Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	374659
Gene name	HD domain containing 3
Gene symbol	HDDC3
Synonyms (NCBI Gene)	(ppGpp)aseMESH1MYNRL15
Chromosome	15
Chromosome location	15q26.1

116

Show/Hide all (116)

miRTarBase ID	miRNA	Experiments	Reference
MIRT617208	hsa-miR-4708-3p	HITS-CLIP	23824327
MIRT617208	hsa-miR-4708-3p	HITS-CLIP	23824327
MIRT617208	hsa-miR-4708-3p	HITS-CLIP	23824327
MIRT617208	hsa-miR-4708-3p	HITS-CLIP	23824327
MIRT617208	hsa-miR-4708-3p	HITS-CLIP	23824327
MIRT617208	hsa-miR-4708-3p	HITS-CLIP	23824327
MIRT617208	hsa-miR-4708-3p	HITS-CLIP	23824327
MIRT617208	hsa-miR-4708-3p	HITS-CLIP	23824327
MIRT617208	hsa-miR-4708-3p	HITS-CLIP	23824327
MIRT617208	hsa-miR-4708-3p	HITS-CLIP	23824327
MIRT1042615	hsa-miR-1193	CLIP-seq
MIRT1042616	hsa-miR-1224-3p	CLIP-seq
MIRT1042617	hsa-miR-1225-5p	CLIP-seq
MIRT1042618	hsa-miR-125a-5p	CLIP-seq
MIRT1042619	hsa-miR-125b	CLIP-seq
MIRT1042620	hsa-miR-1260	CLIP-seq
MIRT1042621	hsa-miR-1260b	CLIP-seq
MIRT1042622	hsa-miR-1264	CLIP-seq
MIRT1042623	hsa-miR-1280	CLIP-seq
MIRT1042624	hsa-miR-129-5p	CLIP-seq
MIRT1042625	hsa-miR-188-3p	CLIP-seq
MIRT1042626	hsa-miR-2114	CLIP-seq
MIRT1042627	hsa-miR-216a	CLIP-seq
MIRT1042628	hsa-miR-216b	CLIP-seq
MIRT1042629	hsa-miR-2355-5p	CLIP-seq
MIRT1042630	hsa-miR-24	CLIP-seq
MIRT1042631	hsa-miR-3156-3p	CLIP-seq
MIRT1042632	hsa-miR-3184	CLIP-seq
MIRT1042633	hsa-miR-3186-3p	CLIP-seq
MIRT1042634	hsa-miR-3664-3p	CLIP-seq
MIRT1042635	hsa-miR-3679-3p	CLIP-seq
MIRT1042636	hsa-miR-3920	CLIP-seq
MIRT1042637	hsa-miR-423-5p	CLIP-seq
MIRT1042638	hsa-miR-4283	CLIP-seq
MIRT1042639	hsa-miR-4286	CLIP-seq
MIRT1042640	hsa-miR-4319	CLIP-seq
MIRT1042641	hsa-miR-4426	CLIP-seq
MIRT1042642	hsa-miR-4433	CLIP-seq
MIRT1042643	hsa-miR-4437	CLIP-seq
MIRT1042644	hsa-miR-4446-5p	CLIP-seq
MIRT1042645	hsa-miR-4459	CLIP-seq
MIRT1042646	hsa-miR-4508	CLIP-seq
MIRT1042647	hsa-miR-4640-5p	CLIP-seq
MIRT1042648	hsa-miR-4647	CLIP-seq
MIRT1042649	hsa-miR-4662b	CLIP-seq
MIRT1042650	hsa-miR-4726-5p	CLIP-seq
MIRT1042651	hsa-miR-4732-3p	CLIP-seq
MIRT1042652	hsa-miR-4756-3p	CLIP-seq
MIRT1042653	hsa-miR-4757-5p	CLIP-seq
MIRT1042654	hsa-miR-4768-3p	CLIP-seq
MIRT1042655	hsa-miR-513c	CLIP-seq
MIRT1042656	hsa-miR-514b-5p	CLIP-seq
MIRT1042657	hsa-miR-544b	CLIP-seq
MIRT1042658	hsa-miR-548p	CLIP-seq
MIRT1042659	hsa-miR-670	CLIP-seq
MIRT1042660	hsa-miR-744	CLIP-seq
MIRT1042616	hsa-miR-1224-3p	CLIP-seq
MIRT1042618	hsa-miR-125a-5p	CLIP-seq
MIRT1042619	hsa-miR-125b	CLIP-seq
MIRT1042620	hsa-miR-1260	CLIP-seq
MIRT1042621	hsa-miR-1260b	CLIP-seq
MIRT1042623	hsa-miR-1280	CLIP-seq
MIRT1042624	hsa-miR-129-5p	CLIP-seq
MIRT1042625	hsa-miR-188-3p	CLIP-seq
MIRT1042630	hsa-miR-24	CLIP-seq
MIRT1042631	hsa-miR-3156-3p	CLIP-seq
MIRT1042633	hsa-miR-3186-3p	CLIP-seq
MIRT2009041	hsa-miR-3670	CLIP-seq
MIRT1042638	hsa-miR-4283	CLIP-seq
MIRT2009042	hsa-miR-4300	CLIP-seq
MIRT1042640	hsa-miR-4319	CLIP-seq
MIRT2009043	hsa-miR-4419a	CLIP-seq
MIRT1042643	hsa-miR-4437	CLIP-seq
MIRT1042646	hsa-miR-4508	CLIP-seq
MIRT2009044	hsa-miR-4510	CLIP-seq
MIRT1042654	hsa-miR-4768-3p	CLIP-seq
MIRT1042659	hsa-miR-670	CLIP-seq
MIRT1042660	hsa-miR-744	CLIP-seq
MIRT2009045	hsa-miR-920	CLIP-seq
MIRT1042616	hsa-miR-1224-3p	CLIP-seq
MIRT1042620	hsa-miR-1260	CLIP-seq
MIRT1042621	hsa-miR-1260b	CLIP-seq
MIRT1042623	hsa-miR-1280	CLIP-seq
MIRT1042625	hsa-miR-188-3p	CLIP-seq
MIRT2241377	hsa-miR-2110	CLIP-seq
MIRT1042630	hsa-miR-24	CLIP-seq
MIRT2241378	hsa-miR-3150a-3p	CLIP-seq
MIRT1042631	hsa-miR-3156-3p	CLIP-seq
MIRT2241379	hsa-miR-3175	CLIP-seq
MIRT1042633	hsa-miR-3186-3p	CLIP-seq
MIRT1042636	hsa-miR-3920	CLIP-seq
MIRT1042638	hsa-miR-4283	CLIP-seq
MIRT1042643	hsa-miR-4437	CLIP-seq
MIRT1042646	hsa-miR-4508	CLIP-seq
MIRT2241380	hsa-miR-4524	CLIP-seq
MIRT2241381	hsa-miR-4690-5p	CLIP-seq
MIRT2241382	hsa-miR-4694-3p	CLIP-seq
MIRT2241383	hsa-miR-4711-5p	CLIP-seq
MIRT2241384	hsa-miR-4722-5p	CLIP-seq
MIRT1042654	hsa-miR-4768-3p	CLIP-seq
MIRT1042660	hsa-miR-744	CLIP-seq
MIRT2241385	hsa-miR-769-5p	CLIP-seq
MIRT2241386	hsa-miR-939	CLIP-seq
MIRT1042622	hsa-miR-1264	CLIP-seq
MIRT1042624	hsa-miR-129-5p	CLIP-seq
MIRT1042629	hsa-miR-2355-5p	CLIP-seq
MIRT2545064	hsa-miR-2964a-5p	CLIP-seq
MIRT1042635	hsa-miR-3679-3p	CLIP-seq
MIRT1042639	hsa-miR-4286	CLIP-seq
MIRT1042644	hsa-miR-4446-5p	CLIP-seq
MIRT1042653	hsa-miR-4757-5p	CLIP-seq
MIRT2545065	hsa-miR-539	CLIP-seq
MIRT2545066	hsa-miR-621	CLIP-seq
MIRT2545067	hsa-miR-889	CLIP-seq
MIRT1042622	hsa-miR-1264	CLIP-seq
MIRT1042624	hsa-miR-129-5p	CLIP-seq

Show/Hide all (5)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16189514, 25416956, 31515488, 32296183, 33961781
GO:0008893	Function	Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity	IBA
GO:0008893	Function	Guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0046872	Function	Metal ion binding	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q8N4P3

Protein name

Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1 (EC 3.1.7.2) (HD domain-containing protein 3) (Metazoan SpoT homolog 1) (MESH1) (Penta-phosphate guanosine-3'-pyrophosphohydrolase) ((ppGpp)ase)

Protein function

ppGpp hydrolyzing enzyme involved in starvation response.

PDB

3NR1 , 5VXA

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF13328	HD_4	11 → 151		Family

Sequence

MGSEAAQLLEAADFAARKHRQQRRKDPEGTPYINHPIGVARILTHEAGITDIVVLQAALL
HDTVEDTDTTLDEVELHFGAQVRRLVEEVTDDKTLPKLERKRLQVEQAPHSSPGAKLVKL
ADKLYNLRDLNRCTPEGWSEHRVQEYFEWAAQVVKGLQGTNRQLEEALKHLFKQRGLTI

Sequence length

179

Interactions

View interactions

	KEGG
	Purine metabolism Metabolic pathways

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (1)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (4)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Breast Carcinoma	Breast Carcinoma	BEFREE	25390939		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	25390939	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	25390939		★★★★★ ★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic ovary syndrome	Pubtator	35794640	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

HDDC3 (HD domain containing 3)