Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	3801
Gene name	Kinesin family member C3
Gene symbol	KIFC3
Synonyms (NCBI Gene)	-
Chromosome	16
Chromosome location	16q21
Summary	This gene encodes a member of the kinesin-14 family of microtubule motors. Members of this family play a role in the formation, maintenance and remodeling of the bipolar mitotic spindle. The protein encoded by this gene has cytoplasmic functions in the in

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miRTarBase ID	miRNA	Experiments	Reference
MIRT028959	hsa-miR-26b-5p	Microarray	19088304
MIRT708800	hsa-miR-6865-3p	HITS-CLIP	19536157
MIRT708799	hsa-miR-4258	HITS-CLIP	19536157
MIRT708798	hsa-miR-7108-3p	HITS-CLIP	19536157
MIRT708797	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT708796	hsa-miR-5193	HITS-CLIP	19536157
MIRT708795	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT708794	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT708800	hsa-miR-6865-3p	HITS-CLIP	19536157
MIRT708799	hsa-miR-4258	HITS-CLIP	19536157
MIRT708798	hsa-miR-7108-3p	HITS-CLIP	19536157
MIRT708797	hsa-miR-4667-3p	HITS-CLIP	19536157
MIRT708796	hsa-miR-5193	HITS-CLIP	19536157
MIRT708795	hsa-miR-4691-5p	HITS-CLIP	19536157
MIRT708794	hsa-miR-6792-3p	HITS-CLIP	19536157
MIRT1095193	hsa-miR-1202	CLIP-seq
MIRT1095194	hsa-miR-1908	CLIP-seq
MIRT1095195	hsa-miR-3177-3p	CLIP-seq
MIRT1095196	hsa-miR-3180	CLIP-seq
MIRT1095197	hsa-miR-3180-3p	CLIP-seq
MIRT1095198	hsa-miR-3184	CLIP-seq
MIRT1095199	hsa-miR-3194-5p	CLIP-seq
MIRT1095200	hsa-miR-3196	CLIP-seq
MIRT1095201	hsa-miR-3972	CLIP-seq
MIRT1095202	hsa-miR-423-5p	CLIP-seq
MIRT1095203	hsa-miR-4446-3p	CLIP-seq
MIRT1095204	hsa-miR-4706	CLIP-seq
MIRT1095205	hsa-miR-4721	CLIP-seq
MIRT1095206	hsa-miR-4727-5p	CLIP-seq
MIRT1095207	hsa-miR-4728-5p	CLIP-seq
MIRT1095208	hsa-miR-4749-5p	CLIP-seq
MIRT1095209	hsa-miR-4769-3p	CLIP-seq
MIRT1095210	hsa-miR-663	CLIP-seq
MIRT2025556	hsa-miR-1184	CLIP-seq
MIRT2025557	hsa-miR-1252	CLIP-seq
MIRT1095194	hsa-miR-1908	CLIP-seq
MIRT1095196	hsa-miR-3180	CLIP-seq
MIRT1095197	hsa-miR-3180-3p	CLIP-seq
MIRT1095198	hsa-miR-3184	CLIP-seq
MIRT1095200	hsa-miR-3196	CLIP-seq
MIRT1095202	hsa-miR-423-5p	CLIP-seq
MIRT2025558	hsa-miR-4428	CLIP-seq
MIRT2025559	hsa-miR-4635	CLIP-seq
MIRT1095204	hsa-miR-4706	CLIP-seq
MIRT1095205	hsa-miR-4721	CLIP-seq
MIRT1095207	hsa-miR-4728-5p	CLIP-seq
MIRT1095208	hsa-miR-4749-5p	CLIP-seq
MIRT1095210	hsa-miR-663	CLIP-seq
MIRT2256779	hsa-miR-103a	CLIP-seq
MIRT2256780	hsa-miR-107	CLIP-seq
MIRT2025556	hsa-miR-1184	CLIP-seq
MIRT2256781	hsa-miR-1281	CLIP-seq
MIRT2256782	hsa-miR-214	CLIP-seq
MIRT2256783	hsa-miR-3619-5p	CLIP-seq
MIRT2256784	hsa-miR-4325	CLIP-seq
MIRT2256785	hsa-miR-4787-5p	CLIP-seq
MIRT2256786	hsa-miR-507	CLIP-seq
MIRT2256787	hsa-miR-557	CLIP-seq
MIRT2256788	hsa-miR-615-5p	CLIP-seq
MIRT2256789	hsa-miR-761	CLIP-seq
MIRT2025557	hsa-miR-1252	CLIP-seq
MIRT1095194	hsa-miR-1908	CLIP-seq
MIRT1095196	hsa-miR-3180	CLIP-seq
MIRT1095197	hsa-miR-3180-3p	CLIP-seq
MIRT1095198	hsa-miR-3184	CLIP-seq
MIRT1095200	hsa-miR-3196	CLIP-seq
MIRT1095202	hsa-miR-423-5p	CLIP-seq
MIRT2025558	hsa-miR-4428	CLIP-seq
MIRT2025559	hsa-miR-4635	CLIP-seq
MIRT1095204	hsa-miR-4706	CLIP-seq
MIRT1095205	hsa-miR-4721	CLIP-seq
MIRT1095207	hsa-miR-4728-5p	CLIP-seq
MIRT1095208	hsa-miR-4749-5p	CLIP-seq
MIRT1095210	hsa-miR-663	CLIP-seq
MIRT2025557	hsa-miR-1252	CLIP-seq
MIRT1095194	hsa-miR-1908	CLIP-seq
MIRT1095196	hsa-miR-3180	CLIP-seq
MIRT1095197	hsa-miR-3180-3p	CLIP-seq
MIRT1095198	hsa-miR-3184	CLIP-seq
MIRT1095200	hsa-miR-3196	CLIP-seq
MIRT1095202	hsa-miR-423-5p	CLIP-seq
MIRT2025558	hsa-miR-4428	CLIP-seq
MIRT2025559	hsa-miR-4635	CLIP-seq
MIRT1095204	hsa-miR-4706	CLIP-seq
MIRT1095205	hsa-miR-4721	CLIP-seq
MIRT1095207	hsa-miR-4728-5p	CLIP-seq
MIRT1095208	hsa-miR-4749-5p	CLIP-seq
MIRT1095210	hsa-miR-663	CLIP-seq
MIRT2025557	hsa-miR-1252	CLIP-seq
MIRT1095194	hsa-miR-1908	CLIP-seq
MIRT1095196	hsa-miR-3180	CLIP-seq
MIRT1095197	hsa-miR-3180-3p	CLIP-seq
MIRT1095198	hsa-miR-3184	CLIP-seq
MIRT1095200	hsa-miR-3196	CLIP-seq
MIRT1095202	hsa-miR-423-5p	CLIP-seq
MIRT2025558	hsa-miR-4428	CLIP-seq
MIRT2025559	hsa-miR-4635	CLIP-seq
MIRT1095204	hsa-miR-4706	CLIP-seq
MIRT1095205	hsa-miR-4721	CLIP-seq
MIRT1095207	hsa-miR-4728-5p	CLIP-seq
MIRT1095208	hsa-miR-4749-5p	CLIP-seq
MIRT1095210	hsa-miR-663	CLIP-seq

Show/Hide all (32)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003777	Function	Microtubule motor activity	IEA
GO:0003777	Function	Microtubule motor activity	TAS	9782090
GO:0005515	Function	Protein binding	IPI	20360068, 21516116, 25416956, 26871637, 29892012, 30886144, 31515488, 32296183, 32814053, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005794	Component	Golgi apparatus	IEA
GO:0005813	Component	Centrosome	IDA	19041755
GO:0005813	Component	Centrosome	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005871	Component	Kinesin complex	IEA
GO:0005871	Component	Kinesin complex	TAS	9782090
GO:0005874	Component	Microtubule	IEA
GO:0005912	Component	Adherens junction	IEA
GO:0005915	Component	Zonula adherens	IDA	19041755
GO:0007017	Process	Microtubule-based process	IBA
GO:0007017	Process	Microtubule-based process	IEA
GO:0007018	Process	Microtubule-based movement	IEA
GO:0007030	Process	Golgi organization	IEA
GO:0007601	Process	Visual perception	TAS	9782090
GO:0008017	Function	Microtubule binding	IBA
GO:0008017	Function	Microtubule binding	IEA
GO:0015630	Component	Microtubule cytoskeleton	IBA
GO:0016020	Component	Membrane	IEA
GO:0030659	Component	Cytoplasmic vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0042802	Function	Identical protein binding	IPI	32296183
GO:0045218	Process	Zonula adherens maintenance	IMP	19041755
GO:0070062	Component	Extracellular exosome	HDA	19056867
GO:0070161	Component	Anchoring junction	IEA
GO:0090136	Process	Epithelial cell-cell adhesion	IMP	19041755

MIM	HGNC	e!Ensembl
604535	6326	ENSG00000140859

Q9BVG8

Protein name

Kinesin-like protein KIFC3

Protein function

Minus-end microtubule-dependent motor protein. Involved in apically targeted transport (By similarity). Required for zonula adherens maintenance.

PDB

5WDE

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00225	Kinesin	451 → 768	Kinesin motor domain	Domain

Sequence

MVPSRRTWNLGATPSLRGLWRVGRAPEPEPGMARPAPAPASPAARPFPHTGPGRLRTGRG
KDTPVCGDEDSSARSAARPALAQCRALSVDWAGPGSPHGLYLTLQVEHLKEKLISQAQEV
SRLRSELGGTDLEKHRDLLMVENERLRQEMRRCEAELQELRTKPAGPCPGCEHSQESAQL
RDKLSQLQLEMAESKGMLSELNLEVQQKTDRLAEVELRLKDCLAEKAQEEERLSRRLRDS
HETIASLRAQSPPVKYVIKTVEVESSKTKQALSESQARNQHLQEQVAMQRQVLKEMEQQL
QSSHQLTARLRAQIAMYESELERAHGQMLEEMQSLEEDKNRAIEEAFARAQVEMKAVHEN
LAGVRTNLLTLQPALRTLTNDYNGLKRQVRGFPLLLQEALRSVKAEIGQAIEEVNSNNQE
LLRKYRRELQLRKKCHNELVRLKGNIRVIARVRPVTKEDGEGPEATNAVTFDADDDSIIH
LLHKGKPVSFELDKVFSPQASQQDVFQEVQALVTSCIDGFNVCIFAYGQTGAGKTYTMEG
TAENPGINQRALQLLFSEVQEKASDWEYTITVSAAEIYNEVLRDLLGKEPQEKLEIRLCP
DGSGQLYVPGLTEFQVQSVDDINKVFEFGHTNRTTEFTNLNEHSSRSHALLIVTVRGVDC
STGLRTTGKLNLVDLAGSERVGKSGAEGSRLREAQHINKSLSALGDVIAALRSRQGHVPF
RNSKLTYLLQDSLSGDSKTLMVVQVSPVEKNTSETLYSLKFAERVRSVELGPGLRRAELG
SWSSQEHLEWEPACQTPQPSARAHSAPSSGTSSRPGSIRRKLQPSGKSRPLPV

Sequence length

833

Interactions

View interactions

	KEGG
	Motor proteins

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (2)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Colon adenocarcinoma	Uncertain significance	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LATE-ONSET ALZHEIMER'S DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
AMYOTROPHIC LATERAL SCLEROSIS 1	Lateral Sclerosis	BEFREE	23006449		★★★★★ ★☆☆☆☆ Found in Text Mining only
Bardet-Biedl Syndrome	Bardet-Biedl Syndrome	BEFREE	9782090		★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	28901309	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholestasis of pregnancy	Cholestasis of pregnancy	BEFREE	23480690		★★★★★ ★☆☆☆☆ Found in Text Mining only
Intrahepatic Cholestasis of Pregnancy	Intrahepatic cholestasis of pregnancy	Pubtator	23480690	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

KIFC3 (kinesin family member C3)