Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	374946
Gene name	Dorsal inhibitory axon guidance protein
Gene symbol	DRAXIN
Synonyms (NCBI Gene)	AGPA3119C1orf187UNQ3119neucrin
Chromosome	1
Chromosome location	1p36.22

175

Show/Hide all (175)

miRTarBase ID	miRNA	Experiments	Reference
MIRT051878	hsa-let-7b-5p	CLASH	23622248
MIRT714655	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT714658	hsa-miR-28-3p	HITS-CLIP	19536157
MIRT714657	hsa-miR-6502-3p	HITS-CLIP	19536157
MIRT658894	hsa-miR-4714-3p	HITS-CLIP	19536157
MIRT714656	hsa-miR-5690	HITS-CLIP	19536157
MIRT714655	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT704133	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT704132	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT704131	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT704130	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT704129	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT704128	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT704127	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT704126	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT704125	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT704124	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT704123	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT704122	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT704121	hsa-miR-302e	HITS-CLIP	23313552
MIRT704120	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT704119	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT704118	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT704117	hsa-miR-520b	HITS-CLIP	23313552
MIRT704116	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT704115	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT704114	hsa-miR-520e	HITS-CLIP	23313552
MIRT704113	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT704112	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT704111	hsa-miR-520h	HITS-CLIP	23313552
MIRT704110	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT704109	hsa-miR-212-5p	HITS-CLIP	23313552
MIRT704108	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT704107	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT704106	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT704105	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT704104	hsa-miR-4757-5p	HITS-CLIP	23313552
MIRT704103	hsa-miR-6744-3p	HITS-CLIP	23313552
MIRT704102	hsa-miR-6878-3p	HITS-CLIP	23313552
MIRT658898	hsa-miR-4418	HITS-CLIP	23824327
MIRT658897	hsa-miR-509-3-5p	HITS-CLIP	23824327
MIRT658896	hsa-miR-509-5p	HITS-CLIP	23824327
MIRT658895	hsa-miR-2681-3p	HITS-CLIP	23824327
MIRT658894	hsa-miR-4714-3p	HITS-CLIP	23824327
MIRT658893	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT658892	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT658891	hsa-miR-1184	HITS-CLIP	23824327
MIRT658890	hsa-miR-635	HITS-CLIP	23824327
MIRT658889	hsa-miR-6774-5p	HITS-CLIP	23824327
MIRT658888	hsa-miR-4284	HITS-CLIP	23824327
MIRT658887	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT658886	hsa-miR-4437	HITS-CLIP	23824327
MIRT658885	hsa-miR-7156-3p	HITS-CLIP	23824327
MIRT658884	hsa-miR-4674	HITS-CLIP	23824327
MIRT658883	hsa-miR-1587	HITS-CLIP	23824327
MIRT658882	hsa-miR-3620-5p	HITS-CLIP	23824327
MIRT509922	hsa-miR-6746-3p	PAR-CLIP	22012620
MIRT509921	hsa-miR-1292-3p	PAR-CLIP	22012620
MIRT509920	hsa-miR-4537	PAR-CLIP	22012620
MIRT509919	hsa-miR-6869-3p	PAR-CLIP	22012620
MIRT509922	hsa-miR-6746-3p	PAR-CLIP	23446348
MIRT509921	hsa-miR-1292-3p	PAR-CLIP	23446348
MIRT509920	hsa-miR-4537	PAR-CLIP	23446348
MIRT509919	hsa-miR-6869-3p	PAR-CLIP	23446348
MIRT509922	hsa-miR-6746-3p	PAR-CLIP	23446348
MIRT509921	hsa-miR-1292-3p	PAR-CLIP	23446348
MIRT509920	hsa-miR-4537	PAR-CLIP	23446348
MIRT509919	hsa-miR-6869-3p	PAR-CLIP	23446348
MIRT450313	hsa-miR-603	PAR-CLIP	22100165
MIRT450312	hsa-miR-28-5p	PAR-CLIP	22100165
MIRT450311	hsa-miR-3139	PAR-CLIP	22100165
MIRT450310	hsa-miR-708-5p	PAR-CLIP	22100165
MIRT450309	hsa-miR-216b-3p	PAR-CLIP	22100165
MIRT450308	hsa-miR-4790-3p	PAR-CLIP	22100165
MIRT450307	hsa-miR-4533	PAR-CLIP	22100165
MIRT450305	hsa-miR-4747-5p	PAR-CLIP	22100165
MIRT450306	hsa-miR-5196-5p	PAR-CLIP	22100165
MIRT450304	hsa-miR-4271	PAR-CLIP	22100165
MIRT450303	hsa-miR-4725-3p	PAR-CLIP	22100165
MIRT450302	hsa-miR-6780b-5p	PAR-CLIP	22100165
MIRT450301	hsa-miR-2110	PAR-CLIP	22100165
MIRT450300	hsa-miR-6810-5p	PAR-CLIP	22100165
MIRT450299	hsa-miR-3150a-3p	PAR-CLIP	22100165
MIRT450298	hsa-miR-6763-5p	PAR-CLIP	22100165
MIRT450297	hsa-miR-6857-5p	PAR-CLIP	22100165
MIRT450296	hsa-miR-450a-2-3p	PAR-CLIP	22100165
MIRT450294	hsa-miR-4260	PAR-CLIP	22100165
MIRT450295	hsa-miR-5572	PAR-CLIP	22100165
MIRT714655	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT714658	hsa-miR-28-3p	HITS-CLIP	19536157
MIRT714657	hsa-miR-6502-3p	HITS-CLIP	19536157
MIRT658894	hsa-miR-4714-3p	HITS-CLIP	19536157
MIRT714656	hsa-miR-5690	HITS-CLIP	19536157
MIRT714655	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT704133	hsa-miR-106a-5p	HITS-CLIP	23313552
MIRT704132	hsa-miR-106b-5p	HITS-CLIP	23313552
MIRT704131	hsa-miR-17-5p	HITS-CLIP	23313552
MIRT704130	hsa-miR-20a-5p	HITS-CLIP	23313552
MIRT704129	hsa-miR-20b-5p	HITS-CLIP	23313552
MIRT704128	hsa-miR-519d-3p	HITS-CLIP	23313552
MIRT704127	hsa-miR-526b-3p	HITS-CLIP	23313552
MIRT704126	hsa-miR-93-5p	HITS-CLIP	23313552
MIRT704125	hsa-miR-302a-3p	HITS-CLIP	23313552
MIRT704124	hsa-miR-302b-3p	HITS-CLIP	23313552
MIRT704123	hsa-miR-302c-3p	HITS-CLIP	23313552
MIRT704122	hsa-miR-302d-3p	HITS-CLIP	23313552
MIRT704121	hsa-miR-302e	HITS-CLIP	23313552
MIRT704120	hsa-miR-372-3p	HITS-CLIP	23313552
MIRT704119	hsa-miR-373-3p	HITS-CLIP	23313552
MIRT704118	hsa-miR-520a-3p	HITS-CLIP	23313552
MIRT704117	hsa-miR-520b	HITS-CLIP	23313552
MIRT704116	hsa-miR-520c-3p	HITS-CLIP	23313552
MIRT704115	hsa-miR-520d-3p	HITS-CLIP	23313552
MIRT704114	hsa-miR-520e	HITS-CLIP	23313552
MIRT704113	hsa-miR-512-3p	HITS-CLIP	23313552
MIRT704112	hsa-miR-520g-3p	HITS-CLIP	23313552
MIRT704111	hsa-miR-520h	HITS-CLIP	23313552
MIRT704110	hsa-miR-186-3p	HITS-CLIP	23313552
MIRT704109	hsa-miR-212-5p	HITS-CLIP	23313552
MIRT704108	hsa-miR-150-5p	HITS-CLIP	23313552
MIRT704107	hsa-miR-6778-3p	HITS-CLIP	23313552
MIRT704106	hsa-miR-4731-5p	HITS-CLIP	23313552
MIRT704105	hsa-miR-5589-5p	HITS-CLIP	23313552
MIRT704104	hsa-miR-4757-5p	HITS-CLIP	23313552
MIRT704103	hsa-miR-6744-3p	HITS-CLIP	23313552
MIRT704102	hsa-miR-6878-3p	HITS-CLIP	23313552
MIRT658898	hsa-miR-4418	HITS-CLIP	23824327
MIRT658897	hsa-miR-509-3-5p	HITS-CLIP	23824327
MIRT658896	hsa-miR-509-5p	HITS-CLIP	23824327
MIRT658895	hsa-miR-2681-3p	HITS-CLIP	23824327
MIRT658894	hsa-miR-4714-3p	HITS-CLIP	23824327
MIRT658893	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT658892	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT658891	hsa-miR-1184	HITS-CLIP	23824327
MIRT658890	hsa-miR-635	HITS-CLIP	23824327
MIRT658889	hsa-miR-6774-5p	HITS-CLIP	23824327
MIRT658888	hsa-miR-4284	HITS-CLIP	23824327
MIRT658887	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT658886	hsa-miR-4437	HITS-CLIP	23824327
MIRT658885	hsa-miR-7156-3p	HITS-CLIP	23824327
MIRT658884	hsa-miR-4674	HITS-CLIP	23824327
MIRT658883	hsa-miR-1587	HITS-CLIP	23824327
MIRT658882	hsa-miR-3620-5p	HITS-CLIP	23824327
MIRT509922	hsa-miR-6746-3p	PAR-CLIP	22012620
MIRT509921	hsa-miR-1292-3p	PAR-CLIP	22012620
MIRT509920	hsa-miR-4537	PAR-CLIP	22012620
MIRT509919	hsa-miR-6869-3p	PAR-CLIP	22012620
MIRT509922	hsa-miR-6746-3p	PAR-CLIP	23446348
MIRT509921	hsa-miR-1292-3p	PAR-CLIP	23446348
MIRT509920	hsa-miR-4537	PAR-CLIP	23446348
MIRT509919	hsa-miR-6869-3p	PAR-CLIP	23446348
MIRT509922	hsa-miR-6746-3p	PAR-CLIP	23446348
MIRT509921	hsa-miR-1292-3p	PAR-CLIP	23446348
MIRT509920	hsa-miR-4537	PAR-CLIP	23446348
MIRT509919	hsa-miR-6869-3p	PAR-CLIP	23446348
MIRT450313	hsa-miR-603	PAR-CLIP	22100165
MIRT450312	hsa-miR-28-5p	PAR-CLIP	22100165
MIRT450311	hsa-miR-3139	PAR-CLIP	22100165
MIRT450310	hsa-miR-708-5p	PAR-CLIP	22100165
MIRT450309	hsa-miR-216b-3p	PAR-CLIP	22100165
MIRT450308	hsa-miR-4790-3p	PAR-CLIP	22100165
MIRT450307	hsa-miR-4533	PAR-CLIP	22100165
MIRT450305	hsa-miR-4747-5p	PAR-CLIP	22100165
MIRT450306	hsa-miR-5196-5p	PAR-CLIP	22100165
MIRT450304	hsa-miR-4271	PAR-CLIP	22100165
MIRT450303	hsa-miR-4725-3p	PAR-CLIP	22100165
MIRT450302	hsa-miR-6780b-5p	PAR-CLIP	22100165
MIRT450301	hsa-miR-2110	PAR-CLIP	22100165
MIRT450300	hsa-miR-6810-5p	PAR-CLIP	22100165
MIRT450299	hsa-miR-3150a-3p	PAR-CLIP	22100165
MIRT450298	hsa-miR-6763-5p	PAR-CLIP	22100165
MIRT450297	hsa-miR-6857-5p	PAR-CLIP	22100165
MIRT450296	hsa-miR-450a-2-3p	PAR-CLIP	22100165
MIRT450294	hsa-miR-4260	PAR-CLIP	22100165
MIRT450295	hsa-miR-5572	PAR-CLIP	22100165

Show/Hide all (27)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	26190107
GO:0005576	Component	Extracellular region	IBA
GO:0005576	Component	Extracellular region	IEA
GO:0005576	Component	Extracellular region	ISS
GO:0007411	Process	Axon guidance	IBA
GO:0007411	Process	Axon guidance	IEA
GO:0007411	Process	Axon guidance	ISS
GO:0010977	Process	Negative regulation of neuron projection development	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0021516	Process	Dorsal spinal cord development	IBA
GO:0021516	Process	Dorsal spinal cord development	IEA
GO:0021516	Process	Dorsal spinal cord development	ISS
GO:0021528	Process	Commissural neuron differentiation in spinal cord	IBA
GO:0021528	Process	Commissural neuron differentiation in spinal cord	IEA
GO:0021528	Process	Commissural neuron differentiation in spinal cord	ISS
GO:0021960	Process	Anterior commissure morphogenesis	IEA
GO:0030517	Process	Negative regulation of axon extension	IEA
GO:0030900	Process	Forebrain development	IBA
GO:0030900	Process	Forebrain development	IEA
GO:0030900	Process	Forebrain development	ISS
GO:0051402	Process	Neuron apoptotic process	IEA
GO:0060090	Function	Molecular adaptor activity	EXP	29503192
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IBA
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	IEA
GO:0090090	Process	Negative regulation of canonical Wnt signaling pathway	ISS
GO:0110088	Process	Hippocampal neuron apoptotic process	IEA
GO:0110091	Process	Negative regulation of hippocampal neuron apoptotic process	IEA

MIM	HGNC	e!Ensembl
612682	25054	ENSG00000162490

Q8NBI3

Protein name

Draxin (Dorsal inhibitory axon guidance protein) (Dorsal repulsive axon guidance protein) (Neucrin)

Protein function

Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsa

PDB

6FKQ

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF15550	Draxin	37 → 349	Draxin	Family

Sequence

MAGPAIHTAPMLFLVLLLPLELSLAGALAPGTPARNLPENHIDLPGPALWTPQASHHRRR
GPGKKEWGPGLPSQAQDGAVVTATRQASRLPEAEGLLPEQSPAGLLQDKDLLLGLALPYP
EKENRPPGWERTRKRSREHKRRRDRLRLHQGRALVRGPSSLMKKAELSEAQVLDAAMEES
STSLAPTMFFLTTFEAAPATEESLILPVTSLRPQQAQPRSDGEVMPTLDMALFDWTDYED
LKPDGWPSAKKKEKHRGKLSSDGNETSPAEGEPCDHHQDCLPGTCCDLREHLCTPHNRGL
NNKCFDDCMCVEGLRCYAKFHRNRRVTRRKGRCVEPETANGDQGSFINV

Sequence length

349

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (12)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTISM SPECTRUM DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of urinary bladder	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OBSESSIVE-COMPULSIVE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PARKINSON DISEASE	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (2)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Glioma	Glioma	Pubtator	36040678	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	CTD_human_DG	25475535		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

DRAXIN (dorsal inhibitory axon guidance protein)