Gene Gene information from NCBI Gene database.
Entrez ID 3843
Gene name Importin 5
Gene symbol IPO5
Synonyms (NCBI Gene)
IMB3KPNB3Pse1RANBP5imp5
Chromosome 13
Chromosome location 13q32.2
Summary Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a het
miRNA miRNA information provided by mirtarbase database.
504
miRTarBase ID miRNA Experiments Reference
MIRT051154 hsa-miR-16-5p CLASH 23622248
MIRT049490 hsa-miR-92a-3p CLASH 23622248
MIRT048827 hsa-miR-93-5p CLASH 23622248
MIRT048251 hsa-miR-196a-5p CLASH 23622248
MIRT046603 hsa-miR-222-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
42
GO ID Ontology Definition Evidence Reference
GO:0002753 Process Cytoplasmic pattern recognition receptor signaling pathway IDA 8524823
GO:0002753 Process Cytoplasmic pattern recognition receptor signaling pathway IDA 31340999
GO:0003723 Function RNA binding HDA 22681889
GO:0005095 Function GTPase inhibitor activity TAS 9271386
GO:0005515 Function Protein binding IPI 10799599, 15282309, 20562859, 20828572, 21044950, 22730302, 29475951, 32814053, 33961781
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602008 6402 ENSG00000065150
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O00410
Protein name Importin-5 (Imp5) (Importin subunit beta-3) (Karyopherin beta-3) (Ran-binding protein 5) (RanBP5)
Protein function Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) t
PDB 6XTE , 6XU2 , 9IM6
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF18808 Importin_rep_4 268 357 Importin repeat Repeat
PF02985 HEAT 400 430 HEAT repeat Repeat
PF18829 Importin_rep_6 765 874 Importin repeat 6 Repeat
PF02985 HEAT 906 936 HEAT repeat Repeat
PF18816 Importin_rep_5 1005 1061 Importin repeat Repeat
Sequence
MAAAAAEQQQFYLLLGNLLSPDNVVRKQAEETYENIPGQSKITFLLQAIRNTTAAEEARQ
MAAVLLRRLLSSAFDEVYPALPSDVQTAIKSELLMIIQMETQSSMRKKVCDIAAELARNL
IDEDGNNQWPEGLKFLFDSVSSQNVGLREAALHIFWNFPGIFGNQQQHYLDVIKRMLVQC
MQDQEHPSIRTLSARATAAFILANEHNVALFKHFADLLPGFLQAVNDSCYQNDDSVLKSL
VEIADTVPKYLRPHLEATLQLSLKLCGDTSLNNMQRQLALEVIVTLSETAAAMLRKHTNI
VAQTIPQMLAMMVDLEEDEDWANADELEDDDFDSNAVAGESALDRMACGLGGKLVLP
MIK
EHIMQMLQNPDWKYRHAGLMALSAIGEGCHQQMEGILNEIVNFVLLFLQDPHPRVRYAAC
NAVGQMATDF
APGFQKKFHEKVIAALLQTMEDQGNQRVQAHAAAALINFTEDCPKSLLIP
YLDNLVKHLHSIMVLKLQELIQKGTKLVLEQVVTSIASVADTAEEKFVPYYDLFMPSLKH
IVENAVQKELRLLRGKTIECISLIGLAVGKEKFMQDASDVMQLLLKTQTDFNDMEDDDPQ
ISYMISAWARMCKILGKEFQQYLPVVMGPLMKTASIKPEVALLDTQDMENMSDDDGWEFV
NLGDQQSFGIKTAGLEEKSTACQMLVCYAKELKEGFVEYTEQVVKLMVPLLKFYFHDGVR
VAAAESMPLLLECARVRGPEYLTQMWHFMCDALIKAIGTEPDSDVLSEIMHSFAKCIEVM
GDGCLNNEHFEELGGILKAKLEEHFKNQELRQVKRQDEDYDEQVEESLQDEDDNDVYILT
KVSDILHSIFSSYKEKVLPWFEQLLPLIVNLICP
HRPWPDRQWGLCIFDDVIEHCSPASF
KYAEYFLRPMLQYVCDNSPEVRQAAAYGLGVMAQYGGDNYRPFCTEALPLLVRVIQSADS
KTKENVNATENCISAVGKIMKFKPDCVNVEEVLPHWLSWLPLHEDKEEAVQTFNYLCDLI
ESNHPIVLGPNNTNLPKIFSIIAEGEMHEAIKHEDPCAKRL
ANVVRQVQTSGGLWTECIA
QLSPEQQAAIQELLNSA
Sequence length 1097
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Nucleocytoplasmic transport   vRNP Assembly
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
6
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
Acute myeloid leukemia Uncertain significance ClinVar
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ALZHEIMER DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
NON-MELANOMA SKIN CARCINOMA GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Adenocarcinoma of lung (disorder) Lung adenocarcinoma CTD_human_DG 27602772
★☆☆☆☆
Found in Text Mining only
Cardiomyopathy Dilated Dilated cardiomyopathy Pubtator 25137373 Associate
★☆☆☆☆
Found in Text Mining only
Colorectal Carcinoma Colorectal Cancer BEFREE 31288861
★☆☆☆☆
Found in Text Mining only
Esophageal Neoplasms Esophageal neoplasm Pubtator 32373960 Associate
★☆☆☆☆
Found in Text Mining only
Keratoconus Keratoconus BEFREE 24940934
★☆☆☆☆
Found in Text Mining only
Keratoconus Keratoconus Pubtator 28159702 Associate
★☆☆☆☆
Found in Text Mining only
Lung Neoplasms Lung neoplasms Pubtator 36380607 Associate
★☆☆☆☆
Found in Text Mining only
Peripheral Arterial Disease Peripheral arterial disease Pubtator 26488411 Associate
★☆☆☆☆
Found in Text Mining only
Peripheral Arterial Diseases Vascular Diseases BEFREE 26488411
★☆☆☆☆
Found in Text Mining only
Schizophrenia Schizophrenia BEFREE 15364420, 16644122, 17458142, 20542336
★★☆☆☆
Found in Text Mining + Unknown/Other Associations