p	CLIP-seq
MIRT1107902	hsa-miR-25	CLIP-seq
MIRT1107903	hsa-miR-298	CLIP-seq
MIRT2029865	hsa-miR-3064-3p	CLIP-seq
MIRT2029866	hsa-miR-3117-5p	CLIP-seq
MIRT2029867	hsa-miR-3122	CLIP-seq
MIRT1107906	hsa-miR-3123	CLIP-seq
MIRT1107907	hsa-miR-3140-5p	CLIP-seq
MIRT2029869	hsa-miR-3158-5p	CLIP-seq
MIRT1107909	hsa-miR-3165	CLIP-seq
MIRT1107913	hsa-miR-3178	CLIP-seq
MIRT1107915	hsa-miR-3187-5p	CLIP-seq
MIRT2260730	hsa-miR-3192	CLIP-seq
MIRT1107916	hsa-miR-3197	CLIP-seq
MIRT1107917	hsa-miR-32	CLIP-seq
MIRT2260731	hsa-miR-320a	CLIP-seq
MIRT2260732	hsa-miR-320b	CLIP-seq
MIRT2260733	hsa-miR-320c	CLIP-seq
MIRT2260734	hsa-miR-320d	CLIP-seq
MIRT1107919	hsa-miR-34a	CLIP-seq
MIRT1107920	hsa-miR-34c-5p	CLIP-seq
MIRT2029872	hsa-miR-3605-5p	CLIP-seq
MIRT1107923	hsa-miR-3622a-3p	CLIP-seq
MIRT1107924	hsa-miR-3622b-3p	CLIP-seq
MIRT1107926	hsa-miR-363	CLIP-seq
MIRT1107928	hsa-miR-3656	CLIP-seq
MIRT1107930	hsa-miR-3664-3p	CLIP-seq
MIRT1107932	hsa-miR-367	CLIP-seq
MIRT1550726	hsa-miR-3689a-3p	CLIP-seq
MIRT1550727	hsa-miR-3689c	CLIP-seq
MIRT1107933	hsa-miR-3689d	CLIP-seq
MIRT1107935	hsa-miR-376c	CLIP-seq
MIRT1107936	hsa-miR-3911	CLIP-seq
MIRT2029874	hsa-miR-3913-5p	CLIP-seq
MIRT1107938	hsa-miR-3925-5p	CLIP-seq
MIRT1107939	hsa-miR-3929	CLIP-seq
MIRT1107940	hsa-miR-3934	CLIP-seq
MIRT2029877	hsa-miR-3944-5p	CLIP-seq
MIRT1107943	hsa-miR-3974	CLIP-seq
MIRT1107944	hsa-miR-3976	CLIP-seq
MIRT1107948	hsa-miR-4253	CLIP-seq
MIRT1107949	hsa-miR-4275	CLIP-seq
MIRT1107950	hsa-miR-4284	CLIP-seq
MIRT2260735	hsa-miR-4288	CLIP-seq
MIRT2029880	hsa-miR-4294	CLIP-seq
MIRT1107954	hsa-miR-4327	CLIP-seq
MIRT2029886	hsa-miR-4418	CLIP-seq
MIRT1107955	hsa-miR-4419b	CLIP-seq
MIRT2260736	hsa-miR-4429	CLIP-seq
MIRT1107956	hsa-miR-4433	CLIP-seq
MIRT1107957	hsa-miR-4436a	CLIP-seq
MIRT2260737	hsa-miR-4436b-3p	CLIP-seq
MIRT1107959	hsa-miR-4459	CLIP-seq
MIRT1107960	hsa-miR-4478	CLIP-seq
MIRT2260738	hsa-miR-4492	CLIP-seq
MIRT2260739	hsa-miR-4498	CLIP-seq
MIRT1107963	hsa-miR-449a	CLIP-seq
MIRT1107964	hsa-miR-449b	CLIP-seq
MIRT2029888	hsa-miR-4505	CLIP-seq
MIRT2029889	hsa-miR-4534	CLIP-seq
MIRT1107967	hsa-miR-4537	CLIP-seq
MIRT2029890	hsa-miR-4540	CLIP-seq
MIRT1107968	hsa-miR-4633-3p	CLIP-seq
MIRT1107969	hsa-miR-4649-3p	CLIP-seq
MIRT1107970	hsa-miR-4650-5p	CLIP-seq
MIRT2260740	hsa-miR-4654	CLIP-seq
MIRT2260741	hsa-miR-4656	CLIP-seq
MIRT2260742	hsa-miR-4675	CLIP-seq
MIRT2260743	hsa-miR-4682	CLIP-seq
MIRT2260744	hsa-miR-4683	CLIP-seq
MIRT2260745	hsa-miR-4684-3p	CLIP-seq
MIRT2260746	hsa-miR-4685-5p	CLIP-seq
MIRT2260747	hsa-miR-4687-3p	CLIP-seq
MIRT2260748	hsa-miR-4693-3p	CLIP-seq
MIRT1107977	hsa-miR-4695-5p	CLIP-seq
MIRT2260749	hsa-miR-4696	CLIP-seq
MIRT2029892	hsa-miR-4700-3p	CLIP-seq
MIRT1550728	hsa-miR-4728-5p	CLIP-seq
MIRT2260750	hsa-miR-4741	CLIP-seq
MIRT2029894	hsa-miR-4755-3p	CLIP-seq
MIRT1107985	hsa-miR-4766-5p	CLIP-seq
MIRT1107986	hsa-miR-4768-3p	CLIP-seq
MIRT2260751	hsa-miR-4769-5p	CLIP-seq
MIRT1107988	hsa-miR-4786-3p	CLIP-seq
MIRT1107989	hsa-miR-4786-5p	CLIP-seq
MIRT1107990	hsa-miR-4793-5p	CLIP-seq
MIRT1107991	hsa-miR-4794	CLIP-seq
MIRT1107993	hsa-miR-4802-5p	CLIP-seq
MIRT1107994	hsa-miR-485-5p	CLIP-seq
MIRT2029898	hsa-miR-509-3-5p	CLIP-seq
MIRT2029899	hsa-miR-509-5p	CLIP-seq
MIRT1107996	hsa-miR-510	CLIP-seq
MIRT1107997	hsa-miR-512-5p	CLIP-seq
MIRT2260752	hsa-miR-513c	CLIP-seq
MIRT2260753	hsa-miR-514b-5p	CLIP-seq
MIRT1107998	hsa-miR-520a-5p	CLIP-seq
MIRT1108002	hsa-miR-525-5p	CLIP-seq
MIRT1108003	hsa-miR-544b	CLIP-seq
MIRT2029902	hsa-miR-595	CLIP-seq
MIRT1108009	hsa-miR-612	CLIP-seq
MIRT2260754	hsa-miR-632	CLIP-seq
MIRT2260755	hsa-miR-636	CLIP-seq
MIRT2029905	hsa-miR-648	CLIP-seq
MIRT2260756	hsa-miR-658	CLIP-seq
MIRT1108013	hsa-miR-671-5p	CLIP-seq
MIRT2029906	hsa-miR-7	CLIP-seq
MIRT2260757	hsa-miR-762	CLIP-seq
MIRT1108014	hsa-miR-766	CLIP-seq
MIRT1108015	hsa-miR-875-3p	CLIP-seq
MIRT1108016	hsa-miR-92a	CLIP-seq
MIRT1108017	hsa-miR-92b	CLIP-seq
MIRT2390088	hsa-miR-1202	CLIP-seq
MIRT2029862	hsa-miR-1976	CLIP-seq
MIRT2029867	hsa-miR-3122	CLIP-seq
MIRT1107909	hsa-miR-3165	CLIP-seq
MIRT1107916	hsa-miR-3197	CLIP-seq
MIRT1107923	hsa-miR-3622a-3p	CLIP-seq
MIRT1107924	hsa-miR-3622b-3p	CLIP-seq
MIRT1107928	hsa-miR-3656	CLIP-seq
MIRT1550726	hsa-miR-3689a-3p	CLIP-seq
MIRT1550727	hsa-miR-3689c	CLIP-seq
MIRT2029874	hsa-miR-3913-5p	CLIP-seq
MIRT1107939	hsa-miR-3929	CLIP-seq
MIRT2390089	hsa-miR-3972	CLIP-seq
MIRT1107950	hsa-miR-4284	CLIP-seq
MIRT1107955	hsa-miR-4419b	CLIP-seq
MIRT1107956	hsa-miR-4433	CLIP-seq
MIRT1107959	hsa-miR-4459	CLIP-seq
MIRT1107960	hsa-miR-4478	CLIP-seq
MIRT1107969	hsa-miR-4649-3p	CLIP-seq
MIRT1107975	hsa-miR-4690-3p	CLIP-seq
MIRT2390090	hsa-miR-4722-3p	CLIP-seq
MIRT1550728	hsa-miR-4728-5p	CLIP-seq
MIRT2029894	hsa-miR-4755-3p	CLIP-seq
MIRT1107986	hsa-miR-4768-3p	CLIP-seq
MIRT1107991	hsa-miR-4794	CLIP-seq
MIRT1107994	hsa-miR-485-5p	CLIP-seq
MIRT1108003	hsa-miR-544b	CLIP-seq
MIRT2438334	hsa-miR-1343	CLIP-seq
MIRT2438335	hsa-miR-1914	CLIP-seq
MIRT2438336	hsa-miR-3690	CLIP-seq
MIRT2438337	hsa-miR-4254	CLIP-seq
MIRT2438338	hsa-miR-4421	CLIP-seq
MIRT2029867	hsa-miR-3122	CLIP-seq
MIRT1107909	hsa-miR-3165	CLIP-seq
MIRT1107916	hsa-miR-3197	CLIP-seq
MIRT1107923	hsa-miR-3622a-3p	CLIP-seq
MIRT1107924	hsa-miR-3622b-3p	CLIP-seq
MIRT1107928	hsa-miR-3656	CLIP-seq
MIRT1550726	hsa-miR-3689a-3p	CLIP-seq
MIRT1550727	hsa-miR-3689c	CLIP-seq
MIRT2029874	hsa-miR-3913-5p	CLIP-seq
MIRT1107939	hsa-miR-3929	CLIP-seq
MIRT1107955	hsa-miR-4419b	CLIP-seq
MIRT1107960	hsa-miR-4478	CLIP-seq
MIRT1107969	hsa-miR-4649-3p	CLIP-seq
MIRT1550728	hsa-miR-4728-5p	CLIP-seq
MIRT1107994	hsa-miR-485-5p	CLIP-seq
MIRT1108003	hsa-miR-544b	CLIP-seq
MIRT2029856	hsa-miR-1200	CLIP-seq
MIRT2560733	hsa-miR-1252	CLIP-seq
MIRT1107893	hsa-miR-1285	CLIP-seq
MIRT2260724	hsa-miR-141	CLIP-seq
MIRT2560734	hsa-miR-1908	CLIP-seq
MIRT1107898	hsa-miR-1972	CLIP-seq
MIRT2029862	hsa-miR-1976	CLIP-seq
MIRT2260727	hsa-miR-200a	CLIP-seq
MIRT1107900	hsa-miR-219-1-3p	CLIP-seq
MIRT2560735	hsa-miR-2355-5p	CLIP-seq
MIRT1107901	hsa-miR-24	CLIP-seq
MIRT1107902	hsa-miR-25	CLIP-seq
MIRT1107903	hsa-miR-298	CLIP-seq
MIRT2029866	hsa-miR-3117-5p	CLIP-seq
MIRT2560736	hsa-miR-3120-5p	CLIP-seq
MIRT2029867	hsa-miR-3122	CLIP-seq
MIRT1107907	hsa-miR-3140-5p	CLIP-seq
MIRT2029869	hsa-miR-3158-5p	CLIP-seq
MIRT1107909	hsa-miR-3165	CLIP-seq
MIRT1107913	hsa-miR-3178	CLIP-seq
MIRT1107915	hsa-miR-3187-5p	CLIP-seq
MIRT2260730	hsa-miR-3192	CLIP-seq
MIRT2029870	hsa-miR-3193	CLIP-seq
MIRT1107916	hsa-miR-3197	CLIP-seq
MIRT1107917	hsa-miR-32	CLIP-seq
MIRT1107919	hsa-miR-34a	CLIP-seq
MIRT1107920	hsa-miR-34c-5p	CLIP-seq
MIRT2560737	hsa-miR-3613-3p	CLIP-seq
MIRT1107923	hsa-miR-3622a-3p	CLIP-seq
MIRT1107924	hsa-miR-3622b-3p	CLIP-seq
MIRT1107926	hsa-miR-363	CLIP-seq
MIRT1107928	hsa-miR-3656	CLIP-seq
MIRT1107932	hsa-miR-367	CLIP-seq
MIRT1550726	hsa-miR-3689a-3p	CLIP-seq
MIRT1550727	hsa-miR-3689c	CLIP-seq
MIRT2560738	hsa-miR-370	CLIP-seq
MIRT2560739	hsa-miR-371-5p	CLIP-seq
MIRT2560740	hsa-miR-371b-5p	CLIP-seq
MIRT2029874	hsa-miR-3913-5p	CLIP-seq
MIRT1107939	hsa-miR-3929	CLIP-seq
MIRT1107940	hsa-miR-3934	CLIP-seq
MIRT1107950	hsa-miR-4284	CLIP-seq
MIRT2029880	hsa-miR-4294	CLIP-seq
MIRT2029886	hsa-miR-4418	CLIP-seq
MIRT1107955	hsa-miR-4419b	CLIP-seq
MIRT2560741	hsa-miR-4432	CLIP-seq
MIRT1107956	hsa-miR-4433	CLIP-seq
MIRT1107959	hsa-miR-4459	CLIP-seq
MIRT1107960	hsa-miR-4478	CLIP-seq
MIRT1107961	hsa-miR-4487	CLIP-seq
MIRT1107963	hsa-miR-449a	CLIP-seq
MIRT1107964	hsa-miR-449b	CLIP-seq
MIRT2560742	hsa-miR-451b	CLIP-seq
MIRT1107967	hsa-miR-4537	CLIP-seq
MIRT2029890	hsa-miR-4540	CLIP-seq
MIRT1107969	hsa-miR-4649-3p	CLIP-seq
MIRT1107970	hsa-miR-4650-5p	CLIP-seq
MIRT2560743	hsa-miR-4662a-5p	CLIP-seq
MIRT2560744	hsa-miR-4676-5p	CLIP-seq
MIRT2260744	hsa-miR-4683	CLIP-seq
MIRT2260748	hsa-miR-4693-3p	CLIP-seq
MIRT2260749	hsa-miR-4696	CLIP-seq
MIRT1550728	hsa-miR-4728-5p	CLIP-seq
MIRT1107985	hsa-miR-4766-5p	CLIP-seq
MIRT1107986	hsa-miR-4768-3p	CLIP-seq
MIRT1107989	hsa-miR-4786-5p	CLIP-seq
MIRT1107990	hsa-miR-4793-5p	CLIP-seq
MIRT1107991	hsa-miR-4794	CLIP-seq
MIRT1107994	hsa-miR-485-5p	CLIP-seq
MIRT2029898	hsa-miR-509-3-5p	CLIP-seq
MIRT2029899	hsa-miR-509-5p	CLIP-seq
MIRT1107999	hsa-miR-520d-5p	CLIP-seq
MIRT1108001	hsa-miR-524-5p	CLIP-seq
MIRT1108003	hsa-miR-544b	CLIP-seq
MIRT2560745	hsa-miR-548ac	CLIP-seq
MIRT2560746	hsa-miR-548ae	CLIP-seq
MIRT2560747	hsa-miR-548aj	CLIP-seq
MIRT2560748	hsa-miR-548am	CLIP-seq
MIRT2560749	hsa-miR-548c-3p	CLIP-seq
MIRT2560750	hsa-miR-548d-3p	CLIP-seq
MIRT2560751	hsa-miR-548x	CLIP-seq
MIRT2560752	hsa-miR-548z	CLIP-seq
MIRT2560753	hsa-miR-575	CLIP-seq
MIRT2560754	hsa-miR-579	CLIP-seq
MIRT2560755	hsa-miR-593	CLIP-seq
MIRT1108009	hsa-miR-612	CLIP-seq
MIRT2260755	hsa-miR-636	CLIP-seq
MIRT2560756	hsa-miR-663	CLIP-seq
MIRT1108014	hsa-miR-766	CLIP-seq
MIRT2560757	hsa-miR-873	CLIP-seq
MIRT1108016	hsa-miR-92a	CLIP-seq
MIRT1108017	hsa-miR-92b	CLIP-seq
MIRT2029856	hsa-miR-1200	CLIP-seq
MIRT2260724	hsa-miR-141	CLIP-seq
MIRT2560734	hsa-miR-1908	CLIP-seq
MIRT1107898	hsa-miR-1972	CLIP-seq
MIRT2260727	hsa-miR-200a	CLIP-seq
MIRT1107900	hsa-miR-219-1-3p	CLIP-seq
MIRT1107901	hsa-miR-24	CLIP-seq
MIRT1107902	hsa-miR-25	CLIP-seq
MIRT1107903	hsa-miR-298	CLIP-seq
MIRT2029866	hsa-miR-3117-5p	CLIP-seq
MIRT2560736	hsa-miR-3120-5p	CLIP-seq
MIRT2029867	hsa-miR-3122	CLIP-seq
MIRT1107907	hsa-miR-3140-5p	CLIP-seq
MIRT2029869	hsa-miR-3158-5p	CLIP-seq
MIRT1107909	hsa-miR-3165	CLIP-seq
MIRT1107913	hsa-miR-3178	CLIP-seq
MIRT2260730	hsa-miR-3192	CLIP-seq
MIRT2029870	hsa-miR-3193	CLIP-seq
MIRT1107916	hsa-miR-3197	CLIP-seq
MIRT1107917	hsa-miR-32	CLIP-seq
MIRT1107919	hsa-miR-34a	CLIP-seq
MIRT1107920	hsa-miR-34c-5p	CLIP-seq
MIRT2560737	hsa-miR-3613-3p	CLIP-seq
MIRT1107923	hsa-miR-3622a-3p	CLIP-seq
MIRT1107924	hsa-miR-3622b-3p	CLIP-seq
MIRT1107926	hsa-miR-363	CLIP-seq
MIRT1107928	hsa-miR-3656	CLIP-seq
MIRT1107932	hsa-miR-367	CLIP-seq
MIRT1550726	hsa-miR-3689a-3p	CLIP-seq
MIRT1550727	hsa-miR-3689c	CLIP-seq
MIRT1107933	hsa-miR-3689d	CLIP-seq
MIRT2560739	hsa-miR-371-5p	CLIP-seq
MIRT2560740	hsa-miR-371b-5p	CLIP-seq
MIRT2029874	hsa-miR-3913-5p	CLIP-seq
MIRT1107939	hsa-miR-3929	CLIP-seq
MIRT1107940	hsa-miR-3934	CLIP-seq
MIRT1107950	hsa-miR-4284	CLIP-seq
MIRT2029880	hsa-miR-4294	CLIP-seq
MIRT2029886	hsa-miR-4418	CLIP-seq
MIRT1107955	hsa-miR-4419b	CLIP-seq
MIRT2560741	hsa-miR-4432	CLIP-seq
MIRT1107956	hsa-miR-4433	CLIP-seq
MIRT1107959	hsa-miR-4459	CLIP-seq
MIRT1107960	hsa-miR-4478	CLIP-seq
MIRT1107961	hsa-miR-4487	CLIP-seq
MIRT1107963	hsa-miR-449a	CLIP-seq
MIRT1107964	hsa-miR-449b	CLIP-seq
MIRT2560742	hsa-miR-451b	CLIP-seq
MIRT1107967	hsa-miR-4537	CLIP-seq
MIRT2029890	hsa-miR-4540	CLIP-seq
MIRT1107969	hsa-miR-4649-3p	CLIP-seq
MIRT1107970	hsa-miR-4650-5p	CLIP-seq
MIRT2560743	hsa-miR-4662a-5p	CLIP-seq
MIRT2560744	hsa-miR-4676-5p	CLIP-seq
MIRT2260744	hsa-miR-4683	CLIP-seq
MIRT2260748	hsa-miR-4693-3p	CLIP-seq
MIRT2260749	hsa-miR-4696	CLIP-seq
MIRT1550728	hsa-miR-4728-5p	CLIP-seq
MIRT1107985	hsa-miR-4766-5p	CLIP-seq
MIRT1107986	hsa-miR-4768-3p	CLIP-seq
MIRT1107989	hsa-miR-4786-5p	CLIP-seq
MIRT1107990	hsa-miR-4793-5p	CLIP-seq
MIRT1107991	hsa-miR-4794	CLIP-seq
MIRT1107994	hsa-miR-485-5p	CLIP-seq
MIRT2029898	hsa-miR-509-3-5p	CLIP-seq
MIRT2029899	hsa-miR-509-5p	CLIP-seq
MIRT1108003	hsa-miR-544b	CLIP-seq
MIRT2560745	hsa-miR-548ac	CLIP-seq
MIRT2560746	hsa-miR-548ae	CLIP-seq
MIRT2560747	hsa-miR-548aj	CLIP-seq
MIRT2560748	hsa-miR-548am	CLIP-seq
MIRT2560749	hsa-miR-548c-3p	CLIP-seq
MIRT2560750	hsa-miR-548d-3p	CLIP-seq
MIRT2560751	hsa-miR-548x	CLIP-seq
MIRT2560752	hsa-miR-548z	CLIP-seq
MIRT2560753	hsa-miR-575	CLIP-seq
MIRT2560754	hsa-miR-579	CLIP-seq
MIRT2560755	hsa-miR-593	CLIP-seq
MIRT2260755	hsa-miR-636	CLIP-seq
MIRT2560756	hsa-miR-663	CLIP-seq
MIRT1108014	hsa-miR-766	CLIP-seq
MIRT2560757	hsa-miR-873	CLIP-seq
MIRT1108016	hsa-miR-92a	CLIP-seq
MIRT1108017	hsa-miR-92b	CLIP-seq

Show/Hide all (41)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005509	Function	Calcium ion binding	IEA
GO:0005509	Function	Calcium ion binding	TAS	10486213, 26975899
GO:0005515	Function	Protein binding	IPI	18628306, 25416956, 32296183, 36321428
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	TAS	26975899
GO:0005743	Component	Mitochondrial inner membrane	IDA	18628306, 19797662, 32139798
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0006813	Process	Potassium ion transport	IEA
GO:0006816	Process	Calcium ion transport	IEA
GO:0006816	Process	Calcium ion transport	IMP	36321428
GO:0006851	Process	Mitochondrial calcium ion transmembrane transport	IBA
GO:0006851	Process	Mitochondrial calcium ion transmembrane transport	IDA	19797662
GO:0006851	Process	Mitochondrial calcium ion transmembrane transport	IEA
GO:0006851	Process	Mitochondrial calcium ion transmembrane transport	IMP	32139798
GO:0007005	Process	Mitochondrion organization	IBA
GO:0007007	Process	Inner mitochondrial membrane organization	IMP	32139798
GO:0015297	Function	Antiporter activity	IEA
GO:0015369	Function	Calcium:proton antiporter activity	IBA
GO:0015369	Function	Calcium:proton antiporter activity	IDA	19797662
GO:0015369	Function	Calcium:proton antiporter activity	IEA
GO:0016020	Component	Membrane	IEA
GO:0034214	Process	Protein hexamerization	IEA
GO:0034214	Process	Protein hexamerization	ISS
GO:0042407	Process	Cristae formation	IMP	18628306
GO:0043022	Function	Ribosome binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051260	Process	Protein homooligomerization	IEA
GO:0051260	Process	Protein homooligomerization	ISS
GO:0051560	Process	Mitochondrial calcium ion homeostasis	IDA	19797662
GO:0051560	Process	Mitochondrial calcium ion homeostasis	IEA
GO:0051562	Process	Negative regulation of mitochondrial calcium ion concentration	IMP	26975899
GO:0099093	Process	Calcium export from the mitochondrion	IDA	19797662
GO:0099093	Process	Calcium export from the mitochondrion	IEA
GO:0099093	Process	Calcium export from the mitochondrion	IMP	32139798
GO:0140141	Process	Mitochondrial potassium ion transmembrane transport	IMP	36055214
GO:1900069	Process	Regulation of cellular hyperosmotic salinity response	IMP	26975899
GO:1902600	Process	Proton transmembrane transport	IEA

MIM	HGNC	e!Ensembl
604407	6556	ENSG00000168924

O95202

Protein name

Mitochondrial proton/calcium exchanger protein (Electroneutral mitochondrial K(+)/H(+)exchanger) (KHE) (Leucine zipper-EF-hand-containing transmembrane protein 1)

Protein function

Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport (PubMed:18628306, PubMed:19797662, PubMed:24344246, PubMed:24898248, PubMed:29123128, PubMed:32139798, PubMed:3605521

PDB

9BA1

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF07766	LETM1	153 → 418	LETM1-like protein	Family

Sequence

MASILLRSCRGRAPARLPPPPRYTVPRGSPGDPAHLSCASTLGLRNCLNVPFGCCTPIHP
VYTSSRGDHLGCWALRPECLRIVSRAPWTSTSVGFVAVGPQCLPVRGWHSSRPVRDDSVV
EKSLKSLKDKNKKLEEGGPVYSPPAEVVVKKSLGQRVLDELKHYYHGFRLLWIDTKIAAR
MLWRILNGHSLTRRERRQFLRICADLFRLVPFLVFVVVPFMEFLLPVAVKLFPNMLPSTF
ETQSLKEERLKKELRVKLELAKFLQDTIEEMALKNKAAKGSATKDFSVFFQKIRETGERP
SNEEIMRFSKLFEDELTLDNLTRPQLVALCKLLELQSIGTNNFLRFQLTMRLRSIKADDK
LIAEEGVDSLNVKELQAACRARGMRALGVTEDRLRGQLKQWLDLHLHQEIPTSLLILSRA
MYLPDTLSPADQLKSTLQTLPEIVAKEAQVKVAEVEGEQVDNKAKLEATLQEEAAIQQEH
REKELQKRSEVAKDFEPERVVAAPQRPGTEPQPEMPDTVLQSETLKDTAPVLEGLKEEEI
TKEEIDILSDACSKLQEQKKSLTKEKEELELLKEDVQDYSEDLQEIKKELSKTGEEKYVE
ESKASKRLTKRVQQMIGQIDGLISQLEMDQQAGKLAPANGMPTGENVISVAELINAMKQV
KHIPESKLTSLAAALDENKDGKVNIDDLVKVIELVDKEDVHISTSQVAEIVATLEKEEKV
EEKEKAKEKAEKEVAEVKS

Sequence length

739

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
LETM1-associated clinical spectrum with predominant nervous system involvement	Pathogenic; Likely pathogenic	rs2108846420, rs2108846393, rs2108832976, rs2108847729, rs750286012, rs2108846252, rs2108840447, rs753284434	RCV002221675 RCV002221676 RCV002221677 RCV002221679 RCV002221680 RCV002221681 RCV002221683 RCV002221684 View all (3 more)	★★★★★ ★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Neurodegeneration, childhood-onset, with multisystem involvement due to mitochondrial dysfunction	Pathogenic	rs2108846420, rs2108832976, rs750286012, rs753284434	RCV002294478 RCV002294479 RCV002294481 RCV002294482	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (16)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
4p partial monosomy syndrome	Benign; Likely benign; Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CRANIOFACIAL ABNORMALITIES	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ependymoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Global developmental delay	Uncertain significance	ClinVar Disgenet	★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
INTELLECTUAL DISABILITY	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LETM1-related disorder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MENTAL RETARDATION	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SEIZURES	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
WOLF-HIRSCHHORN SYNDROME	—	CTD, Disgenet, HPO, Orphanet CTD, Disgenet, HPO, Orphanet CTD, Disgenet, HPO, Orphanet CTD, Disgenet, HPO, Orphanet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (126)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Absence of septum pellucidum	Absence Of Septum Pellucidum	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of large intestine	Colorectal Cancer	BEFREE	31101574		★★★★★ ★☆☆☆☆ Found in Text Mining only
Agenesis of corpus callosum	Agenesis Of Corpus Callosum	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Aplasia cutis congenita of scalp	Aplasia Cutis Congenita	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Arachnodactyly	Arachnodactyly	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Atrial Septal Defects	Atrial Septal Defect	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Bladder Neoplasm	Bladder Neoplasm	BEFREE	29048663		★★★★★ ★☆☆☆☆ Found in Text Mining only
Blepharoptosis	Ptosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Brain Diseases Metabolic	Brain disease	Pubtator	36055214	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	26722481	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	26722481	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of bladder	Bladder carcinoma	BEFREE	29048663		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	20824095		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	32163372	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	Pubtator	36055214	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	Pubtator	36055214	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cerebellar Ataxia	Cerebellar ataxia	Pubtator	36055214	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Chronic otitis media	Otitis media	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Clonic Seizures	Clonic Seizures	CTD_human_DG	14706454		★★★★★ ★☆☆☆☆ Found in Text Mining only
Clumsiness - motor delay	Motor delay	BEFREE	24626991		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	33314691	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Complex partial seizures	Seizure	CTD_human_DG	14706454		★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital anomaly of the kidney	Multicystic renal dysplasia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital clubfoot	Congenital Clubfoot	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital coloboma of iris	Congenital Coloboma Of Iris	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital diaphragmatic hernia	Congenital diaphragmatic hernia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital ectopic pupil	Congenital anomaly of eye	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital Epicanthus	Congenital Epicanthus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital fusion of ribs	Rib fusion	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital keratoglobus	Congenital Keratoglobus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Congenital small ears	Microtia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	30405774		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cryptorchidism	Cryptorchidism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	36055214	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	24333006		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	24333006, 25970163		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	36055214	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dwarfism	Dwarfism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Dysmorphic features	Dysmorphic Features	BEFREE	14706454		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	BEFREE	17606466, 23645710, 24738919, 26002316, 30896806		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	Pubtator	24738919, 36055214	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Epilepsy, Temporal Lobe	Epilepsy	BEFREE	23645710		★★★★★ ★☆☆☆☆ Found in Text Mining only
Epileptic drop attack	Hypotonic seizures	CTD_human_DG	14706454		★★★★★ ★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	34605738	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Exophthalmos	Proptosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Exostoses Multiple Hereditary	Exostoses	Pubtator	32705272	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Frontal bossing	Frontal bossing	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Gallbladder anomaly congenital	Congenital Gallbladder Anomaly	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastric Adenocarcinoma	Gastric Cancer	BEFREE	31705880		★★★★★ ★☆☆☆☆ Found in Text Mining only
Gastroesophageal reflux disease	Gastroesophageal Reflux Disease	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Generalized seizures	Seizure	CTD_human_DG	14706454		★★★★★ ★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★★★★★ ★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Growth Disorders	Growth disorder	Pubtator	23963300	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hearing Loss Sensorineural	Hearing loss	Pubtator	36055214	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hemangioma	Hemangioma	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypodontia	Hypodontia	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypoplasia of thumb	Hypoplasia Of Thumb	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypospadias	Hypospadias	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Immunologic Deficiency Syndromes	Immunologic Deficiency Syndromes	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	14706454, 30896806		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Intellectual Disability	Mental retardation	CTD_human_DG	14706454		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Jacksonian Seizure	Jacksonian Seizure	CTD_human_DG	14706454		★★★★★ ★☆☆☆☆ Found in Text Mining only
Language Development Disorders	Language development disorders	Pubtator	23963300	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Learning Disabilities	Learning disorders	Pubtator	24738919	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	CTD_human_DG	23392203		★★★★★ ★☆☆☆☆ Found in Text Mining only
Long narrow head	Dolichocephaly	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	BEFREE	20824095		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	24689060, 27556512	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	26722481, 31500591	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	20824095		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of thyroid	Thyroid cancer	BEFREE	27556512		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of urinary bladder	Urinary bladder cancer	BEFREE	29048663		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29048663, 30031102, 30405774, 30896806, 31101574, 31500591, 31705880		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental deficiency	Mental retardation	CTD_human_DG	14706454		★★★★★ ★☆☆☆☆ Found in Text Mining only
Mental Retardation	Mental retardation	BEFREE	14706454		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Microcephaly	Microcephaly	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Micrognathism	Micrognathism	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Mitochondrial Diseases	Mitochondrial disease	Pubtator	36055214	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Movement Disorders	Movement Disorders	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Neonatal Hypotonia	Hypotonia	CTD_human_DG	14706454		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	27556512, 29048663, 31705880		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nervous System Diseases	Nervous system disease	Pubtator	36055214	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	36055214	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	31500591		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nystagmus	Nystagmus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	24333006		★★★★★ ★☆☆☆☆ Found in Text Mining only
Optic Atrophy	Optic atrophy	Pubtator	36055214	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Optic Atrophy	Optic Atrophy	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Orofacial Cleft 1	Orofacial cleft	Pubtator	26561393	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Otofaciocervical Syndrome	Otofaciocervical syndrome	Pubtator	26561393	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	32163372	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Pitt-Rogers-Danks Syndrome	Pitt-Rogers-Danks Syndrome	CTD_human_DG	14706454		★★★★★ ★☆☆☆☆ Found in Text Mining only
Polydactyly preaxial type 1	Polydactyly	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Precocious Puberty	Precocious puberty	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Profound Mental Retardation	Mental retardation	CTD_human_DG	14706454		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ptosis	Ptosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Radioulnar Synostosis	Radioulnar Synostosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	30405774		★★★★★ ★☆☆☆☆ Found in Text Mining only
Retinal Diseases	Retinal Diseases	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Rieger eye malformation sequence	Axenfeld anomaly	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Rieger syndrome	Rieger syndrome	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Sclerocornea	Sclerocornea	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Scoliosis, unspecified	Scoliosis	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Seizures	Seizures	Pubtator	12563561, 20197279, 24738919	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Severe intellectual disability	Mental retardation	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Single Seizure	Seizure	CTD_human_DG	14706454		★★★★★ ★☆☆☆☆ Found in Text Mining only
Situs Inversus	Situs Inversus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Speech Delay	Speech Delay	BEFREE	23963300		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of esophagus	Esophagus Neoplasm	BEFREE	30031102		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	24689060	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Stenosis of external auditory canal	Stenosis Of External Auditory Canal	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Stereotyped Behavior	Stereotyped Behavior	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Strabismus	Strabismus	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Tethered Cord Syndrome	Primary Tethered cord syndrome	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid carcinoma	Thyroid Carcinoma	BEFREE	27556512		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasm	Thyroid Neoplasm	BEFREE	27556512		★★★★★ ★☆☆☆☆ Found in Text Mining only
Thyroid Neoplasms	Thyroid cancer	Pubtator	27556512	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Tonic - clonic seizures	Seizure	CTD_human_DG	14706454		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	32633345	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ventricular Septal Defects	Ventricular septal defect	HPO_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Visual seizure	Seizure	CTD_human_DG	14706454		★★★★★ ★☆☆☆☆ Found in Text Mining only
Wolf-Hirschhorn Syndrome	Wolf-Hirschhorn Syndrome	BEFREE	10486213, 14706454, 15138253, 17606466, 17696124, 17925330, 19729912, 20026556, 23637096, 23645710, 23716663, 23963300, 24626991, 24738919, 30012579, 30378700, 30642051, 31101453 View all (3 more)		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Wolf-Hirschhorn Syndrome	Wolf-Hirschhorn Syndrome	CTD_human_DG	14706454		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Wolf-Hirschhorn Syndrome	Wolf-Hirschhorn Syndrome	ORPHANET_DG			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Wolf-Hirschhorn syndrome	Wolf-Hirschhorn Syndrome	Orphanet			★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

LETM1 (leucine zipper and EF-hand containing transmembrane protein 1)