IYD (iodotyrosine deiodinase)

Gene

• Entrez ID: 389434
• Gene name: Iodotyrosine deiodinase
• Gene symbol: IYD
• Synonyms (NCBI Gene): C6orf71, DEHAL1, IYD-1, TDH4
• Chromosome: 6
• Chromosome location: 6q25.1
• Summary: This gene encodes an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs121918138	C>T	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant, synonymous variant
rs121918139	T>C	Pathogenic	Missense variant, non coding transcript variant, intron variant, coding sequence variant
rs121918140	G>A	Pathogenic	Missense variant, non coding transcript variant, coding sequence variant
rs863223276	CAT>-	Pathogenic	Inframe indel, coding sequence variant, intron variant, non coding transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT017241	hsa-miR-335-5p	Microarray	18185580
MIRT693866	hsa-miR-4781-3p	HITS-CLIP	23313552
MIRT693865	hsa-miR-4716-5p	HITS-CLIP	23313552
MIRT693864	hsa-miR-3663-5p	HITS-CLIP	23313552
MIRT693863	hsa-miR-4680-5p	HITS-CLIP	23313552
MIRT693862	hsa-miR-4755-3p	HITS-CLIP	23313552
MIRT693861	hsa-miR-6131	HITS-CLIP	23313552
MIRT693860	hsa-miR-197-3p	HITS-CLIP	23313552
MIRT693859	hsa-miR-526b-5p	HITS-CLIP	23313552
MIRT693858	hsa-miR-548s	HITS-CLIP	23313552
MIRT693857	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT693856	hsa-miR-588	HITS-CLIP	23313552
MIRT693855	hsa-miR-4435	HITS-CLIP	23313552
MIRT693853	hsa-miR-3187-3p	HITS-CLIP	23313552
MIRT693854	hsa-miR-6843-3p	HITS-CLIP	23313552
MIRT693852	hsa-miR-6848-3p	HITS-CLIP	23313552
MIRT693851	hsa-miR-5096	HITS-CLIP	23313552
MIRT663502	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT663501	hsa-miR-1267	HITS-CLIP	23824327
MIRT663500	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT663499	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT663498	hsa-miR-3135b	HITS-CLIP	23824327
MIRT663497	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT663496	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT663495	hsa-miR-3652	HITS-CLIP	23824327
MIRT663494	hsa-miR-4430	HITS-CLIP	23824327
MIRT663492	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT663491	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT663490	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT663489	hsa-miR-4642	HITS-CLIP	23824327
MIRT663488	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT663487	hsa-miR-5698	HITS-CLIP	23824327
MIRT663503	hsa-miR-6812-3p	HITS-CLIP	23824327
MIRT663502	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT663501	hsa-miR-1267	HITS-CLIP	23824327
MIRT663500	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT663499	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT663498	hsa-miR-3135b	HITS-CLIP	23824327
MIRT663497	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT663496	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT663495	hsa-miR-3652	HITS-CLIP	23824327
MIRT663494	hsa-miR-4430	HITS-CLIP	23824327
MIRT663493	hsa-miR-597-3p	HITS-CLIP	23824327
MIRT663492	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT663491	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT663490	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT663489	hsa-miR-4642	HITS-CLIP	23824327
MIRT663488	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT663487	hsa-miR-5698	HITS-CLIP	23824327
MIRT529512	hsa-miR-532-5p	PAR-CLIP	22012620
MIRT529511	hsa-miR-4778-5p	PAR-CLIP	22012620
MIRT529510	hsa-miR-6760-3p	PAR-CLIP	22012620
MIRT529509	hsa-miR-1208	PAR-CLIP	22012620
MIRT529508	hsa-miR-26a-1-3p	PAR-CLIP	22012620
MIRT529507	hsa-miR-26a-2-3p	PAR-CLIP	22012620
MIRT529506	hsa-miR-3920	PAR-CLIP	22012620
MIRT529505	hsa-miR-29a-5p	PAR-CLIP	22012620
MIRT529504	hsa-miR-4633-5p	PAR-CLIP	22012620
MIRT529503	hsa-miR-181b-2-3p	PAR-CLIP	22012620
MIRT529502	hsa-miR-181b-3p	PAR-CLIP	22012620
MIRT529501	hsa-miR-4420	PAR-CLIP	22012620
MIRT529500	hsa-miR-653-3p	PAR-CLIP	22012620
MIRT529499	hsa-miR-3192-3p	PAR-CLIP	22012620
MIRT529498	hsa-miR-676-3p	PAR-CLIP	22012620
MIRT529497	hsa-miR-491-3p	PAR-CLIP	22012620
MIRT529496	hsa-miR-4762-3p	PAR-CLIP	22012620
MIRT693866	hsa-miR-4781-3p	HITS-CLIP	23313552
MIRT693865	hsa-miR-4716-5p	HITS-CLIP	23313552
MIRT693864	hsa-miR-3663-5p	HITS-CLIP	23313552
MIRT693863	hsa-miR-4680-5p	HITS-CLIP	23313552
MIRT693862	hsa-miR-4755-3p	HITS-CLIP	23313552
MIRT693861	hsa-miR-6131	HITS-CLIP	23313552
MIRT693860	hsa-miR-197-3p	HITS-CLIP	23313552
MIRT693859	hsa-miR-526b-5p	HITS-CLIP	23313552
MIRT693858	hsa-miR-548s	HITS-CLIP	23313552
MIRT693857	hsa-miR-4701-5p	HITS-CLIP	23313552
MIRT693856	hsa-miR-588	HITS-CLIP	23313552
MIRT693855	hsa-miR-4435	HITS-CLIP	23313552
MIRT693853	hsa-miR-3187-3p	HITS-CLIP	23313552
MIRT693854	hsa-miR-6843-3p	HITS-CLIP	23313552
MIRT693852	hsa-miR-6848-3p	HITS-CLIP	23313552
MIRT693851	hsa-miR-5096	HITS-CLIP	23313552
MIRT663502	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT663501	hsa-miR-1267	HITS-CLIP	23824327
MIRT663500	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT663499	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT663498	hsa-miR-3135b	HITS-CLIP	23824327
MIRT663497	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT663496	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT663495	hsa-miR-3652	HITS-CLIP	23824327
MIRT663494	hsa-miR-4430	HITS-CLIP	23824327
MIRT663492	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT663491	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT663490	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT663489	hsa-miR-4642	HITS-CLIP	23824327
MIRT663488	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT663487	hsa-miR-5698	HITS-CLIP	23824327
MIRT663503	hsa-miR-6812-3p	HITS-CLIP	23824327
MIRT663502	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT663501	hsa-miR-1267	HITS-CLIP	23824327
MIRT663500	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT663499	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT663498	hsa-miR-3135b	HITS-CLIP	23824327
MIRT663497	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT663496	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT663495	hsa-miR-3652	HITS-CLIP	23824327
MIRT663494	hsa-miR-4430	HITS-CLIP	23824327
MIRT663493	hsa-miR-597-3p	HITS-CLIP	23824327
MIRT663492	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT663491	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT663490	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT663489	hsa-miR-4642	HITS-CLIP	23824327
MIRT663488	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT663487	hsa-miR-5698	HITS-CLIP	23824327
MIRT529512	hsa-miR-532-5p	PAR-CLIP	22012620
MIRT529511	hsa-miR-4778-5p	PAR-CLIP	22012620
MIRT529510	hsa-miR-6760-3p	PAR-CLIP	22012620
MIRT529509	hsa-miR-1208	PAR-CLIP	22012620
MIRT529508	hsa-miR-26a-1-3p	PAR-CLIP	22012620
MIRT529507	hsa-miR-26a-2-3p	PAR-CLIP	22012620
MIRT529506	hsa-miR-3920	PAR-CLIP	22012620
MIRT529505	hsa-miR-29a-5p	PAR-CLIP	22012620
MIRT529504	hsa-miR-4633-5p	PAR-CLIP	22012620
MIRT529503	hsa-miR-181b-2-3p	PAR-CLIP	22012620
MIRT529502	hsa-miR-181b-3p	PAR-CLIP	22012620
MIRT529501	hsa-miR-4420	PAR-CLIP	22012620
MIRT529500	hsa-miR-653-3p	PAR-CLIP	22012620
MIRT529499	hsa-miR-3192-3p	PAR-CLIP	22012620
MIRT529498	hsa-miR-676-3p	PAR-CLIP	22012620
MIRT529497	hsa-miR-491-3p	PAR-CLIP	22012620
MIRT529496	hsa-miR-4762-3p	PAR-CLIP	22012620
MIRT1075723	hsa-miR-1224-5p	CLIP-seq
MIRT1075724	hsa-miR-1305	CLIP-seq
MIRT1075725	hsa-miR-146a	CLIP-seq
MIRT1075726	hsa-miR-146b-5p	CLIP-seq
MIRT1075727	hsa-miR-197	CLIP-seq
MIRT1075728	hsa-miR-2116	CLIP-seq
MIRT1075729	hsa-miR-3144-3p	CLIP-seq
MIRT1075730	hsa-miR-3662	CLIP-seq
MIRT1075731	hsa-miR-3671	CLIP-seq
MIRT1075732	hsa-miR-3675-5p	CLIP-seq
MIRT1075733	hsa-miR-3688-3p	CLIP-seq
MIRT1075734	hsa-miR-4253	CLIP-seq
MIRT1075735	hsa-miR-4495	CLIP-seq
MIRT1075736	hsa-miR-4659a-3p	CLIP-seq
MIRT1075737	hsa-miR-4659b-3p	CLIP-seq
MIRT1075738	hsa-miR-4677-5p	CLIP-seq
MIRT1075739	hsa-miR-4751	CLIP-seq
MIRT1075740	hsa-miR-4762-5p	CLIP-seq
MIRT1075741	hsa-miR-4799-5p	CLIP-seq
MIRT1075742	hsa-miR-486-3p	CLIP-seq
MIRT1075743	hsa-miR-513c	CLIP-seq
MIRT1075744	hsa-miR-514b-5p	CLIP-seq
MIRT1075745	hsa-miR-543	CLIP-seq
MIRT1075746	hsa-miR-548ac	CLIP-seq
MIRT1075747	hsa-miR-548ae	CLIP-seq
MIRT1075748	hsa-miR-548aj	CLIP-seq
MIRT1075749	hsa-miR-548am	CLIP-seq
MIRT1075750	hsa-miR-548d-3p	CLIP-seq
MIRT1075751	hsa-miR-548x	CLIP-seq
MIRT1075752	hsa-miR-548z	CLIP-seq
MIRT1075753	hsa-miR-568	CLIP-seq
MIRT1075754	hsa-miR-578	CLIP-seq
MIRT1075755	hsa-miR-589	CLIP-seq
MIRT1075756	hsa-miR-607	CLIP-seq
MIRT1075757	hsa-miR-643	CLIP-seq
MIRT1075758	hsa-miR-875-5p	CLIP-seq
MIRT1075759	hsa-miR-106a	CLIP-seq
MIRT1075760	hsa-miR-106b	CLIP-seq
MIRT1075761	hsa-miR-1224-3p	CLIP-seq
MIRT1075762	hsa-miR-1234	CLIP-seq
MIRT1075763	hsa-miR-1275	CLIP-seq
MIRT1075764	hsa-miR-1323	CLIP-seq
MIRT1075765	hsa-miR-150	CLIP-seq
MIRT1075766	hsa-miR-17	CLIP-seq
MIRT1075767	hsa-miR-1913	CLIP-seq
MIRT1075768	hsa-miR-20a	CLIP-seq
MIRT1075769	hsa-miR-20b	CLIP-seq
MIRT1075770	hsa-miR-2276	CLIP-seq
MIRT1075771	hsa-miR-302a	CLIP-seq
MIRT1075772	hsa-miR-302b	CLIP-seq
MIRT1075773	hsa-miR-302c	CLIP-seq
MIRT1075774	hsa-miR-302d	CLIP-seq
MIRT1075775	hsa-miR-302e	CLIP-seq
MIRT1075776	hsa-miR-3176	CLIP-seq
MIRT1075777	hsa-miR-324-3p	CLIP-seq
MIRT1075778	hsa-miR-3670	CLIP-seq
MIRT1075779	hsa-miR-372	CLIP-seq
MIRT1075780	hsa-miR-373	CLIP-seq
MIRT1075781	hsa-miR-3908	CLIP-seq
MIRT1075782	hsa-miR-3922-3p	CLIP-seq
MIRT1075783	hsa-miR-409-5p	CLIP-seq
MIRT1075784	hsa-miR-4252	CLIP-seq
MIRT1075785	hsa-miR-4269	CLIP-seq
MIRT1075786	hsa-miR-4272	CLIP-seq
MIRT1075787	hsa-miR-4307	CLIP-seq
MIRT1075788	hsa-miR-4434	CLIP-seq
MIRT1075789	hsa-miR-4438	CLIP-seq
MIRT1075790	hsa-miR-4447	CLIP-seq
MIRT1075791	hsa-miR-4472	CLIP-seq
MIRT1075792	hsa-miR-4514	CLIP-seq
MIRT1075793	hsa-miR-4516	CLIP-seq
MIRT1075794	hsa-miR-4525	CLIP-seq
MIRT1075795	hsa-miR-4529-5p	CLIP-seq
MIRT1075796	hsa-miR-4531	CLIP-seq
MIRT1075797	hsa-miR-4665-5p	CLIP-seq
MIRT1075798	hsa-miR-4692	CLIP-seq
MIRT1075799	hsa-miR-4723-5p	CLIP-seq
MIRT1075800	hsa-miR-4731-5p	CLIP-seq
MIRT1075801	hsa-miR-4742-5p	CLIP-seq
MIRT1075802	hsa-miR-5095	CLIP-seq
MIRT1075803	hsa-miR-512-3p	CLIP-seq
MIRT1075804	hsa-miR-516b	CLIP-seq
MIRT1075805	hsa-miR-519d	CLIP-seq
MIRT1075806	hsa-miR-520a-3p	CLIP-seq
MIRT1075807	hsa-miR-520b	CLIP-seq
MIRT1075808	hsa-miR-520c-3p	CLIP-seq
MIRT1075809	hsa-miR-520d-3p	CLIP-seq
MIRT1075810	hsa-miR-520e	CLIP-seq
MIRT1075811	hsa-miR-520g	CLIP-seq
MIRT1075812	hsa-miR-520h	CLIP-seq
MIRT1075813	hsa-miR-526b	CLIP-seq
MIRT1075814	hsa-miR-548o	CLIP-seq
MIRT1075815	hsa-miR-625	CLIP-seq
MIRT1075816	hsa-miR-651	CLIP-seq
MIRT1075817	hsa-miR-802	CLIP-seq
MIRT1075818	hsa-miR-93	CLIP-seq
MIRT1075819	hsa-miR-1	CLIP-seq
MIRT1075820	hsa-miR-15a	CLIP-seq
MIRT1075821	hsa-miR-15b	CLIP-seq
MIRT1075822	hsa-miR-16	CLIP-seq
MIRT1075823	hsa-miR-184	CLIP-seq
MIRT1075824	hsa-miR-18a	CLIP-seq
MIRT1075825	hsa-miR-18b	CLIP-seq
MIRT1075826	hsa-miR-1910	CLIP-seq
MIRT1075827	hsa-miR-195	CLIP-seq
MIRT1075828	hsa-miR-206	CLIP-seq
MIRT1075829	hsa-miR-218	CLIP-seq
MIRT1075830	hsa-miR-298	CLIP-seq
MIRT1075831	hsa-miR-3121-5p	CLIP-seq
MIRT1075832	hsa-miR-3122	CLIP-seq
MIRT1075833	hsa-miR-3132	CLIP-seq
MIRT1075834	hsa-miR-3136-5p	CLIP-seq
MIRT1075835	hsa-miR-3151	CLIP-seq
MIRT1075836	hsa-miR-3154	CLIP-seq
MIRT1075837	hsa-miR-3160-3p	CLIP-seq
MIRT1075838	hsa-miR-342-5p	CLIP-seq
MIRT1075839	hsa-miR-3591-5p	CLIP-seq
MIRT1075840	hsa-miR-3612	CLIP-seq
MIRT1075841	hsa-miR-3614-5p	CLIP-seq
MIRT1075842	hsa-miR-3657	CLIP-seq
MIRT1075843	hsa-miR-3689a-3p	CLIP-seq
MIRT1075844	hsa-miR-3689c	CLIP-seq
MIRT1075845	hsa-miR-3689d	CLIP-seq
MIRT1075846	hsa-miR-3913-5p	CLIP-seq
MIRT1075847	hsa-miR-3942-3p	CLIP-seq
MIRT1075848	hsa-miR-424	CLIP-seq
MIRT1075849	hsa-miR-4260	CLIP-seq
MIRT1075850	hsa-miR-4439	CLIP-seq
MIRT1075790	hsa-miR-4447	CLIP-seq
MIRT1075851	hsa-miR-4455	CLIP-seq
MIRT1075791	hsa-miR-4472	CLIP-seq
MIRT1075852	hsa-miR-4505	CLIP-seq
MIRT1075853	hsa-miR-4524	CLIP-seq
MIRT1075854	hsa-miR-455-3p	CLIP-seq
MIRT1075855	hsa-miR-4650-3p	CLIP-seq
MIRT1075856	hsa-miR-4651	CLIP-seq
MIRT1075857	hsa-miR-4664-5p	CLIP-seq
MIRT1075858	hsa-miR-4669	CLIP-seq
MIRT1075859	hsa-miR-4675	CLIP-seq
MIRT1075860	hsa-miR-4677-3p	CLIP-seq
MIRT1075861	hsa-miR-4725-5p	CLIP-seq
MIRT1075862	hsa-miR-4728-5p	CLIP-seq
MIRT1075800	hsa-miR-4731-5p	CLIP-seq
MIRT1075863	hsa-miR-4735-3p	CLIP-seq
MIRT1075864	hsa-miR-4741	CLIP-seq
MIRT1075865	hsa-miR-4804-5p	CLIP-seq
MIRT1075742	hsa-miR-486-3p	CLIP-seq
MIRT1075866	hsa-miR-491-5p	CLIP-seq
MIRT1075867	hsa-miR-497	CLIP-seq
MIRT1075868	hsa-miR-503	CLIP-seq
MIRT1075869	hsa-miR-504	CLIP-seq
MIRT1075870	hsa-miR-539	CLIP-seq
MIRT1075871	hsa-miR-587	CLIP-seq
MIRT1075872	hsa-miR-592	CLIP-seq
MIRT1075873	hsa-miR-599	CLIP-seq
MIRT1075874	hsa-miR-608	CLIP-seq
MIRT1075875	hsa-miR-613	CLIP-seq
MIRT1075876	hsa-miR-636	CLIP-seq
MIRT1075877	hsa-miR-637	CLIP-seq
MIRT1075878	hsa-miR-646	CLIP-seq
MIRT1075879	hsa-miR-648	CLIP-seq
MIRT1075880	hsa-miR-650	CLIP-seq
MIRT1075881	hsa-miR-668	CLIP-seq
MIRT1075882	hsa-miR-892a	CLIP-seq
MIRT1075883	hsa-miR-922	CLIP-seq
MIRT1075884	hsa-miR-943	CLIP-seq
MIRT1075840	hsa-miR-3612	CLIP-seq
MIRT1550355	hsa-miR-4443	CLIP-seq
MIRT1550356	hsa-miR-485-5p	CLIP-seq
MIRT1550357	hsa-miR-610	CLIP-seq
MIRT1075880	hsa-miR-650	CLIP-seq
MIRT2018825	hsa-miR-1292	CLIP-seq
MIRT1075832	hsa-miR-3122	CLIP-seq
MIRT2018826	hsa-miR-3145-5p	CLIP-seq
MIRT2018827	hsa-miR-323b-3p	CLIP-seq
MIRT1075846	hsa-miR-3913-5p	CLIP-seq
MIRT2018828	hsa-miR-4471	CLIP-seq
MIRT2018829	hsa-miR-9	CLIP-seq
MIRT1075759	hsa-miR-106a	CLIP-seq
MIRT1075760	hsa-miR-106b	CLIP-seq
MIRT2250707	hsa-miR-1206	CLIP-seq
MIRT1075761	hsa-miR-1224-3p	CLIP-seq
MIRT2250708	hsa-miR-1260	CLIP-seq
MIRT2250709	hsa-miR-1260b	CLIP-seq
MIRT2250710	hsa-miR-1262	CLIP-seq
MIRT2250711	hsa-miR-1269	CLIP-seq
MIRT2250712	hsa-miR-1269b	CLIP-seq
MIRT2250713	hsa-miR-1273f	CLIP-seq
MIRT1075724	hsa-miR-1305	CLIP-seq
MIRT2250714	hsa-miR-1321	CLIP-seq
MIRT2250715	hsa-miR-145	CLIP-seq
MIRT1075766	hsa-miR-17	CLIP-seq
MIRT2250716	hsa-miR-188-3p	CLIP-seq
MIRT1075727	hsa-miR-197	CLIP-seq
MIRT2250717	hsa-miR-2052	CLIP-seq
MIRT1075768	hsa-miR-20a	CLIP-seq
MIRT1075769	hsa-miR-20b	CLIP-seq
MIRT2250718	hsa-miR-2110	CLIP-seq
MIRT1075728	hsa-miR-2116	CLIP-seq
MIRT2250719	hsa-miR-2117	CLIP-seq
MIRT2250720	hsa-miR-217	CLIP-seq
MIRT2250721	hsa-miR-224	CLIP-seq
MIRT2250722	hsa-miR-3140-5p	CLIP-seq
MIRT1075729	hsa-miR-3144-3p	CLIP-seq
MIRT2250723	hsa-miR-3150a-3p	CLIP-seq
MIRT2250724	hsa-miR-3156-3p	CLIP-seq
MIRT2250725	hsa-miR-3170	CLIP-seq
MIRT2250726	hsa-miR-3173-3p	CLIP-seq
MIRT2250727	hsa-miR-3609	CLIP-seq
MIRT1075840	hsa-miR-3612	CLIP-seq
MIRT2250728	hsa-miR-3622a-3p	CLIP-seq
MIRT2250729	hsa-miR-3622b-3p	CLIP-seq
MIRT1075731	hsa-miR-3671	CLIP-seq
MIRT2250730	hsa-miR-377	CLIP-seq
MIRT1075847	hsa-miR-3942-3p	CLIP-seq
MIRT2250731	hsa-miR-411	CLIP-seq
MIRT1075734	hsa-miR-4253	CLIP-seq
MIRT2250732	hsa-miR-4255	CLIP-seq
MIRT1075849	hsa-miR-4260	CLIP-seq
MIRT2250733	hsa-miR-4271	CLIP-seq
MIRT2250734	hsa-miR-4293	CLIP-seq
MIRT1075787	hsa-miR-4307	CLIP-seq
MIRT2250735	hsa-miR-4452	CLIP-seq
MIRT2250736	hsa-miR-451b	CLIP-seq
MIRT2250737	hsa-miR-4529-3p	CLIP-seq
MIRT1075860	hsa-miR-4677-3p	CLIP-seq
MIRT1075738	hsa-miR-4677-5p	CLIP-seq
MIRT2250738	hsa-miR-4701-3p	CLIP-seq
MIRT2250739	hsa-miR-4724-3p	CLIP-seq
MIRT2250740	hsa-miR-4725-3p	CLIP-seq
MIRT1075800	hsa-miR-4731-5p	CLIP-seq
MIRT2250741	hsa-miR-4733-5p	CLIP-seq
MIRT2250742	hsa-miR-4739	CLIP-seq
MIRT2250743	hsa-miR-4756-5p	CLIP-seq
MIRT2250744	hsa-miR-4796-3p	CLIP-seq
MIRT1075805	hsa-miR-519d	CLIP-seq
MIRT1075811	hsa-miR-520g	CLIP-seq
MIRT1075812	hsa-miR-520h	CLIP-seq
MIRT1075870	hsa-miR-539	CLIP-seq
MIRT2250745	hsa-miR-542-3p	CLIP-seq
MIRT2250746	hsa-miR-548ah	CLIP-seq
MIRT1075871	hsa-miR-587	CLIP-seq
MIRT2250747	hsa-miR-596	CLIP-seq
MIRT1075756	hsa-miR-607	CLIP-seq
MIRT2250748	hsa-miR-617	CLIP-seq
MIRT2250749	hsa-miR-619	CLIP-seq
MIRT1075880	hsa-miR-650	CLIP-seq
MIRT2250750	hsa-miR-661	CLIP-seq
MIRT1075758	hsa-miR-875-5p	CLIP-seq
MIRT1075883	hsa-miR-922	CLIP-seq
MIRT1075818	hsa-miR-93	CLIP-seq
MIRT2389534	hsa-miR-2467-5p	CLIP-seq
MIRT2250725	hsa-miR-3170	CLIP-seq
MIRT2389535	hsa-miR-4266	CLIP-seq
MIRT2389536	hsa-miR-4695-5p	CLIP-seq
MIRT2389537	hsa-miR-4779	CLIP-seq
MIRT2389538	hsa-miR-615-5p	CLIP-seq
MIRT2250707	hsa-miR-1206	CLIP-seq
MIRT2452055	hsa-miR-1261	CLIP-seq
MIRT2250713	hsa-miR-1273f	CLIP-seq
MIRT2452056	hsa-miR-129-5p	CLIP-seq
MIRT2452057	hsa-miR-3149	CLIP-seq
MIRT2250725	hsa-miR-3170	CLIP-seq
MIRT2452058	hsa-miR-3681	CLIP-seq
MIRT2250731	hsa-miR-411	CLIP-seq
MIRT2452059	hsa-miR-4735-5p	CLIP-seq
MIRT2452060	hsa-miR-4775	CLIP-seq
MIRT2250744	hsa-miR-4796-3p	CLIP-seq
MIRT2452061	hsa-miR-519a	CLIP-seq
MIRT2452062	hsa-miR-519b-3p	CLIP-seq
MIRT2452063	hsa-miR-519c-3p	CLIP-seq
MIRT1075811	hsa-miR-520g	CLIP-seq
MIRT1075812	hsa-miR-520h	CLIP-seq
MIRT2452064	hsa-miR-586	CLIP-seq
MIRT2452065	hsa-miR-590-3p	CLIP-seq
MIRT2452066	hsa-miR-720	CLIP-seq
MIRT2250707	hsa-miR-1206	CLIP-seq
MIRT2452055	hsa-miR-1261	CLIP-seq
MIRT2250711	hsa-miR-1269	CLIP-seq
MIRT2250712	hsa-miR-1269b	CLIP-seq
MIRT2465499	hsa-miR-3616-3p	CLIP-seq
MIRT2452058	hsa-miR-3681	CLIP-seq
MIRT2250737	hsa-miR-4529-3p	CLIP-seq
MIRT2250744	hsa-miR-4796-3p	CLIP-seq
MIRT1075811	hsa-miR-520g	CLIP-seq
MIRT1075812	hsa-miR-520h	CLIP-seq
MIRT2452064	hsa-miR-586	CLIP-seq
MIRT2250748	hsa-miR-617	CLIP-seq
MIRT1075759	hsa-miR-106a	CLIP-seq
MIRT1075760	hsa-miR-106b	CLIP-seq
MIRT1075762	hsa-miR-1234	CLIP-seq
MIRT2250713	hsa-miR-1273f	CLIP-seq
MIRT2452056	hsa-miR-129-5p	CLIP-seq
MIRT1075765	hsa-miR-150	CLIP-seq
MIRT1075766	hsa-miR-17	CLIP-seq
MIRT1075727	hsa-miR-197	CLIP-seq
MIRT1075768	hsa-miR-20a	CLIP-seq
MIRT1075769	hsa-miR-20b	CLIP-seq
MIRT1075771	hsa-miR-302a	CLIP-seq
MIRT1075772	hsa-miR-302b	CLIP-seq
MIRT1075773	hsa-miR-302c	CLIP-seq
MIRT1075774	hsa-miR-302d	CLIP-seq
MIRT1075775	hsa-miR-302e	CLIP-seq
MIRT2452057	hsa-miR-3149	CLIP-seq
MIRT2250725	hsa-miR-3170	CLIP-seq
MIRT1075779	hsa-miR-372	CLIP-seq
MIRT1075780	hsa-miR-373	CLIP-seq
MIRT2250731	hsa-miR-411	CLIP-seq
MIRT1075800	hsa-miR-4731-5p	CLIP-seq
MIRT2452059	hsa-miR-4735-5p	CLIP-seq
MIRT2452060	hsa-miR-4775	CLIP-seq
MIRT1075802	hsa-miR-5095	CLIP-seq
MIRT1075803	hsa-miR-512-3p	CLIP-seq
MIRT2452061	hsa-miR-519a	CLIP-seq
MIRT2452062	hsa-miR-519b-3p	CLIP-seq
MIRT2452063	hsa-miR-519c-3p	CLIP-seq
MIRT1075805	hsa-miR-519d	CLIP-seq
MIRT1075806	hsa-miR-520a-3p	CLIP-seq
MIRT1075807	hsa-miR-520b	CLIP-seq
MIRT1075808	hsa-miR-520c-3p	CLIP-seq
MIRT1075809	hsa-miR-520d-3p	CLIP-seq
MIRT1075810	hsa-miR-520e	CLIP-seq
MIRT1075811	hsa-miR-520g	CLIP-seq
MIRT1075812	hsa-miR-520h	CLIP-seq
MIRT2452065	hsa-miR-590-3p	CLIP-seq
MIRT1075818	hsa-miR-93	CLIP-seq
MIRT2250713	hsa-miR-1273f	CLIP-seq
MIRT2452056	hsa-miR-129-5p	CLIP-seq
MIRT1075727	hsa-miR-197	CLIP-seq
MIRT2452057	hsa-miR-3149	CLIP-seq
MIRT2250725	hsa-miR-3170	CLIP-seq
MIRT2250731	hsa-miR-411	CLIP-seq
MIRT2452059	hsa-miR-4735-5p	CLIP-seq
MIRT2452060	hsa-miR-4775	CLIP-seq
MIRT2452061	hsa-miR-519a	CLIP-seq
MIRT2452062	hsa-miR-519b-3p	CLIP-seq
MIRT2452063	hsa-miR-519c-3p	CLIP-seq
MIRT2452065	hsa-miR-590-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 25910212
GO:0005654	Component	Nucleoplasm	IDA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	15289438
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006570	Process	Tyrosine metabolic process	IBA
GO:0006570	Process	Tyrosine metabolic process	IDA	25395621, 28157283
GO:0006570	Process	Tyrosine metabolic process	IEA
GO:0010181	Function	FMN binding	IDA	25395621, 28157283
GO:0010181	Function	FMN binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0016491	Function	Oxidoreductase activity	IBA
GO:0016491	Function	Oxidoreductase activity	IEA
GO:0030659	Component	Cytoplasmic vesicle membrane	IDA	15289438
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0042403	Process	Thyroid hormone metabolic process	IBA
GO:0042403	Process	Thyroid hormone metabolic process	IDA	25395621
GO:0140616	Function	Iodotyrosine deiodinase activity	IDA	15289438, 25395621, 28157283
GO:0140616	Function	Iodotyrosine deiodinase activity	IEA
GO:0140616	Function	Iodotyrosine deiodinase activity	IMP	18434651

Other IDs

• MIM: 612025
• HGNC: 21071
• e!Ensembl: ENSG00000009765

Protein

• UniProt ID: Q6PHW0
• Protein name: Iodotyrosine deiodinase 1 (IYD-1) (EC 1.21.1.1) (Iodotyrosine dehalogenase 1)
• Protein function: Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine (PubMed:15289438, PubMed:18434651, PubMed:25395621, PubMed:28157283). During thyroid hormone biosynthesis,
• PDB: 4TTB, 4TTC, 5YAK
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00881	Nitroreductase	97 → 267	Nitroreductase family	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed at a high level in thyroid gland (at protein level). Expressed at a high level in thyroid gland and at lower level in kidney and trachea. {ECO:0000269|PubMed:15289438}.
• Sequence:

  MYFLTPILVAILCILVVWIFKNADRSMEKKKGEPRTRAEARPWVDEDLKDSSDLHQAEED
  ADEWQESEENVEHIPFSHNHYPEKEMVKRSQEFYELLNKRRSVRFISNEQVPMEVIDNVI
  RTAGTAPSGAHTEPWTFVVVKDPDVKHKIRKIIEEEEEINYMKRMGHRWVTDLKKLRTNW
  IKEYLDTAPILILIFKQVHGFAANGKKKVHYYNEISVSIACGILLAALQNAGLVTVTTTP
  LNCGPRLRVLLGRPAHEKLLMLLPVGYPSKEATVPDLKRKPLDQIMVTV

• Sequence length: 289

Pathways

KEGG:

Thyroid hormone synthesis

Reactome:

Thyroxine biosynthesis

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Iodotyrosine deiodination defect	Likely pathogenic; Pathogenic	rs121918138, rs121918139, rs121918140, rs1052959039	RCV000000773 RCV000000775 RCV000000776 RCV003324290	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
IYD-related disorder	Likely pathogenic	rs121918138	RCV003430626	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Clear cell carcinoma of kidney	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Congenital hypothyroidism	Uncertain significance; Likely benign; Benign	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
FAMILIAL THYROID DYSHORMONOGENESIS	—	Disgenet, Orphanet Disgenet, Orphanet Disgenet, Orphanet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LIVER CIRRHOSIS, EXPERIMENTAL	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PANIC DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
THYROID DYSHORMONOGENESIS 4	—	CTD, Disgenet, GWAS catalog, HPO CTD, Disgenet, GWAS catalog, HPO CTD, Disgenet, GWAS catalog, HPO CTD, Disgenet, GWAS catalog, HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Anaplastic thyroid carcinoma	Anaplastic thyroid cancer	BEFREE	17322488		★☆☆☆☆ Found in Text Mining only
Ataxia Telangiectasia	Ataxia Telangiectasia	BEFREE	17322488		★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	39512680	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	36582227	Associate	★☆☆☆☆ Found in Text Mining only
Cognition Disorders	Cognition disorder	Pubtator	18434651	Associate	★☆☆☆☆ Found in Text Mining only
Congenital exomphalos	Congenital Exomphalos	HPO_DG			★☆☆☆☆ Found in Text Mining only
Congenital Hypothyroidism	Congenital Hypothyroidism	BEFREE	14671405, 18434651, 18765512, 28215547		★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Congenital Hypothyroidism	Congenital hypothyroidism	Pubtator	18434651, 34200080, 36633921	Associate	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Congenital Hypothyroidism	Congenital Hypothyroidism	LHGDN	18765512		★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Congenital Hypothyroidism	Congenital Hypothyroidism	GENOMICS_ENGLAND_DG	18765512		★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Dwarfism	Dwarfism	HPO_DG			★☆☆☆☆ Found in Text Mining only
Familial thyroid dyshormonogenesis	Thyroid Dyshormonogenesis	Orphanet			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Follicular thyroid carcinoma	Follicular Thyroid Carcinoma	BEFREE	17322488		★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	BEFREE	30137636		★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★☆☆☆☆ Found in Text Mining only
Graves Disease	Graves Disease	BEFREE	17322488		★☆☆☆☆ Found in Text Mining only
Hypersomnia	Hypersomnia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Hypothyroidism	Hypothyroidism	BEFREE	18434651, 20298747, 24629858		★☆☆☆☆ Found in Text Mining only
Hypothyroidism	Hypothyroidism	LHGDN	18434651		★☆☆☆☆ Found in Text Mining only
Hypothyroidism	Hypothyroidism	Pubtator	18434651, 36633921	Associate	★☆☆☆☆ Found in Text Mining only
Hypothyroidism	Hypothyroidism	HPO_DG			★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	HPO_DG			★☆☆☆☆ Found in Text Mining only
Macroglossia	Macroglossia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of thyroid	Thyroid cancer	BEFREE	17322488		★☆☆☆☆ Found in Text Mining only
Papillary thyroid carcinoma	Papillary thyroid carcinoma	BEFREE	17322488		★☆☆☆☆ Found in Text Mining only
Thyroid carcinoma	Thyroid Carcinoma	BEFREE	17322488		★☆☆☆☆ Found in Text Mining only
Thyroid Dyshormonogenesis 1	Thyroid Dyshormonogenesis	ORPHANET_DG	20537182, 21543982		★☆☆☆☆ Found in Text Mining only
Thyroid Dyshormonogenesis 4	Thyroid Dyshormonogenesis	UNIPROT_DG	18434651		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid Dyshormonogenesis 4	Thyroid dyshormonogenesis	Pubtator	18434651	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid Dyshormonogenesis 4	Thyroid Dyshormonogenesis	BEFREE	18765512, 20298747, 24629858		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid Dyshormonogenesis 4	Thyroid Dyshormonogenesis	GENOMICS_ENGLAND_DG	18765512		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid Dyshormonogenesis 4	Thyroid Dyshormonogenesis	CTD_human_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid Dyshormonogenesis 4	Thyroid Dyshormonogenesis	CLINVAR_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyrotoxicosis	Thyrotoxicosis	BEFREE	17322488		★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	30642841	Associate	★☆☆☆☆ Found in Text Mining only