SLC22A10 (solute carrier family 22 member 10 (gene/pseudogene))

Gene

• Entrez ID: 387775
• Gene name: Solute carrier family 22 member 10 (gene/pseudogene)
• Gene symbol: SLC22A10
• Synonyms (NCBI Gene): OAT5, hOAT5
• Chromosome: 11
• Chromosome location: 11q12.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2104818	hsa-miR-4282	CLIP-seq
MIRT2690933	hsa-miR-133a	CLIP-seq
MIRT2690934	hsa-miR-133b	CLIP-seq
MIRT2690935	hsa-miR-2113	CLIP-seq
MIRT2690936	hsa-miR-3908	CLIP-seq
MIRT2690937	hsa-miR-3942-5p	CLIP-seq
MIRT2690938	hsa-miR-4703-5p	CLIP-seq
MIRT2690939	hsa-miR-4766-3p	CLIP-seq
MIRT2690940	hsa-miR-599	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
HNF1A	Activation	20829431

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0015711	Process	Organic anion transport	IBA
GO:0016020	Component	Membrane	IEA
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0055085	Process	Transmembrane transport	IEA

Other IDs

• MIM: 607580
• HGNC: 18057
• e!Ensembl: ENSG00000184999

Protein

• UniProt ID: Q63ZE4
• Protein name: Solute carrier family 22 member 10 (Organic anion transporter 5)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00083	Sugar_tr	102 → 527	Sugar (and other) transporter	Family

• Tissue specificity: TISSUE SPECIFICITY: Detected in fetal and adult liver, and in adult kidney. {ECO:0000269|PubMed:11327718, ECO:0000269|PubMed:12372408}.
• Sequence:

  MAFEELLSQVGGLGRFQMLHLVFILPSLMLLIPHILLENFAAAIPGHRCWVHMLDNNTGS
  GNETGILSEDALLRISIPLDSNLRPEKCRRFVHPQWQLLHLNGTIHSTSEADTEPCVDGW
  VYDQSYFPSTIVTKWDLVCDYQSLKSVVQFLLLTGMLVGGIIGGHVSDRFGRRFILRWCL
  LQLAITDTCAAFAPTFPVYCVLRFLAGFSSMIIISNNSLPITEWIRPNSKALVVILSSGA
  LSIGQIILGGLAYVFRDWQTLHVVASVPFFVFFLLSRWLVESARWLIITNKLDEGLKALR
  KVARTNGIKNAEETLNIEVVRSTMQEELDAAQTKTTVCDLFRNPSMRKRICILVFLRFAN
  TIPFYGTMVNLQHVGSNIFLLQVLYGAVALIVRCLALLTLNHMGRRISQILFMFLVGLSI
  LANTFVPKEMQTLRVALACLGIGCSAATFSSVAVHFIELIPTVLRARASGIDLTASRIGA
  ALAPLLMTLTVFFTTLPWIIYGIFPIIGGLIVFLLPETKNLPLPDTIKDVENQKKNLKEK
  A

• Sequence length: 541

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
CARCINOMA, HEPATOCELLULAR	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, NON-SMALL-CELL LUNG	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONOTRUNCAL HEART MALFORMATIONS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOBLASTOMA	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LYMPHATIC METASTASIS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	35173266	Associate	★☆☆☆☆ Found in Text Mining only
Conotruncal defect	Conotruncal defect	GWASDB_DG	24800985		★☆☆☆☆ Found in Text Mining only
CONOTRUNCAL HEART MALFORMATIONS (disorder)	Conotruncal heart defect	GWASCAT_DG	24800985		★☆☆☆☆ Found in Text Mining only
Dementia	Dementia	Pubtator	35173266	Associate	★☆☆☆☆ Found in Text Mining only
Giant Cell Glioblastoma	Giant Cell Glioblastoma	CTD_human_DG	30705370		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	CTD_human_DG	30705370		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Glioblastoma Multiforme	Glioblastoma	CTD_human_DG	30705370		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	CTD_human_DG	28284560, 30705370		★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic Metastasis	CTD_human_DG	30705370		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant neoplasm of ovary	Ovarian cancer	CTD_human_DG	30705370		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	CTD_human_DG	30705370		★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	CTD_human_DG	30705370		★☆☆☆☆ Found in Text Mining only