Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	387712
Gene name	Enolase 4
Gene symbol	ENO4
Synonyms (NCBI Gene)	C10orf134ENOS
Chromosome	10
Chromosome location	10q25.3

174

Show/Hide all (174)

miRTarBase ID	miRNA	Experiments	Reference
MIRT616453	hsa-miR-34c-3p	HITS-CLIP	23824327
MIRT616452	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT616451	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT616450	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT616449	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616448	hsa-miR-6850-5p	HITS-CLIP	23824327
MIRT616447	hsa-miR-4754	HITS-CLIP	23824327
MIRT616446	hsa-miR-374a-3p	HITS-CLIP	23824327
MIRT616453	hsa-miR-34c-3p	HITS-CLIP	23824327
MIRT616452	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT616451	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT616450	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT616449	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616448	hsa-miR-6850-5p	HITS-CLIP	23824327
MIRT616447	hsa-miR-4754	HITS-CLIP	23824327
MIRT616446	hsa-miR-374a-3p	HITS-CLIP	23824327
MIRT616453	hsa-miR-34c-3p	HITS-CLIP	23824327
MIRT616452	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT616451	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT616448	hsa-miR-6850-5p	HITS-CLIP	23824327
MIRT616447	hsa-miR-4754	HITS-CLIP	23824327
MIRT616446	hsa-miR-374a-3p	HITS-CLIP	23824327
MIRT616453	hsa-miR-34c-3p	HITS-CLIP	23824327
MIRT616452	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT616451	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT616450	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT616449	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT635160	hsa-miR-190a-5p	HITS-CLIP	23824327
MIRT635159	hsa-miR-190b	HITS-CLIP	23824327
MIRT635158	hsa-miR-3201	HITS-CLIP	23824327
MIRT635157	hsa-miR-4791	HITS-CLIP	23824327
MIRT616448	hsa-miR-6850-5p	HITS-CLIP	23824327
MIRT616447	hsa-miR-4754	HITS-CLIP	23824327
MIRT616446	hsa-miR-374a-3p	HITS-CLIP	23824327
MIRT616453	hsa-miR-34c-3p	HITS-CLIP	23824327
MIRT616452	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT616451	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT616450	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT616449	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616448	hsa-miR-6850-5p	HITS-CLIP	23824327
MIRT616447	hsa-miR-4754	HITS-CLIP	23824327
MIRT616446	hsa-miR-374a-3p	HITS-CLIP	23824327
MIRT616453	hsa-miR-34c-3p	HITS-CLIP	23824327
MIRT616452	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT616451	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT616450	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT616449	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616448	hsa-miR-6850-5p	HITS-CLIP	23824327
MIRT616447	hsa-miR-4754	HITS-CLIP	23824327
MIRT616446	hsa-miR-374a-3p	HITS-CLIP	23824327
MIRT512682	hsa-miR-3609	PAR-CLIP	23446348
MIRT512681	hsa-miR-548ah-5p	PAR-CLIP	23446348
MIRT512679	hsa-miR-4496	PAR-CLIP	23446348
MIRT512680	hsa-miR-6755-5p	PAR-CLIP	23446348
MIRT512678	hsa-miR-143-3p	PAR-CLIP	23446348
MIRT512677	hsa-miR-4770	PAR-CLIP	23446348
MIRT512676	hsa-miR-6088	PAR-CLIP	23446348
MIRT512675	hsa-miR-4708-5p	PAR-CLIP	23446348
MIRT512674	hsa-miR-1273f	PAR-CLIP	23446348
MIRT512673	hsa-miR-8065	PAR-CLIP	23446348
MIRT616450	hsa-miR-1250-3p	HITS-CLIP	27418678
MIRT616450	hsa-miR-1250-3p	HITS-CLIP	27418678
MIRT616450	hsa-miR-1250-3p	HITS-CLIP	27418678
MIRT616449	hsa-miR-153-5p	HITS-CLIP	27418678
MIRT616449	hsa-miR-153-5p	HITS-CLIP	27418678
MIRT616449	hsa-miR-153-5p	HITS-CLIP	27418678
MIRT616453	hsa-miR-34c-3p	HITS-CLIP	27418678
MIRT616453	hsa-miR-34c-3p	HITS-CLIP	27418678
MIRT616453	hsa-miR-34c-3p	HITS-CLIP	27418678
MIRT616452	hsa-miR-3614-5p	HITS-CLIP	27418678
MIRT616452	hsa-miR-3614-5p	HITS-CLIP	27418678
MIRT616452	hsa-miR-3614-5p	HITS-CLIP	27418678
MIRT616446	hsa-miR-374a-3p	HITS-CLIP	27418678
MIRT616446	hsa-miR-374a-3p	HITS-CLIP	27418678
MIRT616446	hsa-miR-374a-3p	HITS-CLIP	27418678
MIRT616447	hsa-miR-4754	HITS-CLIP	27418678
MIRT616451	hsa-miR-6500-3p	HITS-CLIP	27418678
MIRT616451	hsa-miR-6500-3p	HITS-CLIP	27418678
MIRT616451	hsa-miR-6500-3p	HITS-CLIP	27418678
MIRT616448	hsa-miR-6850-5p	HITS-CLIP	27418678
MIRT734305	hsa-miR-21-5p	ImmunofluorescenceqRT-PCRRNA-seqWestern blotting	31735554
MIRT734306	hsa-miR-146b-3p	ImmunofluorescenceqRT-PCRRNA-seqWestern blotting	31735554
MIRT734307	hsa-miR-5571-3p	ImmunofluorescenceqRT-PCRRNA-seqWestern blotting	31735554
MIRT734308	hsa-miR-6503-3p	ImmunofluorescenceqRT-PCRRNA-seqWestern blotting	31735554
MIRT616453	hsa-miR-34c-3p	HITS-CLIP	23824327
MIRT616452	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT616451	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT616450	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT616449	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616448	hsa-miR-6850-5p	HITS-CLIP	23824327
MIRT616447	hsa-miR-4754	HITS-CLIP	23824327
MIRT616446	hsa-miR-374a-3p	HITS-CLIP	23824327
MIRT616453	hsa-miR-34c-3p	HITS-CLIP	23824327
MIRT616452	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT616451	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT616450	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT616449	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616448	hsa-miR-6850-5p	HITS-CLIP	23824327
MIRT616447	hsa-miR-4754	HITS-CLIP	23824327
MIRT616446	hsa-miR-374a-3p	HITS-CLIP	23824327
MIRT616453	hsa-miR-34c-3p	HITS-CLIP	23824327
MIRT616452	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT616451	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT616448	hsa-miR-6850-5p	HITS-CLIP	23824327
MIRT616447	hsa-miR-4754	HITS-CLIP	23824327
MIRT616446	hsa-miR-374a-3p	HITS-CLIP	23824327
MIRT616453	hsa-miR-34c-3p	HITS-CLIP	23824327
MIRT616452	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT616451	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT616450	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT616449	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT635160	hsa-miR-190a-5p	HITS-CLIP	23824327
MIRT635159	hsa-miR-190b	HITS-CLIP	23824327
MIRT635158	hsa-miR-3201	HITS-CLIP	23824327
MIRT635157	hsa-miR-4791	HITS-CLIP	23824327
MIRT616448	hsa-miR-6850-5p	HITS-CLIP	23824327
MIRT616447	hsa-miR-4754	HITS-CLIP	23824327
MIRT616446	hsa-miR-374a-3p	HITS-CLIP	23824327
MIRT616453	hsa-miR-34c-3p	HITS-CLIP	23824327
MIRT616452	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT616451	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT616450	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT616449	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616448	hsa-miR-6850-5p	HITS-CLIP	23824327
MIRT616447	hsa-miR-4754	HITS-CLIP	23824327
MIRT616446	hsa-miR-374a-3p	HITS-CLIP	23824327
MIRT616453	hsa-miR-34c-3p	HITS-CLIP	23824327
MIRT616452	hsa-miR-3614-5p	HITS-CLIP	23824327
MIRT616451	hsa-miR-6500-3p	HITS-CLIP	23824327
MIRT616450	hsa-miR-1250-3p	HITS-CLIP	23824327
MIRT616449	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT616448	hsa-miR-6850-5p	HITS-CLIP	23824327
MIRT616447	hsa-miR-4754	HITS-CLIP	23824327
MIRT616446	hsa-miR-374a-3p	HITS-CLIP	23824327
MIRT512682	hsa-miR-3609	PAR-CLIP	23446348
MIRT512681	hsa-miR-548ah-5p	PAR-CLIP	23446348
MIRT512679	hsa-miR-4496	PAR-CLIP	23446348
MIRT512680	hsa-miR-6755-5p	PAR-CLIP	23446348
MIRT512678	hsa-miR-143-3p	PAR-CLIP	23446348
MIRT512677	hsa-miR-4770	PAR-CLIP	23446348
MIRT512676	hsa-miR-6088	PAR-CLIP	23446348
MIRT512675	hsa-miR-4708-5p	PAR-CLIP	23446348
MIRT512674	hsa-miR-1273f	PAR-CLIP	23446348
MIRT512673	hsa-miR-8065	PAR-CLIP	23446348
MIRT963636	hsa-miR-27a	CLIP-seq
MIRT963637	hsa-miR-27b	CLIP-seq
MIRT963638	hsa-miR-4269	CLIP-seq
MIRT963639	hsa-miR-4514	CLIP-seq
MIRT963640	hsa-miR-4670-3p	CLIP-seq
MIRT963641	hsa-miR-4692	CLIP-seq
MIRT963642	hsa-miR-4709-3p	CLIP-seq
MIRT963643	hsa-miR-4742-5p	CLIP-seq
MIRT963644	hsa-miR-4783-3p	CLIP-seq
MIRT963645	hsa-miR-513a-5p	CLIP-seq
MIRT963646	hsa-miR-571	CLIP-seq
MIRT1985655	hsa-miR-190	CLIP-seq
MIRT963638	hsa-miR-4269	CLIP-seq
MIRT963639	hsa-miR-4514	CLIP-seq
MIRT963641	hsa-miR-4692	CLIP-seq
MIRT963643	hsa-miR-4742-5p	CLIP-seq
MIRT2220087	hsa-miR-106a	CLIP-seq
MIRT2220088	hsa-miR-106b	CLIP-seq
MIRT2220089	hsa-miR-142-5p	CLIP-seq
MIRT2220090	hsa-miR-17	CLIP-seq
MIRT2220091	hsa-miR-20a	CLIP-seq
MIRT2220092	hsa-miR-20b	CLIP-seq
MIRT2220093	hsa-miR-4796-3p	CLIP-seq
MIRT2220094	hsa-miR-519d	CLIP-seq
MIRT2220095	hsa-miR-548ad	CLIP-seq
MIRT2220096	hsa-miR-548ah	CLIP-seq
MIRT2220097	hsa-miR-595	CLIP-seq
MIRT2220098	hsa-miR-604	CLIP-seq
MIRT2220099	hsa-miR-647	CLIP-seq
MIRT2220100	hsa-miR-93	CLIP-seq

Show/Hide all (8)

GO ID	Ontology	Definition	Evidence
GO:0000015	Component	Phosphopyruvate hydratase complex	IBA
GO:0000015	Component	Phosphopyruvate hydratase complex	IEA
GO:0000287	Function	Magnesium ion binding	IEA
GO:0004634	Function	Phosphopyruvate hydratase activity	IBA
GO:0004634	Function	Phosphopyruvate hydratase activity	IEA
GO:0006096	Process	Glycolytic process	IBA
GO:0006096	Process	Glycolytic process	IEA
GO:0016829	Function	Lyase activity	IEA

MIM	HGNC	e!Ensembl
131375	31670	ENSG00000188316

A6NNW6

Protein name

Enolase 4 (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase)

Protein function

May be required for sperm motility and function.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00113	Enolase_C	273 → 581	Enolase, C-terminal TIM barrel domain	Domain

Sequence

MEEEGGGRSCGTTRELQKLKQQAMEYYRENDVPRRLEELLNSTFYLQPADVYGHLANCFS
KLAKPPTICKIVGKDVLDGLGLPTLQVDIFCTIQNFPKNVCSVVISTHFEVHENALPELA
KAEEAERASAVSTAVQWVNSTITHELQGMAPSDQAEVDHLLRIFFASKVQEDKGRKELEK
SLEYSTVPTPLPPVPPPPPPPPPTKKKGQKPGRKDTITEKPIAPAEPVEPVLSGSMAIGA
VSLAVAKACAMLLNKPLYLNIALLKHNQEQPTTLSMPLLMVSLVSCGKSSSGKLNLMKEV
ICIPHPELTTKQGVEMLMEMQKHINKIIEMPSPPKAETKKGHDGSKRGQQQITGKMSHLG
CLTINCDSIEQPLLLIQEICANLGLELGTNLHLAINCAGHELMDYNKGKYEVIMGTYKNA
AEMVDLYVDLINKYPSIIALIDPFRKEDSEQWDSIYHALGSRCYIIAGTASKSISKLLEQ
GNISIPKSNGLIIKHTNQTTMSDLVEITNLIDSKKHITVFGSTEGESSDDSLVDLAVGLG
VRFIKLGGLSRGERVTKYNRLLTIEEELVQNGTLGFKEEHTFFYFNEEAEKAAEALEAAA
AREPLVPTFPTQGVEESAETGASSG

Sequence length

625

Interactions

View interactions

	KEGG
	Glycolysis / Gluconeogenesis Metabolic pathways Carbon metabolism Biosynthesis of amino acids

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (6)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
CANNABIS DEPENDENCE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFERTILITY, MALE	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MALE INFERTILITY	—	Disgenet, GWAS catalog Disgenet, GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Neoplasms	Breast neoplasm	Pubtator	22806168	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glaucoma Open Angle	Open angle glaucoma	Pubtator	30352225	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ENO4 (enolase 4)