Gene Gene information from NCBI Gene database.
Entrez ID 3927
Gene name LIM and SH3 protein 1
Gene symbol LASP1
Synonyms (NCBI Gene)
Lasp-1MLN50
Chromosome 17
Chromosome location 17q12
Summary This gene encodes a member of a subfamily of LIM proteins, characterized by a LIM motif and a domain of Src homology region 3, and also a member of the nebulin family of actin-binding proteins. The encoded protein is a cAMP and cGMP dependent signaling pr
miRNA miRNA information provided by mirtarbase database.
1510
miRTarBase ID miRNA Experiments Reference
MIRT003708 hsa-miR-218-5p qRT-PCR 19168627
MIRT003708 hsa-miR-218-5p MicroarrayqRT-PCR 19168627
MIRT002808 hsa-miR-1-3p Microarray 15685193
MIRT002808 hsa-miR-1-3p Luciferase reporter assayqRT-PCRWestern blot 20843712
MIRT005813 hsa-miR-133a-3p Luciferase reporter assayqRT-PCRWestern blot 20843712
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
21
GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding IEA
GO:0005515 Function Protein binding IPI 16189514, 19060904, 21516116, 22665060, 24705354, 25416956, 25814554, 27107012, 31515488, 32296183, 32814053
GO:0005737 Component Cytoplasm IDA 25468996
GO:0005737 Component Cytoplasm IEA
GO:0005856 Component Cytoskeleton IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602920 6513 ENSG00000002834
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q14847
Protein name LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50)
Protein function Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but
PDB 3I35
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00412 LIM 5 61 LIM domain Domain
PF00880 Nebulin 67 94 Nebulin repeat Repeat
PF00880 Nebulin 103 130 Nebulin repeat Repeat
PF14604 SH3_9 209 259 Variant SH3 domain Domain
Sequence
Sequence length 261
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Acute myeloid leukemia Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
AUTISTIC DISORDER CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL NEOPLASMS CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Gastric cancer Benign ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adult Medulloblastoma Medulloblastoma BEFREE 20924110, 29042998
★☆☆☆☆
Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA Syndromic microphthalmia BEFREE 25385028
★☆☆☆☆
Found in Text Mining only
Autistic Disorder Autism BEFREE 17376794
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Autistic Disorder Autism CTD_human_DG 17376794
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Benign Prostatic Hyperplasia Benign Prostatic Hyperplasia BEFREE 24980827
★☆☆☆☆
Found in Text Mining only
Bladder Neoplasm Bladder Neoplasm BEFREE 20843712, 22481019, 24980827, 27588391, 29085487
★☆☆☆☆
Found in Text Mining only
Breast Carcinoma Breast Carcinoma BEFREE 12527918, 16430883, 17211471, 17956604, 20461080, 25454514, 25622104, 25982273, 27938497, 28546132, 29207145, 31106142, 7589475
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 17211471, 17956604, 18419822, 20461080, 24980827, 25982273, 27588391, 32075106, 7589475 Associate
★☆☆☆☆
Found in Text Mining only
Carcinoma Carcinoma BEFREE 17956604
★☆☆☆☆
Found in Text Mining only
Carcinoma Hepatocellular Hepatocellular carcinoma Pubtator 19177205, 22897902, 25760690, 28266596, 32344996, 35081873, 36670097 Associate
★☆☆☆☆
Found in Text Mining only