Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	388531
Gene name	Regulator of G protein signaling 9 binding protein
Gene symbol	RGS9BP
Synonyms (NCBI Gene)	PERRSPERRS2R9APRGS9
Chromosome	19
Chromosome location	19q13.11
Summary	The protein encoded by this gene functions as a regulator of G protein-coupled receptor signaling in phototransduction. Studies in bovine and mouse show that this gene is expressed only in the retina, and is localized in the rod outer segment membranes. T

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Show/Hide all (222)

miRTarBase ID	miRNA	Experiments	Reference
MIRT694266	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT694265	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT694264	hsa-miR-940	HITS-CLIP	23313552
MIRT694263	hsa-miR-3929	HITS-CLIP	23313552
MIRT694262	hsa-miR-4419b	HITS-CLIP	23313552
MIRT694261	hsa-miR-4478	HITS-CLIP	23313552
MIRT694260	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT694259	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT694258	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT694257	hsa-miR-146a-5p	HITS-CLIP	23313552
MIRT694256	hsa-miR-146b-5p	HITS-CLIP	23313552
MIRT694255	hsa-miR-7153-5p	HITS-CLIP	23313552
MIRT694254	hsa-miR-1827	HITS-CLIP	23313552
MIRT694253	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT694252	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT694251	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT694250	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT694249	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT694248	hsa-miR-1273e	HITS-CLIP	23313552
MIRT694247	hsa-miR-665	HITS-CLIP	23313552
MIRT637539	hsa-miR-5693	HITS-CLIP	23824327
MIRT666588	hsa-miR-4317	HITS-CLIP	23824327
MIRT637536	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT637534	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT637535	hsa-miR-3135b	HITS-CLIP	23824327
MIRT637533	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT637532	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT637531	hsa-miR-3652	HITS-CLIP	23824327
MIRT637530	hsa-miR-4430	HITS-CLIP	23824327
MIRT637529	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT637528	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT637525	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT637523	hsa-miR-5698	HITS-CLIP	23824327
MIRT637539	hsa-miR-5693	HITS-CLIP	23824327
MIRT637538	hsa-miR-1267	HITS-CLIP	23824327
MIRT637537	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT637536	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT637534	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT637535	hsa-miR-3135b	HITS-CLIP	23824327
MIRT637533	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT637532	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT637531	hsa-miR-3652	HITS-CLIP	23824327
MIRT637530	hsa-miR-4430	HITS-CLIP	23824327
MIRT637529	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT637528	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT637527	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT637526	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT637525	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT637524	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT637523	hsa-miR-5698	HITS-CLIP	23824327
MIRT457977	hsa-miR-1288-5p	PAR-CLIP	23592263
MIRT457976	hsa-miR-1273g-3p	PAR-CLIP	23592263
MIRT457974	hsa-miR-4793-3p	PAR-CLIP	23592263
MIRT457975	hsa-miR-1225-3p	PAR-CLIP	23592263
MIRT457973	hsa-miR-1233-3p	PAR-CLIP	23592263
MIRT457971	hsa-miR-4252	PAR-CLIP	23592263
MIRT457975	hsa-miR-1225-3p	PAR-CLIP	27292025
MIRT457973	hsa-miR-1233-3p	PAR-CLIP	27292025
MIRT457977	hsa-miR-1288-5p	PAR-CLIP	27292025
MIRT694254	hsa-miR-1827	PAR-CLIP	27292025
MIRT637536	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT694247	hsa-miR-665	PAR-CLIP	27292025
MIRT694266	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT694265	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT694264	hsa-miR-940	HITS-CLIP	23313552
MIRT694263	hsa-miR-3929	HITS-CLIP	23313552
MIRT694262	hsa-miR-4419b	HITS-CLIP	23313552
MIRT694261	hsa-miR-4478	HITS-CLIP	23313552
MIRT694260	hsa-miR-4768-3p	HITS-CLIP	23313552
MIRT694259	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT694258	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT694257	hsa-miR-146a-5p	HITS-CLIP	23313552
MIRT694256	hsa-miR-146b-5p	HITS-CLIP	23313552
MIRT694255	hsa-miR-7153-5p	HITS-CLIP	23313552
MIRT694254	hsa-miR-1827	HITS-CLIP	23313552
MIRT694253	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT694252	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT694251	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT694250	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT694249	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT694248	hsa-miR-1273e	HITS-CLIP	23313552
MIRT694247	hsa-miR-665	HITS-CLIP	23313552
MIRT637539	hsa-miR-5693	HITS-CLIP	23824327
MIRT666588	hsa-miR-4317	HITS-CLIP	23824327
MIRT637536	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT637534	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT637535	hsa-miR-3135b	HITS-CLIP	23824327
MIRT637533	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT637532	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT637531	hsa-miR-3652	HITS-CLIP	23824327
MIRT637530	hsa-miR-4430	HITS-CLIP	23824327
MIRT637529	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT637528	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT637525	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT637523	hsa-miR-5698	HITS-CLIP	23824327
MIRT637539	hsa-miR-5693	HITS-CLIP	23824327
MIRT637538	hsa-miR-1267	HITS-CLIP	23824327
MIRT637537	hsa-miR-367-5p	HITS-CLIP	23824327
MIRT637536	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT637534	hsa-miR-6847-3p	HITS-CLIP	23824327
MIRT637535	hsa-miR-3135b	HITS-CLIP	23824327
MIRT637533	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT637532	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT637531	hsa-miR-3652	HITS-CLIP	23824327
MIRT637530	hsa-miR-4430	HITS-CLIP	23824327
MIRT637529	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT637528	hsa-miR-891a-3p	HITS-CLIP	23824327
MIRT637527	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT637526	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT637525	hsa-miR-1178-3p	HITS-CLIP	23824327
MIRT637524	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT637523	hsa-miR-5698	HITS-CLIP	23824327
MIRT457977	hsa-miR-1288-5p	PAR-CLIP	23592263
MIRT457976	hsa-miR-1273g-3p	PAR-CLIP	23592263
MIRT457974	hsa-miR-4793-3p	PAR-CLIP	23592263
MIRT457975	hsa-miR-1225-3p	PAR-CLIP	23592263
MIRT457973	hsa-miR-1233-3p	PAR-CLIP	23592263
MIRT457971	hsa-miR-4252	PAR-CLIP	23592263
MIRT1304572	hsa-miR-1207-5p	CLIP-seq
MIRT1304573	hsa-miR-1233	CLIP-seq
MIRT1304574	hsa-miR-1243	CLIP-seq
MIRT1304575	hsa-miR-1273d	CLIP-seq
MIRT1304576	hsa-miR-1276	CLIP-seq
MIRT1304577	hsa-miR-129-3p	CLIP-seq
MIRT1304578	hsa-miR-181a	CLIP-seq
MIRT1304579	hsa-miR-181b	CLIP-seq
MIRT1304580	hsa-miR-181c	CLIP-seq
MIRT1304581	hsa-miR-181d	CLIP-seq
MIRT1304582	hsa-miR-1909	CLIP-seq
MIRT1304583	hsa-miR-1972	CLIP-seq
MIRT1304584	hsa-miR-1976	CLIP-seq
MIRT1304585	hsa-miR-2277-5p	CLIP-seq
MIRT1304586	hsa-miR-302a	CLIP-seq
MIRT1304587	hsa-miR-302b	CLIP-seq
MIRT1304588	hsa-miR-302c	CLIP-seq
MIRT1304589	hsa-miR-302d	CLIP-seq
MIRT1304590	hsa-miR-302e	CLIP-seq
MIRT1304591	hsa-miR-3130-5p	CLIP-seq
MIRT1304592	hsa-miR-3150a-3p	CLIP-seq
MIRT1304593	hsa-miR-3158-5p	CLIP-seq
MIRT1304594	hsa-miR-3159	CLIP-seq
MIRT1304595	hsa-miR-3166	CLIP-seq
MIRT1304596	hsa-miR-3175	CLIP-seq
MIRT1304597	hsa-miR-3180	CLIP-seq
MIRT1304598	hsa-miR-3180-3p	CLIP-seq
MIRT1304599	hsa-miR-3184	CLIP-seq
MIRT1304600	hsa-miR-3196	CLIP-seq
MIRT1304601	hsa-miR-320a	CLIP-seq
MIRT1304602	hsa-miR-320b	CLIP-seq
MIRT1304603	hsa-miR-320c	CLIP-seq
MIRT1304604	hsa-miR-320d	CLIP-seq
MIRT1304605	hsa-miR-3691-3p	CLIP-seq
MIRT1304606	hsa-miR-372	CLIP-seq
MIRT1304607	hsa-miR-373	CLIP-seq
MIRT1304608	hsa-miR-423-5p	CLIP-seq
MIRT1304609	hsa-miR-4262	CLIP-seq
MIRT1304610	hsa-miR-4311	CLIP-seq
MIRT1304611	hsa-miR-4321	CLIP-seq
MIRT1304612	hsa-miR-4429	CLIP-seq
MIRT1304613	hsa-miR-4482	CLIP-seq
MIRT1304614	hsa-miR-4488	CLIP-seq
MIRT1304615	hsa-miR-4505	CLIP-seq
MIRT1304616	hsa-miR-4509	CLIP-seq
MIRT1304617	hsa-miR-4651	CLIP-seq
MIRT1304618	hsa-miR-4667-5p	CLIP-seq
MIRT1304619	hsa-miR-4697-5p	CLIP-seq
MIRT1304620	hsa-miR-4700-5p	CLIP-seq
MIRT1304621	hsa-miR-4731-5p	CLIP-seq
MIRT1304622	hsa-miR-4736	CLIP-seq
MIRT1304623	hsa-miR-4742-5p	CLIP-seq
MIRT1304624	hsa-miR-4744	CLIP-seq
MIRT1304625	hsa-miR-4763-3p	CLIP-seq
MIRT1304626	hsa-miR-4771	CLIP-seq
MIRT1304627	hsa-miR-4787-5p	CLIP-seq
MIRT1304628	hsa-miR-519a	CLIP-seq
MIRT1304629	hsa-miR-519b-3p	CLIP-seq
MIRT1304630	hsa-miR-519c-3p	CLIP-seq
MIRT1304631	hsa-miR-520a-3p	CLIP-seq
MIRT1304632	hsa-miR-520b	CLIP-seq
MIRT1304633	hsa-miR-520c-3p	CLIP-seq
MIRT1304634	hsa-miR-520d-3p	CLIP-seq
MIRT1304635	hsa-miR-520e	CLIP-seq
MIRT1304636	hsa-miR-583	CLIP-seq
MIRT1304637	hsa-miR-595	CLIP-seq
MIRT1304638	hsa-miR-602	CLIP-seq
MIRT1304639	hsa-miR-608	CLIP-seq
MIRT1304640	hsa-miR-648	CLIP-seq
MIRT1304641	hsa-miR-660	CLIP-seq
MIRT1304642	hsa-miR-718	CLIP-seq
MIRT1304643	hsa-miR-885-3p	CLIP-seq
MIRT1304644	hsa-miR-933	CLIP-seq
MIRT1304645	hsa-miR-939	CLIP-seq
MIRT1304576	hsa-miR-1276	CLIP-seq
MIRT2090238	hsa-miR-22	CLIP-seq
MIRT2090239	hsa-miR-3194-5p	CLIP-seq
MIRT2090240	hsa-miR-4290	CLIP-seq
MIRT2090241	hsa-miR-4300	CLIP-seq
MIRT1304610	hsa-miR-4311	CLIP-seq
MIRT2090242	hsa-miR-4687-5p	CLIP-seq
MIRT1304624	hsa-miR-4744	CLIP-seq
MIRT2090243	hsa-miR-558	CLIP-seq
MIRT1304636	hsa-miR-583	CLIP-seq
MIRT2090244	hsa-miR-920	CLIP-seq
MIRT2315019	hsa-miR-4271	CLIP-seq
MIRT2315020	hsa-miR-4447	CLIP-seq
MIRT2315021	hsa-miR-4472	CLIP-seq
MIRT2315022	hsa-miR-4725-3p	CLIP-seq
MIRT2315023	hsa-miR-4796-3p	CLIP-seq
MIRT2315024	hsa-miR-548t	CLIP-seq
MIRT2315025	hsa-miR-625	CLIP-seq
MIRT2315026	hsa-miR-7	CLIP-seq
MIRT2611337	hsa-miR-3613-3p	CLIP-seq
MIRT2611338	hsa-miR-371-5p	CLIP-seq
MIRT2611339	hsa-miR-371b-5p	CLIP-seq
MIRT2611340	hsa-miR-4421	CLIP-seq
MIRT2315024	hsa-miR-548t	CLIP-seq
MIRT2611337	hsa-miR-3613-3p	CLIP-seq
MIRT2611338	hsa-miR-371-5p	CLIP-seq
MIRT2611339	hsa-miR-371b-5p	CLIP-seq
MIRT2611340	hsa-miR-4421	CLIP-seq
MIRT2315023	hsa-miR-4796-3p	CLIP-seq
MIRT2315024	hsa-miR-548t	CLIP-seq

Show/Hide all (8)

GO ID	Ontology	Definition	Evidence
GO:0007186	Process	G protein-coupled receptor signaling pathway	IBA
GO:0007601	Process	Visual perception	IEA
GO:0009968	Process	Negative regulation of signal transduction	IEA
GO:0016020	Component	Membrane	IEA
GO:0043005	Component	Neuron projection	IBA
GO:0050908	Process	Detection of light stimulus involved in visual perception	IBA
GO:0050908	Process	Detection of light stimulus involved in visual perception	IEA
GO:0120200	Component	Rod photoreceptor outer segment	IEA

MIM	HGNC	e!Ensembl
607814	30304	ENSG00000186326

Q6ZS82

Protein name

Regulator of G-protein signaling 9-binding protein (RGS9-anchoring protein)

Protein function

Regulator of G protein-coupled receptor (GPCR) signaling in phototransduction. Participates in the recovery phase of visual transduction via its interaction with RGS9-1 isoform. Acts as a membrane-anchor that mediates the targeting of RGS9-1 to

Family and domains

Sequence

MAREECKALLDGLNKTTACYHHLVLTVGGSADSQNLRQELQKTRQKAQELAVSTCARLTA
VLRDRGLAADERAEFERLWVAFSGCLDLLEADMRRALELGAAFPLHAPRRPLVRTGVAGA
SSGVAARALSTRSLRLEAEGDFDVADLRELEREVLQVGEMIDNMEMKVNVPRWTVQARQA
AGAELLSTVSAGPSSVVSLQERGGGCDPRKALAAILFGAVLLAAVALAVCVAKLS

Sequence length

235

Interactions

View interactions

	Reactome
			Inactivation, recovery and regulation of the phototransduction cascade

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (2)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Bradyopsia	Pathogenic	rs758583548, rs1968005848	RCV000002965 RCV001283837	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Prolonged electroretinal response suppression 2	Pathogenic	rs1968006085	RCV003990409	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (3)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Retinal dystrophy	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RETINITIS PIGMENTOSA 1	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RGS9BP-related disorder	Likely benign; Uncertain significance; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (15)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Abnormal involuntary movement	Abnormal Involuntary Movement	BEFREE	15728856		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bradyopsia	Bradyopsia	Orphanet			★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Cone Dystrophy	Cone dystrophy	Pubtator	26957898	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Disorder of eye	Disorder Of Eye	GENOMICS_ENGLAND_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Dyskinesia, Drug-Induced	Dyskinesia	CTD_human_DG	18160641, 24663062		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dyskinetic syndrome	Dyskinetic Syndrome	BEFREE	15728856, 18548510		★★★★★ ★☆☆☆☆ Found in Text Mining only
Dystonia Disorders	Dystonia	BEFREE	30552094		★★★★★ ★☆☆☆☆ Found in Text Mining only
Graves Disease	Graves Disease	GWASCAT_DG	30067105		★★★★★ ★☆☆☆☆ Found in Text Mining only
Leber Congenital Amaurosis	Leber Congenital Amaurosis	CLINVAR_DG	30718709		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	24317514		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nonorganic psychosis	Nonorganic Psychosis	BEFREE	17318883		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	BEFREE	15728856		★★★★★ ★☆☆☆☆ Found in Text Mining only
Psychotic Disorders	Psychosis	BEFREE	15728856, 17318883		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	16786561, 17318883, 18548510		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	CTD_human_DG	17318883		★★★★★ ★☆☆☆☆ Found in Text Mining only

RGS9BP (regulator of G protein signaling 9 binding protein)