ASPG (asparaginase)

Gene Gene information from NCBI Gene database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID 374569
Gene name Asparaginase
Gene symbol ASPG
Synonyms (NCBI Gene)
C14orf76GPA/WTLYSOLPhASNase1
Chromosome 14
Chromosome location 14q32.33
miRNA miRNA information provided by mirtarbase database.
1
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (1)
miRTarBase ID miRNA Experiments Reference
MIRT018153 hsa-miR-335-5p Microarray 18185580
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Show/Hide all (17)
GO ID Ontology Definition Evidence Reference
GO:0003847 Function 1-alkyl-2-acetylglycerophosphocholine esterase activity IEA
GO:0004067 Function Asparaginase activity IBA
GO:0004067 Function Asparaginase activity IEA
GO:0004067 Function Asparaginase activity TAS
GO:0004622 Function Phosphatidylcholine lysophospholipase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
MIM HGNC e!Ensembl
618472 20123 ENSG00000166183
Protein Protein information from UniProt database.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q86U10
Protein name 60 kDa lysophospholipase (LysoLP) (EC 3.1.1.5) (Lysophospholipase-transacylase) [Includes: L-asparaginase (EC 3.5.1.1) (L-asparagine amidohydrolase); 1-alkyl-2-acetylglycerophosphocholine esterase (EC 3.1.1.47) (Platelet-activating factor acetylhydrolase)
Protein function Exhibits lysophospholipase, transacylase, PAF acetylhydrolase and asparaginase activities (By similarity). Can catalyze three types of transacylation reactions: (1) acyl transfer from 1-acyl-sn-glycero-3-phosphocholine (1-acyl-GPC) to the sn-1(3
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00710 Asparaginase 10 → 220 Asparaginase, N-terminal Domain
PF17763 Asparaginase_C 237 → 352 Glutaminase/Asparaginase C-terminal domain Domain
PF12796 Ank_2 404 → 497 Ankyrin repeats (3 copies) Repeat
Sequence
Sequence length 573
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
  Reactome
    Aspartate and asparagine metabolism
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
9
Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Show/Hide Unknown Diseases (9)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
ANAPHYLAXIS — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
ANEMIA — CTD, Disgenet
CTD, Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CALCULUS OF BILE DUCT WITHOUT MENTION OF CHOLECYSTITIS — Disgenet
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR — CTD
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Show/Hide Text Mining Associations (77)
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute leukemia Leukemia BEFREE 30991026
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 11505079, 12518376, 12923578, 16023613, 17380207, 19438471, 21172890, 22005787, 24907114, 25626693, 25987655, 25999454, 26457809, 27019981, 27114598
View all (65 more)
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute pancreatitis Pancreatitis BEFREE 27114598, 28349445, 28552244
★★★★★
★☆☆☆☆
Found in Text Mining only
Acute Promyelocytic Leukemia Promyelocytic Leukemia BEFREE 29401102
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult Acute Lymphocytic Leukemia Lymphocytic Leukemia BEFREE 11505079, 16023613, 17380207, 21172890, 22005787, 25987655, 25999454, 27019981, 27442338, 27546298, 28090653, 28244643, 28331334, 28355969, 28358370
View all (23 more)
★★★★★
★☆☆☆☆
Found in Text Mining only
Adult Medulloblastoma Medulloblastoma BEFREE 29715082
★★★★★
★☆☆☆☆
Found in Text Mining only
Agranulocytosis Agranulocytosis BEFREE 29387211
★★★★★
★☆☆☆☆
Found in Text Mining only
Anemia Anemia CTD_human_DG 2187653
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Blood Coagulation Disorders Blood Coagulation Disorders BEFREE 29401102
★★★★★
★☆☆☆☆
Found in Text Mining only
Burkitt Leukemia Burkitt`s Lymphoma BEFREE 30842058
★★★★★
★☆☆☆☆
Found in Text Mining only