LCN2 (lipocalin 2)

Gene Gene information from NCBI Gene database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 3934
Gene name Lipocalin 2
Gene symbol LCN2
Synonyms (NCBI Gene)
24p3MSFINGALp25
Chromosome 9
Chromosome location 9q34.11
Summary This gene encodes a protein that belongs to the lipocalin family. Members of this family transport small hydrophobic molecules such as lipids, steroid hormones and retinoids. The protein encoded by this gene is a neutrophil gelatinase-associated lipocalin
miRNA miRNA information provided by mirtarbase database.
8
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (8)
miRTarBase ID miRNA Experiments Reference
MIRT438755 hsa-miR-138-5p Luciferase reporter assayqRT-PCRWestern blot 23300839
MIRT438755 hsa-miR-138-5p Luciferase reporter assayqRT-PCRWestern blot 23300839
MIRT438755 hsa-miR-138-5p Luciferase reporter assayqRT-PCRWestern blot 23300839
MIRT438755 hsa-miR-138-5p Luciferase reporter assayqRT-PCRWestern blot 23300839
MIRT2029206 hsa-miR-1293 CLIP-seq
Transcription factors Transcription factors information provided by TRRUST V2 database.
6
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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Transcription factor Regulation Reference
NFKB1 Activation 15536164
NFKB1 Unknown 19707556;20220144;24391115
NR3C2 Unknown 22469622
RELA Activation 15536164
RELA Unknown 19707556;20220144;24391115
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
74
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
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GO ID Ontology Definition Evidence Reference
GO:0002020 Function Protease binding IEA
GO:0002376 Process Immune system process IEA
GO:0005506 Function Iron ion binding IDA 27780864
GO:0005506 Function Iron ion binding IEA
GO:0005506 Function Iron ion binding ISS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
600181 6526 ENSG00000148346
Protein Protein information from UniProt database.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P80188
Protein name Neutrophil gelatinase-associated lipocalin (NGAL) (25 kDa alpha-2-microglobulin-related subunit of MMP-9) (Lipocalin-2) (Oncogene 24p3) (Siderocalin) (p25)
Protein function Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development (PubMed:12453413, PubMed:20581821, PubMed:27780864). Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a sid
PDB 1DFV , 1L6M , 1NGL , 1QQS , 1X71 , 1X89 , 1X8U , 3BY0 , 3CBC , 3CMP , 3DSZ , 3DTQ , 3FW4 , 3FW5 , 3HWD , 3HWE , 3HWF , 3HWG , 3I0A , 3K3L , 3PEC , 3PED , 3T1D , 3TF6 , 3TZS , 3U0D , 4GH7 , 4IAW , 4IAX , 4K19 , 4MVI , 4MVK , 4MVL , 4QAE , 4ZFX , 4ZHC , 4ZHD , 4ZHF , 4ZHG , 4ZHH , 5JR8 , 5KHP , 5KIC , 5KID , 5MHH , 5N47 , 5N48 , 5NKN , 6GQZ , 6GR0 , 6O5D
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00061 Lipocalin 48 → 193 Lipocalin / cytosolic fatty-acid binding protein family Domain
Tissue specificity TISSUE SPECIFICITY: Detected in neutrophils (at protein level) (PubMed:7683678, PubMed:8298140). Expressed in bone marrow and in tissues that are prone to exposure to microorganism (PubMed:9339356). High expression is found in bone marrow as well as in ut
Sequence
Sequence length 198
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
  KEGG  Reactome
  IL-17 signaling pathway   Interleukin-4 and Interleukin-13 signaling
Neutrophil degranulation
Metal sequestration by antimicrobial proteins
Iron uptake and transport
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (25)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ARTHRITIS, RHEUMATOID — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BETA THALASSEMIA — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
BETA-THALASSEMIA — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CALCINOSIS — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (464)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acne Acne BEFREE 29473202
★★★★★
★☆☆☆☆
Found in Text Mining only
Acne Vulgaris Acne BEFREE 29473202
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute Coronary Syndrome Coronary Syndrome BEFREE 29622507, 30477800
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute Kidney Insufficiency Acute Kidney Insufficiency CTD_human_DG 20623750, 22005293, 23052191, 27888128, 28885000
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute Kidney Tubular Necrosis Renal tubular necrosis BEFREE 28013112
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 31676986
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute pancreatitis Pancreatitis BEFREE 28279688, 31366007
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 16733850
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 18927283, 8675096
★★★★★
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 25542236, 26573874, 29296216, 30268479
★★★★★
★☆☆☆☆
Found in Text Mining only