Gene Gene information from NCBI Gene database.
Entrez ID 3779
Gene name Potassium calcium-activated channel subfamily M regulatory beta subunit 1
Gene symbol KCNMB1
Synonyms (NCBI Gene)
BKbeta1K(VCA)betaSLO-BETAhbeta1hslo-betak(VCA)beta-1slo-beta-1
Chromosome 5
Chromosome location 5q35.1
Summary MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the
miRNA miRNA information provided by mirtarbase database.
356
miRTarBase ID miRNA Experiments Reference
MIRT724289 hsa-miR-4677-3p HITS-CLIP 19536157
MIRT724288 hsa-miR-4679 HITS-CLIP 19536157
MIRT724287 hsa-miR-1180-5p HITS-CLIP 19536157
MIRT724286 hsa-miR-7114-3p HITS-CLIP 19536157
MIRT724285 hsa-miR-4316 HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
GO ID Ontology Definition Evidence Reference
GO:0005513 Process Detection of calcium ion IBA
GO:0005515 Function Protein binding IPI 32296183
GO:0005886 Component Plasma membrane TAS
GO:0006811 Process Monoatomic ion transport IEA
GO:0006813 Process Potassium ion transport IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
603951 6285 ENSG00000145936
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q16558
Protein name Calcium-activated potassium channel subunit beta-1 (BK channel subunit beta-1) (BKbeta) (BKbeta1) (Hbeta1) (Calcium-activated potassium channel, subfamily M subunit beta-1) (Calcium-activated potassium channel subunit beta) (Charybdotoxin receptor subunit
Protein function Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03185 CaKB 7 190 Calcium-activated potassium channel, beta subunit Family
Tissue specificity TISSUE SPECIFICITY: Abundantly expressed in smooth muscle. Low levels of expression in most other tissues. Within the brain, relatively high levels found in hippocampus and corpus callosum.
Sequence
Sequence length 191
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  cGMP-PKG signaling pathway
Vascular smooth muscle contraction
Insulin secretion
  Ca2+ activated K+ channels
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CHRONIC OBSTRUCTIVE PULMONARY DISEASE GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPERTENSION CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HYPERTENSION, DIASTOLIC, RESISTANCE TO Benign; protective ClinVar
CTD, ClinVar, Disgenet
CTD, ClinVar, Disgenet
CTD, ClinVar, Disgenet
★★★☆☆
Reported in Unknown/Other Associations (≥2 sources)
HYPERTENSIVE DISEASE Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Alzheimer Disease Alzheimer disease Pubtator 16371011 Associate
★☆☆☆☆
Found in Text Mining only
Arteriosclerosis Arteriosclerosis BEFREE 25576871
★☆☆☆☆
Found in Text Mining only
Asthma Asthma BEFREE 18535015
★☆☆☆☆
Found in Text Mining only
Asthma Asthma LHGDN 18535015
★☆☆☆☆
Found in Text Mining only
Asthma Asthma Pubtator 18535015 Associate
★☆☆☆☆
Found in Text Mining only
Atherosclerosis Atherosclerosis BEFREE 25576871
★☆☆☆☆
Found in Text Mining only
Cardiovascular Diseases Cardiovascular disease Pubtator 16293791 Associate
★☆☆☆☆
Found in Text Mining only
Chronic Kidney Diseases Kidney Disease BEFREE 20861615
★☆☆☆☆
Found in Text Mining only
Coronary Arteriosclerosis Coronary Arteriosclerosis BEFREE 16155733
★☆☆☆☆
Found in Text Mining only
Diabetes Mellitus Diabetes mellitus Pubtator 20966391 Inhibit
★☆☆☆☆
Found in Text Mining only