GLYATL3 (glycine-N-acyltransferase like 3)

Gene

• Entrez ID: 389396
• Gene name: Glycine-N-acyltransferase like 3
• Gene symbol: GLYATL3
• Synonyms (NCBI Gene): C6orf140, bA28H17.2
• Chromosome: 6
• Chromosome location: 6p12.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1022139	hsa-miR-1266	CLIP-seq
MIRT1022140	hsa-miR-154	CLIP-seq
MIRT1022141	hsa-miR-3153	CLIP-seq
MIRT1022142	hsa-miR-331-3p	CLIP-seq
MIRT1022143	hsa-miR-335	CLIP-seq
MIRT1022144	hsa-miR-3936	CLIP-seq
MIRT1022145	hsa-miR-4270	CLIP-seq
MIRT1022146	hsa-miR-4441	CLIP-seq
MIRT1022147	hsa-miR-4518	CLIP-seq
MIRT1022148	hsa-miR-4656	CLIP-seq
MIRT1022149	hsa-miR-513c	CLIP-seq
MIRT1022150	hsa-miR-514b-5p	CLIP-seq
MIRT1022151	hsa-miR-548a-5p	CLIP-seq
MIRT1022152	hsa-miR-548aa	CLIP-seq
MIRT1022153	hsa-miR-548ab	CLIP-seq
MIRT1022154	hsa-miR-548ak	CLIP-seq
MIRT1022155	hsa-miR-548b-5p	CLIP-seq
MIRT1022156	hsa-miR-548c-5p	CLIP-seq
MIRT1022157	hsa-miR-548d-5p	CLIP-seq
MIRT1022158	hsa-miR-548h	CLIP-seq
MIRT1022159	hsa-miR-548i	CLIP-seq
MIRT1022160	hsa-miR-548j	CLIP-seq
MIRT1022161	hsa-miR-548w	CLIP-seq
MIRT1022162	hsa-miR-548y	CLIP-seq
MIRT1022163	hsa-miR-559	CLIP-seq
MIRT2002852	hsa-miR-4436b-3p	CLIP-seq
MIRT2235876	hsa-miR-15a	CLIP-seq
MIRT2235877	hsa-miR-15b	CLIP-seq
MIRT2235878	hsa-miR-16	CLIP-seq
MIRT2235879	hsa-miR-195	CLIP-seq
MIRT2235880	hsa-miR-2467-3p	CLIP-seq
MIRT2235881	hsa-miR-424	CLIP-seq
MIRT2235882	hsa-miR-4257	CLIP-seq
MIRT2235883	hsa-miR-4468	CLIP-seq
MIRT2235884	hsa-miR-497	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005739	Component	Mitochondrion	IEA
GO:0006629	Process	Lipid metabolic process	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0016746	Function	Acyltransferase activity	IEA
GO:0047961	Function	Glycine N-acyltransferase activity	IBA
GO:0047961	Function	Glycine N-acyltransferase activity	IEA
GO:0047961	Function	Glycine N-acyltransferase activity	ISS

Other IDs

• MIM: 614763
• HGNC: 21349
• e!Ensembl: ENSG00000203972

Protein

• UniProt ID: Q5SZD4
• Protein name: Glycine N-acyltransferase-like protein 3 (EC 2.3.1.13) (Acyl-CoA:glycine-N-acyltransferase-like protein 3)
• Protein function: Catalyzes the conjugation of long-chain fatty acyl-CoA thioester and glycine to produce long-chain N-(fatty acyl)glycine, an intermediate in the primary fatty acid amide biosynthetic pathway.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06021	Gly_acyl_tr_N	1 → 190	Aralkyl acyl-CoA:amino acid N-acyltransferase	Family
  PF08444	Gly_acyl_tr_C	191 → 279	Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region	Family

• Sequence:

  MLVLNCSTKLLILEKMLKSCFPESLKVYGAVMNINRGNPFQKEVVLDSWPDFKAVITRRQ
  REAETDNLDHYTNAYAVFYKDVRAYRQLLEECDVFNWDQVFQIQGLQSELYDVSKAVANS
  KQLNIKLTSFKAVHFSPVSSLPDTSFLKGPSPRLTYLSVANADLLNRTWSRGGNEQCLRY
  IANLISCFPSVCVRDEKGNPVSWSITDQFATMCHGYTLPEHRRKGYSRLVALTLARKLQS
  RGFPSQGNVLDDNTASISLLKSLHAEFLPCRFHRLILTPATFSGLPHL

• Sequence length: 288

Pathways

Reactome:

Conjugation of salicylate with glycine
Conjugation of benzoate with glycine

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CONOTRUNCAL HEART MALFORMATIONS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Neoplasms	Breast neoplasm	Pubtator	27993161	Associate	★☆☆☆☆ Found in Text Mining only