PSMG4 (proteasome assembly chaperone 4)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID 389362
Gene name Proteasome assembly chaperone 4
Gene symbol PSMG4
Synonyms (NCBI Gene)
C6orf86PAC4Pba4bA506K6.2
Chromosome 6
Chromosome location 6p25.2
miRNA miRNA information provided by mirtarbase database.
6
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (6)
miRTarBase ID miRNA Experiments Reference
MIRT052258 hsa-let-7b-5p CLASH 23622248
MIRT035828 hsa-miR-1292-5p CLASH 23622248
MIRT1271072 hsa-miR-1229 CLIP-seq
MIRT1271073 hsa-miR-4699-3p CLIP-seq
MIRT1271074 hsa-miR-520d-5p CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
6
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Show/Hide all (6)
GO ID Ontology Definition Evidence Reference
GO:0005829 Component Cytosol TAS
GO:0032991 Component Protein-containing complex IEA
GO:0032991 Component Protein-containing complex ISS 17707236
GO:0043248 Process Proteasome assembly IEA
GO:0044877 Function Protein-containing complex binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
MIM HGNC e!Ensembl
617550 21108 ENSG00000180822
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q5JS54
Protein name Proteasome assembly chaperone 4 (PAC-4) (hPAC4) (Proteasome chaperone homolog 4) (Pba4)
Protein function Chaperone protein which promotes assembly of the 20S proteasome.
PDB 5WTQ , 8QYJ , 8TM3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF16093 PAC4 25 → 97 Proteasome assembly chaperone 4 Family
Sequence 
MEGLVVAAGGDVSLHNFSARLWEQLVHFHVMRLTDSLFLWVGATPHLRNLAVAMCSRYDS
IPVSTSLLGDTSDTTSTGLAQRLARKTNKQVFVSYNLQNTDSNFALLVENRIKEEMEAFP
EKF
Sequence length 123
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Gene miRNA Gene ontology Other IDs Protein Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (5)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
BILIARY LIVER CIRRHOSIS — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
OBESITY — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
PRIMARY BILIARY CIRRHOSIS — GWAS catalog
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (4)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Inflammatory Bowel Diseases Inflammatory Bowel Disease GWASCAT_DG 29603369
★★★★★
★☆☆☆☆
Found in Text Mining only
Lung Neoplasms Lung neoplasms Pubtator 36619227 Stimulate
★★★★★
★☆☆☆☆
Found in Text Mining only
Multiple Sclerosis Multiple Sclerosis BEFREE 28501589
★★★★★
★☆☆☆☆
Found in Text Mining only
Primary biliary cirrhosis Biliary Cirrhosis GWASCAT_DG 28425483
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations