LCT (lactase)

Gene

• Entrez ID: 3938
• Gene name: Lactase
• Gene symbol: LCT
• Synonyms (NCBI Gene): LAC, LPH, LPH1
• Chromosome: 2
• Chromosome location: 2q21.3
• Summary: The protein encoded by this gene belongs to the glycosyl hydrolase 1 family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme is integral to the plasma membrane and has both phlorizin hydrolase

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs121908936	A>T	Pathogenic	Stop gained, coding sequence variant
rs121908937	C>G	Pathogenic	Coding sequence variant, missense variant
rs386833832	ACTCC>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs386833833	C>T	Likely-pathogenic	Coding sequence variant, missense variant
rs386833834	G>A,C	Likely-pathogenic	Coding sequence variant, synonymous variant, stop gained
rs386833835	C>A,T	Likely-pathogenic	Coding sequence variant, missense variant, stop gained
rs386833836	ACTC>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs386833837	T>-	Likely-pathogenic	Frameshift variant, coding sequence variant, genic downstream transcript variant
rs386833838	AG>-	Likely-pathogenic	Coding sequence variant, frameshift variant
rs1553436217	CTTTTCTGTGGGCATCACTGAG>-	Likely-pathogenic	Frameshift variant, coding sequence variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT039283	hsa-miR-671-5p	CLASH	23622248
MIRT2029362	hsa-miR-1299	CLIP-seq
MIRT2029363	hsa-miR-3148	CLIP-seq
MIRT2029364	hsa-miR-4731-3p	CLIP-seq
MIRT2029365	hsa-miR-4782-5p	CLIP-seq
MIRT2029366	hsa-miR-4801	CLIP-seq
MIRT2029367	hsa-miR-516b	CLIP-seq
MIRT2029368	hsa-miR-570	CLIP-seq
MIRT2029369	hsa-miR-875-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
CDX2	Activation	9148757
HNF1A	Activation	9582375
HOXC11	Unknown	9582375
POU2F1	Activation	20960210

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000016	Function	Lactase activity	IBA
GO:0000016	Function	Lactase activity	IDA	3929764, 9762914, 12594539
GO:0000016	Function	Lactase activity	IEA
GO:0000016	Function	Lactase activity	IMP	16400612
GO:0003824	Function	Catalytic activity	IEA
GO:0004336	Function	Galactosylceramidase activity	ISS
GO:0004348	Function	Glucosylceramidase activity	ISS
GO:0004553	Function	Hydrolase activity, hydrolyzing O-glycosyl compounds	IEA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	2460343
GO:0005975	Process	Carbohydrate metabolic process	IEA
GO:0005990	Process	Lactose catabolic process	IBA
GO:0005990	Process	Lactose catabolic process	IDA	3929764, 9762914, 12594539
GO:0008422	Function	Beta-glucosidase activity	IBA
GO:0008422	Function	Beta-glucosidase activity	IDA	3929764, 12594539
GO:0008422	Function	Beta-glucosidase activity	IEA
GO:0008422	Function	Beta-glucosidase activity	ISS
GO:0016020	Component	Membrane	IEA
GO:0016324	Component	Apical plasma membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016798	Function	Hydrolase activity, acting on glycosyl bonds	IEA
GO:0042803	Function	Protein homodimerization activity	IDA	9593732
GO:0046477	Process	Glycosylceramide catabolic process	ISS
GO:0080079	Function	Cellobiose glucosidase activity	IEA
GO:0098591	Component	External side of apical plasma membrane	IBA
GO:0098591	Component	External side of apical plasma membrane	IDA	9593732
GO:0140749	Function	Phlorizin hydrolase activity	IDA	3929764, 9762914, 12594539
GO:0140749	Function	Phlorizin hydrolase activity	IEA
GO:1901733	Process	Quercetin catabolic process	IDA	12594539
GO:2000892	Process	Cellobiose catabolic process	IBA
GO:2000892	Process	Cellobiose catabolic process	IDA	3929764

Other IDs

• MIM: 603202
• HGNC: 6530
• e!Ensembl: ENSG00000115850

Protein

• UniProt ID: P09848
• Protein name: Lactase/phlorizin hydrolase (Lactase/glycosylceramidase) [Includes: Lactase (EC 3.2.1.108); Glycosylceramidase (EC 3.2.1.62) (Phlorizin hydrolase)]
• Protein function: Broad specificity glycosidase of the intestinal brush border membrane that hydrolyzes lactose, the main sugar in mammalian milk, to produce D-glucose and D-galactose (PubMed:12594539, PubMed:16400612, PubMed:3929764, PubMed:9762914). The mature
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00232	Glyco_hydro_1	74 → 225	Glycosyl hydrolase family 1	Domain
  PF00232	Glyco_hydro_1	378 → 847	Glycosyl hydrolase family 1	Domain
  PF00232	Glyco_hydro_1	899 → 1364	Glycosyl hydrolase family 1	Domain
  PF00232	Glyco_hydro_1	1373 → 1840	Glycosyl hydrolase family 1	Domain

• Tissue specificity: TISSUE SPECIFICITY: Specifically expressed in small intestine. {ECO:0000269|PubMed:2460343}.
• Sequence:

  MELSWHVVFIALLSFSCWGSDWESDRNFISTAGPLTNDLLHNLSGLLGDQSSNFVAGDKD
  MYVCHQPLPTFLPEYFSSLHASQITHYKVFLSWAQLLPAGSTQNPDEKTVQCYRRLLKAL
  KTARLQPMVILHHQTLPASTLRRTEAFADLFADYATFAFHSFGDLVGIWFTFSDLEEVIK
  ELPHQESRASQLQTLSDAHRKAYEIYHESYAFQGGKLSVVLRAEDIPELLLEPPISALAQ
  DTVDFLSLDLSYECQNEASLRQKLSKLQTIEPKVKVFIFNLKLPDCPSTMKNPASLLFSL
  FEAINKDQVLTIGFDINEFLSCSSSSKKSMSCSLTGSLALQPDQQQDHETTDSSPASAYQ
  RIWEAFANQSRAERDAFLQDTFPEGFLWGASTGAFNVEGGWAEGGRGVSIWDPRRPLNTT
  EGQATLEVASDSYHKVASDVALLCGLRAQVYKFSISWSRIFPMGHGSSPSLPGVAYYNKL
  IDRLQDAGIEPMATLFHWDLPQALQDHGGWQNESVVDAFLDYAAFCFSTFGDRVKLWVTF
  HEPWVMSYAGYGTGQHPPGISDPGVASFKVAHLVLKAHARTWHHYNSHHRPQQQGHVGIV
  LNSDWAEPLSPERPEDLRASERFLHFMLGWFAHPVFVDGDYPATLRTQIQQMNRQCSHPV
  AQLPEFTEAEKQLLKGSADFLGLSHYTSRLISNAPQNTCIPSYDTIGGFSQHVNHVWPQT
  SSSWIRVVPWGIRRLLQFVSLEYTRGKVPIYLAGNGMPIGESENLFDDSLRVDYFNQYIN
  EVLKAIKEDSVDVRSYIARSLIDGFEGPSGYSQRFGLHHVNFSDSSKSRTPRKSAYFFTS
  IIEKNGFLTKGAKRLLPPNTVNLPSKVRAFTFPSEVPSKAKVVWEKFSSQPKFERDLFYH
  GTFRDDFLWGVSSSAYQIEGAWDADGKGPSIWDNFTHTPGSNVKDNATGDIACDSYHQLD
  ADLNMLRALKVKAYRFSISWSRIFPTGRNSSINSHGVDYYNRLINGLVASNIFPMVTLFH
  WDLPQALQDIGGWENPALIDLFDSYADFCFQTFGDRVKFWMTFNEPMYLAWLGYGSGEFP
  PGVKDPGWAPYRIAHAVIKAHARVYHTYDEKYRQEQKGVISLSLSTHWAEPKSPGVPRDV
  EAADRMLQFSLGWFAHPIFRNGDYPDTMKWKVGNRSELQHLATSRLPSFTEEEKRFIRAT
  ADVFCLNTYYSRIVQHKTPRLNPPSYEDDQEMAEEEDPSWPSTAMNRAAPWGTRRLLNWI
  KEEYGDIPIYITENGVGLTNPNTEDTDRIFYHKTYINEALKAYRLDGIDLRGYVAWSLMD
  NFEWLNGYTVKFGLYHVDFNNTNRPRTARASARYYTEVITNNGMPLAREDEFLYGRFPEG
  FIWSAASAAYQIEGAWRADGKGLSIWDTFSHTPLRVENDAIGDVACDSYHKIAEDLVTLQ
  NLGVSHYRFSISWSRILPDGTTRYINEAGLNYYVRLIDTLLAASIQPQVTIYHWDLPQTL
  QDVGGWENETIVQRFKEYADVLFQRLGDKVKFWITLNEPFVIAYQGYGYGTAAPGVSNRP
  GTAPYIVGHNLIKAHAEAWHLYNDVYRASQGGVISITISSDWAEPRDPSNQEDVEAARRY
  VQFMGGWFAHPIFKNGDYNEVMKTRIRDRSLAAGLNKSRLPEFTESEKRRINGTYDFFGF
  NHYTTVLAYNLNYATAISSFDADRGVASIADRSWPDSGSFWLKMTPFGFRRILNWLKEEY
  NDPPIYVTENGVSQREETDLNDTARIYYLRTYINEALKAVQDKVDLRGYTVWSAMDNFEW
  ATGFSERFGLHFVNYSDPSLPRIPKASAKFYASVVRCNGFPDPATGPHACLHQPDAGPTI
  SPVRQEEVQFLGLMLGTTEAQTALYVLFSLVLLGVCGLAFLSYKYCKRSKQGKTQRSQQE
  LSPVSSF

• Sequence length: 1927

Pathways

KEGG:

Galactose metabolism
Metabolic pathways
Carbohydrate digestion and absorption

Reactome:

Digestion of dietary carbohydrate
Intestinal saccharidase deficiencies

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Congenital lactase deficiency	Likely pathogenic; Pathogenic	rs749118441, rs121908936, rs121908937, rs1276818330, rs386833832, rs386833833, rs386833834, rs386833835, rs386833836, rs386833837, rs386833838, rs1312031160, rs763006562	RCV002506946 RCV000006964 RCV000006966 RCV003335938 RCV000049800 RCV000049801 RCV000049802 RCV000049803 RCV000049804 RCV000049805 RCV000049806 RCV003222281 RCV003222282	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
LCT-related disorder	Pathogenic; Likely pathogenic	rs2077596325, rs2467240516, rs2467223826	RCV003983884 RCV003414172 RCV003414182	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lactose intolerance	Likely benign; Benign; Conflicting classifications of pathogenicity; Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lymphoma	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OSTEOARTHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign; Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Adenomatous Polyposis Coli	Multiple polyposis syndrome	BEFREE	31137035		★☆☆☆☆ Found in Text Mining only
Adult T-Cell Lymphoma/Leukemia	T-Cell Lymphoma/Leukemia	BEFREE	2898099		★☆☆☆☆ Found in Text Mining only
AMYLOIDOSIS, HEREDITARY, TRANSTHYRETIN-RELATED	Amyloidosis	BEFREE	31137035		★☆☆☆☆ Found in Text Mining only
Anemia Sickle Cell	Sickle cell anemia	Pubtator	23731540	Associate	★☆☆☆☆ Found in Text Mining only
Antiphospholipid Syndrome	Antiphospholipid Syndrome	BEFREE	30079628		★☆☆☆☆ Found in Text Mining only
Antithrombin III Deficiency	Antithrombin Deficiency	BEFREE	16953278		★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	33462485	Associate	★☆☆☆☆ Found in Text Mining only
Asthenozoospermia	Asthenozoospermia	BEFREE	31160241		★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	BEFREE	29211546		★☆☆☆☆ Found in Text Mining only
Bronchopulmonary Dysplasia	Bronchopulmonary Dysplasia	BEFREE	31723236		★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular disease	Pubtator	23420841	Associate	★☆☆☆☆ Found in Text Mining only
Celiac Disease	Celiac disease	BEFREE	25495501		★☆☆☆☆ Found in Text Mining only
Celiac Disease	Celiac disease	Pubtator	39203877, 428824	Associate	★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	25003680	Inhibit	★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	33462485	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	15831909, 17478481		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	15831909, 18980667, 19686745	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	LHGDN	17478481, 18980667		★☆☆☆☆ Found in Text Mining only
Congenital lactase deficiency	Congenital Lactase Deficiency	Orphanet			★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)
Coronary Artery Disease	Coronary artery disease	BEFREE	27742581		★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	10500062		★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn disease	Pubtator	25003680	Inhibit	★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Cystic Fibrosis	BEFREE	21407263		★☆☆☆☆ Found in Text Mining only
Cystic Fibrosis	Cystic fibrosis	Pubtator	21407263	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	11804845, 33577048	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	33577048	Associate	★☆☆☆☆ Found in Text Mining only
ECTRODACTYLY, ECTODERMAL DYSPLASIA, AND CLEFT LIP/PALATE SYNDROME 1	Ectrodactyly	BEFREE	30706130		★☆☆☆☆ Found in Text Mining only
Eosinophilic esophagitis	Eosinophilia	BEFREE	29086329		★☆☆☆☆ Found in Text Mining only
Gastritis	Gastritis	BEFREE	12544691		★☆☆☆☆ Found in Text Mining only
Gilles de la Tourette syndrome	Tourette Syndrome	BEFREE	23630162		★☆☆☆☆ Found in Text Mining only
Gingival Recession	Gingival Recession	BEFREE	29889911		★☆☆☆☆ Found in Text Mining only
Glut1 Deficiency Syndrome	GLUT1 Deficiency Syndrome	BEFREE	16217704		★☆☆☆☆ Found in Text Mining only
Hypercholesterolemia	Hypercholesterolemia	BEFREE	28051762		★☆☆☆☆ Found in Text Mining only
Hyperglycemia	Hyperglycemia	Pubtator	33577048	Associate	★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	28302601, 28756941		★☆☆☆☆ Found in Text Mining only
Ichthyosis Bullosa of Siemens	Ichthyosis Bullosa Of Siemens	BEFREE	17706627		★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	31104025		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	25003680	Associate	★☆☆☆☆ Found in Text Mining only
Insulin Resistance	Diabetes mellitus, type 2	Pubtator	32036847	Associate	★☆☆☆☆ Found in Text Mining only
Intestinal Diseases	Intestinal Diseases	BEFREE	11332711		★☆☆☆☆ Found in Text Mining only
Irritable Bowel Syndrome	Irritable Bowel Syndrome	BEFREE	17706627, 22989008		★☆☆☆☆ Found in Text Mining only
Irritable Bowel Syndrome	Irritable bowel syndrome	Pubtator	19943975, 29912753	Associate	★☆☆☆☆ Found in Text Mining only
Lactase Deficiency Congenital	Congenital lactase deficiency	Pubtator	16400612, 1702075, 19161632, 22688420, 23029545, 23327608, 26215149, 28132945, 29063188, 30689919, 9758622	Associate	★☆☆☆☆ Found in Text Mining only
Lactase Deficiency Congenital	Congenital lactase deficiency	Pubtator	28132945	Inhibit	★☆☆☆☆ Found in Text Mining only
Lactose Intolerance	Lactose Intolerance	BEFREE	11332711, 11788828, 12795467, 14753735, 15287817, 15365657, 15667380, 16299058, 16301215, 16391332, 16805112, 17103297, 17318022, 17651714, 18704543, 18980667, 1916106, 19889824, 19960866, 23415628, 25096822, 25281930, 27593109, 29378630, 31226742, 31802224, 7820203, 9041235		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lactose Intolerance	Lactose Intolerance	LHGDN	18237552		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lactose Intolerance	Lactose Intolerance	HPO_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lactose Intolerance, Adult Type	Lactose Intolerance	BEFREE	15667380, 16301215, 17103297, 17327935, 17345962, 17651714, 17934640, 18237552, 19639477, 19799794, 21152447, 23415628, 26334798, 30790118, 31137035		★☆☆☆☆ Found in Text Mining only
Left posterior fascicular block	Left posterior fascicular block	BEFREE	9194541		★☆☆☆☆ Found in Text Mining only
Leydig Cell Tumor	Leydig Cell Tumor	BEFREE	27594555		★☆☆☆☆ Found in Text Mining only
Lupus anticoagulant disorder	Lupus anticoagulant	BEFREE	30079628, 31487115		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus	Lupus Erythematosus	BEFREE	30903876		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Discoid	Lupus Erythematosus	BEFREE	30903876		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	30903876		★☆☆☆☆ Found in Text Mining only
Lupus Vulgaris	Lupus Vulgaris	BEFREE	30903876		★☆☆☆☆ Found in Text Mining only
Malabsorption Syndrome	Malabsorption Syndrome	BEFREE	19208354		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	22965418		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	22965418		★☆☆☆☆ Found in Text Mining only
Malnutrition	Malnutrition	BEFREE	9041235		★☆☆☆☆ Found in Text Mining only
Metabolic Syndrome X	Metabolic Syndrome	BEFREE	19844753		★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	BEFREE	26085675		★☆☆☆☆ Found in Text Mining only
Myocardial Ischemia	Myocardial Ischemia	BEFREE	26085675		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30362621		★☆☆☆☆ Found in Text Mining only
Neural Tube Defects	Neural tube defect	Pubtator	30689919	Associate	★☆☆☆☆ Found in Text Mining only
NON RARE IN EUROPE: Lactase non-persistence in adulthood	Lactase Non-Persistence	Orphanet			★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	BEFREE	20015952, 21193851, 22937140, 26156736, 27577176		★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	20015952, 21193851, 32036847, 33577048	Associate	★☆☆☆☆ Found in Text Mining only
Obesity Abdominal	Obesity	Pubtator	23252911	Associate	★☆☆☆☆ Found in Text Mining only
Obsessive-Compulsive Disorder	Obsessive-Compulsive Disorder	BEFREE	23630162		★☆☆☆☆ Found in Text Mining only
Oligospermia	Oligospermia	BEFREE	31160241		★☆☆☆☆ Found in Text Mining only
Osteomyelitis	Osteomyelitis	BEFREE	31722523, 31740526		★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	BEFREE	14753735, 17103297, 31802224		★☆☆☆☆ Found in Text Mining only
Osteoporosis	Osteoporosis	Pubtator	23985982	Associate	★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome	BEFREE	31197967		★☆☆☆☆ Found in Text Mining only
Polyendocrinopathies, Autoimmune	Autoimmune Polyendocrinopathy	BEFREE	30079628		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	22965418		★☆☆☆☆ Found in Text Mining only
Respiratory Distress Syndrome, Adult	Respiratory Distress Syndrome	CTD_human_DG	25070658		★☆☆☆☆ Found in Text Mining only
Rhinitis Allergic Seasonal	Seasonal allergic rhinitis	Pubtator	34978666	Associate	★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	29052315		★☆☆☆☆ Found in Text Mining only
Teratozoospermia	Teratozoospermia	BEFREE	31160241		★☆☆☆☆ Found in Text Mining only
Testicular Neoplasms	Testicular Neoplasms	BEFREE	27594555		★☆☆☆☆ Found in Text Mining only
Trifascicular block	Trifascicular block	BEFREE	9194541		★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	BEFREE	10500062		★☆☆☆☆ Found in Text Mining only
Xerocytosis	Xerocytosis	BEFREE	31373362		★☆☆☆☆ Found in Text Mining only