KIF5C (kinesin family member 5C)

Gene

• Entrez ID: 3800
• Gene name: Kinesin family member 5C
• Gene symbol: KIF5C
• Synonyms (NCBI Gene): CDCBM2, KINN, NKHC, NKHC-2, NKHC2
• Chromosome: 2
• Chromosome location: 2q23.1-q23.2
• Summary: The protein encoded by this gene is a kinesin heavy chain subunit involved in the transport of cargo within the central nervous system. The encoded protein, which acts as a tetramer by associating with another heavy chain and two light chains, interacts w

SNPs

SNP ID	Visualize variation	Clinical significance	Consequence
rs587777035	A>T	Pathogenic	Missense variant, coding sequence variant, genic upstream transcript variant, upstream transcript variant
rs587777570	G>A	Pathogenic	Missense variant, coding sequence variant, genic upstream transcript variant, upstream transcript variant

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT024749	hsa-miR-215-5p	Microarray	19074876
MIRT026185	hsa-miR-192-5p	Microarray	19074876
MIRT050891	hsa-miR-17-5p	CLASH	23622248
MIRT047105	hsa-miR-183-5p	CLASH	23622248
MIRT046723	hsa-miR-222-3p	CLASH	23622248
MIRT044274	hsa-miR-106b-5p	CLASH	23622248
MIRT607567	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT607566	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT607565	hsa-miR-603	HITS-CLIP	23313552
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23313552
MIRT609724	hsa-miR-610	HITS-CLIP	23313552
MIRT607565	hsa-miR-603	HITS-CLIP	23313552
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23313552
MIRT609724	hsa-miR-610	HITS-CLIP	23313552
MIRT607568	hsa-miR-8485	HITS-CLIP	23824327
MIRT607565	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT607568	hsa-miR-8485	HITS-CLIP	23824327
MIRT607565	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT607568	hsa-miR-8485	HITS-CLIP	23824327
MIRT607565	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT607568	hsa-miR-8485	HITS-CLIP	23824327
MIRT607565	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT607568	hsa-miR-8485	HITS-CLIP	23824327
MIRT607565	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT625337	hsa-miR-4724-3p	HITS-CLIP	23824327
MIRT607568	hsa-miR-8485	HITS-CLIP	23824327
MIRT607565	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT607568	hsa-miR-8485	HITS-CLIP	23824327
MIRT607565	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT607568	hsa-miR-8485	HITS-CLIP	23824327
MIRT607565	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT625337	hsa-miR-4724-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT607565	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT607568	hsa-miR-8485	HITS-CLIP	23824327
MIRT607565	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT625337	hsa-miR-4724-3p	HITS-CLIP	23824327
MIRT607568	hsa-miR-8485	HITS-CLIP	23824327
MIRT607565	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT607568	hsa-miR-8485	HITS-CLIP	23824327
MIRT607565	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT607568	hsa-miR-8485	HITS-CLIP	23824327
MIRT607565	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT607568	hsa-miR-8485	HITS-CLIP	23824327
MIRT607565	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT625337	hsa-miR-4724-3p	HITS-CLIP	23824327
MIRT607568	hsa-miR-8485	HITS-CLIP	23824327
MIRT607565	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT607568	hsa-miR-8485	HITS-CLIP	23824327
MIRT607565	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT607568	hsa-miR-8485	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT607568	hsa-miR-8485	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT607565	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT625337	hsa-miR-4724-3p	HITS-CLIP	23824327
MIRT607568	hsa-miR-8485	HITS-CLIP	23824327
MIRT607565	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT607568	hsa-miR-8485	HITS-CLIP	23824327
MIRT607565	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT607568	hsa-miR-8485	HITS-CLIP	23824327
MIRT607565	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT607568	hsa-miR-8485	HITS-CLIP	23824327
MIRT607565	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT607568	hsa-miR-8485	HITS-CLIP	23824327
MIRT607565	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT607568	hsa-miR-8485	HITS-CLIP	24906430
MIRT607567	hsa-miR-329-3p	HITS-CLIP	24906430
MIRT607566	hsa-miR-362-3p	HITS-CLIP	24906430
MIRT607565	hsa-miR-603	HITS-CLIP	24906430
MIRT607564	hsa-miR-4789-3p	HITS-CLIP	24906430
MIRT607563	hsa-miR-3941	HITS-CLIP	24906430
MIRT607562	hsa-miR-4672	HITS-CLIP	24906430
MIRT607561	hsa-miR-466	HITS-CLIP	24906430
MIRT440366	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT440364	hsa-miR-376a-3p	HITS-CLIP	24374217
MIRT440365	hsa-miR-382-5p	HITS-CLIP	24374217
MIRT440366	hsa-miR-485-5p	HITS-CLIP	24374217
MIRT440364	hsa-miR-376a-3p	HITS-CLIP	24374217
MIRT440365	hsa-miR-382-5p	HITS-CLIP	24374217
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	27418678
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	27418678
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	27418678
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	27418678
MIRT575874	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT575873	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT575870	hsa-miR-3941	HITS-CLIP	27418678
MIRT575872	hsa-miR-603	HITS-CLIP	27418678
MIRT575872	hsa-miR-603	HITS-CLIP	27418678
MIRT575872	hsa-miR-603	HITS-CLIP	27418678
MIRT575872	hsa-miR-603	HITS-CLIP	27418678
MIRT609724	hsa-miR-610	HITS-CLIP	27418678
MIRT609724	hsa-miR-610	HITS-CLIP	27418678
MIRT609724	hsa-miR-610	HITS-CLIP	27418678
MIRT609724	hsa-miR-610	HITS-CLIP	27418678
MIRT575875	hsa-miR-8485	HITS-CLIP	27418678
MIRT575875	hsa-miR-8485	HITS-CLIP	27418678
MIRT575875	hsa-miR-8485	HITS-CLIP	27418678
MIRT575875	hsa-miR-8485	HITS-CLIP	27418678
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	28735896
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	28735896
MIRT575874	hsa-miR-329-3p	HITS-CLIP	28735896
MIRT575873	hsa-miR-362-3p	HITS-CLIP	28735896
MIRT575870	hsa-miR-3941	HITS-CLIP	28735896
MIRT575872	hsa-miR-603	HITS-CLIP	28735896
MIRT575872	hsa-miR-603	HITS-CLIP	28735896
MIRT609724	hsa-miR-610	HITS-CLIP	28735896
MIRT609724	hsa-miR-610	HITS-CLIP	28735896
MIRT575875	hsa-miR-8485	HITS-CLIP	28735896
MIRT575875	hsa-miR-8485	HITS-CLIP	28735896
MIRT575874	hsa-miR-329-3p	HITS-CLIP	23313552
MIRT575873	hsa-miR-362-3p	HITS-CLIP	23313552
MIRT575872	hsa-miR-603	HITS-CLIP	23313552
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23313552
MIRT609724	hsa-miR-610	HITS-CLIP	23313552
MIRT575872	hsa-miR-603	HITS-CLIP	23313552
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23313552
MIRT609724	hsa-miR-610	HITS-CLIP	23313552
MIRT575875	hsa-miR-8485	HITS-CLIP	23824327
MIRT575872	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT575875	hsa-miR-8485	HITS-CLIP	23824327
MIRT575872	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT575875	hsa-miR-8485	HITS-CLIP	23824327
MIRT575872	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT575875	hsa-miR-8485	HITS-CLIP	23824327
MIRT575872	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT575875	hsa-miR-8485	HITS-CLIP	23824327
MIRT575872	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT625337	hsa-miR-4724-3p	HITS-CLIP	23824327
MIRT575875	hsa-miR-8485	HITS-CLIP	23824327
MIRT575872	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT575875	hsa-miR-8485	HITS-CLIP	23824327
MIRT575872	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT575875	hsa-miR-8485	HITS-CLIP	23824327
MIRT575872	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT625337	hsa-miR-4724-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT575872	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT575875	hsa-miR-8485	HITS-CLIP	23824327
MIRT575872	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT625337	hsa-miR-4724-3p	HITS-CLIP	23824327
MIRT575875	hsa-miR-8485	HITS-CLIP	23824327
MIRT575872	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT575875	hsa-miR-8485	HITS-CLIP	23824327
MIRT575872	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT575875	hsa-miR-8485	HITS-CLIP	23824327
MIRT575872	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT575875	hsa-miR-8485	HITS-CLIP	23824327
MIRT575872	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT625337	hsa-miR-4724-3p	HITS-CLIP	23824327
MIRT575875	hsa-miR-8485	HITS-CLIP	23824327
MIRT575872	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT575875	hsa-miR-8485	HITS-CLIP	23824327
MIRT575872	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT575875	hsa-miR-8485	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT575875	hsa-miR-8485	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT575872	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT625337	hsa-miR-4724-3p	HITS-CLIP	23824327
MIRT575875	hsa-miR-8485	HITS-CLIP	23824327
MIRT575872	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT575875	hsa-miR-8485	HITS-CLIP	23824327
MIRT575872	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT575875	hsa-miR-8485	HITS-CLIP	23824327
MIRT575872	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT575875	hsa-miR-8485	HITS-CLIP	23824327
MIRT575872	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT575875	hsa-miR-8485	HITS-CLIP	23824327
MIRT575872	hsa-miR-603	HITS-CLIP	23824327
MIRT609725	hsa-miR-216b-3p	HITS-CLIP	23824327
MIRT609724	hsa-miR-610	HITS-CLIP	23824327
MIRT1095089	hsa-miR-1256	CLIP-seq
MIRT1095090	hsa-miR-1271	CLIP-seq
MIRT1095091	hsa-miR-154	CLIP-seq
MIRT1095092	hsa-miR-182	CLIP-seq
MIRT1095093	hsa-miR-2116	CLIP-seq
MIRT1095094	hsa-miR-299-3p	CLIP-seq
MIRT1095095	hsa-miR-329	CLIP-seq
MIRT1095096	hsa-miR-3618	CLIP-seq
MIRT1095097	hsa-miR-3688-5p	CLIP-seq
MIRT1095098	hsa-miR-3692	CLIP-seq
MIRT1095099	hsa-miR-370	CLIP-seq
MIRT1095100	hsa-miR-4277	CLIP-seq
MIRT1095101	hsa-miR-4446-5p	CLIP-seq
MIRT1095102	hsa-miR-4477b	CLIP-seq
MIRT1095103	hsa-miR-4491	CLIP-seq
MIRT1095104	hsa-miR-4523	CLIP-seq
MIRT1095105	hsa-miR-4528	CLIP-seq
MIRT1095106	hsa-miR-4642	CLIP-seq
MIRT1095107	hsa-miR-4657	CLIP-seq
MIRT1095108	hsa-miR-4661-3p	CLIP-seq
MIRT1095109	hsa-miR-4755-5p	CLIP-seq
MIRT1095110	hsa-miR-4764-5p	CLIP-seq
MIRT1095111	hsa-miR-495	CLIP-seq
MIRT1095112	hsa-miR-498	CLIP-seq
MIRT1095113	hsa-miR-509-3p	CLIP-seq
MIRT1095114	hsa-miR-556-3p	CLIP-seq
MIRT1095115	hsa-miR-562	CLIP-seq
MIRT1095116	hsa-miR-934	CLIP-seq
MIRT1095117	hsa-miR-96	CLIP-seq
MIRT1095098	hsa-miR-3692	CLIP-seq
MIRT1095104	hsa-miR-4523	CLIP-seq
MIRT1095113	hsa-miR-509-3p	CLIP-seq
MIRT1095095	hsa-miR-329	CLIP-seq
MIRT1095095	hsa-miR-329	CLIP-seq
MIRT1095098	hsa-miR-3692	CLIP-seq
MIRT1095104	hsa-miR-4523	CLIP-seq
MIRT2025491	hsa-miR-4760-5p	CLIP-seq
MIRT1095113	hsa-miR-509-3p	CLIP-seq
MIRT2025492	hsa-miR-548t	CLIP-seq
MIRT2025493	hsa-miR-635	CLIP-seq
MIRT2025494	hsa-miR-646	CLIP-seq
MIRT2256742	hsa-miR-1205	CLIP-seq
MIRT2256743	hsa-miR-1305	CLIP-seq
MIRT2256744	hsa-miR-15a	CLIP-seq
MIRT2256745	hsa-miR-15b	CLIP-seq
MIRT2256746	hsa-miR-16	CLIP-seq
MIRT2256747	hsa-miR-195	CLIP-seq
MIRT1095093	hsa-miR-2116	CLIP-seq
MIRT1095095	hsa-miR-329	CLIP-seq
MIRT2256748	hsa-miR-33a	CLIP-seq
MIRT2256749	hsa-miR-33b	CLIP-seq
MIRT1095098	hsa-miR-3692	CLIP-seq
MIRT2256750	hsa-miR-375	CLIP-seq
MIRT2256751	hsa-miR-424	CLIP-seq
MIRT1095100	hsa-miR-4277	CLIP-seq
MIRT1095104	hsa-miR-4523	CLIP-seq
MIRT2256752	hsa-miR-4524	CLIP-seq
MIRT2256753	hsa-miR-497	CLIP-seq
MIRT2256754	hsa-miR-503	CLIP-seq
MIRT1095113	hsa-miR-509-3p	CLIP-seq
MIRT2025494	hsa-miR-646	CLIP-seq
MIRT1095098	hsa-miR-3692	CLIP-seq
MIRT1095104	hsa-miR-4523	CLIP-seq
MIRT1095113	hsa-miR-509-3p	CLIP-seq
MIRT2442307	hsa-miR-1296	CLIP-seq
MIRT2442308	hsa-miR-1302	CLIP-seq
MIRT2442309	hsa-miR-2909	CLIP-seq
MIRT2442310	hsa-miR-3141	CLIP-seq
MIRT2442311	hsa-miR-4298	CLIP-seq
MIRT2442312	hsa-miR-585	CLIP-seq
MIRT2558148	hsa-miR-105	CLIP-seq
MIRT2558149	hsa-miR-1202	CLIP-seq
MIRT1095089	hsa-miR-1256	CLIP-seq
MIRT1095090	hsa-miR-1271	CLIP-seq
MIRT2558150	hsa-miR-128	CLIP-seq
MIRT2442307	hsa-miR-1296	CLIP-seq
MIRT2442308	hsa-miR-1302	CLIP-seq
MIRT2558151	hsa-miR-144	CLIP-seq
MIRT2558152	hsa-miR-148a	CLIP-seq
MIRT2558153	hsa-miR-148b	CLIP-seq
MIRT2558154	hsa-miR-152	CLIP-seq
MIRT1095092	hsa-miR-182	CLIP-seq
MIRT2558155	hsa-miR-186	CLIP-seq
MIRT2558156	hsa-miR-1912	CLIP-seq
MIRT2558157	hsa-miR-2467-5p	CLIP-seq
MIRT2442309	hsa-miR-2909	CLIP-seq
MIRT2558158	hsa-miR-299-5p	CLIP-seq
MIRT2558159	hsa-miR-3127-5p	CLIP-seq
MIRT2558160	hsa-miR-3133	CLIP-seq
MIRT2442310	hsa-miR-3141	CLIP-seq
MIRT2558161	hsa-miR-3158-5p	CLIP-seq
MIRT2558162	hsa-miR-3194-5p	CLIP-seq
MIRT2558163	hsa-miR-331-3p	CLIP-seq
MIRT2558164	hsa-miR-3591-5p	CLIP-seq
MIRT2558165	hsa-miR-3646	CLIP-seq
MIRT2558166	hsa-miR-3682-5p	CLIP-seq
MIRT2558167	hsa-miR-371-5p	CLIP-seq
MIRT2558168	hsa-miR-371b-5p	CLIP-seq
MIRT2558169	hsa-miR-3914	CLIP-seq
MIRT2558170	hsa-miR-3918	CLIP-seq
MIRT2558171	hsa-miR-3972	CLIP-seq
MIRT2558172	hsa-miR-4255	CLIP-seq
MIRT2558173	hsa-miR-4267	CLIP-seq
MIRT2558174	hsa-miR-4272	CLIP-seq
MIRT2558175	hsa-miR-4279	CLIP-seq
MIRT2558176	hsa-miR-4282	CLIP-seq
MIRT2442311	hsa-miR-4298	CLIP-seq
MIRT1095105	hsa-miR-4528	CLIP-seq
MIRT1095106	hsa-miR-4642	CLIP-seq
MIRT2558177	hsa-miR-4659a-5p	CLIP-seq
MIRT2558178	hsa-miR-4659b-5p	CLIP-seq
MIRT2558179	hsa-miR-4695-5p	CLIP-seq
MIRT2558180	hsa-miR-4720-5p	CLIP-seq
MIRT2558181	hsa-miR-4731-3p	CLIP-seq
MIRT2558182	hsa-miR-4735-5p	CLIP-seq
MIRT2558183	hsa-miR-4771	CLIP-seq
MIRT2558184	hsa-miR-4776-3p	CLIP-seq
MIRT2558185	hsa-miR-4793-5p	CLIP-seq
MIRT2558186	hsa-miR-4799-3p	CLIP-seq
MIRT2558187	hsa-miR-4799-5p	CLIP-seq
MIRT2558188	hsa-miR-4801	CLIP-seq
MIRT2558189	hsa-miR-490-5p	CLIP-seq
MIRT1095111	hsa-miR-495	CLIP-seq
MIRT2558190	hsa-miR-499a-5p	CLIP-seq
MIRT2558191	hsa-miR-539	CLIP-seq
MIRT2558192	hsa-miR-543	CLIP-seq
MIRT2558193	hsa-miR-548a-3p	CLIP-seq
MIRT2558194	hsa-miR-548e	CLIP-seq
MIRT2558195	hsa-miR-548f	CLIP-seq
MIRT2558196	hsa-miR-582-5p	CLIP-seq
MIRT2442312	hsa-miR-585	CLIP-seq
MIRT2025493	hsa-miR-635	CLIP-seq
MIRT2558197	hsa-miR-665	CLIP-seq
MIRT2558198	hsa-miR-873	CLIP-seq
MIRT1095117	hsa-miR-96	CLIP-seq
MIRT2442307	hsa-miR-1296	CLIP-seq
MIRT2442308	hsa-miR-1302	CLIP-seq
MIRT2558152	hsa-miR-148a	CLIP-seq
MIRT2558153	hsa-miR-148b	CLIP-seq
MIRT2558154	hsa-miR-152	CLIP-seq
MIRT2442309	hsa-miR-2909	CLIP-seq
MIRT2442310	hsa-miR-3141	CLIP-seq
MIRT2558163	hsa-miR-331-3p	CLIP-seq
MIRT2442311	hsa-miR-4298	CLIP-seq
MIRT2558180	hsa-miR-4720-5p	CLIP-seq
MIRT2558181	hsa-miR-4731-3p	CLIP-seq
MIRT2558186	hsa-miR-4799-3p	CLIP-seq
MIRT2558188	hsa-miR-4801	CLIP-seq
MIRT2558191	hsa-miR-539	CLIP-seq
MIRT2442312	hsa-miR-585	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003777	Function	Microtubule motor activity	IEA
GO:0003777	Function	Microtubule motor activity	TAS	9782088
GO:0005515	Function	Protein binding	IPI	15644324, 19011756, 19135897, 32296183
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005871	Component	Kinesin complex	IBA
GO:0005871	Component	Kinesin complex	TAS	9782088
GO:0005874	Component	Microtubule	IBA
GO:0005874	Component	Microtubule	IEA
GO:0006996	Process	Organelle organization	TAS	9782088
GO:0007018	Process	Microtubule-based movement	IEA
GO:0007411	Process	Axon guidance	IBA
GO:0008017	Function	Microtubule binding	IBA
GO:0008017	Function	Microtubule binding	IEA
GO:0008045	Process	Motor neuron axon guidance	IEA
GO:0008298	Process	Intracellular mRNA localization	IEA
GO:0008574	Function	Plus-end-directed microtubule motor activity	IBA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016887	Function	ATP hydrolysis activity	IBA
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0030425	Component	Dendrite	IEA
GO:0032839	Component	Dendrite cytoplasm	IEA
GO:0034190	Function	Apolipoprotein receptor binding	IEA
GO:0035253	Component	Ciliary rootlet	IEA
GO:0042995	Component	Cell projection	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0043025	Component	Neuronal cell body	ISS
GO:0044295	Component	Axonal growth cone	IEA
GO:0044295	Component	Axonal growth cone	ISS
GO:0048489	Process	Synaptic vesicle transport	IBA
GO:0051028	Process	MRNA transport	IEA
GO:0051028	Process	MRNA transport	ISS
GO:0098964	Process	Anterograde dendritic transport of messenger ribonucleoprotein complex	IEA
GO:0098971	Process	Anterograde dendritic transport of neurotransmitter receptor complex	IBA
GO:0098982	Component	GABA-ergic synapse	IEA
GO:0099524	Component	Postsynaptic cytosol	IEA
GO:0099641	Process	Anterograde axonal protein transport	IEA
GO:0099641	Process	Anterograde axonal protein transport	ISS
GO:0150034	Component	Distal axon	IEA
GO:0150034	Component	Distal axon	ISS
GO:1904115	Component	Axon cytoplasm	IEA

Other IDs

• MIM: 604593
• HGNC: 6325
• e!Ensembl: ENSG00000168280

Protein

• UniProt ID: O60282
• Protein name: Kinesin heavy chain isoform 5C (EC 3.6.4.-) (Kinesin heavy chain neuron-specific 2) (Kinesin-1)
• Protein function: Microtubule-associated force-producing protein that may play a role in organelle transport. Has ATPase activity (By similarity). Involved in synaptic transmission (PubMed:24812067). Mediates dendritic trafficking of mRNAs (By similarity). Requir
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00225	Kinesin	14 → 327	Kinesin motor domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Highest expression in brain, prostate and testis, and moderate expression in kidney, small intestine and ovary.
• Sequence:

  MADPAECSIKVMCRFRPLNEAEILRGDKFIPKFKGDETVVIGQGKPYVFDRVLPPNTTQE
  QVYNACAKQIVKDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPQLMGIIPRIAHDIFDHI
  YSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLAVHEDKNRVPYVKGCTERFVSSPEEV
  MDVIDEGKANRHVAVTNMNEHSSRSHSIFLINIKQENVETEKKLSGKLYLVDLAGSEKVS
  KTGAEGAVLDEAKNINKSLSALGNVISALAEGTKTHVPYRDSKMTRILQDSLGGNCRTTI
  VICCSPSVFNEAETKSTLMFGQRAKTIKNTVSVNLELTAEEWKKKYEKEKEKNKTLKNVI
  QHLEMELNRWRNGEAVPEDEQISAKDQKNLEPCDNTPIIDNIAPVVAGISTEEKEKYDEE
  ISSLYRQLDDKDDEINQQSQLAEKLKQQMLDQDELLASTRRDYEKIQEELTRLQIENEAA
  KDEVKEVLQALEELAVNYDQKSQEVEDKTRANEQLTDELAQKTTTLTTTQRELSQLQELS
  NHQKKRATEILNLLLKDLGEIGGIIGTNDVKTLADVNGVIEEEFTMARLYISKMKSEVKS
  LVNRSKQLESAQMDSNRKMNASERELAACQLLISQHEAKIKSLTDYMQNMEQKRRQLEES
  QDSLSEELAKLRAQEKMHEVSFQDKEKEHLTRLQDAEEMKKALEQQMESHREAHQKQLSR
  LRDEIEEKQKIIDEIRDLNQKLQLEQEKLSSDYNKLKIEDQEREMKLEKLLLLNDKREQA
  REDLKGLEETVSRELQTLHNLRKLFVQDLTTRVKKSVELDNDDGGGSAAQKQKISFLENN
  LEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENAMRDRKRYQQE
  VDRIKEAVRAKNMARRAHSAQIAKPIRPGHYPASSPTAVHAIRGGGGSSSNSTHYQK

• Sequence length: 957

Pathways

KEGG:

Endocytosis
Dopaminergic synapse
Motor proteins
Alzheimer disease
Parkinson disease
Amyotrophic lateral sclerosis
Huntington disease
Prion disease
Pathways of neurodegeneration - multiple diseases
Salmonella infection
Non-small cell lung cancer

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Complex cortical dysplasia with other brain malformations 2	Likely pathogenic; Pathogenic	rs2105091650, rs587777570, rs1215264639, rs2468202034, rs587777035, rs1553463778	RCV004804254 RCV000128852 RCV002510719 RCV004804589 RCV003326039 RCV004802286 RCV000055625	★★★★★ ClinVar: Pathogenic / Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
Acute myeloid leukemia	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATTENTION DEFICIT HYPERACTIVITY DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BIPOLAR DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BREAST CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cervical cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORTICAL DYSPLASIA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 2	—	CTD, Disgenet, HPO CTD, Disgenet, HPO CTD, Disgenet, HPO	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Craniosynostosis syndrome	Conflicting classifications of pathogenicity	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEVELOPMENTAL DISABILITIES	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Developmental disorder	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Duane retraction syndrome	Uncertain significance	ClinVar Disgenet	★★★☆☆ Reported in Unknown/Other Associations (≥2 sources)
Jaw-winking syndrome	Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
KIF5C-related disorder	Likely benign; Benign; Uncertain significance	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MAJOR DEPRESSIVE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MALFORMATIONS OF CORTICAL DEVELOPMENT	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MICROCEPHALY	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet, GWAS catalog Disgenet, GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine corpus endometrial carcinoma	Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Arthrogryposis	Arthrogryposis multiplex congenita	HPO_DG			★☆☆☆☆ Found in Text Mining only
Congenital anomaly of brain	Brain malformation	BEFREE	29048727		★☆☆☆☆ Found in Text Mining only
Cortical Dysplasia	Cortical Dysplasia	CTD_human_DG	23603762		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cortical Dysplasia	Cortical Dysplasia	HPO_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 2	Cortical Dysplasia With Other Brain Malformations	UNIPROT_DG	23033978, 23603762, 24812067, 29048727		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 2	Cortical Dysplasia With Other Brain Malformations	CLINVAR_DG	23033978, 24812067, 26633545		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 2	Cortical Dysplasia With Other Brain Malformations	GENOMICS_ENGLAND_DG	23603762, 29048727		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 2	Cortical Dysplasia With Other Brain Malformations	CTD_human_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Developmental Disabilities	Developmental disability	Pubtator	29048727	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Epilepsy	Epilepsy	BEFREE	29048727		★☆☆☆☆ Found in Text Mining only
Epilepsy	Epilepsy	Pubtator	29048727	Associate	★☆☆☆☆ Found in Text Mining only
Epilepsy Benign Neonatal	Benign neonatal epilepsy	Pubtator	29048727	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	7501111		★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	7501111		★☆☆☆☆ Found in Text Mining only
Global developmental delay	Developmental Delay	HPO_DG			★☆☆☆☆ Found in Text Mining only
Henoch-Schoenlein Purpura	Henoch-Schonlein Nephritis	BEFREE	22714410		★☆☆☆☆ Found in Text Mining only
Hypoplasia of corpus callosum	Hypoplasia Of Corpus Callosum	HPO_DG			★☆☆☆☆ Found in Text Mining only
Intellectual Disability	Mental retardation	BEFREE	24812067		★☆☆☆☆ Found in Text Mining only
Language Disorders	Language development disorders	Pubtator	29048727	Associate	★☆☆☆☆ Found in Text Mining only
Lissencephaly	Lissencephaly	Pubtator	25140959	Associate	★☆☆☆☆ Found in Text Mining only
Macular dystrophy corneal type 1	Macular dystrophy	Pubtator	29048727	Associate	★☆☆☆☆ Found in Text Mining only
Macular dystrophy, corneal type 1	Macular corneal dystrophy	BEFREE	23603762, 29048727		★☆☆☆☆ Found in Text Mining only
Malformations of Cortical Development	Malformation of cortical development	CTD_human_DG	23603762		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malformations of Cortical Development	Cortical development malformation	Pubtator	29048727	Associate	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Microcephaly	Microcephaly	CTD_human_DG	23603762		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Microcephaly	Microcephaly	HPO_DG			★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Microlissencephaly	Microlissencephaly	CTD_human_DG	23603762		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	31844033		★☆☆☆☆ Found in Text Mining only
Neurodevelopmental Disorders	Neurodevelopmental Disorders	BEFREE	29048727		★☆☆☆☆ Found in Text Mining only
Pachygyria	Pachygyria	BEFREE	25140959		★☆☆☆☆ Found in Text Mining only
Pena-Shokeir syndrome type I	Pena Shokeir syndrome	HPO_DG			★☆☆☆☆ Found in Text Mining only
Polymicrogyria	Polymicrogyria	Pubtator	29048727	Associate	★☆☆☆☆ Found in Text Mining only
Polymicrogyria	Polymicrogyria	HPO_DG			★☆☆☆☆ Found in Text Mining only
Severe Congenital Microcephaly	Congenital Microcephaly	CTD_human_DG	23603762		★☆☆☆☆ Found in Text Mining only
Spastic paraplegia 10, autosomal dominant	Spondylometaphyseal dysplasia	BEFREE	12355402		★☆☆☆☆ Found in Text Mining only
Spastic Paraplegia, Hereditary	Spastic paraplegia	BEFREE	12355402, 18245137		★☆☆☆☆ Found in Text Mining only
Spastic Quadriplegia	Spastic Quadriplegia	HPO_DG			★☆☆☆☆ Found in Text Mining only
Thyroid cancer medullary	Medullary thyroid cancer	Pubtator	36713370	Associate	★☆☆☆☆ Found in Text Mining only