Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Other IDs Protein Associated diseases
Entrez ID	389170
Gene name	Leucine, glutamate and lysine rich 1
Gene symbol	LEKR1
Synonyms (NCBI Gene)	-
Chromosome	3
Chromosome location	3q25.31

Show/Hide all (47)

miRTarBase ID	miRNA	Experiments
MIRT1107244	hsa-miR-1252	CLIP-seq
MIRT1107245	hsa-miR-214	CLIP-seq
MIRT1107246	hsa-miR-298	CLIP-seq
MIRT1107247	hsa-miR-300	CLIP-seq
MIRT1107248	hsa-miR-3619-5p	CLIP-seq
MIRT1107249	hsa-miR-3678-3p	CLIP-seq
MIRT1107250	hsa-miR-381	CLIP-seq
MIRT1107251	hsa-miR-4282	CLIP-seq
MIRT1107252	hsa-miR-4457	CLIP-seq
MIRT1107253	hsa-miR-4528	CLIP-seq
MIRT1107254	hsa-miR-4666-3p	CLIP-seq
MIRT1107255	hsa-miR-4670-3p	CLIP-seq
MIRT1107256	hsa-miR-4760-3p	CLIP-seq
MIRT1107257	hsa-miR-4802-5p	CLIP-seq
MIRT1107258	hsa-miR-513b	CLIP-seq
MIRT1107259	hsa-miR-548c-3p	CLIP-seq
MIRT1107260	hsa-miR-570	CLIP-seq
MIRT1107261	hsa-miR-590-3p	CLIP-seq
MIRT1107262	hsa-miR-657	CLIP-seq
MIRT1107263	hsa-miR-664	CLIP-seq
MIRT1107264	hsa-miR-761	CLIP-seq
MIRT1107265	hsa-miR-944	CLIP-seq
MIRT2260526	hsa-miR-494	CLIP-seq
MIRT2452905	hsa-miR-186	CLIP-seq
MIRT2452906	hsa-miR-3133	CLIP-seq
MIRT2452907	hsa-miR-376a	CLIP-seq
MIRT2452908	hsa-miR-376b	CLIP-seq
MIRT2452909	hsa-miR-4509	CLIP-seq
MIRT2452910	hsa-miR-4744	CLIP-seq
MIRT2452911	hsa-miR-610	CLIP-seq
MIRT2452905	hsa-miR-186	CLIP-seq
MIRT2452906	hsa-miR-3133	CLIP-seq
MIRT2452907	hsa-miR-376a	CLIP-seq
MIRT2452908	hsa-miR-376b	CLIP-seq
MIRT2452909	hsa-miR-4509	CLIP-seq
MIRT2452910	hsa-miR-4744	CLIP-seq
MIRT2452911	hsa-miR-610	CLIP-seq
MIRT1107247	hsa-miR-300	CLIP-seq
MIRT1107250	hsa-miR-381	CLIP-seq
MIRT1107254	hsa-miR-4666-3p	CLIP-seq
MIRT1107259	hsa-miR-548c-3p	CLIP-seq
MIRT1107261	hsa-miR-590-3p	CLIP-seq
MIRT1107247	hsa-miR-300	CLIP-seq
MIRT1107250	hsa-miR-381	CLIP-seq
MIRT1107254	hsa-miR-4666-3p	CLIP-seq
MIRT1107259	hsa-miR-548c-3p	CLIP-seq
MIRT1107261	hsa-miR-590-3p	CLIP-seq

MIM	HGNC	e!Ensembl
613536	33765	ENSG00000197980

Q6ZMV7

Protein name

Protein LEKR1

Family and domains

Sequence

MLLKEKEDSLMTCQQIYKALQEELTVKEKQEEDIKRRINLAENELEITKTLLNQTREEVL
TLKNERELMLISHQKSIEQLQETLRQKLLSDDNWKEKIEAELAKERAQHLVEFEEQALLF
KEETKLQLDIEKEKHQDVIQKYKKEQEELQMKISDLITGATRDLRQEVTTLKEKLHKSHI
RYTEESNSKEKEIENLKNLVAEFESRLKKEIDSNDSVSENLRKEMEQKSDELKRVMLAQT
QLIEQFNQSQEENTFLQETVRRECEERFELTEALSQAREQLLELSKLRGSLPFSPCSLSK
GSLTSPAAAVSNHGERSLARLNSEKGIQIPNLRGVSKPTTFPTSDKPKRVRSGVPILPQP
HPPRGGASSANETRQRLAAILRRRRSQQ

Sequence length

388

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (7)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
BREAST CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CARCINOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MELANOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MULTIPLE SCLEROSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TREATMENT-RESISTANT HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
VENOUS THROMBOEMBOLISM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	GWASCAT_DG	29059683		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Carcinoma Ovarian Epithelial	Epithelial ovarian carcinoma	Pubtator	27378695	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus, Non-Insulin-Dependent	Diabetes Mellitus	BEFREE	27607899		★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetic Retinopathy	Diabetic Retinopathy	BEFREE	27607899		★★★★★ ★☆☆☆☆ Found in Text Mining only

LEKR1 (leucine, glutamate and lysine rich 1)