KCTD8 (potassium channel tetramerization domain containing 8)

Gene

• Entrez ID: 386617
• Gene name: Potassium channel tetramerization domain containing 8
• Gene symbol: KCTD8
• Synonyms (NCBI Gene): -
• Chromosome: 4
• Chromosome location: 4p13

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT2021085	hsa-miR-1298	CLIP-seq
MIRT2021086	hsa-miR-3065-5p	CLIP-seq
MIRT2021087	hsa-miR-3074-3p	CLIP-seq
MIRT2021088	hsa-miR-3124-3p	CLIP-seq
MIRT2021089	hsa-miR-3662	CLIP-seq
MIRT2021090	hsa-miR-4775	CLIP-seq
MIRT2021091	hsa-miR-495	CLIP-seq
MIRT2021092	hsa-miR-522	CLIP-seq
MIRT2021093	hsa-miR-578	CLIP-seq
MIRT2021094	hsa-miR-590-3p	CLIP-seq
MIRT2021095	hsa-miR-643	CLIP-seq
MIRT2252714	hsa-miR-1208	CLIP-seq
MIRT2252715	hsa-miR-15a	CLIP-seq
MIRT2252716	hsa-miR-15b	CLIP-seq
MIRT2252717	hsa-miR-16	CLIP-seq
MIRT2252718	hsa-miR-195	CLIP-seq
MIRT2252719	hsa-miR-2278	CLIP-seq
MIRT2021086	hsa-miR-3065-5p	CLIP-seq
MIRT2021088	hsa-miR-3124-3p	CLIP-seq
MIRT2252720	hsa-miR-424	CLIP-seq
MIRT2252721	hsa-miR-451b	CLIP-seq
MIRT2021091	hsa-miR-495	CLIP-seq
MIRT2252722	hsa-miR-497	CLIP-seq
MIRT2252723	hsa-miR-513b	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183, 36931259
GO:0005886	Component	Plasma membrane	IEA
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	IBA
GO:0008277	Process	Regulation of G protein-coupled receptor signaling pathway	IEA
GO:0016020	Component	Membrane	IEA
GO:0042734	Component	Presynaptic membrane	IEA
GO:0042734	Component	Presynaptic membrane	IEA
GO:0042802	Function	Identical protein binding	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043235	Component	Receptor complex	IBA
GO:0043235	Component	Receptor complex	IEA
GO:0045202	Component	Synapse	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0048787	Component	Presynaptic active zone membrane	IEA
GO:0051260	Process	Protein homooligomerization	IEA
GO:0098794	Component	Postsynapse	IEA

Other IDs

• MIM: 618442
• HGNC: 22394
• e!Ensembl: ENSG00000183783

Protein

• UniProt ID: Q6ZWB6
• Protein name: BTB/POZ domain-containing protein KCTD8
• Protein function: Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitizatio
• PDB: 6G57
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02214	BTB_2	46 → 146	BTB/POZ domain	Domain

• Sequence:

  MALKDTGSGGSTILPISEMVSSSSSPGASAAAAPGPCAPSPFPEVVELNVGGQVYVTKHS
  TLLSVPDSTLASMFSPSSPRGGARRRGELPRDSRARFFIDRDGFLFRYVLDYLRDKQLAL
  PEHFPEKERLLREAEYFQLTDLVKLLSPKVTKQNSLNDEGCQSDLEDNVSQGSSDALLLR
  GAAAAVPSGPGAHGGGGGGGAQDKRSGFLTLGYRGSYTTVRDNQADAKFRRVARIMVCGR
  IALAKEVFGDTLNESRDPDRQPEKYTSRFYLKFTYLEQAFDRLSEAGFHMVACNSSGTAA
  FVNQYRDDKIWSSYTEYIFFRPPQKIVSPKQEHEDRKHDKVTDKGSESGTSCNELSTSSC
  DSHSEASTPQDNPSSAQQATAHQPNTLTLDRPSKKAPVQWIPPPDKRRNSELFQTLISKS
  RETNLSKKKVCEKLSVEEEMKKCIQDFKKIHIPDYFPERKRQWQSELLQKYGL

• Sequence length: 473

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
AORTIC DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATOPIC ECZEMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EXOSTOSIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSORIASIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations