RPSA (ribosomal protein SA)

Gene

• Entrez ID: 3921
• Gene name: Ribosomal protein SA
• Gene symbol: RPSA
• Synonyms (NCBI Gene): 37LRP, 67LR, ICAS, LAMBR, LAMR1, LBP, LBP/p40, LRP, LRP/LR, NEM/1CHD4, SA, lamR, p40, uS2
• Chromosome: 3
• Chromosome location: 3p22.1
• Summary: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, n

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs398122389	->TCATG	Pathogenic	Coding sequence variant, frameshift variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT031978	hsa-miR-16-5p	Proteomics	18668040
MIRT052459	hsa-let-7a-5p	CLASH	23622248
MIRT051967	hsa-let-7b-5p	CLASH	23622248
MIRT051511	hsa-let-7e-5p	CLASH	23622248
MIRT051008	hsa-miR-17-5p	CLASH	23622248
MIRT050472	hsa-miR-22-3p	CLASH	23622248
MIRT050204	hsa-miR-25-3p	CLASH	23622248
MIRT048301	hsa-miR-107	CLASH	23622248
MIRT045843	hsa-miR-132-3p	CLASH	23622248
MIRT039727	hsa-miR-615-3p	CLASH	23622248
MIRT039076	hsa-miR-769-3p	CLASH	23622248
MIRT036398	hsa-miR-1227-3p	CLASH	23622248
MIRT052824	hsa-miR-3200-3p	CLASH	23622248
MIRT1319054	hsa-miR-4696	CLIP-seq
MIRT1319055	hsa-miR-4720-3p	CLIP-seq
MIRT1319056	hsa-miR-4804-3p	CLIP-seq
MIRT1319057	hsa-miR-587	CLIP-seq
MIRT1319054	hsa-miR-4696	CLIP-seq
MIRT1319055	hsa-miR-4720-3p	CLIP-seq
MIRT1319058	hsa-miR-4773	CLIP-seq
MIRT1319056	hsa-miR-4804-3p	CLIP-seq
MIRT1319057	hsa-miR-587	CLIP-seq
MIRT1319054	hsa-miR-4696	CLIP-seq
MIRT1319055	hsa-miR-4720-3p	CLIP-seq
MIRT1319058	hsa-miR-4773	CLIP-seq
MIRT1319056	hsa-miR-4804-3p	CLIP-seq
MIRT1319057	hsa-miR-587	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000028	Process	Ribosomal small subunit assembly	IBA
GO:0000028	Process	Ribosomal small subunit assembly	IEA
GO:0001618	Function	Virus receptor activity	IEA
GO:0002181	Process	Cytoplasmic translation	IBA
GO:0002181	Process	Cytoplasmic translation	IC	23636399
GO:0002181	Process	Cytoplasmic translation	NAS	25901680
GO:0003677	Function	DNA binding	IDA	38114488
GO:0003723	Function	RNA binding	HDA	22681889
GO:0003735	Function	Structural constituent of ribosome	HDA	15883184
GO:0003735	Function	Structural constituent of ribosome	IBA
GO:0003735	Function	Structural constituent of ribosome	IDA	23636399
GO:0003735	Function	Structural constituent of ribosome	IEA
GO:0005055	Function	Laminin receptor activity	IEA
GO:0005515	Function	Protein binding	IPI	16169070, 16263087, 21044950, 24212136, 24983501, 25277244, 28514442, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IDA	38114488
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	16130169
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IDA	16263087
GO:0005737	Component	Cytoplasm	IEA
GO:0005737	Component	Cytoplasm	NAS	25901680
GO:0005737	Component	Cytoplasm	TAS	16130169
GO:0005829	Component	Cytosol	TAS
GO:0005840	Component	Ribosome	IEA
GO:0005886	Component	Plasma membrane	IDA	16263087
GO:0005886	Component	Plasma membrane	IEA
GO:0006338	Process	Chromatin remodeling	IDA	38114488
GO:0006412	Process	Translation	IC	8706699
GO:0006412	Process	Translation	IEA
GO:0007155	Process	Cell adhesion	IEA
GO:0015935	Component	Small ribosomal subunit	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IEA
GO:0022626	Component	Cytosolic ribosome	IDA	23636399
GO:0022627	Component	Cytosolic small ribosomal subunit	IBA
GO:0022627	Component	Cytosolic small ribosomal subunit	IDA	8706699
GO:0022627	Component	Cytosolic small ribosomal subunit	IEA
GO:0022627	Component	Cytosolic small ribosomal subunit	NAS	25901680
GO:0043022	Function	Ribosome binding	IPI	10079194
GO:0043236	Function	Laminin binding	IEA
GO:0046718	Process	Symbiont entry into host cell	IEA
GO:0070062	Component	Extracellular exosome	HDA	20458337
GO:0140374	Process	Antiviral innate immune response	IDA	38114488
GO:0140374	Process	Antiviral innate immune response	IDA	38114488
GO:1990904	Component	Ribonucleoprotein complex	IEA

Other IDs

• MIM: 150370
• HGNC: 6502
• e!Ensembl: ENSG00000168028

Protein

• UniProt ID: P08865
• Protein name: Small ribosomal subunit protein uS2 (37 kDa laminin receptor precursor) (37LRP) (37/67 kDa laminin receptor) (LRP/LR) (40S ribosomal protein SA) (67 kDa laminin receptor) (67LR) (Colon carcinoma laminin-binding protein) (Laminin receptor 1) (LamR) (Lamini
• Protein function: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface recept
• PDB: 3BCH, 4UG0, 4V5Z, 4V6X, 5A2Q, 5AJ0, 5FLX, 5LKS, 5OA3, 5T2C, 5VYC, 6FEC, 6G18, 6G4S, 6G51, 6G53, 6G5H, 6G5I, 6IP5, 6IP6, 6IP8, 6OLE, 6OLF, 6OLG, 6OLI, 6OLZ, 6OM0, 6OM7, 6QZP, 6XA1, 6Y0G, 6Y2L, 6Y57, 6YBD, 6YBW, 6Z6L, 6Z6M, 6Z6N, 6ZLW, 6ZM7, 6ZME, 6ZMI, 6ZMO, 6ZMT, 6ZMW, 6ZN5, 6ZOJ, 6ZOK, 6ZON, 6ZP4, 6ZUO
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00318	Ribosomal_S2	18 → 118	Ribosomal protein S2	Family
  PF00318	Ribosomal_S2	111 → 184	Ribosomal protein S2	Family
  PF16122	40S_SA_C	202 → 295	40S ribosomal protein SA C-terminus	Family

• Sequence:

  MSGALDVLQMKEEDVLKFLAAGTHLGGTNLDFQMEQYIYKRKSDGIYIINLKRTWEKLLL
  AARAIVAIENPADVSVISSRNTGQRAVLKFAAATGATPIAGRFTPGTFTNQIQAAFREPR
  LLVVTDPRADHQPLTEASYVNLPTIALCNTDSPLRYVDIAIPCNNKGAHSVGLMWWMLAR
  EVLRMRGTISREHPWEVMPDLYFYRDPEEIEKEEQAAAEKAVTKEEFQGEWTAPAPEFTA
  TQPEVADWSEGVQVPSVPIQQFPTEDWSAQPATEDWSAAPTAQATEWVGATTDWS

• Sequence length: 295

Pathways

KEGG:

Ribosome
Coronavirus disease - COVID-19

Reactome:

L13a-mediated translational silencing of Ceruloplasmin expression
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Major pathway of rRNA processing in the nucleolus and cytosol
Translation initiation complex formation
Formation of a pool of free 40S subunits
Formation of the ternary complex, and subsequently, the 43S complex
Ribosomal scanning and start codon recognition
GTP hydrolysis and joining of the 60S ribosomal subunit
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Familial isolated congenital asplenia	Pathogenic; Likely pathogenic	rs397514759, rs398122389, rs397514760, rs397514761, rs397514762, rs397514763	RCV000054822 RCV000054823 RCV000054824 RCV000054825 RCV000054826 RCV000054827 RCV000054828	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ASPLENIA, ISOLATED CONGENITAL	—	CTD, HPO CTD, HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FRONTOTEMPORAL DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RPSA-related disorder	Uncertain significance; Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SPLENIC HYPOPLASIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Acute Coronary Syndrome	Coronary Syndrome	BEFREE	31057022		★☆☆☆☆ Found in Text Mining only
Acute leukemia	Leukemia	BEFREE	22664042		★☆☆☆☆ Found in Text Mining only
Acute lymphocytic leukemia	Lymphocytic Leukemia	BEFREE	15543372, 19672972, 22037714		★☆☆☆☆ Found in Text Mining only
Acute monocytic leukemia	Monocytic Leukemia	BEFREE	11986944		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma	Adenocarcinoma	BEFREE	22071786, 24194854, 25189640, 26317919, 28298147, 28394798, 28498881, 30718697, 31653135, 31786484, 8257781		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of colon	Adenocarcinoma Of Colon	BEFREE	18423375		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	BEFREE	24722356, 26469326, 28618937		★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	CTD_human_DG	27602772		★☆☆☆☆ Found in Text Mining only
Adenoid Cystic Carcinoma	Adenocarcinoma	BEFREE	31653135		★☆☆☆☆ Found in Text Mining only
Adenoma	Adenoma	BEFREE	25015728		★☆☆☆☆ Found in Text Mining only
Adult Acute Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	19672972, 22037714		★☆☆☆☆ Found in Text Mining only
Adult Acute Myeloblastic Leukemia	Myeloblastic Leukemia	BEFREE	11986944		★☆☆☆☆ Found in Text Mining only
Adult T-Cell Lymphoma/Leukemia	T-Cell Lymphoma/Leukemia	BEFREE	10404077, 11937269		★☆☆☆☆ Found in Text Mining only
Alzheimer Disease	Alzheimer disease	Pubtator	24048171, 24048412, 35766008, 40037473	Associate	★☆☆☆☆ Found in Text Mining only
ALZHEIMER DISEASE 2	Alzheimer disease	BEFREE	10737120		★☆☆☆☆ Found in Text Mining only
Alzheimer Disease, Late Onset	Alzheimer disease	BEFREE	10394937, 11076057, 11425005, 9350853, 9637403		★☆☆☆☆ Found in Text Mining only
Ameloblastoma	Ameloblastoma	BEFREE	30285997		★☆☆☆☆ Found in Text Mining only
Ankylosing spondylitis	Ankylosing Spondylitis	BEFREE	29880011		★☆☆☆☆ Found in Text Mining only
ANOPHTHALMIA AND PULMONARY HYPOPLASIA	Syndromic microphthalmia	BEFREE	28507327		★☆☆☆☆ Found in Text Mining only
Aortic Aneurysm, Abdominal	Aortic Aneurysm	BEFREE	31320700		★☆☆☆☆ Found in Text Mining only
Arteriosclerosis	Arteriosclerosis	BEFREE	15988104, 27796172		★☆☆☆☆ Found in Text Mining only
Arthritis	Arthritis	BEFREE	16482511		★☆☆☆☆ Found in Text Mining only
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	30718719	Inhibit	★☆☆☆☆ Found in Text Mining only
Asthma	Asthma	BEFREE	15007350		★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	BEFREE	17429576		★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	BEFREE	15988104, 27796172		★☆☆☆☆ Found in Text Mining only
Atypical Endometrial Hyperplasia	Endometrial Hyperplasia	BEFREE	30028353		★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune Diseases	BEFREE	28850053, 31342656		★☆☆☆☆ Found in Text Mining only
Behcet Syndrome	Behcet Syndrome	BEFREE	18205865		★☆☆☆☆ Found in Text Mining only
Bone Diseases	Bone Disease	BEFREE	26048454		★☆☆☆☆ Found in Text Mining only
Bone Marrow Diseases	Bone marrow diseases	Pubtator	7911032	Associate	★☆☆☆☆ Found in Text Mining only
Brain Neoplasms	Brain Neoplasms	BEFREE	9832203		★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	1399148, 26330357, 29107218, 30486550, 8895199		★☆☆☆☆ Found in Text Mining only
Breast Diseases	Breast Diseases	BEFREE	8895199		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	26427016, 26545108	Associate	★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	40141206	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma	Carcinoma	BEFREE	10066078, 11006321, 11862483, 25015728, 26330357, 30258209		★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	32964027	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	1534510, 22071786, 24722356, 26575266, 30354850, 31151274, 9459150, 9713513, 9891461		★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	22285843		★☆☆☆☆ Found in Text Mining only
Carcinoma, Spindle-Cell	Carcinoma	BEFREE	22071786, 24418859		★☆☆☆☆ Found in Text Mining only
Cerebral Infarction	Ischemic stroke	Pubtator	40696650	Associate	★☆☆☆☆ Found in Text Mining only
Cerebrovascular accident	Stroke	BEFREE	25042724, 27169840, 28797616		★☆☆☆☆ Found in Text Mining only
Cervix carcinoma	Cervix carcinoma	BEFREE	9792813		★☆☆☆☆ Found in Text Mining only
Childhood Acute Lymphoblastic Leukemia	Lymphoblastic Leukemia	BEFREE	15543372, 19672972, 22037714		★☆☆☆☆ Found in Text Mining only
Childhood Acute Myeloid Leukemia	Acute Myeloid Leukemia	BEFREE	11986944		★☆☆☆☆ Found in Text Mining only
Cholangiocarcinoma	Cholangiocarcinoma	BEFREE	20101459, 24794791		★☆☆☆☆ Found in Text Mining only
Classical Lissencephalies and Subcortical Band Heterotopias	Lissencephaly	Pubtator	34347028	Associate	★☆☆☆☆ Found in Text Mining only
Colitis	Colitis	BEFREE	22356855, 31010817		★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	1386115		★☆☆☆☆ Found in Text Mining only
Colonic Neoplasms	Colonic neoplasm	Pubtator	40141206	Associate	★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	23784800, 24460263, 29843646		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	BEFREE	1443045		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	24460263, 26293895, 29843646, 33836696, 40141206	Associate	★☆☆☆☆ Found in Text Mining only
Congenital absence of spleen	Asplenia	BEFREE	30337486, 31498527		★☆☆☆☆ Found in Text Mining only
Congenital absence of spleen	Asplenia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Congenital contractural arachnodactyly	Congenital Contractural Arachnodactyly	BEFREE	23313142		★☆☆☆☆ Found in Text Mining only
Coronary Arteriosclerosis	Coronary Arteriosclerosis	BEFREE	11074235		★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	BEFREE	11074235, 12732394, 15988104		★☆☆☆☆ Found in Text Mining only
Coronary Artery Disease	Coronary artery disease	Pubtator	38267845	Associate	★☆☆☆☆ Found in Text Mining only
Coronary heart disease	Coronary Heart Disease	BEFREE	11074235		★☆☆☆☆ Found in Text Mining only
Creutzfeldt-Jakob Disease, Sporadic	Creutzfeldt-Jakob disease	BEFREE	21838916		★☆☆☆☆ Found in Text Mining only
Crohn Disease	Crohn Disease	BEFREE	11515847, 12424624, 17007011, 18830267, 24138637, 28365485, 29409871, 29846261, 29909019, 30060945, 30169620, 30563755, 30884245, 31327402, 31722356, 31828765, 9502407		★☆☆☆☆ Found in Text Mining only
Degenerative polyarthritis	Arthritis	BEFREE	18276743, 29880011		★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	BEFREE	28464009		★☆☆☆☆ Found in Text Mining only
Dermatitis	Dermatitis	BEFREE	29544684		★☆☆☆☆ Found in Text Mining only
Dermatitis, Atopic	Dermatitis	BEFREE	11080718, 27745907		★☆☆☆☆ Found in Text Mining only
Dermatologic disorders	Dermatologic Disorders	BEFREE	29879253		★☆☆☆☆ Found in Text Mining only
Developmental Disabilities	Developmental disability	Pubtator	34347028	Associate	★☆☆☆☆ Found in Text Mining only
Diabetes	Diabetes	BEFREE	15988104		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes Mellitus	BEFREE	15988104		★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Insulin-Dependent	Diabetes Mellitus	BEFREE	12424623, 15603869		★☆☆☆☆ Found in Text Mining only
Eczema	Eczema	BEFREE	11080718, 27745907		★☆☆☆☆ Found in Text Mining only
Endometrial Carcinoma	Endometrial carcinoma	BEFREE	11006321, 30028353		★☆☆☆☆ Found in Text Mining only
Endometrial Hyperplasia	Endometrial Hyperplasia	BEFREE	30028353		★☆☆☆☆ Found in Text Mining only
Ependymoma	Ependymoma	BEFREE	17429576		★☆☆☆☆ Found in Text Mining only
Epithelial ovarian cancer	Ovarian cancer	BEFREE	22285843		★☆☆☆☆ Found in Text Mining only
Esophageal Neoplasms	Esophageal neoplasm	Pubtator	17960614	Associate	★☆☆☆☆ Found in Text Mining only
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	17960614	Associate	★☆☆☆☆ Found in Text Mining only
Ewings sarcoma	Ewing sarcoma	BEFREE	30285997		★☆☆☆☆ Found in Text Mining only
Fibrosis, Liver	Liver Fibrosis	BEFREE	28325896		★☆☆☆☆ Found in Text Mining only
Giant Cell Arteritis	Giant Cell Arteritis	BEFREE	29731755		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	25778325, 27748570, 9832203		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	25778325	Associate	★☆☆☆☆ Found in Text Mining only
Graft-vs-Host Disease	Graft-Vs-Host Disease	BEFREE	25846718		★☆☆☆☆ Found in Text Mining only
Hamartoma Syndrome, Multiple	Hamartoma	BEFREE	31722356		★☆☆☆☆ Found in Text Mining only
Hemoglobinopathies	Hemoglobinopathy	BEFREE	1655580		★☆☆☆☆ Found in Text Mining only
Heterotaxy Syndrome	Heterotaxy syndrome	Pubtator	31498527	Associate	★☆☆☆☆ Found in Text Mining only
Howell-Jolly Bodies	Howell-Jolly Bodies	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hyperlipidemia	Hyperlipidemia	BEFREE	15639492		★☆☆☆☆ Found in Text Mining only
Hypoxia	Hypoxia	Pubtator	20491781, 28618937	Stimulate	★☆☆☆☆ Found in Text Mining only
Idiopathic pulmonary arterial hypertension	Pulmonary arterial hypertension	BEFREE	11282888		★☆☆☆☆ Found in Text Mining only
Idiopathic Pulmonary Fibrosis	Pulmonary Fibrosis	BEFREE	12914676		★☆☆☆☆ Found in Text Mining only
Idiopathic pulmonary hypertension	Pulmonary Hypertension	BEFREE	11282888		★☆☆☆☆ Found in Text Mining only
Immunologic Deficiency Syndromes	Immunologic Deficiency Syndromes	BEFREE	8656012		★☆☆☆☆ Found in Text Mining only
Impaired cognition	Impaired Cognition	BEFREE	14575236, 28464009		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory Bowel Disease	BEFREE	11515847, 23573954, 28100093, 29754190, 29788053		★☆☆☆☆ Found in Text Mining only
Inflammatory Bowel Diseases	Inflammatory bowel disease	Pubtator	29723847	Inhibit	★☆☆☆☆ Found in Text Mining only
Ischemic stroke	Ischemic Stroke	BEFREE	25042724		★☆☆☆☆ Found in Text Mining only
leukemia	Leukemia	BEFREE	17671794, 28699539		★☆☆☆☆ Found in Text Mining only
Leukemia	Leukemia	Pubtator	21056082	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia Myeloid Acute	Myeloid leukemia	Pubtator	23916810	Associate	★☆☆☆☆ Found in Text Mining only
Leukemia, Myelocytic, Acute	Leukemia	BEFREE	11355932, 11726321, 11986944, 12962366, 15642669, 28805931, 8630412, 9031075, 9357965, 9473213		★☆☆☆☆ Found in Text Mining only
Leukemia, T-Cell	T-cell leukemia	BEFREE	10404077, 11937269, 9778689		★☆☆☆☆ Found in Text Mining only
Liposarcoma	Liposarcoma	Pubtator	18820673	Associate	★☆☆☆☆ Found in Text Mining only
Liposarcoma, Myxoid	liposarcoma	BEFREE	1318779, 2548950		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	14578863		★☆☆☆☆ Found in Text Mining only
Liver neoplasms	Liver neoplasms	BEFREE	31488173		★☆☆☆☆ Found in Text Mining only
Lung Diseases	Lung disease	Pubtator	23472084	Associate	★☆☆☆☆ Found in Text Mining only
Lung diseases	Lung Diseases	BEFREE	29779777		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	LHGDN	18794547		★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	23374247, 23472084, 28618937, 36579897	Associate	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung Neoplasms	BEFREE	9891461		★☆☆☆☆ Found in Text Mining only
Lupus Erythematosus, Systemic	Lupus Erythematosus	BEFREE	10525320, 11014347, 30664357, 31342656		★☆☆☆☆ Found in Text Mining only
Lymphoma	Lymphoma	BEFREE	10066078, 15161039, 28699539		★☆☆☆☆ Found in Text Mining only
Lymphoma, Large-Cell, Follicular	Lymphoma	BEFREE	12153001		★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin	Non-Hodgkin lymphoma	BEFREE	12153001		★☆☆☆☆ Found in Text Mining only
Lymphoma, Non-Hodgkin, Familial	Lymphoma	BEFREE	12153001		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	1399148, 29107218, 30486550, 8895199		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of endometrium	Endometrial Cancer	BEFREE	30028353		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of esophagus	Esophagus Neoplasm	BEFREE	26427016		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	1534510, 22071786, 24722356, 30354850, 30718697, 31151274, 9459150, 9713513, 9891461		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of pancreas	Pancreatic cancer	BEFREE	28899658, 30894280		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	10362802, 21480311, 29073075		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	19123465, 20491781, 24703465, 25060631, 29069734		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	10066078, 1386115, 1443045, 15072883, 17535553, 18387633, 19724263, 20491781, 27748570, 28699539, 29073075, 29464047, 29867512, 30563268, 30739912, 8257781, 8862006, 8895199		★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	1386115		★☆☆☆☆ Found in Text Mining only
Mammary Neoplasms	Mammary Neoplasms	BEFREE	22433869		★☆☆☆☆ Found in Text Mining only
Medulloblastoma	Medulloblastoma	BEFREE	17429576		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	10735498, 20548792	Associate	★☆☆☆☆ Found in Text Mining only
melanoma	Melanoma	BEFREE	15563845, 1833053, 25294877, 29653110		★☆☆☆☆ Found in Text Mining only
Moyamoya Disease	Moyamoya Disease	BEFREE	28797616		★☆☆☆☆ Found in Text Mining only
Moyamoya disease 1	Moyamoya disease	BEFREE	28797616		★☆☆☆☆ Found in Text Mining only
Mucosa-Associated Lymphoid Tissue Lymphoma	Mucosa-associated lymphoma	BEFREE	11553588		★☆☆☆☆ Found in Text Mining only
Multiple Myeloma	Multiple myeloma	BEFREE	10809991, 16809610, 19961481, 24077352		★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple Sclerosis	BEFREE	10516776, 15988104, 26000455		★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial infarction	Pubtator	36769107	Associate	★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial Infarction	BEFREE	9694437		★☆☆☆☆ Found in Text Mining only
Myxoid/Round Cell Liposarcoma	Myxoid Liposarcoma	BEFREE	1318779		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	10066078, 11268451, 11358987, 12850476, 12875970, 1386115, 15947111, 16763609, 16823838, 1833053, 19231538, 19724263, 21895963, 23249701, 25130377, 25294877, 27748570, 28699539, 28808017, 29486285, 29867512, 30216599, 30285997, 31548087, 31786484, 9607416, 9614572		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	16516231, 16609945, 28899658		★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	20515747, 21862871		★☆☆☆☆ Found in Text Mining only
Neuroendocrine Tumors	Neuroendocrine Tumors	BEFREE	30354850		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	11004683, 23178957, 27258567, 27268921, 29410129		★☆☆☆☆ Found in Text Mining only
Noninfiltrating Intraductal Carcinoma	Ductal carcinoma	BEFREE	26330357		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	21193558	Associate	★☆☆☆☆ Found in Text Mining only
Pancreatic carcinoma	Pancreatic carcinoma	BEFREE	28899658, 30894280		★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	30894280	Associate	★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	10495048		★☆☆☆☆ Found in Text Mining only
Peptic Ulcer	Peptic Ulcer	BEFREE	15620465		★☆☆☆☆ Found in Text Mining only
Pilocytic Astrocytoma	Astrocytoma	BEFREE	17429576		★☆☆☆☆ Found in Text Mining only
Precursor Cell Lymphoblastic Leukemia Lymphoma	Lymphoblastic Leukemia	BEFREE	15543372		★☆☆☆☆ Found in Text Mining only
Prion Diseases	Prion disease	Pubtator	21838916	Associate	★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	10362802, 21480311, 29073075		★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	BEFREE	23376980, 25354400, 28100093, 29544684, 30215632		★☆☆☆☆ Found in Text Mining only
Psoriasis vulgaris	Psoriasis vulgaris	BEFREE	14707118		★☆☆☆☆ Found in Text Mining only
Retinal Diseases	Retinal Diseases	BEFREE	9588904		★☆☆☆☆ Found in Text Mining only
Rheumatoid Arthritis	Rheumatoid arthritis	BEFREE	11145021, 18276743, 26956410, 29880011, 30718719		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	31155012		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Small cell carcinoma of lung	Lung carcinoma	BEFREE	17671723, 30957413, 8760291		★☆☆☆☆ Found in Text Mining only
Splenic Hypoplasia	Splenic Hypoplasia	BEFREE	23579497, 30072435, 30355204, 30941084		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Splenic Hypoplasia	Splenic Hypoplasia	ORPHANET_DG	23579497		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Splenic Hypoplasia	Splenic Hypoplasia	UNIPROT_DG	23579497		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Splenic Hypoplasia	Splenic Hypoplasia	GENOMICS_ENGLAND_DG	23579497		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Splenic Hypoplasia	Splenic Hypoplasia	CTD_human_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Splenic Hypoplasia	Splenic Hypoplasia	CLINVAR_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Squamous cell carcinoma	Carcinoma	BEFREE	22071786, 24166777, 24194854, 26317919, 28298147, 30216599, 30546464, 31366562, 31786484, 31845086		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	19123465, 20491781, 24703465, 25060631, 29069734		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	12440778, 20491781, 24706505	Associate	★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach Neoplasms	LHGDN	19123465		★☆☆☆☆ Found in Text Mining only
T-Cell Lymphoma	T-Cell Lymphoma	BEFREE	18972317		★☆☆☆☆ Found in Text Mining only
Ulcerative Colitis	Ulcerative colitis	BEFREE	11515847, 24138637, 30563755, 30884245		★☆☆☆☆ Found in Text Mining only
Varicose Veins	Varicose veins	Pubtator	31498527	Associate	★☆☆☆☆ Found in Text Mining only