Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	388121
Gene name	TNF alpha induced protein 8 like 3
Gene symbol	TNFAIP8L3
Synonyms (NCBI Gene)	TIPE3
Chromosome	15
Chromosome location	15q21.2

211

Show/Hide all (211)

miRTarBase ID	miRNA	Experiments	Reference
MIRT458319	hsa-miR-4476	PAR-CLIP	23592263
MIRT458318	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT458317	hsa-miR-4514	PAR-CLIP	23592263
MIRT458316	hsa-miR-4692	PAR-CLIP	23592263
MIRT458315	hsa-miR-6841-3p	PAR-CLIP	23592263
MIRT458314	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT458313	hsa-miR-3179	PAR-CLIP	23592263
MIRT458312	hsa-miR-3665	PAR-CLIP	23592263
MIRT458311	hsa-miR-4533	PAR-CLIP	23592263
MIRT458310	hsa-miR-3202	PAR-CLIP	23592263
MIRT458309	hsa-miR-505-5p	PAR-CLIP	23592263
MIRT458308	hsa-miR-4736	PAR-CLIP	23592263
MIRT458307	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT458306	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT458305	hsa-miR-6827-5p	PAR-CLIP	23592263
MIRT458304	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT458303	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT458302	hsa-miR-6511b-5p	PAR-CLIP	23592263
MIRT458300	hsa-miR-6811-5p	PAR-CLIP	23592263
MIRT458301	hsa-miR-6748-5p	PAR-CLIP	23592263
MIRT458319	hsa-miR-4476	PAR-CLIP	23592263
MIRT458318	hsa-miR-6876-5p	PAR-CLIP	23592263
MIRT458317	hsa-miR-4514	PAR-CLIP	23592263
MIRT458316	hsa-miR-4692	PAR-CLIP	23592263
MIRT458315	hsa-miR-6841-3p	PAR-CLIP	23592263
MIRT458314	hsa-miR-1252-5p	PAR-CLIP	23592263
MIRT458313	hsa-miR-3179	PAR-CLIP	23592263
MIRT458312	hsa-miR-3665	PAR-CLIP	23592263
MIRT458311	hsa-miR-4533	PAR-CLIP	23592263
MIRT458310	hsa-miR-3202	PAR-CLIP	23592263
MIRT458309	hsa-miR-505-5p	PAR-CLIP	23592263
MIRT458308	hsa-miR-4736	PAR-CLIP	23592263
MIRT458307	hsa-miR-4747-5p	PAR-CLIP	23592263
MIRT458306	hsa-miR-5196-5p	PAR-CLIP	23592263
MIRT458305	hsa-miR-6827-5p	PAR-CLIP	23592263
MIRT458304	hsa-miR-1343-5p	PAR-CLIP	23592263
MIRT458303	hsa-miR-939-5p	PAR-CLIP	23592263
MIRT458302	hsa-miR-6511b-5p	PAR-CLIP	23592263
MIRT458300	hsa-miR-6811-5p	PAR-CLIP	23592263
MIRT458301	hsa-miR-6748-5p	PAR-CLIP	23592263
MIRT1442521	hsa-miR-1267	CLIP-seq
MIRT1442522	hsa-miR-3135b	CLIP-seq
MIRT1442523	hsa-miR-3194-3p	CLIP-seq
MIRT1442524	hsa-miR-3545-3p	CLIP-seq
MIRT1442525	hsa-miR-3652	CLIP-seq
MIRT1442526	hsa-miR-3687	CLIP-seq
MIRT1442527	hsa-miR-4269	CLIP-seq
MIRT1442528	hsa-miR-431	CLIP-seq
MIRT1442529	hsa-miR-4423-5p	CLIP-seq
MIRT1442530	hsa-miR-4430	CLIP-seq
MIRT1442531	hsa-miR-4442	CLIP-seq
MIRT1442532	hsa-miR-4635	CLIP-seq
MIRT1442533	hsa-miR-4680-5p	CLIP-seq
MIRT1442534	hsa-miR-4695-3p	CLIP-seq
MIRT1442535	hsa-miR-4742-5p	CLIP-seq
MIRT1442536	hsa-miR-924	CLIP-seq
MIRT1442522	hsa-miR-3135b	CLIP-seq
MIRT1442525	hsa-miR-3652	CLIP-seq
MIRT1442529	hsa-miR-4423-5p	CLIP-seq
MIRT1442530	hsa-miR-4430	CLIP-seq
MIRT2132454	hsa-miR-1184	CLIP-seq
MIRT2132455	hsa-miR-1200	CLIP-seq
MIRT2132456	hsa-miR-150	CLIP-seq
MIRT2132457	hsa-miR-15a	CLIP-seq
MIRT2132458	hsa-miR-15b	CLIP-seq
MIRT2132459	hsa-miR-16	CLIP-seq
MIRT2132460	hsa-miR-1915	CLIP-seq
MIRT2132461	hsa-miR-195	CLIP-seq
MIRT2132462	hsa-miR-1976	CLIP-seq
MIRT1442522	hsa-miR-3135b	CLIP-seq
MIRT1442525	hsa-miR-3652	CLIP-seq
MIRT2132463	hsa-miR-3910	CLIP-seq
MIRT2132464	hsa-miR-424	CLIP-seq
MIRT2132465	hsa-miR-4266	CLIP-seq
MIRT2132466	hsa-miR-4279	CLIP-seq
MIRT2132467	hsa-miR-4286	CLIP-seq
MIRT2132468	hsa-miR-4324	CLIP-seq
MIRT2132469	hsa-miR-4418	CLIP-seq
MIRT2132470	hsa-miR-4422	CLIP-seq
MIRT1442529	hsa-miR-4423-5p	CLIP-seq
MIRT1442530	hsa-miR-4430	CLIP-seq
MIRT2132471	hsa-miR-4438	CLIP-seq
MIRT1442534	hsa-miR-4695-3p	CLIP-seq
MIRT2132472	hsa-miR-4695-5p	CLIP-seq
MIRT2132473	hsa-miR-4712-5p	CLIP-seq
MIRT2132474	hsa-miR-4713-5p	CLIP-seq
MIRT2132475	hsa-miR-4722-3p	CLIP-seq
MIRT2132476	hsa-miR-4726-3p	CLIP-seq
MIRT2132477	hsa-miR-4779	CLIP-seq
MIRT2132478	hsa-miR-497	CLIP-seq
MIRT2132479	hsa-miR-509-3-5p	CLIP-seq
MIRT2132480	hsa-miR-5095	CLIP-seq
MIRT2132481	hsa-miR-509-5p	CLIP-seq
MIRT2132482	hsa-miR-512-3p	CLIP-seq
MIRT2132483	hsa-miR-532-3p	CLIP-seq
MIRT2132484	hsa-miR-544b	CLIP-seq
MIRT2132485	hsa-miR-545	CLIP-seq
MIRT2132486	hsa-miR-770-5p	CLIP-seq
MIRT2353448	hsa-miR-106a	CLIP-seq
MIRT2353449	hsa-miR-106b	CLIP-seq
MIRT2132454	hsa-miR-1184	CLIP-seq
MIRT2132455	hsa-miR-1200	CLIP-seq
MIRT2353450	hsa-miR-1224-3p	CLIP-seq
MIRT2353451	hsa-miR-1234	CLIP-seq
MIRT2353452	hsa-miR-1254	CLIP-seq
MIRT1442521	hsa-miR-1267	CLIP-seq
MIRT2132456	hsa-miR-150	CLIP-seq
MIRT2353453	hsa-miR-17	CLIP-seq
MIRT2353454	hsa-miR-1913	CLIP-seq
MIRT2132460	hsa-miR-1915	CLIP-seq
MIRT2132462	hsa-miR-1976	CLIP-seq
MIRT2353455	hsa-miR-20a	CLIP-seq
MIRT2353456	hsa-miR-20b	CLIP-seq
MIRT2353457	hsa-miR-2116	CLIP-seq
MIRT2353458	hsa-miR-302a	CLIP-seq
MIRT2353459	hsa-miR-302b	CLIP-seq
MIRT2353460	hsa-miR-302c	CLIP-seq
MIRT2353461	hsa-miR-302d	CLIP-seq
MIRT2353462	hsa-miR-302e	CLIP-seq
MIRT2353463	hsa-miR-3116	CLIP-seq
MIRT1442522	hsa-miR-3135b	CLIP-seq
MIRT1442523	hsa-miR-3194-3p	CLIP-seq
MIRT2353464	hsa-miR-324-3p	CLIP-seq
MIRT1442525	hsa-miR-3652	CLIP-seq
MIRT2353465	hsa-miR-372	CLIP-seq
MIRT2353466	hsa-miR-373	CLIP-seq
MIRT2353467	hsa-miR-3926	CLIP-seq
MIRT2353468	hsa-miR-3934	CLIP-seq
MIRT1442527	hsa-miR-4269	CLIP-seq
MIRT2132466	hsa-miR-4279	CLIP-seq
MIRT1442528	hsa-miR-431	CLIP-seq
MIRT2132468	hsa-miR-4324	CLIP-seq
MIRT2132469	hsa-miR-4418	CLIP-seq
MIRT1442529	hsa-miR-4423-5p	CLIP-seq
MIRT1442530	hsa-miR-4430	CLIP-seq
MIRT2132471	hsa-miR-4438	CLIP-seq
MIRT2353469	hsa-miR-4677-5p	CLIP-seq
MIRT1442534	hsa-miR-4695-3p	CLIP-seq
MIRT2132474	hsa-miR-4713-5p	CLIP-seq
MIRT2132475	hsa-miR-4722-3p	CLIP-seq
MIRT2132476	hsa-miR-4726-3p	CLIP-seq
MIRT2353470	hsa-miR-4731-5p	CLIP-seq
MIRT2353471	hsa-miR-4735-5p	CLIP-seq
MIRT1442535	hsa-miR-4742-5p	CLIP-seq
MIRT2353472	hsa-miR-4775	CLIP-seq
MIRT2353473	hsa-miR-4794	CLIP-seq
MIRT2132479	hsa-miR-509-3-5p	CLIP-seq
MIRT2132480	hsa-miR-5095	CLIP-seq
MIRT2132481	hsa-miR-509-5p	CLIP-seq
MIRT2132482	hsa-miR-512-3p	CLIP-seq
MIRT2353474	hsa-miR-519d	CLIP-seq
MIRT2353475	hsa-miR-520a-3p	CLIP-seq
MIRT2353476	hsa-miR-520b	CLIP-seq
MIRT2353477	hsa-miR-520c-3p	CLIP-seq
MIRT2353478	hsa-miR-520d-3p	CLIP-seq
MIRT2353479	hsa-miR-520e	CLIP-seq
MIRT2353480	hsa-miR-520g	CLIP-seq
MIRT2353481	hsa-miR-520h	CLIP-seq
MIRT2132483	hsa-miR-532-3p	CLIP-seq
MIRT2132484	hsa-miR-544b	CLIP-seq
MIRT2353482	hsa-miR-548s	CLIP-seq
MIRT2353483	hsa-miR-552	CLIP-seq
MIRT2353484	hsa-miR-590-3p	CLIP-seq
MIRT2353485	hsa-miR-661	CLIP-seq
MIRT1442536	hsa-miR-924	CLIP-seq
MIRT2353486	hsa-miR-93	CLIP-seq
MIRT1442521	hsa-miR-1267	CLIP-seq
MIRT1442522	hsa-miR-3135b	CLIP-seq
MIRT1442523	hsa-miR-3194-3p	CLIP-seq
MIRT1442525	hsa-miR-3652	CLIP-seq
MIRT1442528	hsa-miR-431	CLIP-seq
MIRT1442529	hsa-miR-4423-5p	CLIP-seq
MIRT1442530	hsa-miR-4430	CLIP-seq
MIRT2462052	hsa-miR-4797-5p	CLIP-seq
MIRT1442536	hsa-miR-924	CLIP-seq
MIRT2132454	hsa-miR-1184	CLIP-seq
MIRT1442521	hsa-miR-1267	CLIP-seq
MIRT2132456	hsa-miR-150	CLIP-seq
MIRT2132460	hsa-miR-1915	CLIP-seq
MIRT1442522	hsa-miR-3135b	CLIP-seq
MIRT1442523	hsa-miR-3194-3p	CLIP-seq
MIRT1442525	hsa-miR-3652	CLIP-seq
MIRT1442528	hsa-miR-431	CLIP-seq
MIRT2132469	hsa-miR-4418	CLIP-seq
MIRT1442529	hsa-miR-4423-5p	CLIP-seq
MIRT1442530	hsa-miR-4430	CLIP-seq
MIRT2132471	hsa-miR-4438	CLIP-seq
MIRT1442534	hsa-miR-4695-3p	CLIP-seq
MIRT2132474	hsa-miR-4713-5p	CLIP-seq
MIRT2132476	hsa-miR-4726-3p	CLIP-seq
MIRT2353471	hsa-miR-4735-5p	CLIP-seq
MIRT2353472	hsa-miR-4775	CLIP-seq
MIRT2353473	hsa-miR-4794	CLIP-seq
MIRT2462052	hsa-miR-4797-5p	CLIP-seq
MIRT2132479	hsa-miR-509-3-5p	CLIP-seq
MIRT2132480	hsa-miR-5095	CLIP-seq
MIRT2132481	hsa-miR-509-5p	CLIP-seq
MIRT2132483	hsa-miR-532-3p	CLIP-seq
MIRT2353484	hsa-miR-590-3p	CLIP-seq
MIRT1442536	hsa-miR-924	CLIP-seq
MIRT1442521	hsa-miR-1267	CLIP-seq
MIRT1442522	hsa-miR-3135b	CLIP-seq
MIRT1442523	hsa-miR-3194-3p	CLIP-seq
MIRT1442525	hsa-miR-3652	CLIP-seq
MIRT1442528	hsa-miR-431	CLIP-seq
MIRT1442529	hsa-miR-4423-5p	CLIP-seq
MIRT1442530	hsa-miR-4430	CLIP-seq
MIRT2132471	hsa-miR-4438	CLIP-seq
MIRT1442534	hsa-miR-4695-3p	CLIP-seq
MIRT2132480	hsa-miR-5095	CLIP-seq
MIRT1442536	hsa-miR-924	CLIP-seq

Show/Hide all (20)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	25479791
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0006644	Process	Phospholipid metabolic process	TAS
GO:0006869	Process	Lipid transport	IEA
GO:0008526	Function	Phosphatidylinositol transfer activity	ISS
GO:0008526	Function	Phosphatidylinositol transfer activity	TAS
GO:0015914	Process	Phospholipid transport	ISS
GO:0016020	Component	Membrane	IEA
GO:0035091	Function	Phosphatidylinositol binding	ISS
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0070374	Process	Positive regulation of ERK1 and ERK2 cascade	ISS
GO:0120009	Process	Intermembrane lipid transfer	IEA
GO:1902633	Process	1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process	ISS

MIM	HGNC	e!Ensembl
616438	20620	ENSG00000183578

Q5GJ75

Protein name

Tumor necrosis factor alpha-induced protein 8-like protein 3 (TNF alpha-induced protein 8-like protein 3) (TNFAIP8-like protein 3)

Protein function

Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Addi

PDB

4Q9V

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF05527	DUF758	110 → 290	Domain of unknown function (DUF758)	Family

Tissue specificity

TISSUE SPECIFICITY: Widely expressed (at protein level) (PubMed:25479791). Highly expressed in most carcinoma cell lines (PubMed:25242044, PubMed:25479791). {ECO:0000269|PubMed:25242044, ECO:0000269|PubMed:25479791}.

Sequence

MGKPRQNPSTLVSTLCEAEPKGKLWVNGYAGTQGTRDATLQTRLIPLSFHLQRGKGLAAP
LSALSAPRLPERPADGRVAVDAQPAARSMDSDSGEQSEGEPVTAAGPDVFSSKSLALQAQ
KKILSKIASKTVANMLIDDTSSEIFDELYKVTKEHTHNKKEAHKIMKDLIKVAIKIGILY
RNNQFSQEELVIVEKFRKKLNQTAMTIVSFYEVEYTFDRNVLSNLLHECKDLVHELVQRH
LTPRTHGRINHVFNHFADVEFLSTLYSLDGDCRPNLKRICEGINKLLDEKVL

Sequence length

292

Interactions

View interactions

	Reactome
			PI Metabolism

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Familial cancer of breast	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KERATOCONUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (26)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Arthritis Rheumatoid	Rheumatoid arthritis	Pubtator	18369459	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Autoimmune Diseases	Autoimmune disease	Pubtator	18369459	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	28388580		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinogenesis	Carcinogenesis	Pubtator	25242044	Stimulate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	29510688		★★★★★ ★☆☆☆☆ Found in Text Mining only
Celiac Disease	Celiac disease	Pubtator	18369459	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	36755222	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Diabetes Mellitus Type 1	Diabetes mellitus, type 1	Pubtator	18369459	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	30639532		★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	30639532		★★★★★ ★☆☆☆☆ Found in Text Mining only
Graves Disease	Graves disease	Pubtator	18369459	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Head and Neck Neoplasms	Head and neck neoplasm	Pubtator	34344926	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Invasive Ductal Breast Carcinoma	Invasive Duct and Lobular Carcinoma	BEFREE	28388580		★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Diseases	Lung disease	Pubtator	30217224	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	40311306	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	28388580		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	29510688		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	25242044, 25479791, 28388580		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	30217224		★★★★★ ★☆☆☆☆ Found in Text Mining only
Nasopharyngeal Carcinoma	Nasopharyngeal carcinoma	Pubtator	30217224	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	29510688, 30217224		★★★★★ ★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	29510688		★★★★★ ★☆☆☆☆ Found in Text Mining only
Noninfiltrating Intraductal Carcinoma	Ductal carcinoma	BEFREE	28388580		★★★★★ ★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	32149080	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Psoriasis	Psoriasis	Pubtator	18369459	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Regular astigmatism - corneal	Corneal astigmatism	BEFREE	29422769		★★★★★ ★☆☆☆☆ Found in Text Mining only

TNFAIP8L3 (TNF alpha induced protein 8 like 3)