Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	389840
Gene name	Mitogen-activated protein kinase kinase kinase 15
Gene symbol	MAP3K15
Synonyms (NCBI Gene)	ASK3bA723P2.3
Chromosome	X
Chromosome location	Xp22.12
Summary	The protein encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a protein kinase signal transduction cascade, where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a

202

Show/Hide all (202)

miRTarBase ID	miRNA	Experiments
MIRT1128587	hsa-miR-181a	CLIP-seq
MIRT1128588	hsa-miR-181b	CLIP-seq
MIRT1128589	hsa-miR-181c	CLIP-seq
MIRT1128590	hsa-miR-181d	CLIP-seq
MIRT1128591	hsa-miR-1827	CLIP-seq
MIRT1128592	hsa-miR-197	CLIP-seq
MIRT1128593	hsa-miR-2682	CLIP-seq
MIRT1128594	hsa-miR-3168	CLIP-seq
MIRT1128595	hsa-miR-338-3p	CLIP-seq
MIRT1128596	hsa-miR-340	CLIP-seq
MIRT1128597	hsa-miR-34a	CLIP-seq
MIRT1128598	hsa-miR-34c-5p	CLIP-seq
MIRT1128599	hsa-miR-3657	CLIP-seq
MIRT1128600	hsa-miR-3941	CLIP-seq
MIRT1128601	hsa-miR-4262	CLIP-seq
MIRT1128602	hsa-miR-4277	CLIP-seq
MIRT1128603	hsa-miR-4303	CLIP-seq
MIRT1128604	hsa-miR-4307	CLIP-seq
MIRT1128605	hsa-miR-449a	CLIP-seq
MIRT1128606	hsa-miR-449b	CLIP-seq
MIRT1128607	hsa-miR-449c	CLIP-seq
MIRT1128608	hsa-miR-4530	CLIP-seq
MIRT1128609	hsa-miR-4643	CLIP-seq
MIRT1128610	hsa-miR-4649-3p	CLIP-seq
MIRT1128611	hsa-miR-466	CLIP-seq
MIRT1128612	hsa-miR-4672	CLIP-seq
MIRT1128613	hsa-miR-4684-5p	CLIP-seq
MIRT1128614	hsa-miR-4789-3p	CLIP-seq
MIRT1128615	hsa-miR-5096	CLIP-seq
MIRT2036500	hsa-miR-1184	CLIP-seq
MIRT2036501	hsa-miR-122	CLIP-seq
MIRT2036502	hsa-miR-1267	CLIP-seq
MIRT2036503	hsa-miR-24	CLIP-seq
MIRT2036504	hsa-miR-2681	CLIP-seq
MIRT2036505	hsa-miR-3135b	CLIP-seq
MIRT2036506	hsa-miR-3650	CLIP-seq
MIRT2036507	hsa-miR-3652	CLIP-seq
MIRT2036508	hsa-miR-4284	CLIP-seq
MIRT2036509	hsa-miR-4418	CLIP-seq
MIRT2036510	hsa-miR-4423-5p	CLIP-seq
MIRT2036511	hsa-miR-4430	CLIP-seq
MIRT2036512	hsa-miR-509-3-5p	CLIP-seq
MIRT2036513	hsa-miR-509-5p	CLIP-seq
MIRT2036514	hsa-miR-760	CLIP-seq
MIRT2036500	hsa-miR-1184	CLIP-seq
MIRT2036501	hsa-miR-122	CLIP-seq
MIRT2266803	hsa-miR-1224-3p	CLIP-seq
MIRT2266804	hsa-miR-1228	CLIP-seq
MIRT2266805	hsa-miR-1260	CLIP-seq
MIRT2266806	hsa-miR-1260b	CLIP-seq
MIRT2036502	hsa-miR-1267	CLIP-seq
MIRT2266807	hsa-miR-1280	CLIP-seq
MIRT2266808	hsa-miR-1343	CLIP-seq
MIRT2036503	hsa-miR-24	CLIP-seq
MIRT2036504	hsa-miR-2681	CLIP-seq
MIRT2036505	hsa-miR-3135b	CLIP-seq
MIRT2036506	hsa-miR-3650	CLIP-seq
MIRT2036507	hsa-miR-3652	CLIP-seq
MIRT2266809	hsa-miR-378g	CLIP-seq
MIRT2266810	hsa-miR-3944-3p	CLIP-seq
MIRT2036508	hsa-miR-4284	CLIP-seq
MIRT2036509	hsa-miR-4418	CLIP-seq
MIRT2036510	hsa-miR-4423-5p	CLIP-seq
MIRT2036511	hsa-miR-4430	CLIP-seq
MIRT2266811	hsa-miR-4437	CLIP-seq
MIRT2266812	hsa-miR-4674	CLIP-seq
MIRT2036512	hsa-miR-509-3-5p	CLIP-seq
MIRT2036513	hsa-miR-509-5p	CLIP-seq
MIRT2266813	hsa-miR-532-3p	CLIP-seq
MIRT2036514	hsa-miR-760	CLIP-seq
MIRT2036501	hsa-miR-122	CLIP-seq
MIRT2036503	hsa-miR-24	CLIP-seq
MIRT2036504	hsa-miR-2681	CLIP-seq
MIRT2036505	hsa-miR-3135b	CLIP-seq
MIRT2036506	hsa-miR-3650	CLIP-seq
MIRT2036507	hsa-miR-3652	CLIP-seq
MIRT2036508	hsa-miR-4284	CLIP-seq
MIRT2036511	hsa-miR-4430	CLIP-seq
MIRT2453671	hsa-miR-1206	CLIP-seq
MIRT2036501	hsa-miR-122	CLIP-seq
MIRT2453672	hsa-miR-124	CLIP-seq
MIRT2453673	hsa-miR-127-5p	CLIP-seq
MIRT1128587	hsa-miR-181a	CLIP-seq
MIRT1128588	hsa-miR-181b	CLIP-seq
MIRT1128589	hsa-miR-181c	CLIP-seq
MIRT1128590	hsa-miR-181d	CLIP-seq
MIRT2036504	hsa-miR-2681	CLIP-seq
MIRT2036505	hsa-miR-3135b	CLIP-seq
MIRT2036506	hsa-miR-3650	CLIP-seq
MIRT2036507	hsa-miR-3652	CLIP-seq
MIRT1128600	hsa-miR-3941	CLIP-seq
MIRT1128601	hsa-miR-4262	CLIP-seq
MIRT2036510	hsa-miR-4423-5p	CLIP-seq
MIRT2036511	hsa-miR-4430	CLIP-seq
MIRT2453674	hsa-miR-4517	CLIP-seq
MIRT1128609	hsa-miR-4643	CLIP-seq
MIRT2453675	hsa-miR-4652-3p	CLIP-seq
MIRT1128611	hsa-miR-466	CLIP-seq
MIRT1128612	hsa-miR-4672	CLIP-seq
MIRT1128614	hsa-miR-4789-3p	CLIP-seq
MIRT2453676	hsa-miR-506	CLIP-seq
MIRT2453677	hsa-miR-606	CLIP-seq
MIRT2453678	hsa-miR-624	CLIP-seq
MIRT2036500	hsa-miR-1184	CLIP-seq
MIRT2453671	hsa-miR-1206	CLIP-seq
MIRT2036501	hsa-miR-122	CLIP-seq
MIRT2453672	hsa-miR-124	CLIP-seq
MIRT2036502	hsa-miR-1267	CLIP-seq
MIRT2453673	hsa-miR-127-5p	CLIP-seq
MIRT1128587	hsa-miR-181a	CLIP-seq
MIRT1128588	hsa-miR-181b	CLIP-seq
MIRT1128589	hsa-miR-181c	CLIP-seq
MIRT1128590	hsa-miR-181d	CLIP-seq
MIRT1128591	hsa-miR-1827	CLIP-seq
MIRT2566354	hsa-miR-2113	CLIP-seq
MIRT2036503	hsa-miR-24	CLIP-seq
MIRT2036504	hsa-miR-2681	CLIP-seq
MIRT1128593	hsa-miR-2682	CLIP-seq
MIRT2036505	hsa-miR-3135b	CLIP-seq
MIRT1128597	hsa-miR-34a	CLIP-seq
MIRT1128598	hsa-miR-34c-5p	CLIP-seq
MIRT2566355	hsa-miR-3616-5p	CLIP-seq
MIRT2566356	hsa-miR-3647-5p	CLIP-seq
MIRT2036506	hsa-miR-3650	CLIP-seq
MIRT2036507	hsa-miR-3652	CLIP-seq
MIRT1128599	hsa-miR-3657	CLIP-seq
MIRT2566357	hsa-miR-371-5p	CLIP-seq
MIRT2566358	hsa-miR-371b-5p	CLIP-seq
MIRT1128600	hsa-miR-3941	CLIP-seq
MIRT2266810	hsa-miR-3944-3p	CLIP-seq
MIRT1128601	hsa-miR-4262	CLIP-seq
MIRT1128602	hsa-miR-4277	CLIP-seq
MIRT2036508	hsa-miR-4284	CLIP-seq
MIRT1128603	hsa-miR-4303	CLIP-seq
MIRT2566359	hsa-miR-4328	CLIP-seq
MIRT2036509	hsa-miR-4418	CLIP-seq
MIRT2036510	hsa-miR-4423-5p	CLIP-seq
MIRT2036511	hsa-miR-4430	CLIP-seq
MIRT1128605	hsa-miR-449a	CLIP-seq
MIRT1128606	hsa-miR-449b	CLIP-seq
MIRT1128607	hsa-miR-449c	CLIP-seq
MIRT2453674	hsa-miR-4517	CLIP-seq
MIRT1128609	hsa-miR-4643	CLIP-seq
MIRT1128610	hsa-miR-4649-3p	CLIP-seq
MIRT2453675	hsa-miR-4652-3p	CLIP-seq
MIRT1128611	hsa-miR-466	CLIP-seq
MIRT1128612	hsa-miR-4672	CLIP-seq
MIRT1128614	hsa-miR-4789-3p	CLIP-seq
MIRT2453676	hsa-miR-506	CLIP-seq
MIRT2036512	hsa-miR-509-3-5p	CLIP-seq
MIRT2036513	hsa-miR-509-5p	CLIP-seq
MIRT2566360	hsa-miR-513c	CLIP-seq
MIRT2566361	hsa-miR-514b-5p	CLIP-seq
MIRT2566362	hsa-miR-573	CLIP-seq
MIRT2566363	hsa-miR-599	CLIP-seq
MIRT2453677	hsa-miR-606	CLIP-seq
MIRT2453678	hsa-miR-624	CLIP-seq
MIRT2036514	hsa-miR-760	CLIP-seq
MIRT2036500	hsa-miR-1184	CLIP-seq
MIRT2453671	hsa-miR-1206	CLIP-seq
MIRT2036501	hsa-miR-122	CLIP-seq
MIRT2453672	hsa-miR-124	CLIP-seq
MIRT2036502	hsa-miR-1267	CLIP-seq
MIRT2453673	hsa-miR-127-5p	CLIP-seq
MIRT1128587	hsa-miR-181a	CLIP-seq
MIRT1128588	hsa-miR-181b	CLIP-seq
MIRT1128589	hsa-miR-181c	CLIP-seq
MIRT1128590	hsa-miR-181d	CLIP-seq
MIRT2566354	hsa-miR-2113	CLIP-seq
MIRT2036503	hsa-miR-24	CLIP-seq
MIRT2036504	hsa-miR-2681	CLIP-seq
MIRT2036505	hsa-miR-3135b	CLIP-seq
MIRT2566355	hsa-miR-3616-5p	CLIP-seq
MIRT2566356	hsa-miR-3647-5p	CLIP-seq
MIRT2036506	hsa-miR-3650	CLIP-seq
MIRT2036507	hsa-miR-3652	CLIP-seq
MIRT2566357	hsa-miR-371-5p	CLIP-seq
MIRT2566358	hsa-miR-371b-5p	CLIP-seq
MIRT1128600	hsa-miR-3941	CLIP-seq
MIRT2266810	hsa-miR-3944-3p	CLIP-seq
MIRT1128601	hsa-miR-4262	CLIP-seq
MIRT2036508	hsa-miR-4284	CLIP-seq
MIRT2566359	hsa-miR-4328	CLIP-seq
MIRT2036509	hsa-miR-4418	CLIP-seq
MIRT2036510	hsa-miR-4423-5p	CLIP-seq
MIRT2036511	hsa-miR-4430	CLIP-seq
MIRT2453674	hsa-miR-4517	CLIP-seq
MIRT1128609	hsa-miR-4643	CLIP-seq
MIRT2453675	hsa-miR-4652-3p	CLIP-seq
MIRT1128611	hsa-miR-466	CLIP-seq
MIRT1128612	hsa-miR-4672	CLIP-seq
MIRT1128614	hsa-miR-4789-3p	CLIP-seq
MIRT2453676	hsa-miR-506	CLIP-seq
MIRT2036512	hsa-miR-509-3-5p	CLIP-seq
MIRT2036513	hsa-miR-509-5p	CLIP-seq
MIRT2566360	hsa-miR-513c	CLIP-seq
MIRT2566361	hsa-miR-514b-5p	CLIP-seq
MIRT2566362	hsa-miR-573	CLIP-seq
MIRT2566363	hsa-miR-599	CLIP-seq
MIRT2453677	hsa-miR-606	CLIP-seq
MIRT2453678	hsa-miR-624	CLIP-seq
MIRT2036514	hsa-miR-760	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000165	Process	MAPK cascade	IEA
GO:0000166	Function	Nucleotide binding	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0004709	Function	MAP kinase kinase kinase activity	IBA
GO:0004709	Function	MAP kinase kinase kinase activity	IDA	26732173
GO:0004709	Function	MAP kinase kinase kinase activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0007254	Process	JNK cascade	IBA
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0038066	Process	P38MAPK cascade	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0106310	Function	Protein serine kinase activity	IEA

MIM	HGNC	e!Ensembl
300820	31689	ENSG00000180815

Q6ZN16

Protein name

Mitogen-activated protein kinase kinase kinase 15 (EC 2.7.11.25) (Apoptosis signal-regulating kinase 3) (MAPK/ERK kinase kinase 15) (MEK kinase 15) (MEKK 15)

Protein function

Serine/threonine kinase which acts as a component of the MAP kinase signal transduction pathway (PubMed:20362554, PubMed:26732173). Once activated, acts as an upstream activator of the p38 MAPK signal transduction cascade through the phosphoryla

PDB

6V0M

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13281	DUF4071	136 → 515	Domain of unknown function (DUF4071)	Family
PF19039	ASK_PH	525 → 624	ASK kinase PH domain	Domain
PF00069	Pkinase	653 → 908	Protein kinase domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Isoform 2 and isoform 3 are widely expressed. Isoform 2 highest levels are observed in fetal brain, and isoform 3 highest levels in pancreas, peripheral blood leukocytes, fetal brain and spleen. {ECO:0000269|PubMed:20362554}.

Sequence

MESGGGNAPAGALGAASESPQCPPPPGVEGAAGPAEPDGAAEGAAGGSGEGESGGGPRRA
LRAVYVRSESSQGGAAGGPEAGARQCLLRACEAEGAHLTSVPFGELDFGETAVLDAFYDA
DVAVVDMSDVSRQPSLFYHLGVRESFDMANNVILYHDTDADTALSLKDMVTQKNTASSGN
YYFIPYIVTPCADYFCCESDAQRRASEYMQPNWDNILGPLCMPLVDRFISLLKDIHVTSC
VYYKETLLNDIRKAREKYQGEELAKELARIKLRMDNTEVLTSDIIINLLLSYRDIQDYDA
MVKLVETLEMLPTCDLADQHNIKFHYAFALNRRNSTGDREKALQIMLQVLQSCDHPGPDM
FCLCGRIYKDIFLDSDCKDDTSRDSAIEWYRKGFELQSSLYSGINLAVLLIVAGQQFETS
LELRKIGVRLNSLLGRKGSLEKMNNYWDVGQFFSVSMLAHDVGKAVQAAERLFKLKPPVW
YLRSLVQNLLLIRRFKKTIIEHSPRQERLNFWLDIIFEATNEVTNGLRFPVLVIEPTKVY
QPSYVSINNEAEERTVSLWHVSPTEMKQMHEWNFTASSIKGISLSKFDERCCFLYVHDNS
DDFQIYFSTEEQCSRFFSLVKEMITNTAGSTVELEGETDGDTLEYEYDHDANGERVVLGK
GTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIALHKYLKHRNIVQYLGSVSENG
YIKIFMEQVPGGSLSALLRSKWGPMKEPTIKFYTKQILEGLKYLHENQIVHRDIKGDNVL
VNTYSGVVKISDFGTSKRLAGVNPCTETFTGTLQYMAPEIIDQGPRGYGAPADIWSLGCT
IIEMATSKPPFHELGEPQAAMFKVGMFKIHPEIPEALSAEARAFILSCFEPDPHKRATTA
ELLREGFLRQVNKGKKNRIAFKPSEGPRGVVLALPTQGEPMATSSSEHGSVSPDSDAQPD
ALFERTRAPRHHLGHLLSVPDESSALEDRGLASSPEDRDQGLFLLRKDSERRAILYKILW
EEQNQVASNLQECVAQSSEELHLSVGHIKQIIGILRDFIRSPEHRVMATTISKLKVDLDF
DSSSISQIHLVLFGFQDAVNKILRNHLIRPHWMFAMDNIIRRAVQAAVTILIPELRAHFE
PTCETEGVDKDMDEAEEGYPPATGPGQEAQPHQQHLSLQLGELRQETNRLLEHLVEKERE
YQNLLRQTLEQKTQELYHLQLKLKSNCITENPAGPYGQRTDKELIDWLRLQGADAKTIEK
IVEEGYTLSDILNEITKEDLRYLRLRGGLLCRLWSAVSQYRRAQEASETKDKA

Sequence length

1313

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (11)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Cervical cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colorectal cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Gastric cancer	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GESTATIONAL DIABETES	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LEWY BODY DEMENTIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAP3K15-related disorder	Uncertain significance; Benign; Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Neurodevelopmental disorder	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
NEURODEVELOPMENTAL DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Pyruvate dehydrogenase E1-alpha deficiency	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (19)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of large intestine	Colorectal Cancer	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenocarcinoma of lung (disorder)	Lung adenocarcinoma	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Azoospermia Nonobstructive	Nonobstructive azoospermia	Pubtator	36017582	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	35311629	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	34662886	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus	Diabetes mellitus	Pubtator	36383675	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 2	Diabetes mellitus, type 2	Pubtator	36383675	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	34662886	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Hypertensive disease	Hypertension	BEFREE	31196660		★★★★★ ★☆☆☆☆ Found in Text Mining only
Insulin Resistance	Diabetes mellitus, type 2	Pubtator	36383675	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Kidney Failure, Acute	Kidney Failure	BEFREE	31196660		★★★★★ ★☆☆☆☆ Found in Text Mining only
Melanocytic nevus syndrome congenital	Melanocytic nevus	Pubtator	36085074	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Metastatic melanoma	Metastatic Melanoma	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	36383675	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Failure, Premature	Ovarian Failure	BEFREE	31745224		★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome	BEFREE	31745224		★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic ovary syndrome	Pubtator	31745224	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Premature Menopause	Premature Menopause	BEFREE	31745224		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of lung	Lung carcinoma	UNIPROT_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only

MAP3K15 (mitogen-activated protein kinase kinase kinase 15)