Gene Gene information from NCBI Gene database.
Entrez ID 389015
Gene name Solute carrier family 9 member A4
Gene symbol SLC9A4
Synonyms (NCBI Gene)
NHE4
Chromosome 2
Chromosome location 2q12.1
miRNA miRNA information provided by mirtarbase database.
717
miRTarBase ID miRNA Experiments Reference
MIRT531082 hsa-miR-548a-5p PAR-CLIP 21572407
MIRT531081 hsa-miR-548ab PAR-CLIP 21572407
MIRT531080 hsa-miR-548ad-5p PAR-CLIP 21572407
MIRT531079 hsa-miR-548ae-5p PAR-CLIP 21572407
MIRT531078 hsa-miR-548ak PAR-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
29
GO ID Ontology Definition Evidence Reference
GO:0001696 Process Gastric acid secretion IEA
GO:0002068 Process Glandular epithelial cell development IEA
GO:0005886 Component Plasma membrane IBA
GO:0005886 Component Plasma membrane IEA
GO:0005886 Component Plasma membrane TAS
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600531 11077 ENSG00000180251
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6AI14
Protein name Sodium/hydrogen exchanger 4 (Na(+)/H(+) exchanger 4) (NHE-4) (Solute carrier family 9 member 4)
Protein function Electroneutral antiporter that exchanges sodium for protons or ammonium ions at the basolateral membrane of epithelia to regulate cell volume and intracellular pH upon hypertonic conditions (By similarity). As part of transcellular ammonia trans
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00999 Na_H_Exchanger 73 477 Sodium/hydrogen exchanger family Family
PF16644 NEXCaM_BD 566 675 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin Domain
Sequence
Sequence length 798
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Gastric acid secretion   Sodium/Proton exchangers
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
24
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANKYLOSING SPONDYLITIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ANUS, IMPERFORATE Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Ascending aortic dissection association ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ASTHMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Asthma Asthma Pubtator 35524249 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Celiac Disease Celiac disease GWASCAT_DG 25920553
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Celiac Disease Celiac disease Pubtator 27836013 Associate
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Deep Vein Thrombosis Thrombosis BEFREE 29864786
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Type 2 Diabetes mellitus, type 2 Pubtator 34134627 Inhibit
★☆☆☆☆
Found in Text Mining only
Graft vs Host Disease Graft-versus-host disease Pubtator 31455667 Associate
★☆☆☆☆
Found in Text Mining only
Obesity Obesity Pubtator 35524249 Associate
★☆☆☆☆
Found in Text Mining only
Obstructive azoospermia Obstructive azoospermia BEFREE 30956978
★☆☆☆☆
Found in Text Mining only