SPATC1 (spermatogenesis and centriole associated 1)

Gene

• Entrez ID: 375686
• Gene name: Spermatogenesis and centriole associated 1
• Gene symbol: SPATC1
• Synonyms (NCBI Gene): SPATA15
• Chromosome: 8
• Chromosome location: 8q24.3

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT1382806	hsa-miR-1538	CLIP-seq
MIRT1382807	hsa-miR-1827	CLIP-seq
MIRT1382808	hsa-miR-29a	CLIP-seq
MIRT1382809	hsa-miR-29b	CLIP-seq
MIRT1382810	hsa-miR-29c	CLIP-seq
MIRT1382811	hsa-miR-3065-3p	CLIP-seq
MIRT1382812	hsa-miR-3612	CLIP-seq
MIRT1382813	hsa-miR-4695-5p	CLIP-seq
MIRT1382814	hsa-miR-4745-3p	CLIP-seq
MIRT1382815	hsa-miR-4783-3p	CLIP-seq
MIRT1382816	hsa-miR-4792	CLIP-seq
MIRT1382817	hsa-miR-650	CLIP-seq
MIRT1382818	hsa-miR-665	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IBA
GO:0005813	Component	Centrosome	IDA	20542897
GO:0005813	Component	Centrosome	IEA
GO:0005856	Component	Cytoskeleton	IEA

Other IDs

• MIM: 610874
• HGNC: 30510
• e!Ensembl: ENSG00000186583

Protein

• UniProt ID: Q76KD6
• Protein name: Speriolin (Spermatogenesis and centriole-associated protein 1) (Spermatogenesis-associated protein 15) (Spermatogenic cell-specific Cdc20-binding protein)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15058	Speriolin_N	1 → 228	Speriolin N terminus	Family
  PF15059	Speriolin_C	445 → 591	Speriolin C-terminus	Family

• Tissue specificity: TISSUE SPECIFICITY: Detected only in testis. {ECO:0000269|PubMed:20542897}.
• Sequence:

  MSLLTNYEGLRHQIERLVRENEELKKLVRLIRENHELKSAIKTQAGGLGISGFTSGLGEA
  TAGLSSRQNNGVFLPPSPAVANERVLEEVGIMALAPLAEMLTSLQPSATPGSLMSPLTGT
  LSTLLSGPAPTSQSSPLTSFLTSPIAGPLTGTLASSLGLPSTGTLTPSSLVAGPVAMSQS
  SPLIAPVMGTVAVSLSSPLLSSTATPPGVSQNLLANPMSNLVLPEAPRLRLAEPLRGGPT
  GPQSPACVVPTATTKVPLSTEPPQSTQDPEPLSMAFAGAPLQTSTPIGAMGTPAPKTAFS
  FNTSDTQAQPSAAQEQVVPASVPTSPTTSPTVTVLASAPALAPQVATSYTPSSTTHIAQG
  APHPPSRMHNSPTQNLPVPHCPPHNAHSPPRTSSSPASVNDSRGPRTTEPSTKSMMEVER
  KLAHRKTSKFPENPRESKQLAWERLVGEIAFQLDRRILSSIFPERVRLYGFTVSNIPEKI
  IQASLNPSDHKLDEKLCQRLTQRYVSVMNRLQSLGYNGRVHPALTEQLVNAYGILRERPE
  LAASEGGPYTVDFLQRVVVETVHPGMLADALLLLSCLSQLAHDDGKPMFIW

• Sequence length: 591

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CROHN'S DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DEMENTIA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GASTROESOPHAGEAL REFLUX DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INFLAMMATORY BOWEL DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations