Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	381
Gene name	ARF GTPase 5
Gene symbol	ARF5
Synonyms (NCBI Gene)	-
Chromosome	7
Chromosome location	7q32.1
Summary	This gene is a member of the human ADP-ribosylation factor (ARF) gene family. These genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as

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miRTarBase ID	miRNA	Experiments	Reference
MIRT040754	hsa-miR-18a-3p	CLASH	23622248
MIRT038717	hsa-miR-99a-3p	CLASH	23622248
MIRT792481	hsa-miR-1227	CLIP-seq
MIRT792482	hsa-miR-1299	CLIP-seq
MIRT792483	hsa-miR-1825	CLIP-seq
MIRT792484	hsa-miR-199a-5p	CLIP-seq
MIRT792485	hsa-miR-199b-5p	CLIP-seq
MIRT792486	hsa-miR-2467-3p	CLIP-seq
MIRT792487	hsa-miR-29a	CLIP-seq
MIRT792488	hsa-miR-29b	CLIP-seq
MIRT792489	hsa-miR-29c	CLIP-seq
MIRT792490	hsa-miR-3064-3p	CLIP-seq
MIRT792491	hsa-miR-3155	CLIP-seq
MIRT792492	hsa-miR-3155b	CLIP-seq
MIRT792493	hsa-miR-3925-5p	CLIP-seq
MIRT792494	hsa-miR-4268	CLIP-seq
MIRT792495	hsa-miR-4448	CLIP-seq
MIRT792496	hsa-miR-4468	CLIP-seq
MIRT792497	hsa-miR-4514	CLIP-seq
MIRT792498	hsa-miR-4528	CLIP-seq
MIRT792499	hsa-miR-4645-5p	CLIP-seq
MIRT792500	hsa-miR-4673	CLIP-seq
MIRT792501	hsa-miR-4692	CLIP-seq
MIRT792502	hsa-miR-4708-3p	CLIP-seq
MIRT792503	hsa-miR-4722-5p	CLIP-seq
MIRT792504	hsa-miR-4800-5p	CLIP-seq
MIRT792505	hsa-miR-484	CLIP-seq
MIRT792506	hsa-miR-556-3p	CLIP-seq
MIRT792507	hsa-miR-7	CLIP-seq
MIRT792508	hsa-miR-711	CLIP-seq
MIRT792509	hsa-miR-875-3p	CLIP-seq
MIRT792510	hsa-miR-888	CLIP-seq
MIRT792511	hsa-miR-940	CLIP-seq
MIRT792503	hsa-miR-4722-5p	CLIP-seq
MIRT1933852	hsa-miR-1289	CLIP-seq
MIRT792482	hsa-miR-1299	CLIP-seq
MIRT1933853	hsa-miR-214	CLIP-seq
MIRT1933854	hsa-miR-3150b-3p	CLIP-seq
MIRT1933855	hsa-miR-3619-5p	CLIP-seq
MIRT1933856	hsa-miR-3689a-3p	CLIP-seq
MIRT1933857	hsa-miR-3689c	CLIP-seq
MIRT792494	hsa-miR-4268	CLIP-seq
MIRT1933858	hsa-miR-4294	CLIP-seq
MIRT792495	hsa-miR-4448	CLIP-seq
MIRT1933859	hsa-miR-4497	CLIP-seq
MIRT792497	hsa-miR-4514	CLIP-seq
MIRT1933860	hsa-miR-4530	CLIP-seq
MIRT1933861	hsa-miR-4689	CLIP-seq
MIRT792501	hsa-miR-4692	CLIP-seq
MIRT792503	hsa-miR-4722-5p	CLIP-seq
MIRT1933862	hsa-miR-4728-5p	CLIP-seq
MIRT1933863	hsa-miR-4784	CLIP-seq
MIRT1933864	hsa-miR-544b	CLIP-seq
MIRT792507	hsa-miR-7	CLIP-seq
MIRT1933865	hsa-miR-761	CLIP-seq
MIRT792509	hsa-miR-875-3p	CLIP-seq
MIRT792511	hsa-miR-940	CLIP-seq
MIRT1933853	hsa-miR-214	CLIP-seq
MIRT792486	hsa-miR-2467-3p	CLIP-seq
MIRT792491	hsa-miR-3155	CLIP-seq
MIRT792492	hsa-miR-3155b	CLIP-seq
MIRT1933855	hsa-miR-3619-5p	CLIP-seq
MIRT2173755	hsa-miR-3675-5p	CLIP-seq
MIRT792493	hsa-miR-3925-5p	CLIP-seq
MIRT792496	hsa-miR-4468	CLIP-seq
MIRT2173756	hsa-miR-4474-3p	CLIP-seq
MIRT792497	hsa-miR-4514	CLIP-seq
MIRT1933860	hsa-miR-4530	CLIP-seq
MIRT792499	hsa-miR-4645-5p	CLIP-seq
MIRT792500	hsa-miR-4673	CLIP-seq
MIRT2173757	hsa-miR-4690-5p	CLIP-seq
MIRT792501	hsa-miR-4692	CLIP-seq
MIRT792502	hsa-miR-4708-3p	CLIP-seq
MIRT792503	hsa-miR-4722-5p	CLIP-seq
MIRT792505	hsa-miR-484	CLIP-seq
MIRT2173758	hsa-miR-587	CLIP-seq
MIRT1933865	hsa-miR-761	CLIP-seq
MIRT792511	hsa-miR-940	CLIP-seq
MIRT2477374	hsa-miR-1275	CLIP-seq
MIRT2477375	hsa-miR-150	CLIP-seq
MIRT792487	hsa-miR-29a	CLIP-seq
MIRT792488	hsa-miR-29b	CLIP-seq
MIRT792489	hsa-miR-29c	CLIP-seq
MIRT792490	hsa-miR-3064-3p	CLIP-seq
MIRT2173755	hsa-miR-3675-5p	CLIP-seq
MIRT2477376	hsa-miR-3679-3p	CLIP-seq
MIRT2173756	hsa-miR-4474-3p	CLIP-seq
MIRT2477377	hsa-miR-4525	CLIP-seq
MIRT792498	hsa-miR-4528	CLIP-seq
MIRT2477378	hsa-miR-4665-5p	CLIP-seq
MIRT2477379	hsa-miR-4687-5p	CLIP-seq
MIRT2477380	hsa-miR-4723-5p	CLIP-seq
MIRT2477381	hsa-miR-4796-3p	CLIP-seq
MIRT2477382	hsa-miR-490-3p	CLIP-seq
MIRT2477383	hsa-miR-548t	CLIP-seq
MIRT2477384	hsa-miR-625	CLIP-seq
MIRT2477374	hsa-miR-1275	CLIP-seq
MIRT2173755	hsa-miR-3675-5p	CLIP-seq
MIRT2173756	hsa-miR-4474-3p	CLIP-seq
MIRT2477377	hsa-miR-4525	CLIP-seq
MIRT2477378	hsa-miR-4665-5p	CLIP-seq
MIRT2477380	hsa-miR-4723-5p	CLIP-seq
MIRT2477381	hsa-miR-4796-3p	CLIP-seq
MIRT2477383	hsa-miR-548t	CLIP-seq
MIRT2477384	hsa-miR-625	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003924	Function	GTPase activity	IEA
GO:0003924	Function	GTPase activity	TAS	1993656
GO:0005515	Function	Protein binding	IPI	17030804, 32296183
GO:0005525	Function	GTP binding	IBA
GO:0005525	Function	GTP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0006886	Process	Intracellular protein transport	IBA
GO:0006890	Process	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IEA
GO:0006890	Process	Retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IGI	24768165
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IBA
GO:0016192	Process	Vesicle-mediated transport	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145

MIM	HGNC	e!Ensembl
103188	658	ENSG00000004059

P84085

Protein name

ADP-ribosylation factor 5

Protein function

GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. ; (Microbial infection) Functions as an allosteric activator of the cholera toxi

PDB

2B6H

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00025	Arf	5 → 177	ADP-ribosylation factor family	Domain

Sequence

MGLTVSALFSRIFGKKQMRILMVGLDAAGKTTILYKLKLGEIVTTIPTIGFNVETVEYKN
ICFTVWDVGGQDKIRPLWRHYFQNTQGLIFVVDSNDRERVQESADELQKMLQEDELRDAV
LLVFANKQDMPNAMPVSELTDKLGLQHLRSRTWYVQATCATQGTGLYDGLDWLSHELSKR

Sequence length

180

Interactions

View interactions

	KEGG		Reactome
	Endocytosis		COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

ARF5 (ARF GTPase 5)