NSUN4 (NOP2/Sun RNA methyltransferase 4)

Gene

• Entrez ID: 387338
• Gene name: NOP2/Sun RNA methyltransferase 4
• Gene symbol: NSUN4
• Synonyms (NCBI Gene): SHTAP
• Chromosome: 1
• Chromosome location: 1p33

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT005275	hsa-miR-1-3p	pSILAC	18668040
MIRT005275	hsa-miR-1-3p	Proteomics;Other	18668040
MIRT052818	hsa-miR-3200-3p	CLASH	23622248
MIRT687407	hsa-miR-4438	HITS-CLIP	23313552
MIRT687406	hsa-miR-6813-3p	HITS-CLIP	23313552
MIRT687405	hsa-miR-1245a	HITS-CLIP	23313552
MIRT687404	hsa-miR-8079	HITS-CLIP	23313552
MIRT687403	hsa-miR-141-5p	HITS-CLIP	23313552
MIRT687402	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT687401	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT687400	hsa-miR-520h	HITS-CLIP	23313552
MIRT687399	hsa-miR-6513-3p	HITS-CLIP	23313552
MIRT687398	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT687397	hsa-miR-1224-3p	HITS-CLIP	23313552
MIRT687396	hsa-miR-212-5p	HITS-CLIP	23313552
MIRT687395	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT687394	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT687393	hsa-miR-4757-5p	HITS-CLIP	23313552
MIRT687392	hsa-miR-6744-3p	HITS-CLIP	23313552
MIRT687391	hsa-miR-5095	HITS-CLIP	23313552
MIRT687390	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT687389	hsa-miR-188-3p	HITS-CLIP	23313552
MIRT687388	hsa-miR-1260a	HITS-CLIP	23313552
MIRT687387	hsa-miR-1260b	HITS-CLIP	23313552
MIRT687386	hsa-miR-3156-3p	HITS-CLIP	23313552
MIRT687385	hsa-miR-6878-3p	HITS-CLIP	23313552
MIRT471917	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT471916	hsa-miR-651-3p	PAR-CLIP	23592263
MIRT471915	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT471914	hsa-miR-6077	PAR-CLIP	23592263
MIRT471913	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT471912	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT471911	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT471910	hsa-miR-4736	PAR-CLIP	23592263
MIRT471909	hsa-miR-7150	PAR-CLIP	23592263
MIRT687407	hsa-miR-4438	HITS-CLIP	23313552
MIRT687406	hsa-miR-6813-3p	HITS-CLIP	23313552
MIRT687405	hsa-miR-1245a	HITS-CLIP	23313552
MIRT687404	hsa-miR-8079	HITS-CLIP	23313552
MIRT687403	hsa-miR-141-5p	HITS-CLIP	23313552
MIRT687402	hsa-miR-6504-3p	HITS-CLIP	23313552
MIRT687401	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT687400	hsa-miR-520h	HITS-CLIP	23313552
MIRT687399	hsa-miR-6513-3p	HITS-CLIP	23313552
MIRT687398	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT687397	hsa-miR-1224-3p	HITS-CLIP	23313552
MIRT687396	hsa-miR-212-5p	HITS-CLIP	23313552
MIRT687395	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT687394	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT687393	hsa-miR-4757-5p	HITS-CLIP	23313552
MIRT687392	hsa-miR-6744-3p	HITS-CLIP	23313552
MIRT687391	hsa-miR-5095	HITS-CLIP	23313552
MIRT687390	hsa-miR-7151-3p	HITS-CLIP	23313552
MIRT687389	hsa-miR-188-3p	HITS-CLIP	23313552
MIRT687388	hsa-miR-1260a	HITS-CLIP	23313552
MIRT687387	hsa-miR-1260b	HITS-CLIP	23313552
MIRT687386	hsa-miR-3156-3p	HITS-CLIP	23313552
MIRT687385	hsa-miR-6878-3p	HITS-CLIP	23313552
MIRT471917	hsa-miR-4796-3p	PAR-CLIP	23592263
MIRT471916	hsa-miR-651-3p	PAR-CLIP	23592263
MIRT471915	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT471914	hsa-miR-6077	PAR-CLIP	23592263
MIRT471913	hsa-miR-766-5p	PAR-CLIP	23592263
MIRT471912	hsa-miR-1207-5p	PAR-CLIP	23592263
MIRT471911	hsa-miR-4763-3p	PAR-CLIP	23592263
MIRT471910	hsa-miR-4736	PAR-CLIP	23592263
MIRT471909	hsa-miR-7150	PAR-CLIP	23592263
MIRT1195435	hsa-miR-1178	CLIP-seq
MIRT1195436	hsa-miR-1306	CLIP-seq
MIRT1195437	hsa-miR-197	CLIP-seq
MIRT1195438	hsa-miR-214	CLIP-seq
MIRT1195439	hsa-miR-300	CLIP-seq
MIRT1195440	hsa-miR-3119	CLIP-seq
MIRT1195441	hsa-miR-3133	CLIP-seq
MIRT1195442	hsa-miR-3148	CLIP-seq
MIRT1195443	hsa-miR-3158-3p	CLIP-seq
MIRT1195444	hsa-miR-3170	CLIP-seq
MIRT1195445	hsa-miR-3187-3p	CLIP-seq
MIRT1195446	hsa-miR-3545-3p	CLIP-seq
MIRT1195447	hsa-miR-3619-5p	CLIP-seq
MIRT1195448	hsa-miR-3663-5p	CLIP-seq
MIRT1195449	hsa-miR-3688-3p	CLIP-seq
MIRT1195450	hsa-miR-381	CLIP-seq
MIRT1195451	hsa-miR-4435	CLIP-seq
MIRT1195452	hsa-miR-4530	CLIP-seq
MIRT1195453	hsa-miR-4635	CLIP-seq
MIRT1195454	hsa-miR-4639-3p	CLIP-seq
MIRT1195455	hsa-miR-4666-3p	CLIP-seq
MIRT1195456	hsa-miR-4680-5p	CLIP-seq
MIRT1195457	hsa-miR-4701-5p	CLIP-seq
MIRT1195458	hsa-miR-4733-5p	CLIP-seq
MIRT1195459	hsa-miR-4755-3p	CLIP-seq
MIRT1195460	hsa-miR-5096	CLIP-seq
MIRT1195461	hsa-miR-548aa	CLIP-seq
MIRT1195462	hsa-miR-548ac	CLIP-seq
MIRT1195463	hsa-miR-548d-3p	CLIP-seq
MIRT1195464	hsa-miR-548s	CLIP-seq
MIRT1195465	hsa-miR-548z	CLIP-seq
MIRT1195466	hsa-miR-588	CLIP-seq
MIRT1195467	hsa-miR-605	CLIP-seq
MIRT1195468	hsa-miR-761	CLIP-seq
MIRT1195469	hsa-miR-767-3p	CLIP-seq
MIRT1195435	hsa-miR-1178	CLIP-seq
MIRT2056683	hsa-miR-1200	CLIP-seq
MIRT2056684	hsa-miR-122	CLIP-seq
MIRT2056685	hsa-miR-1244	CLIP-seq
MIRT2056686	hsa-miR-1255a	CLIP-seq
MIRT2056687	hsa-miR-1255b	CLIP-seq
MIRT2056688	hsa-miR-1286	CLIP-seq
MIRT2056689	hsa-miR-129-5p	CLIP-seq
MIRT2056690	hsa-miR-140-3p	CLIP-seq
MIRT2056691	hsa-miR-1976	CLIP-seq
MIRT1195438	hsa-miR-214	CLIP-seq
MIRT2056692	hsa-miR-24	CLIP-seq
MIRT2056693	hsa-miR-298	CLIP-seq
MIRT2056694	hsa-miR-3064-5p	CLIP-seq
MIRT1195440	hsa-miR-3119	CLIP-seq
MIRT2056695	hsa-miR-3120-3p	CLIP-seq
MIRT2056696	hsa-miR-3122	CLIP-seq
MIRT2056697	hsa-miR-3135b	CLIP-seq
MIRT2056698	hsa-miR-3140-3p	CLIP-seq
MIRT2056699	hsa-miR-3154	CLIP-seq
MIRT2056700	hsa-miR-3168	CLIP-seq
MIRT2056701	hsa-miR-3614-3p	CLIP-seq
MIRT1195447	hsa-miR-3619-5p	CLIP-seq
MIRT2056702	hsa-miR-3620	CLIP-seq
MIRT2056703	hsa-miR-3622a-3p	CLIP-seq
MIRT2056704	hsa-miR-3622b-3p	CLIP-seq
MIRT2056705	hsa-miR-3649	CLIP-seq
MIRT2056706	hsa-miR-3652	CLIP-seq
MIRT2056707	hsa-miR-3664-5p	CLIP-seq
MIRT2056708	hsa-miR-3672	CLIP-seq
MIRT2056709	hsa-miR-3913-5p	CLIP-seq
MIRT2056710	hsa-miR-3945	CLIP-seq
MIRT2056711	hsa-miR-3973	CLIP-seq
MIRT2056712	hsa-miR-4253	CLIP-seq
MIRT2056713	hsa-miR-4269	CLIP-seq
MIRT2056714	hsa-miR-4284	CLIP-seq
MIRT2056715	hsa-miR-4297	CLIP-seq
MIRT2056716	hsa-miR-4324	CLIP-seq
MIRT2056717	hsa-miR-4420	CLIP-seq
MIRT2056718	hsa-miR-4430	CLIP-seq
MIRT2056719	hsa-miR-4436a	CLIP-seq
MIRT2056720	hsa-miR-4468	CLIP-seq
MIRT2056721	hsa-miR-4494	CLIP-seq
MIRT2056722	hsa-miR-4505	CLIP-seq
MIRT2056723	hsa-miR-450b-3p	CLIP-seq
MIRT2056724	hsa-miR-452	CLIP-seq
MIRT2056725	hsa-miR-4520a-3p	CLIP-seq
MIRT2056726	hsa-miR-4520b-3p	CLIP-seq
MIRT1195454	hsa-miR-4639-3p	CLIP-seq
MIRT2056727	hsa-miR-4645-5p	CLIP-seq
MIRT2056728	hsa-miR-4649-3p	CLIP-seq
MIRT2056729	hsa-miR-4673	CLIP-seq
MIRT2056730	hsa-miR-4676-3p	CLIP-seq
MIRT2056731	hsa-miR-4722-3p	CLIP-seq
MIRT2056732	hsa-miR-4769-3p	CLIP-seq
MIRT2056733	hsa-miR-4781-3p	CLIP-seq
MIRT2056734	hsa-miR-4797-5p	CLIP-seq
MIRT2056735	hsa-miR-499a-5p	CLIP-seq
MIRT2056736	hsa-miR-532-5p	CLIP-seq
MIRT2056737	hsa-miR-544b	CLIP-seq
MIRT2056738	hsa-miR-545	CLIP-seq
MIRT2056739	hsa-miR-548u	CLIP-seq
MIRT2056740	hsa-miR-561	CLIP-seq
MIRT2056741	hsa-miR-645	CLIP-seq
MIRT1195468	hsa-miR-761	CLIP-seq
MIRT2056742	hsa-miR-769-3p	CLIP-seq
MIRT2056743	hsa-miR-938	CLIP-seq
MIRT2056683	hsa-miR-1200	CLIP-seq
MIRT2056684	hsa-miR-122	CLIP-seq
MIRT2285144	hsa-miR-1245	CLIP-seq
MIRT2056686	hsa-miR-1255a	CLIP-seq
MIRT2056687	hsa-miR-1255b	CLIP-seq
MIRT2056688	hsa-miR-1286	CLIP-seq
MIRT1195436	hsa-miR-1306	CLIP-seq
MIRT2285145	hsa-miR-130a	CLIP-seq
MIRT2285146	hsa-miR-130b	CLIP-seq
MIRT2056690	hsa-miR-140-3p	CLIP-seq
MIRT2285147	hsa-miR-146b-3p	CLIP-seq
MIRT2285148	hsa-miR-150	CLIP-seq
MIRT2285149	hsa-miR-1914	CLIP-seq
MIRT1195437	hsa-miR-197	CLIP-seq
MIRT2056691	hsa-miR-1976	CLIP-seq
MIRT1195438	hsa-miR-214	CLIP-seq
MIRT2285150	hsa-miR-216a	CLIP-seq
MIRT2056693	hsa-miR-298	CLIP-seq
MIRT2285151	hsa-miR-301a	CLIP-seq
MIRT2285152	hsa-miR-301b	CLIP-seq
MIRT2056694	hsa-miR-3064-5p	CLIP-seq
MIRT2056695	hsa-miR-3120-3p	CLIP-seq
MIRT2056697	hsa-miR-3135b	CLIP-seq
MIRT1195442	hsa-miR-3148	CLIP-seq
MIRT2056699	hsa-miR-3154	CLIP-seq
MIRT1195444	hsa-miR-3170	CLIP-seq
MIRT1195445	hsa-miR-3187-3p	CLIP-seq
MIRT1195446	hsa-miR-3545-3p	CLIP-seq
MIRT2056701	hsa-miR-3614-3p	CLIP-seq
MIRT1195447	hsa-miR-3619-5p	CLIP-seq
MIRT2056702	hsa-miR-3620	CLIP-seq
MIRT2056703	hsa-miR-3622a-3p	CLIP-seq
MIRT2056704	hsa-miR-3622b-3p	CLIP-seq
MIRT2056705	hsa-miR-3649	CLIP-seq
MIRT2056706	hsa-miR-3652	CLIP-seq
MIRT1195448	hsa-miR-3663-5p	CLIP-seq
MIRT2056707	hsa-miR-3664-5p	CLIP-seq
MIRT2285153	hsa-miR-3666	CLIP-seq
MIRT2285154	hsa-miR-384	CLIP-seq
MIRT2285155	hsa-miR-3915	CLIP-seq
MIRT2285156	hsa-miR-3919	CLIP-seq
MIRT2285157	hsa-miR-3928	CLIP-seq
MIRT2285158	hsa-miR-3944-5p	CLIP-seq
MIRT2285159	hsa-miR-3976	CLIP-seq
MIRT2285160	hsa-miR-412	CLIP-seq
MIRT2056713	hsa-miR-4269	CLIP-seq
MIRT2285161	hsa-miR-4282	CLIP-seq
MIRT2285162	hsa-miR-4295	CLIP-seq
MIRT2285163	hsa-miR-4302	CLIP-seq
MIRT2056716	hsa-miR-4324	CLIP-seq
MIRT2285164	hsa-miR-4330	CLIP-seq
MIRT2056718	hsa-miR-4430	CLIP-seq
MIRT1195451	hsa-miR-4435	CLIP-seq
MIRT2056719	hsa-miR-4436a	CLIP-seq
MIRT2056720	hsa-miR-4468	CLIP-seq
MIRT2285165	hsa-miR-4475	CLIP-seq
MIRT2056722	hsa-miR-4505	CLIP-seq
MIRT2285166	hsa-miR-4509	CLIP-seq
MIRT2056723	hsa-miR-450b-3p	CLIP-seq
MIRT2056725	hsa-miR-4520a-3p	CLIP-seq
MIRT2056726	hsa-miR-4520b-3p	CLIP-seq
MIRT2285167	hsa-miR-454	CLIP-seq
MIRT1195453	hsa-miR-4635	CLIP-seq
MIRT1195454	hsa-miR-4639-3p	CLIP-seq
MIRT1195456	hsa-miR-4680-5p	CLIP-seq
MIRT2285168	hsa-miR-4685-5p	CLIP-seq
MIRT1195457	hsa-miR-4701-5p	CLIP-seq
MIRT2056731	hsa-miR-4722-3p	CLIP-seq
MIRT1195458	hsa-miR-4733-5p	CLIP-seq
MIRT2285169	hsa-miR-4744	CLIP-seq
MIRT1195459	hsa-miR-4755-3p	CLIP-seq
MIRT2285170	hsa-miR-4756-3p	CLIP-seq
MIRT2056734	hsa-miR-4797-5p	CLIP-seq
MIRT2285171	hsa-miR-4799-5p	CLIP-seq
MIRT1195460	hsa-miR-5096	CLIP-seq
MIRT2285172	hsa-miR-510	CLIP-seq
MIRT2285173	hsa-miR-512-5p	CLIP-seq
MIRT2285174	hsa-miR-520g	CLIP-seq
MIRT2056737	hsa-miR-544b	CLIP-seq
MIRT2056738	hsa-miR-545	CLIP-seq
MIRT1195464	hsa-miR-548s	CLIP-seq
MIRT2056740	hsa-miR-561	CLIP-seq
MIRT1195466	hsa-miR-588	CLIP-seq
MIRT2285175	hsa-miR-627	CLIP-seq
MIRT2285176	hsa-miR-652	CLIP-seq
MIRT2285177	hsa-miR-671-5p	CLIP-seq
MIRT1195468	hsa-miR-761	CLIP-seq
MIRT2056742	hsa-miR-769-3p	CLIP-seq
MIRT2285178	hsa-miR-924	CLIP-seq
MIRT2285179	hsa-miR-944	CLIP-seq
MIRT2056684	hsa-miR-122	CLIP-seq
MIRT2056694	hsa-miR-3064-5p	CLIP-seq
MIRT2056697	hsa-miR-3135b	CLIP-seq
MIRT2056702	hsa-miR-3620	CLIP-seq
MIRT2056703	hsa-miR-3622a-3p	CLIP-seq
MIRT2056704	hsa-miR-3622b-3p	CLIP-seq
MIRT2056706	hsa-miR-3652	CLIP-seq
MIRT2056707	hsa-miR-3664-5p	CLIP-seq
MIRT2056713	hsa-miR-4269	CLIP-seq
MIRT2056718	hsa-miR-4430	CLIP-seq
MIRT2056722	hsa-miR-4505	CLIP-seq
MIRT2391771	hsa-miR-4726-3p	CLIP-seq
MIRT2056737	hsa-miR-544b	CLIP-seq
MIRT2455492	hsa-miR-4277	CLIP-seq
MIRT2455493	hsa-miR-4713-5p	CLIP-seq
MIRT2455494	hsa-miR-498	CLIP-seq
MIRT2583166	hsa-miR-1179	CLIP-seq
MIRT2583167	hsa-miR-1207-3p	CLIP-seq
MIRT2583168	hsa-miR-145	CLIP-seq
MIRT2583169	hsa-miR-1827	CLIP-seq
MIRT2583170	hsa-miR-1909	CLIP-seq
MIRT2583171	hsa-miR-1915	CLIP-seq
MIRT1195439	hsa-miR-300	CLIP-seq
MIRT2583172	hsa-miR-3144-5p	CLIP-seq
MIRT2583173	hsa-miR-3149	CLIP-seq
MIRT2583174	hsa-miR-3158-5p	CLIP-seq
MIRT2583175	hsa-miR-3166	CLIP-seq
MIRT2583176	hsa-miR-3180-5p	CLIP-seq
MIRT2583177	hsa-miR-320a	CLIP-seq
MIRT2583178	hsa-miR-320b	CLIP-seq
MIRT2583179	hsa-miR-320c	CLIP-seq
MIRT2583180	hsa-miR-320d	CLIP-seq
MIRT2583181	hsa-miR-324-5p	CLIP-seq
MIRT2583182	hsa-miR-3670	CLIP-seq
MIRT1195450	hsa-miR-381	CLIP-seq
MIRT2583183	hsa-miR-4252	CLIP-seq
MIRT2583184	hsa-miR-4268	CLIP-seq
MIRT2056713	hsa-miR-4269	CLIP-seq
MIRT2455492	hsa-miR-4277	CLIP-seq
MIRT2583185	hsa-miR-4281	CLIP-seq
MIRT2583186	hsa-miR-4299	CLIP-seq
MIRT2583187	hsa-miR-4429	CLIP-seq
MIRT2583188	hsa-miR-4448	CLIP-seq
MIRT2583189	hsa-miR-4452	CLIP-seq
MIRT2583190	hsa-miR-4456	CLIP-seq
MIRT2583191	hsa-miR-4522	CLIP-seq
MIRT2455493	hsa-miR-4713-5p	CLIP-seq
MIRT2056731	hsa-miR-4722-3p	CLIP-seq
MIRT2391771	hsa-miR-4726-3p	CLIP-seq
MIRT1195458	hsa-miR-4733-5p	CLIP-seq
MIRT2056732	hsa-miR-4769-3p	CLIP-seq
MIRT2583192	hsa-miR-4771	CLIP-seq
MIRT2056734	hsa-miR-4797-5p	CLIP-seq
MIRT2583193	hsa-miR-491-3p	CLIP-seq
MIRT2455494	hsa-miR-498	CLIP-seq
MIRT2583194	hsa-miR-518d-5p	CLIP-seq
MIRT2583195	hsa-miR-519b-5p	CLIP-seq
MIRT2583196	hsa-miR-519c-5p	CLIP-seq
MIRT2583197	hsa-miR-520c-5p	CLIP-seq
MIRT2583198	hsa-miR-526a	CLIP-seq
MIRT2056736	hsa-miR-532-5p	CLIP-seq
MIRT2583199	hsa-miR-548q	CLIP-seq
MIRT2583200	hsa-miR-766	CLIP-seq
MIRT2056743	hsa-miR-938	CLIP-seq
MIRT2583201	hsa-miR-940	CLIP-seq
MIRT2583167	hsa-miR-1207-3p	CLIP-seq
MIRT2583168	hsa-miR-145	CLIP-seq
MIRT2583171	hsa-miR-1915	CLIP-seq
MIRT2583174	hsa-miR-3158-5p	CLIP-seq
MIRT2583175	hsa-miR-3166	CLIP-seq
MIRT2583176	hsa-miR-3180-5p	CLIP-seq
MIRT2583181	hsa-miR-324-5p	CLIP-seq
MIRT2583182	hsa-miR-3670	CLIP-seq
MIRT2583183	hsa-miR-4252	CLIP-seq
MIRT2455492	hsa-miR-4277	CLIP-seq
MIRT2583185	hsa-miR-4281	CLIP-seq
MIRT2583186	hsa-miR-4299	CLIP-seq
MIRT2583189	hsa-miR-4452	CLIP-seq
MIRT2583190	hsa-miR-4456	CLIP-seq
MIRT2455493	hsa-miR-4713-5p	CLIP-seq
MIRT2391771	hsa-miR-4726-3p	CLIP-seq
MIRT1195458	hsa-miR-4733-5p	CLIP-seq
MIRT2583192	hsa-miR-4771	CLIP-seq
MIRT2455494	hsa-miR-498	CLIP-seq
MIRT2285172	hsa-miR-510	CLIP-seq
MIRT2285173	hsa-miR-512-5p	CLIP-seq
MIRT2056736	hsa-miR-532-5p	CLIP-seq
MIRT2583199	hsa-miR-548q	CLIP-seq
MIRT2583200	hsa-miR-766	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000957	Process	Mitochondrial RNA catabolic process	IDA	19509288
GO:0000957	Process	Mitochondrial RNA catabolic process	IDA	39019044
GO:0001510	Process	RNA methylation	IEA
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	21531335, 22949673, 23022348
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005759	Component	Mitochondrial matrix	IDA	39019044
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0005762	Component	Mitochondrial large ribosomal subunit	IBA
GO:0006364	Process	RRNA processing	IEA
GO:0006396	Process	RNA processing	IEA
GO:0008168	Function	Methyltransferase activity	IBA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0008173	Function	RNA methyltransferase activity	IDA	39019044
GO:0008173	Function	RNA methyltransferase activity	IEA
GO:0008649	Function	RRNA methyltransferase activity	IDA	23022348
GO:0008757	Function	S-adenosylmethionine-dependent methyltransferase activity	IEA
GO:0009383	Function	RRNA (cytosine-C5-)-methyltransferase activity	EXP	21531335, 23022348
GO:0016740	Function	Transferase activity	IEA
GO:0019843	Function	RRNA binding	IEA
GO:0031167	Process	RRNA methylation	IBA
GO:0031167	Process	RRNA methylation	IDA	23022348
GO:0031167	Process	RRNA methylation	TAS
GO:0032259	Process	Methylation	IEA
GO:0042254	Process	Ribosome biogenesis	IEA
GO:0062152	Function	MRNA (cytidine-5-)-methyltransferase activity	IDA	39019044
GO:0062152	Function	MRNA (cytidine-5-)-methyltransferase activity	IEA
GO:1900864	Process	Mitochondrial RNA modification	IDA	39019044

Other IDs

• MIM: 615394
• HGNC: 31802
• e!Ensembl: ENSG00000117481

Protein

• UniProt ID: Q96CB9
• Protein name: 5-cytosine rRNA methyltransferase NSUN4 (EC 2.1.1.-) (5-cytosine tRNA methyltransferase NSUN4) (EC 2.1.1.-) (NOL1/NOP2/Sun domain family member 4) (mRNA cytosine C(5)-methyltransferase NSUN4) (EC 2.1.1.-)
• Protein function: Mitochondrial RNA cytosine C(5)-methyltransferase that methylates cytosine to 5-methylcytosine (m5C) in various RNAs, such as rRNAs, mRNAs and some long non-coding RNAs (lncRNAs) (PubMed:21531335, PubMed:23022348, PubMed:39019044). Involved in m
• PDB: 4FP9, 4FZV, 7O9K, 7O9M, 7ODR, 7ODS, 7ODT, 7OF0, 7OF3, 7OF5, 7OF7, 7OIC, 7PD3, 8PK0, 8QSJ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01189	Methyltr_RsmB-F	166 → 352	16S rRNA methyltransferase RsmB/F	Family

• Sequence:

  MAALTLRGVRELLKRVDLATVPRRHRYKKKWAATEPKFPAVRLALQNFDMTYSVQFGDLW
  PSIRVSLLSEQKYGALVNNFAAWDHVSAKLEQLSAKDFVNEAISHWELQSEGGQSAAPSP
  ASWACSPNLRCFTFDRGDISRFPPARPGSLGVMEYYLMDAASLLPVLALGLQPGDIVLDL
  CAAPGGKTLALLQTGCCRNLAANDLSPSRIARLQKILHSYVPEEIRDGNQVRVTSWDGRK
  WGELEGDTYDRVLVDVPCTTDRHSLHEEENNIFKRSRKKERQILPVLQVQLLAAGLLATK
  PGGHVVYSTCSLSHLQNEYVVQGAIELLANQYSIQVQVEDLTHFRRVFMDTFCFFSSCQV
  GELVIPNLMANFGPMYFCKMRRLT

• Sequence length: 384

Pathways

Reactome:

rRNA modification in the mitochondrion

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PROSTATE CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Neoplasms	Breast neoplasm	Pubtator	27432226, 36634566	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	34744073	Stimulate	★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	27432226		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	27432226		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of prostate	Prostate cancer	BEFREE	27432226		★☆☆☆☆ Found in Text Mining only
Optic Atrophy Hereditary Leber	Leber hereditary optic neuropathy	Pubtator	36233195	Associate	★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	27432226		★☆☆☆☆ Found in Text Mining only
Ovarian Neoplasms	Ovarian neoplasm	Pubtator	27432226	Associate	★☆☆☆☆ Found in Text Mining only
Prostate carcinoma	Prostate cancer	BEFREE	27432226		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	36634566	Associate	★☆☆☆☆ Found in Text Mining only
Thyroid Carcinoma Anaplastic	Thyroid cancer	Pubtator	36609218	Associate	★☆☆☆☆ Found in Text Mining only