SH2D4B (SH2 domain containing 4B)

Gene

• Entrez ID: 387694
• Gene name: SH2 domain containing 4B
• Gene symbol: SH2D4B
• Synonyms (NCBI Gene): -
• Chromosome: 10
• Chromosome location: 10q23.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1344301	hsa-miR-1245b-3p	CLIP-seq
MIRT1344302	hsa-miR-1283	CLIP-seq
MIRT1344303	hsa-miR-1286	CLIP-seq
MIRT1344304	hsa-miR-4436a	CLIP-seq
MIRT1344305	hsa-miR-4712-3p	CLIP-seq
MIRT1344306	hsa-miR-4722-5p	CLIP-seq
MIRT1344307	hsa-miR-548aa	CLIP-seq
MIRT1344308	hsa-miR-548ag	CLIP-seq
MIRT1344309	hsa-miR-548ai	CLIP-seq
MIRT1344310	hsa-miR-548m	CLIP-seq
MIRT1344311	hsa-miR-549	CLIP-seq
MIRT1344312	hsa-miR-624	CLIP-seq
MIRT1344313	hsa-miR-185	CLIP-seq
MIRT1344314	hsa-miR-2278	CLIP-seq
MIRT1344315	hsa-miR-3148	CLIP-seq
MIRT1344316	hsa-miR-3169	CLIP-seq
MIRT1344317	hsa-miR-3173-3p	CLIP-seq
MIRT1344318	hsa-miR-3185	CLIP-seq
MIRT1344319	hsa-miR-342-3p	CLIP-seq
MIRT1344320	hsa-miR-3714	CLIP-seq
MIRT1344321	hsa-miR-4278	CLIP-seq
MIRT1344322	hsa-miR-4306	CLIP-seq
MIRT1344323	hsa-miR-4459	CLIP-seq
MIRT1344324	hsa-miR-4644	CLIP-seq
MIRT1344325	hsa-miR-4700-3p	CLIP-seq
MIRT1344326	hsa-miR-4708-3p	CLIP-seq
MIRT1344327	hsa-miR-4768-3p	CLIP-seq
MIRT1344328	hsa-miR-5095	CLIP-seq
MIRT1344329	hsa-miR-542-3p	CLIP-seq
MIRT1344330	hsa-miR-600	CLIP-seq
MIRT1344331	hsa-miR-665	CLIP-seq
MIRT2101785	hsa-miR-142-3p	CLIP-seq
MIRT2101786	hsa-miR-197	CLIP-seq
MIRT2101787	hsa-miR-3174	CLIP-seq
MIRT2101788	hsa-miR-491-3p	CLIP-seq
MIRT2101789	hsa-miR-586	CLIP-seq
MIRT2101790	hsa-miR-921	CLIP-seq
MIRT2326196	hsa-miR-224	CLIP-seq
MIRT2326197	hsa-miR-4520a-3p	CLIP-seq
MIRT2326198	hsa-miR-4520b-3p	CLIP-seq
MIRT2326199	hsa-miR-890	CLIP-seq
MIRT2466021	hsa-miR-2355-5p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IBA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q5SQS7
• Protein name: SH2 domain-containing protein 4B
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00017	SH2	325 → 400	SH2 domain	Domain

• Sequence:

  MLQQILHDMYIDPELLAELSDVQKHILFYKMREEQLRRWKERETWEALAQDEGLRPPKTK
  RASDKHIQWLLGADGEVWVWIMGEGPGDKPYEEISEELIAERARLQAQREAEELWRQKEA
  EITKKFRDALANEKARILAEKWKVEMEDRKAAKVLEERIHEEFKRKEEEERKRGEEQIRL
  QEEQRAKELYWTLKQAQLHCQASEKEEREWEEQLRRSKAADEERSRRAQRARDEYRHHSL
  RAIQKGTVAGLSSMFRELGQSHEQEARLYHHLPDPGLPQPLALPVRTWERPLRPVSRDVI
  VRWFKEEQLPRRAGFERNTKFIAPWFHGIISREDAEALLENMTEGAFLVRVSEKIWGYTL
  SYRLQKGFKHFLVDASGDFYSFLGVDPNRHATLTDLVDFHKEEIITVSGGELLQEPCGQR
  DSPPDYHLLFE

• Sequence length: 431

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLOR VISION DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OVARIAN SEROUS CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer`s Disease	Alzheimer disease	GWASCAT_DG	25778476		★☆☆☆☆ Found in Text Mining only
CARDIOMYOPATHY, DILATED, 1C (disorder)	Cardiomyopathy	BEFREE	18197198		★☆☆☆☆ Found in Text Mining only
Cholecystolithiasis	Cholecystolithiasis	GWASDB_DG	17632509		★☆☆☆☆ Found in Text Mining only
Cholelithiasis	Cholelithiasis	GWASDB_DG	17632509		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	31488414	Associate	★☆☆☆☆ Found in Text Mining only
Ewings sarcoma	Ewing sarcoma	BEFREE	9000139		★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	GWASCAT_DG	28935272		★☆☆☆☆ Found in Text Mining only