Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	391059
Gene name	Ferric chelate reductase 1
Gene symbol	FRRS1
Synonyms (NCBI Gene)	SDFR2SDR2
Chromosome	1
Chromosome location	1p21.2
Summary	Members of the cytochrome b561 (CYB561; MIM 600019) family, including FRRS1, reduce ferric to ferrous iron before its transport from the endosome to the cytoplasm (Vargas et al., 2003 [PubMed 14499595]).[supplied by OMIM, Mar 2008]

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Show/Hide all (181)

miRTarBase ID	miRNA	Experiments	Reference
MIRT518443	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT518442	hsa-miR-487b-3p	HITS-CLIP	21572407
MIRT518441	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT518440	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT518440	hsa-miR-1277-5p	HITS-CLIP	22927820
MIRT518443	hsa-miR-5011-5p	HITS-CLIP	22927820
MIRT518442	hsa-miR-487b-3p	HITS-CLIP	22927820
MIRT518441	hsa-miR-190a-3p	HITS-CLIP	22927820
MIRT518443	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT518442	hsa-miR-487b-3p	HITS-CLIP	23313552
MIRT518441	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT518440	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT688183	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT688182	hsa-miR-6732-3p	HITS-CLIP	23313552
MIRT688181	hsa-miR-10a-5p	HITS-CLIP	23313552
MIRT688180	hsa-miR-10b-5p	HITS-CLIP	23313552
MIRT688179	hsa-miR-339-5p	HITS-CLIP	23313552
MIRT688178	hsa-miR-4421	HITS-CLIP	23313552
MIRT688177	hsa-miR-5699-3p	HITS-CLIP	23313552
MIRT688176	hsa-miR-4790-3p	HITS-CLIP	23313552
MIRT688175	hsa-miR-6895-3p	HITS-CLIP	23313552
MIRT688174	hsa-miR-593-3p	HITS-CLIP	23313552
MIRT688173	hsa-miR-1257	HITS-CLIP	23313552
MIRT688172	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT688171	hsa-miR-6818-3p	HITS-CLIP	23313552
MIRT518440	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT518443	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518442	hsa-miR-487b-3p	HITS-CLIP	23824327
MIRT518441	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT518440	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT518443	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518442	hsa-miR-487b-3p	HITS-CLIP	23824327
MIRT518441	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT632923	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT632922	hsa-miR-665	HITS-CLIP	23824327
MIRT632921	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT632920	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT632919	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT632918	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT632917	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT632916	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT632915	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT632914	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT632913	hsa-miR-1271-3p	HITS-CLIP	23824327
MIRT632912	hsa-miR-550a-3-5p	HITS-CLIP	23824327
MIRT632911	hsa-miR-550a-5p	HITS-CLIP	23824327
MIRT632910	hsa-miR-7977	HITS-CLIP	23824327
MIRT632909	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT632908	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT632907	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT632906	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT632905	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT632904	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT632903	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT632902	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT632901	hsa-miR-3689c	HITS-CLIP	23824327
MIRT632900	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT632899	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT632898	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT632897	hsa-miR-3122	HITS-CLIP	23824327
MIRT632896	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT632895	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT632894	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT518440	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT518443	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518442	hsa-miR-487b-3p	HITS-CLIP	23824327
MIRT518441	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT518440	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT518443	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518442	hsa-miR-487b-3p	HITS-CLIP	23824327
MIRT518441	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT518440	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT518443	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518442	hsa-miR-487b-3p	HITS-CLIP	23824327
MIRT518441	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT518443	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT518442	hsa-miR-487b-3p	PAR-CLIP	21572407
MIRT518441	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT518440	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT518443	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT518442	hsa-miR-487b-3p	PAR-CLIP	23446348
MIRT518441	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT518440	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT518443	hsa-miR-5011-5p	HITS-CLIP	21572407
MIRT518442	hsa-miR-487b-3p	HITS-CLIP	21572407
MIRT518441	hsa-miR-190a-3p	HITS-CLIP	21572407
MIRT518440	hsa-miR-1277-5p	HITS-CLIP	21572407
MIRT518440	hsa-miR-1277-5p	HITS-CLIP	22927820
MIRT518443	hsa-miR-5011-5p	HITS-CLIP	22927820
MIRT518442	hsa-miR-487b-3p	HITS-CLIP	22927820
MIRT518441	hsa-miR-190a-3p	HITS-CLIP	22927820
MIRT518443	hsa-miR-5011-5p	HITS-CLIP	23313552
MIRT518442	hsa-miR-487b-3p	HITS-CLIP	23313552
MIRT518441	hsa-miR-190a-3p	HITS-CLIP	23313552
MIRT518440	hsa-miR-1277-5p	HITS-CLIP	23313552
MIRT688183	hsa-miR-548c-3p	HITS-CLIP	23313552
MIRT688182	hsa-miR-6732-3p	HITS-CLIP	23313552
MIRT688181	hsa-miR-10a-5p	HITS-CLIP	23313552
MIRT688180	hsa-miR-10b-5p	HITS-CLIP	23313552
MIRT688179	hsa-miR-339-5p	HITS-CLIP	23313552
MIRT688178	hsa-miR-4421	HITS-CLIP	23313552
MIRT688177	hsa-miR-5699-3p	HITS-CLIP	23313552
MIRT688176	hsa-miR-4790-3p	HITS-CLIP	23313552
MIRT688175	hsa-miR-6895-3p	HITS-CLIP	23313552
MIRT688174	hsa-miR-593-3p	HITS-CLIP	23313552
MIRT688173	hsa-miR-1257	HITS-CLIP	23313552
MIRT688172	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT688171	hsa-miR-6818-3p	HITS-CLIP	23313552
MIRT518440	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT518443	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518442	hsa-miR-487b-3p	HITS-CLIP	23824327
MIRT518441	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT518440	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT518443	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518442	hsa-miR-487b-3p	HITS-CLIP	23824327
MIRT518441	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT632923	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT632922	hsa-miR-665	HITS-CLIP	23824327
MIRT632921	hsa-miR-214-5p	HITS-CLIP	23824327
MIRT632920	hsa-miR-6811-3p	HITS-CLIP	23824327
MIRT632919	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT632918	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT632917	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT632916	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT632915	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT632914	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT632913	hsa-miR-1271-3p	HITS-CLIP	23824327
MIRT632912	hsa-miR-550a-3-5p	HITS-CLIP	23824327
MIRT632911	hsa-miR-550a-5p	HITS-CLIP	23824327
MIRT632910	hsa-miR-7977	HITS-CLIP	23824327
MIRT632909	hsa-miR-6514-3p	HITS-CLIP	23824327
MIRT632908	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT632907	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT632906	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT632905	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT632904	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT632903	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT632902	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT632901	hsa-miR-3689c	HITS-CLIP	23824327
MIRT632900	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT632899	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT632898	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT632897	hsa-miR-3122	HITS-CLIP	23824327
MIRT632896	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT632895	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT632894	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT518440	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT518443	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518442	hsa-miR-487b-3p	HITS-CLIP	23824327
MIRT518441	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT518440	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT518443	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518442	hsa-miR-487b-3p	HITS-CLIP	23824327
MIRT518441	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT518440	hsa-miR-1277-5p	HITS-CLIP	23824327
MIRT518443	hsa-miR-5011-5p	HITS-CLIP	23824327
MIRT518442	hsa-miR-487b-3p	HITS-CLIP	23824327
MIRT518441	hsa-miR-190a-3p	HITS-CLIP	23824327
MIRT518443	hsa-miR-5011-5p	PAR-CLIP	21572407
MIRT518442	hsa-miR-487b-3p	PAR-CLIP	21572407
MIRT518441	hsa-miR-190a-3p	PAR-CLIP	21572407
MIRT518440	hsa-miR-1277-5p	PAR-CLIP	21572407
MIRT518443	hsa-miR-5011-5p	PAR-CLIP	23446348
MIRT518442	hsa-miR-487b-3p	PAR-CLIP	23446348
MIRT518441	hsa-miR-190a-3p	PAR-CLIP	23446348
MIRT518440	hsa-miR-1277-5p	PAR-CLIP	23446348
MIRT1004920	hsa-miR-1912	CLIP-seq
MIRT1004921	hsa-miR-208a	CLIP-seq
MIRT1004922	hsa-miR-208b	CLIP-seq
MIRT1004923	hsa-miR-3124-3p	CLIP-seq
MIRT1004924	hsa-miR-3658	CLIP-seq
MIRT1004925	hsa-miR-3667-5p	CLIP-seq
MIRT1004926	hsa-miR-499-5p	CLIP-seq
MIRT1920046	hsa-miR-34b	CLIP-seq
MIRT1920047	hsa-miR-34c-3p	CLIP-seq
MIRT1920046	hsa-miR-34b	CLIP-seq
MIRT1920047	hsa-miR-34c-3p	CLIP-seq
MIRT1920046	hsa-miR-34b	CLIP-seq
MIRT1920047	hsa-miR-34c-3p	CLIP-seq
MIRT1920046	hsa-miR-34b	CLIP-seq
MIRT1920047	hsa-miR-34c-3p	CLIP-seq

Show/Hide all (8)

GO ID	Ontology	Definition	Evidence	Reference
GO:0006879	Process	Intracellular iron ion homeostasis	IBA
GO:0006879	Process	Intracellular iron ion homeostasis	ISS
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0016722	Function	Oxidoreductase activity, acting on metal ions	IBA
GO:0016722	Function	Oxidoreductase activity, acting on metal ions	ISS	14499595
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
611578	27622	ENSG00000156869

Q6ZNA5

Protein name

Ferric-chelate reductase 1 (EC 1.-.-.-) (Stromal cell-derived receptor 2) (SDR-2)

Protein function

Ferric-chelate reductases reduce Fe(3+) to Fe(2+) before its transport from the endosome to the cytoplasm.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF02014	Reeler	32 → 155	Reeler domain	Family
PF03351	DOMON	214 → 331	DOMON domain	Domain

Sequence

MAVSGFTLGTCILLLHISYVANYPNGKVTQSCHGMIPEHGHSPQSVPVHDIYVSQMTFRP
GDQIEVTLSGHPFKGFLLEARNAEDLNGPPIGSFTLIDSEVSQLLTCEDIQGSAVSHRSA
SKKTEIKVYWNAPSSAPNHTQFLVTVVEKYKIYWVKIPGPIISQPNAFPFTTPKATVVPL
PTLPPVSHLTKPFSASDCGNKKFCIRSPLNCDPEKEASCVFLSFTRDDQSVMVEMSGPSK
GYLSFALSHDQWMGDDDAYLCIHEDQTVYIQPSHLTGRSHPVMDSRDTLEDMAWRLADGV
MQCSFRRNITLPGVKNRFDLNTSYYIFLADGAANDGRIYKHSQQPLITYEKYDVTDSPKN
IGGSHSVLLLKVHGALMFVAWMTTVSIGVLVARFFKPVWSKAFLLGEAAWFQVHRMLMFT
TTVLTCIAFVMPFIYRGGWSRHAGYHPYLGCIVMTLAVLQPLLAVFRPPLHDPRRQMFNW
THWSMGTAARIIAVAAMFLGMDLPGLNLPDSWKTYAMTGFVAWHVGTEVVLEVHAYRLSR
KVEILDDDRIQILQSFTAVETEGHAFKKAVLAIYVCGNVTFLIIFLSAINHL

Sequence length

592

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
OCULAR HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Asthma	Asthma	Pubtator	32277847	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermatitis	Dermatitis	Pubtator	32277847	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	Pubtator	35285582	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Rhinitis	Rhinitis	Pubtator	32277847	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

FRRS1 (ferric chelate reductase 1)