Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	376132
Gene name	Leucine rich repeat containing 10
Gene symbol	LRRC10
Synonyms (NCBI Gene)	HRLRRPLRRC10A
Chromosome	12
Chromosome location	12q15

120

Show/Hide all (120)

miRTarBase ID	miRNA	Experiments	Reference
MIRT710257	hsa-miR-214-5p	HITS-CLIP	19536157
MIRT710256	hsa-miR-6811-3p	HITS-CLIP	19536157
MIRT710255	hsa-miR-6847-3p	HITS-CLIP	19536157
MIRT710254	hsa-miR-4284	HITS-CLIP	19536157
MIRT710253	hsa-miR-24-3p	HITS-CLIP	19536157
MIRT710252	hsa-miR-6772-5p	HITS-CLIP	19536157
MIRT710251	hsa-miR-4455	HITS-CLIP	19536157
MIRT710250	hsa-miR-609	HITS-CLIP	19536157
MIRT710249	hsa-miR-6514-3p	HITS-CLIP	19536157
MIRT710257	hsa-miR-214-5p	HITS-CLIP	19536157
MIRT710256	hsa-miR-6811-3p	HITS-CLIP	19536157
MIRT710255	hsa-miR-6847-3p	HITS-CLIP	19536157
MIRT710254	hsa-miR-4284	HITS-CLIP	19536157
MIRT710253	hsa-miR-24-3p	HITS-CLIP	19536157
MIRT710252	hsa-miR-6772-5p	HITS-CLIP	19536157
MIRT710251	hsa-miR-4455	HITS-CLIP	19536157
MIRT710250	hsa-miR-609	HITS-CLIP	19536157
MIRT710249	hsa-miR-6514-3p	HITS-CLIP	19536157
MIRT1118719	hsa-let-7a	CLIP-seq
MIRT1118720	hsa-let-7b	CLIP-seq
MIRT1118721	hsa-let-7c	CLIP-seq
MIRT1118722	hsa-let-7d	CLIP-seq
MIRT1118723	hsa-let-7e	CLIP-seq
MIRT1118724	hsa-let-7f	CLIP-seq
MIRT1118725	hsa-let-7g	CLIP-seq
MIRT1118726	hsa-let-7i	CLIP-seq
MIRT1118727	hsa-miR-1227	CLIP-seq
MIRT1118728	hsa-miR-1321	CLIP-seq
MIRT1118729	hsa-miR-219-5p	CLIP-seq
MIRT1118730	hsa-miR-3127-5p	CLIP-seq
MIRT1118731	hsa-miR-3529	CLIP-seq
MIRT1118732	hsa-miR-379	CLIP-seq
MIRT1118733	hsa-miR-3927	CLIP-seq
MIRT1118734	hsa-miR-4252	CLIP-seq
MIRT1118735	hsa-miR-4270	CLIP-seq
MIRT1118736	hsa-miR-4310	CLIP-seq
MIRT1118737	hsa-miR-4441	CLIP-seq
MIRT1118738	hsa-miR-4445	CLIP-seq
MIRT1118739	hsa-miR-4458	CLIP-seq
MIRT1118740	hsa-miR-4500	CLIP-seq
MIRT1118741	hsa-miR-4508	CLIP-seq
MIRT1118742	hsa-miR-451b	CLIP-seq
MIRT1118743	hsa-miR-4696	CLIP-seq
MIRT1118744	hsa-miR-4739	CLIP-seq
MIRT1118745	hsa-miR-4756-5p	CLIP-seq
MIRT1118746	hsa-miR-4782-3p	CLIP-seq
MIRT1118747	hsa-miR-4786-5p	CLIP-seq
MIRT1118748	hsa-miR-4797-5p	CLIP-seq
MIRT1118749	hsa-miR-508-3p	CLIP-seq
MIRT1118750	hsa-miR-593	CLIP-seq
MIRT1118751	hsa-miR-759	CLIP-seq
MIRT1118752	hsa-miR-769-5p	CLIP-seq
MIRT1118753	hsa-miR-98	CLIP-seq
MIRT1118727	hsa-miR-1227	CLIP-seq
MIRT2033568	hsa-miR-1299	CLIP-seq
MIRT1118729	hsa-miR-219-5p	CLIP-seq
MIRT2033569	hsa-miR-24	CLIP-seq
MIRT2033570	hsa-miR-3122	CLIP-seq
MIRT2033571	hsa-miR-3689a-3p	CLIP-seq
MIRT2033572	hsa-miR-3689c	CLIP-seq
MIRT2033573	hsa-miR-3913-5p	CLIP-seq
MIRT1118734	hsa-miR-4252	CLIP-seq
MIRT2033574	hsa-miR-4259	CLIP-seq
MIRT2033575	hsa-miR-4311	CLIP-seq
MIRT1118738	hsa-miR-4445	CLIP-seq
MIRT2033576	hsa-miR-4728-5p	CLIP-seq
MIRT1118746	hsa-miR-4782-3p	CLIP-seq
MIRT1118747	hsa-miR-4786-5p	CLIP-seq
MIRT2033577	hsa-miR-4793-3p	CLIP-seq
MIRT1118748	hsa-miR-4797-5p	CLIP-seq
MIRT2033578	hsa-miR-485-5p	CLIP-seq
MIRT1118749	hsa-miR-508-3p	CLIP-seq
MIRT1118751	hsa-miR-759	CLIP-seq
MIRT1118752	hsa-miR-769-5p	CLIP-seq
MIRT2264008	hsa-miR-1257	CLIP-seq
MIRT2033569	hsa-miR-24	CLIP-seq
MIRT2264009	hsa-miR-3136-5p	CLIP-seq
MIRT2264010	hsa-miR-345	CLIP-seq
MIRT1118734	hsa-miR-4252	CLIP-seq
MIRT2264011	hsa-miR-4439	CLIP-seq
MIRT2264012	hsa-miR-4453	CLIP-seq
MIRT2264013	hsa-miR-4493	CLIP-seq
MIRT2264014	hsa-miR-4505	CLIP-seq
MIRT2264015	hsa-miR-4513	CLIP-seq
MIRT2264016	hsa-miR-4538	CLIP-seq
MIRT2264017	hsa-miR-4652-3p	CLIP-seq
MIRT2264018	hsa-miR-4661-5p	CLIP-seq
MIRT2264019	hsa-miR-4677-3p	CLIP-seq
MIRT2264020	hsa-miR-4679	CLIP-seq
MIRT1118747	hsa-miR-4786-5p	CLIP-seq
MIRT1118748	hsa-miR-4797-5p	CLIP-seq
MIRT1118750	hsa-miR-593	CLIP-seq
MIRT2264021	hsa-miR-635	CLIP-seq
MIRT1118751	hsa-miR-759	CLIP-seq
MIRT1118752	hsa-miR-769-5p	CLIP-seq
MIRT1118734	hsa-miR-4252	CLIP-seq
MIRT2033569	hsa-miR-24	CLIP-seq
MIRT2033570	hsa-miR-3122	CLIP-seq
MIRT2033571	hsa-miR-3689a-3p	CLIP-seq
MIRT2033572	hsa-miR-3689c	CLIP-seq
MIRT2033573	hsa-miR-3913-5p	CLIP-seq
MIRT2563163	hsa-miR-3929	CLIP-seq
MIRT2563164	hsa-miR-4419b	CLIP-seq
MIRT2563165	hsa-miR-4478	CLIP-seq
MIRT2264013	hsa-miR-4493	CLIP-seq
MIRT2264014	hsa-miR-4505	CLIP-seq
MIRT2033576	hsa-miR-4728-5p	CLIP-seq
MIRT1118747	hsa-miR-4786-5p	CLIP-seq
MIRT2033578	hsa-miR-485-5p	CLIP-seq
MIRT1118750	hsa-miR-593	CLIP-seq
MIRT1118752	hsa-miR-769-5p	CLIP-seq
MIRT2033570	hsa-miR-3122	CLIP-seq
MIRT2033571	hsa-miR-3689a-3p	CLIP-seq
MIRT2033572	hsa-miR-3689c	CLIP-seq
MIRT2033573	hsa-miR-3913-5p	CLIP-seq
MIRT2563163	hsa-miR-3929	CLIP-seq
MIRT2563164	hsa-miR-4419b	CLIP-seq
MIRT2563165	hsa-miR-4478	CLIP-seq
MIRT2033576	hsa-miR-4728-5p	CLIP-seq
MIRT2033578	hsa-miR-485-5p	CLIP-seq

Show/Hide all (12)

GO ID	Ontology	Definition	Evidence
GO:0003779	Function	Actin binding	IBA
GO:0003779	Function	Actin binding	IEA
GO:0005634	Component	Nucleus	IEA
GO:0005739	Component	Mitochondrion	IEA
GO:0005856	Component	Cytoskeleton	IBA
GO:0005856	Component	Cytoskeleton	IEA
GO:0030016	Component	Myofibril	IEA
GO:0030017	Component	Sarcomere	IBA
GO:0030017	Component	Sarcomere	IEA
GO:0051393	Function	Alpha-actinin binding	IEA
GO:0055013	Process	Cardiac muscle cell development	IBA
GO:0055013	Process	Cardiac muscle cell development	IEA

MIM	HGNC	e!Ensembl
610846	20264	ENSG00000198812

Q5BKY1

Protein name

Leucine-rich repeat-containing protein 10

Protein function

May play important roles in cardiac development and/or cardiac function.

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13855	LRR_8	52 → 110	Leucine rich repeat	Repeat
PF13855	LRR_8	75 → 131	Leucine rich repeat	Repeat

Sequence

MGNTIRALVAFIPADRCQNYVVRDLREMPLDKMVDLSGSQLRRFPLHVCSFRELVKLYLS
DNHLNSLPPELGQLQNLQILALDFNNFKALPQVVCTLKQLCILYLGNNKLCDLPSELSLL
QNLRTLWIEANCLTQLPDVVCELSLLKTLHAGSNALRLLPGQLRRLQELRTIWLSGNRLT
DFPTVLLHMPFLEVIDVDWNSIRYFPSLAHLSSLKLVIYDHNPCRNAPKVAKGVRRVGRW
AEETPEPDPRKARRYALVREESQELQAPVPLLPPTNS

Sequence length

277

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (8)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ATRIAL FIBRILLATION	—	CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog CTD, Disgenet, GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATRIAL FLUTTER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOMYOPATHY, DILATED	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGESTIVE HEART FAILURE	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Dilated Cardiomyopathy, Dominant	Uncertain significance; Likely benign; Conflicting classifications of pathogenicity; Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HEART FAILURE	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LRRC10-related disorder	Benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PSYCHIATRIC DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Atrial Fibrillation	Atrial Fibrillation	CTD_human_DG	30061737		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Brugada Syndrome	Brugada syndrome	Pubtator	28032242	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Brugada Syndrome (disorder)	Brugada Syndrome	BEFREE	28032242		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	BEFREE	28032242		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	Pubtator	28032242	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathy Dilated	Dilated cardiomyopathy	Pubtator	28032242	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiomyopathy, Dilated	Cardiomyopathy	BEFREE	28032242, 29431102		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Cardiomyopathy, Familial Idiopathic	Cardiomyopathy	BEFREE	26017719, 29431102		★★★★★ ★☆☆☆☆ Found in Text Mining only
Paroxysmal atrial fibrillation	Paroxysmal atrial fibrillation	CTD_human_DG	30061737		★★★★★ ★☆☆☆☆ Found in Text Mining only

LRRC10 (leucine rich repeat containing 10)