SHISA2 (shisa family member 2)

Gene

• Entrez ID: 387914
• Gene name: Shisa family member 2
• Gene symbol: SHISA2
• Synonyms (NCBI Gene): C13orf13, PRO28631, TMEM46, WGAR9166, bA398O19.2, hShisa
• Chromosome: 13
• Chromosome location: 13q12.13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT047100	hsa-miR-183-5p	CLASH	23622248
MIRT046670	hsa-miR-222-3p	CLASH	23622248
MIRT044314	hsa-miR-106b-5p	CLASH	23622248
MIRT571218	hsa-miR-138-1-3p	HITS-CLIP	21572407
MIRT670557	hsa-miR-637	HITS-CLIP	23824327
MIRT670556	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT670555	hsa-miR-4284	HITS-CLIP	23824327
MIRT670554	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT670553	hsa-miR-4505	HITS-CLIP	23824327
MIRT670552	hsa-miR-5787	HITS-CLIP	23824327
MIRT670551	hsa-miR-3180	HITS-CLIP	23824327
MIRT670550	hsa-miR-3180-3p	HITS-CLIP	23824327
MIRT670549	hsa-miR-3196	HITS-CLIP	23824327
MIRT670548	hsa-miR-6816-5p	HITS-CLIP	23824327
MIRT670547	hsa-miR-1237-5p	HITS-CLIP	23824327
MIRT670546	hsa-miR-4488	HITS-CLIP	23824327
MIRT670545	hsa-miR-4697-5p	HITS-CLIP	23824327
MIRT670544	hsa-miR-6846-5p	HITS-CLIP	23824327
MIRT670543	hsa-miR-6848-5p	HITS-CLIP	23824327
MIRT670542	hsa-miR-7977	HITS-CLIP	23824327
MIRT571218	hsa-miR-138-1-3p	PAR-CLIP	20371350
MIRT530093	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT530092	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT530091	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT530090	hsa-miR-2681-5p	PAR-CLIP	22012620
MIRT571218	hsa-miR-138-1-3p	PAR-CLIP	27292025
MIRT670542	hsa-miR-7977	HITS-CLIP	27418678
MIRT571218	hsa-miR-138-1-3p	HITS-CLIP	21572407
MIRT670557	hsa-miR-637	HITS-CLIP	23824327
MIRT670556	hsa-miR-4731-5p	HITS-CLIP	23824327
MIRT670555	hsa-miR-4284	HITS-CLIP	23824327
MIRT670554	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT670553	hsa-miR-4505	HITS-CLIP	23824327
MIRT670552	hsa-miR-5787	HITS-CLIP	23824327
MIRT670551	hsa-miR-3180	HITS-CLIP	23824327
MIRT670550	hsa-miR-3180-3p	HITS-CLIP	23824327
MIRT670549	hsa-miR-3196	HITS-CLIP	23824327
MIRT670548	hsa-miR-6816-5p	HITS-CLIP	23824327
MIRT670547	hsa-miR-1237-5p	HITS-CLIP	23824327
MIRT670546	hsa-miR-4488	HITS-CLIP	23824327
MIRT670545	hsa-miR-4697-5p	HITS-CLIP	23824327
MIRT670544	hsa-miR-6846-5p	HITS-CLIP	23824327
MIRT670543	hsa-miR-6848-5p	HITS-CLIP	23824327
MIRT670542	hsa-miR-7977	HITS-CLIP	23824327
MIRT571218	hsa-miR-138-1-3p	PAR-CLIP	20371350
MIRT530093	hsa-miR-1277-5p	PAR-CLIP	22012620
MIRT530092	hsa-miR-5011-5p	PAR-CLIP	22012620
MIRT530091	hsa-miR-190a-3p	PAR-CLIP	22012620
MIRT530090	hsa-miR-2681-5p	PAR-CLIP	22012620
MIRT1346848	hsa-miR-10a	CLIP-seq
MIRT1346849	hsa-miR-10b	CLIP-seq
MIRT1346850	hsa-miR-1273e	CLIP-seq
MIRT1346851	hsa-miR-1285	CLIP-seq
MIRT1346852	hsa-miR-186	CLIP-seq
MIRT1346853	hsa-miR-3120-5p	CLIP-seq
MIRT1346854	hsa-miR-3133	CLIP-seq
MIRT1346855	hsa-miR-3187-5p	CLIP-seq
MIRT1346856	hsa-miR-339-5p	CLIP-seq
MIRT1346857	hsa-miR-3667-5p	CLIP-seq
MIRT1346858	hsa-miR-369-5p	CLIP-seq
MIRT1346859	hsa-miR-410	CLIP-seq
MIRT1346860	hsa-miR-4307	CLIP-seq
MIRT1346861	hsa-miR-4421	CLIP-seq
MIRT1346862	hsa-miR-4433	CLIP-seq
MIRT1346863	hsa-miR-4459	CLIP-seq
MIRT1346864	hsa-miR-451b	CLIP-seq
MIRT1346865	hsa-miR-4537	CLIP-seq
MIRT1346866	hsa-miR-4693-3p	CLIP-seq
MIRT1346867	hsa-miR-4696	CLIP-seq
MIRT1346868	hsa-miR-4704-3p	CLIP-seq
MIRT1346869	hsa-miR-4719	CLIP-seq
MIRT1346870	hsa-miR-4725-5p	CLIP-seq
MIRT1346871	hsa-miR-4747-3p	CLIP-seq
MIRT1346872	hsa-miR-4768-3p	CLIP-seq
MIRT1346873	hsa-miR-4786-5p	CLIP-seq
MIRT1346874	hsa-miR-4789-5p	CLIP-seq
MIRT1346875	hsa-miR-4793-3p	CLIP-seq
MIRT1346876	hsa-miR-485-3p	CLIP-seq
MIRT1346877	hsa-miR-494	CLIP-seq
MIRT1346878	hsa-miR-504	CLIP-seq
MIRT1346879	hsa-miR-508-5p	CLIP-seq
MIRT1346880	hsa-miR-513c	CLIP-seq
MIRT1346881	hsa-miR-514b-5p	CLIP-seq
MIRT1346882	hsa-miR-612	CLIP-seq
MIRT1346883	hsa-miR-661	CLIP-seq
MIRT1346884	hsa-miR-766	CLIP-seq
MIRT1346885	hsa-miR-769-5p	CLIP-seq
MIRT2102694	hsa-miR-128	CLIP-seq
MIRT1346851	hsa-miR-1285	CLIP-seq
MIRT2102695	hsa-miR-27a	CLIP-seq
MIRT2102696	hsa-miR-27b	CLIP-seq
MIRT1346855	hsa-miR-3187-5p	CLIP-seq
MIRT2102697	hsa-miR-3925-3p	CLIP-seq
MIRT1346862	hsa-miR-4433	CLIP-seq
MIRT1346863	hsa-miR-4459	CLIP-seq
MIRT2102698	hsa-miR-4666-3p	CLIP-seq
MIRT1346866	hsa-miR-4693-3p	CLIP-seq
MIRT2102699	hsa-miR-4753-3p	CLIP-seq
MIRT1346872	hsa-miR-4768-3p	CLIP-seq
MIRT1346873	hsa-miR-4786-5p	CLIP-seq
MIRT1346879	hsa-miR-508-5p	CLIP-seq
MIRT1346882	hsa-miR-612	CLIP-seq
MIRT1346883	hsa-miR-661	CLIP-seq
MIRT1346884	hsa-miR-766	CLIP-seq
MIRT1346885	hsa-miR-769-5p	CLIP-seq
MIRT1346848	hsa-miR-10a	CLIP-seq
MIRT1346849	hsa-miR-10b	CLIP-seq
MIRT1346850	hsa-miR-1273e	CLIP-seq
MIRT2327109	hsa-miR-1284	CLIP-seq
MIRT1346851	hsa-miR-1285	CLIP-seq
MIRT2327110	hsa-miR-141	CLIP-seq
MIRT2327111	hsa-miR-147b	CLIP-seq
MIRT2327112	hsa-miR-200a	CLIP-seq
MIRT2327113	hsa-miR-200b	CLIP-seq
MIRT2327114	hsa-miR-200c	CLIP-seq
MIRT2327115	hsa-miR-2054	CLIP-seq
MIRT2327116	hsa-miR-2682	CLIP-seq
MIRT2327117	hsa-miR-300	CLIP-seq
MIRT1346853	hsa-miR-3120-5p	CLIP-seq
MIRT2327118	hsa-miR-3140-5p	CLIP-seq
MIRT2327119	hsa-miR-3163	CLIP-seq
MIRT1346855	hsa-miR-3187-5p	CLIP-seq
MIRT2327120	hsa-miR-3190	CLIP-seq
MIRT2327121	hsa-miR-323-3p	CLIP-seq
MIRT1346856	hsa-miR-339-5p	CLIP-seq
MIRT2327122	hsa-miR-34b	CLIP-seq
MIRT2327123	hsa-miR-361-5p	CLIP-seq
MIRT2327124	hsa-miR-3656	CLIP-seq
MIRT1346857	hsa-miR-3667-5p	CLIP-seq
MIRT2327125	hsa-miR-3672	CLIP-seq
MIRT2327126	hsa-miR-381	CLIP-seq
MIRT2327127	hsa-miR-3919	CLIP-seq
MIRT2327128	hsa-miR-4282	CLIP-seq
MIRT2327129	hsa-miR-429	CLIP-seq
MIRT1346860	hsa-miR-4307	CLIP-seq
MIRT1346861	hsa-miR-4421	CLIP-seq
MIRT1346862	hsa-miR-4433	CLIP-seq
MIRT1346863	hsa-miR-4459	CLIP-seq
MIRT2327130	hsa-miR-4499	CLIP-seq
MIRT2327131	hsa-miR-449c	CLIP-seq
MIRT2327132	hsa-miR-4502	CLIP-seq
MIRT1346864	hsa-miR-451b	CLIP-seq
MIRT1346865	hsa-miR-4537	CLIP-seq
MIRT2102698	hsa-miR-4666-3p	CLIP-seq
MIRT2327133	hsa-miR-4690-3p	CLIP-seq
MIRT1346866	hsa-miR-4693-3p	CLIP-seq
MIRT2327134	hsa-miR-4695-5p	CLIP-seq
MIRT1346867	hsa-miR-4696	CLIP-seq
MIRT1346868	hsa-miR-4704-3p	CLIP-seq
MIRT1346870	hsa-miR-4725-5p	CLIP-seq
MIRT2327135	hsa-miR-4729	CLIP-seq
MIRT2327136	hsa-miR-4754	CLIP-seq
MIRT2327137	hsa-miR-4756-3p	CLIP-seq
MIRT1346872	hsa-miR-4768-3p	CLIP-seq
MIRT1346873	hsa-miR-4786-5p	CLIP-seq
MIRT1346875	hsa-miR-4793-3p	CLIP-seq
MIRT1346876	hsa-miR-485-3p	CLIP-seq
MIRT2327138	hsa-miR-503	CLIP-seq
MIRT1346878	hsa-miR-504	CLIP-seq
MIRT1346879	hsa-miR-508-5p	CLIP-seq
MIRT1346880	hsa-miR-513c	CLIP-seq
MIRT1346881	hsa-miR-514b-5p	CLIP-seq
MIRT2327139	hsa-miR-550a	CLIP-seq
MIRT2327140	hsa-miR-579	CLIP-seq
MIRT1346882	hsa-miR-612	CLIP-seq
MIRT2327141	hsa-miR-617	CLIP-seq
MIRT2327142	hsa-miR-645	CLIP-seq
MIRT1346883	hsa-miR-661	CLIP-seq
MIRT2327143	hsa-miR-665	CLIP-seq
MIRT1346884	hsa-miR-766	CLIP-seq
MIRT1346885	hsa-miR-769-5p	CLIP-seq
MIRT2327144	hsa-miR-940	CLIP-seq
MIRT1346848	hsa-miR-10a	CLIP-seq
MIRT1346849	hsa-miR-10b	CLIP-seq
MIRT1346851	hsa-miR-1285	CLIP-seq
MIRT1346853	hsa-miR-3120-5p	CLIP-seq
MIRT1346855	hsa-miR-3187-5p	CLIP-seq
MIRT1346856	hsa-miR-339-5p	CLIP-seq
MIRT1346857	hsa-miR-3667-5p	CLIP-seq
MIRT1346861	hsa-miR-4421	CLIP-seq
MIRT1346864	hsa-miR-451b	CLIP-seq
MIRT1346867	hsa-miR-4696	CLIP-seq
MIRT1346870	hsa-miR-4725-5p	CLIP-seq
MIRT1346875	hsa-miR-4793-3p	CLIP-seq
MIRT1346878	hsa-miR-504	CLIP-seq
MIRT1346879	hsa-miR-508-5p	CLIP-seq
MIRT1346882	hsa-miR-612	CLIP-seq
MIRT1346883	hsa-miR-661	CLIP-seq
MIRT1346884	hsa-miR-766	CLIP-seq
MIRT1346848	hsa-miR-10a	CLIP-seq
MIRT1346849	hsa-miR-10b	CLIP-seq
MIRT2622420	hsa-miR-1283	CLIP-seq
MIRT1346851	hsa-miR-1285	CLIP-seq
MIRT1346853	hsa-miR-3120-5p	CLIP-seq
MIRT1346855	hsa-miR-3187-5p	CLIP-seq
MIRT1346856	hsa-miR-339-5p	CLIP-seq
MIRT2622421	hsa-miR-3613-3p	CLIP-seq
MIRT1346857	hsa-miR-3667-5p	CLIP-seq
MIRT2622422	hsa-miR-3675-3p	CLIP-seq
MIRT2622423	hsa-miR-3920	CLIP-seq
MIRT1346861	hsa-miR-4421	CLIP-seq
MIRT1346864	hsa-miR-451b	CLIP-seq
MIRT2622424	hsa-miR-4684-5p	CLIP-seq
MIRT2327133	hsa-miR-4690-3p	CLIP-seq
MIRT1346867	hsa-miR-4696	CLIP-seq
MIRT1346870	hsa-miR-4725-5p	CLIP-seq
MIRT1346873	hsa-miR-4786-5p	CLIP-seq
MIRT1346875	hsa-miR-4793-3p	CLIP-seq
MIRT1346878	hsa-miR-504	CLIP-seq
MIRT1346879	hsa-miR-508-5p	CLIP-seq
MIRT1346882	hsa-miR-612	CLIP-seq
MIRT1346883	hsa-miR-661	CLIP-seq
MIRT1346884	hsa-miR-766	CLIP-seq
MIRT1346885	hsa-miR-769-5p	CLIP-seq
MIRT1346848	hsa-miR-10a	CLIP-seq
MIRT1346849	hsa-miR-10b	CLIP-seq
MIRT2622420	hsa-miR-1283	CLIP-seq
MIRT1346851	hsa-miR-1285	CLIP-seq
MIRT1346853	hsa-miR-3120-5p	CLIP-seq
MIRT1346855	hsa-miR-3187-5p	CLIP-seq
MIRT1346856	hsa-miR-339-5p	CLIP-seq
MIRT2622421	hsa-miR-3613-3p	CLIP-seq
MIRT1346857	hsa-miR-3667-5p	CLIP-seq
MIRT2622422	hsa-miR-3675-3p	CLIP-seq
MIRT2622423	hsa-miR-3920	CLIP-seq
MIRT1346861	hsa-miR-4421	CLIP-seq
MIRT1346864	hsa-miR-451b	CLIP-seq
MIRT2622424	hsa-miR-4684-5p	CLIP-seq
MIRT2327133	hsa-miR-4690-3p	CLIP-seq
MIRT1346867	hsa-miR-4696	CLIP-seq
MIRT1346870	hsa-miR-4725-5p	CLIP-seq
MIRT1346873	hsa-miR-4786-5p	CLIP-seq
MIRT1346875	hsa-miR-4793-3p	CLIP-seq
MIRT1346878	hsa-miR-504	CLIP-seq
MIRT1346879	hsa-miR-508-5p	CLIP-seq
MIRT1346882	hsa-miR-612	CLIP-seq
MIRT1346883	hsa-miR-661	CLIP-seq
MIRT1346884	hsa-miR-766	CLIP-seq
MIRT1346885	hsa-miR-769-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0030178	Process	Negative regulation of Wnt signaling pathway	IBA
GO:0030178	Process	Negative regulation of Wnt signaling pathway	IEA
GO:0040037	Process	Negative regulation of fibroblast growth factor receptor signaling pathway	IBA
GO:0040037	Process	Negative regulation of fibroblast growth factor receptor signaling pathway	IEA

Other IDs

• MIM: 617324
• HGNC: 20366
• e!Ensembl: ENSG00000180730

Protein

• UniProt ID: Q6UWI4
• Protein name: Protein shisa-2 homolog (Transmembrane protein 46)
• Protein function: Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13908	Shisa	35 → 242	Wnt and FGF inhibitory regulator	Family

• Sequence:

  MWGARRSSVSSSWNAASLLQLLLAALLAAGARASGEYCHGWLDAQGVWRIGFQCPERFDG
  GDATICCGSCALRYCCSSAEARLDQGGCDNDRQQGAGEPGRADKDGPDGSAVPIYVPFLI
  VGSVFVAFIILGSLVAACCCRCLRPKQDPQQSRAPGGNRLMETIPMIPSASTSRGSSSRQ
  SSTAASSSSSANSGARAPPTRSQTNCCLPEGTMNNVYVNMPTNFSVLNCQQATQIVPHQG
  QYLHPPYVGYTVQHDSVPMTAVPPFMDGLQPGYRQIQSPFPHTNSEQKMYPAVTV

• Sequence length: 295

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
SCOLIOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Malignant neoplasm of prostate	Prostate cancer	BEFREE	29344118		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29344118		★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	29344118		★☆☆☆☆ Found in Text Mining only