Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	388512
Gene name	C-type lectin domain containing 17A
Gene symbol	CLEC17A
Synonyms (NCBI Gene)	-
Chromosome	19
Chromosome location	19p13.12

Show/Hide all (93)

miRTarBase ID	miRNA	Experiments	Reference
MIRT640470	hsa-miR-1255b-2-3p	HITS-CLIP	23824327
MIRT640469	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT640468	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT640467	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT640466	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT640465	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT640464	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT640463	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT640462	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT640461	hsa-miR-607	HITS-CLIP	23824327
MIRT629396	hsa-miR-15a-3p	HITS-CLIP	23824327
MIRT629395	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT629394	hsa-miR-6884-3p	HITS-CLIP	23824327
MIRT629393	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT629392	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT629391	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT629390	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT629389	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT629388	hsa-miR-3122	HITS-CLIP	23824327
MIRT629387	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT629386	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT629385	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT640470	hsa-miR-1255b-2-3p	HITS-CLIP	23824327
MIRT640469	hsa-miR-208a-5p	HITS-CLIP	23824327
MIRT640468	hsa-miR-208b-5p	HITS-CLIP	23824327
MIRT640467	hsa-miR-330-3p	HITS-CLIP	23824327
MIRT640466	hsa-miR-6773-3p	HITS-CLIP	23824327
MIRT640465	hsa-miR-3140-3p	HITS-CLIP	23824327
MIRT640464	hsa-miR-6879-3p	HITS-CLIP	23824327
MIRT640463	hsa-miR-6740-5p	HITS-CLIP	23824327
MIRT640462	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT640461	hsa-miR-607	HITS-CLIP	23824327
MIRT629396	hsa-miR-15a-3p	HITS-CLIP	23824327
MIRT629395	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT629394	hsa-miR-6884-3p	HITS-CLIP	23824327
MIRT629393	hsa-miR-4529-5p	HITS-CLIP	23824327
MIRT629392	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT629391	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT629390	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT629389	hsa-miR-450a-1-3p	HITS-CLIP	23824327
MIRT629388	hsa-miR-3122	HITS-CLIP	23824327
MIRT629387	hsa-miR-3913-5p	HITS-CLIP	23824327
MIRT629386	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT629385	hsa-miR-6513-5p	HITS-CLIP	23824327
MIRT895744	hsa-miR-1225-3p	CLIP-seq
MIRT895745	hsa-miR-1233	CLIP-seq
MIRT895746	hsa-miR-1283	CLIP-seq
MIRT895747	hsa-miR-143	CLIP-seq
MIRT895748	hsa-miR-2110	CLIP-seq
MIRT895749	hsa-miR-2114	CLIP-seq
MIRT895750	hsa-miR-3153	CLIP-seq
MIRT895751	hsa-miR-3187-3p	CLIP-seq
MIRT895752	hsa-miR-3613-3p	CLIP-seq
MIRT895753	hsa-miR-3622b-5p	CLIP-seq
MIRT895754	hsa-miR-4271	CLIP-seq
MIRT895755	hsa-miR-4426	CLIP-seq
MIRT895756	hsa-miR-4433	CLIP-seq
MIRT895757	hsa-miR-4435	CLIP-seq
MIRT895758	hsa-miR-4645-5p	CLIP-seq
MIRT895759	hsa-miR-4647	CLIP-seq
MIRT895760	hsa-miR-4662b	CLIP-seq
MIRT895761	hsa-miR-4673	CLIP-seq
MIRT895762	hsa-miR-4701-5p	CLIP-seq
MIRT895763	hsa-miR-4725-3p	CLIP-seq
MIRT895764	hsa-miR-4755-3p	CLIP-seq
MIRT895765	hsa-miR-510	CLIP-seq
MIRT895766	hsa-miR-548a-5p	CLIP-seq
MIRT895767	hsa-miR-548ab	CLIP-seq
MIRT895768	hsa-miR-548ak	CLIP-seq
MIRT895769	hsa-miR-548b-5p	CLIP-seq
MIRT895770	hsa-miR-548c-3p	CLIP-seq
MIRT895771	hsa-miR-548c-5p	CLIP-seq
MIRT895772	hsa-miR-548d-5p	CLIP-seq
MIRT895773	hsa-miR-548h	CLIP-seq
MIRT895774	hsa-miR-548i	CLIP-seq
MIRT895775	hsa-miR-548j	CLIP-seq
MIRT895776	hsa-miR-548s	CLIP-seq
MIRT895777	hsa-miR-548w	CLIP-seq
MIRT895778	hsa-miR-548y	CLIP-seq
MIRT895779	hsa-miR-559	CLIP-seq
MIRT895780	hsa-miR-588	CLIP-seq
MIRT1965624	hsa-miR-4786-5p	CLIP-seq
MIRT1965625	hsa-miR-769-5p	CLIP-seq
MIRT895744	hsa-miR-1225-3p	CLIP-seq
MIRT895745	hsa-miR-1233	CLIP-seq
MIRT895747	hsa-miR-143	CLIP-seq
MIRT895749	hsa-miR-2114	CLIP-seq
MIRT895756	hsa-miR-4433	CLIP-seq
MIRT2201507	hsa-miR-4466	CLIP-seq
MIRT895765	hsa-miR-510	CLIP-seq
MIRT2201508	hsa-miR-675	CLIP-seq
MIRT2201509	hsa-miR-933	CLIP-seq
MIRT895749	hsa-miR-2114	CLIP-seq

Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005537	Function	D-mannose binding	IBA
GO:0005537	Function	D-mannose binding	IDA	19419970
GO:0005537	Function	D-mannose binding	IEA
GO:0006955	Process	Immune response	IBA
GO:0009897	Component	External side of plasma membrane	IBA
GO:0009986	Component	Cell surface	IDA	19419970
GO:0016020	Component	Membrane	IEA
GO:0030246	Function	Carbohydrate binding	IEA
GO:0038187	Function	Pattern recognition receptor activity	IBA
GO:0042802	Function	Identical protein binding	IPI	32296183
GO:0042806	Function	Fucose binding	IBA
GO:0042806	Function	Fucose binding	IDA	19419970
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
616838	34520	ENSG00000187912

Q6ZS10

Protein name

C-type lectin domain family 17, member A (Prolectin)

Protein function

Cell surface receptor which may be involved in carbohydrate-mediated communication between cells in the germinal center. Binds glycans with terminal alpha-linked mannose or fucose residues.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00059	Lectin_C	271 → 374	Lectin C-type domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed on dividing B-cells of germinal centers in various tissues, including lymph nodes, tonsils, stomach, intestine, appendix and spleen. {ECO:0000269|PubMed:19419970}.

Sequence

MHNLYSITGYPDPPGTMEEEEEDDDYENSTPPYKDLPPKPGTMEEEEEDDDYENSTPPYK
DLPPKPGTMEEEEEDDDYENSTPPYKDLPPKPGSSAPPRPPRAAKETEKPPLPCKPRNMT
GLDLAAVTCPPPQLAVNLEPSPLQPSLAATPVPWLNQRSGGPGCCQKRWMVYLCLLVVTS
LFLGCLGLTVTLIKYQELMEELRMLSFQQMTWRTNMTGMAGLAGLKHDIARVRADTNQSL
VELWGLLDCRRITCPEGWLPFEGKCYYFSPSTKSWDEARMFCQENYSHLVIINSFAEHNF
VAKAHGSPRVYWLGLNDRAQEGDWRWLDGSPVTLSFWEPEEPNNIHDEDCATMNKGGTWN
DLSCYKTTYWICERKCSC

Sequence length

378

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Chronic Lymphocytic Leukemia	Lymphocytic Leukemia	BEFREE	29367434		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	26908442	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only

CLEC17A (C-type lectin domain containing 17A)