ITGB5 (integrin subunit beta 5)

Gene

• Entrez ID: 3693
• Gene name: Integrin subunit beta 5
• Gene symbol: ITGB5
• Synonyms (NCBI Gene): -
• Chromosome: 3
• Chromosome location: 3q21.2
• Summary: This gene encodes a beta subunit of integrin, which can combine with different alpha chains to form a variety of integrin heterodimers. Integrins are integral cell-surface receptors that participate in cell adhesion as well as cell-surface mediated signal

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT018321	hsa-miR-335-5p	Microarray	18185580
MIRT020894	hsa-miR-155-5p	Proteomics	18668040
MIRT051994	hsa-let-7b-5p	CLASH	23622248
MIRT1074167	hsa-miR-1179	CLIP-seq
MIRT1074168	hsa-miR-1207-5p	CLIP-seq
MIRT1074169	hsa-miR-1287	CLIP-seq
MIRT1074170	hsa-miR-1302	CLIP-seq
MIRT1074171	hsa-miR-1321	CLIP-seq
MIRT1074172	hsa-miR-1343	CLIP-seq
MIRT1074173	hsa-miR-185	CLIP-seq
MIRT1074174	hsa-miR-1973	CLIP-seq
MIRT1074175	hsa-miR-3122	CLIP-seq
MIRT1074176	hsa-miR-3136-3p	CLIP-seq
MIRT1074177	hsa-miR-3153	CLIP-seq
MIRT1074178	hsa-miR-3154	CLIP-seq
MIRT1074179	hsa-miR-3155	CLIP-seq
MIRT1074180	hsa-miR-3155b	CLIP-seq
MIRT1074181	hsa-miR-3162-5p	CLIP-seq
MIRT1074182	hsa-miR-3202	CLIP-seq
MIRT1074183	hsa-miR-320a	CLIP-seq
MIRT1074184	hsa-miR-320b	CLIP-seq
MIRT1074185	hsa-miR-320c	CLIP-seq
MIRT1074186	hsa-miR-320d	CLIP-seq
MIRT1074187	hsa-miR-320e	CLIP-seq
MIRT1074188	hsa-miR-338-3p	CLIP-seq
MIRT1074189	hsa-miR-339-3p	CLIP-seq
MIRT1074190	hsa-miR-3682-5p	CLIP-seq
MIRT1074191	hsa-miR-3688-5p	CLIP-seq
MIRT1074192	hsa-miR-3690	CLIP-seq
MIRT1074193	hsa-miR-3913-5p	CLIP-seq
MIRT1074194	hsa-miR-4254	CLIP-seq
MIRT1074195	hsa-miR-4256	CLIP-seq
MIRT1074196	hsa-miR-4264	CLIP-seq
MIRT1074197	hsa-miR-4284	CLIP-seq
MIRT1074198	hsa-miR-4298	CLIP-seq
MIRT1074199	hsa-miR-4300	CLIP-seq
MIRT1074200	hsa-miR-4306	CLIP-seq
MIRT1074201	hsa-miR-4310	CLIP-seq
MIRT1074202	hsa-miR-4429	CLIP-seq
MIRT1074203	hsa-miR-4437	CLIP-seq
MIRT1074204	hsa-miR-4488	CLIP-seq
MIRT1074205	hsa-miR-4505	CLIP-seq
MIRT1074206	hsa-miR-4533	CLIP-seq
MIRT1074207	hsa-miR-4644	CLIP-seq
MIRT1074208	hsa-miR-4674	CLIP-seq
MIRT1074209	hsa-miR-4679	CLIP-seq
MIRT1074210	hsa-miR-4690-3p	CLIP-seq
MIRT1074211	hsa-miR-4697-5p	CLIP-seq
MIRT1074212	hsa-miR-4708-3p	CLIP-seq
MIRT1074213	hsa-miR-4731-5p	CLIP-seq
MIRT1074214	hsa-miR-4733-5p	CLIP-seq
MIRT1074215	hsa-miR-4736	CLIP-seq
MIRT1074216	hsa-miR-4739	CLIP-seq
MIRT1074217	hsa-miR-4756-5p	CLIP-seq
MIRT1074218	hsa-miR-4763-3p	CLIP-seq
MIRT1074219	hsa-miR-4764-5p	CLIP-seq
MIRT1074220	hsa-miR-4797-3p	CLIP-seq
MIRT1074221	hsa-miR-484	CLIP-seq
MIRT1074222	hsa-miR-493	CLIP-seq
MIRT1074223	hsa-miR-622	CLIP-seq
MIRT1074224	hsa-miR-637	CLIP-seq
MIRT1074225	hsa-miR-659	CLIP-seq
MIRT1074226	hsa-miR-920	CLIP-seq
MIRT1074227	hsa-miR-942	CLIP-seq
MIRT1074168	hsa-miR-1207-5p	CLIP-seq
MIRT1074169	hsa-miR-1287	CLIP-seq
MIRT1074170	hsa-miR-1302	CLIP-seq
MIRT1074173	hsa-miR-185	CLIP-seq
MIRT1074175	hsa-miR-3122	CLIP-seq
MIRT2018327	hsa-miR-3127-3p	CLIP-seq
MIRT2018328	hsa-miR-3189-5p	CLIP-seq
MIRT1074182	hsa-miR-3202	CLIP-seq
MIRT1074183	hsa-miR-320a	CLIP-seq
MIRT1074184	hsa-miR-320b	CLIP-seq
MIRT1074185	hsa-miR-320c	CLIP-seq
MIRT1074186	hsa-miR-320d	CLIP-seq
MIRT1074187	hsa-miR-320e	CLIP-seq
MIRT1074188	hsa-miR-338-3p	CLIP-seq
MIRT1074189	hsa-miR-339-3p	CLIP-seq
MIRT1074191	hsa-miR-3688-5p	CLIP-seq
MIRT1074193	hsa-miR-3913-5p	CLIP-seq
MIRT2018329	hsa-miR-421	CLIP-seq
MIRT1074196	hsa-miR-4264	CLIP-seq
MIRT1074198	hsa-miR-4298	CLIP-seq
MIRT1074200	hsa-miR-4306	CLIP-seq
MIRT2018330	hsa-miR-4323	CLIP-seq
MIRT1074202	hsa-miR-4429	CLIP-seq
MIRT2018331	hsa-miR-450b-5p	CLIP-seq
MIRT1074207	hsa-miR-4644	CLIP-seq
MIRT1074210	hsa-miR-4690-3p	CLIP-seq
MIRT2018332	hsa-miR-4709-5p	CLIP-seq
MIRT1074214	hsa-miR-4733-5p	CLIP-seq
MIRT1074215	hsa-miR-4736	CLIP-seq
MIRT1074218	hsa-miR-4763-3p	CLIP-seq
MIRT1074219	hsa-miR-4764-5p	CLIP-seq
MIRT1074220	hsa-miR-4797-3p	CLIP-seq
MIRT2018333	hsa-miR-518a-5p	CLIP-seq
MIRT2018334	hsa-miR-527	CLIP-seq
MIRT2250200	hsa-miR-103b	CLIP-seq
MIRT1074167	hsa-miR-1179	CLIP-seq
MIRT2250201	hsa-miR-1266	CLIP-seq
MIRT1074169	hsa-miR-1287	CLIP-seq
MIRT1074172	hsa-miR-1343	CLIP-seq
MIRT1074173	hsa-miR-185	CLIP-seq
MIRT2250202	hsa-miR-3163	CLIP-seq
MIRT1074182	hsa-miR-3202	CLIP-seq
MIRT1074187	hsa-miR-320e	CLIP-seq
MIRT1074188	hsa-miR-338-3p	CLIP-seq
MIRT2250203	hsa-miR-340	CLIP-seq
MIRT2250204	hsa-miR-3664-3p	CLIP-seq
MIRT1074192	hsa-miR-3690	CLIP-seq
MIRT2018329	hsa-miR-421	CLIP-seq
MIRT1074194	hsa-miR-4254	CLIP-seq
MIRT1074196	hsa-miR-4264	CLIP-seq
MIRT1074200	hsa-miR-4306	CLIP-seq
MIRT1074201	hsa-miR-4310	CLIP-seq
MIRT2250205	hsa-miR-4436a	CLIP-seq
MIRT2018331	hsa-miR-450b-5p	CLIP-seq
MIRT2250206	hsa-miR-4518	CLIP-seq
MIRT2250207	hsa-miR-4528	CLIP-seq
MIRT1074206	hsa-miR-4533	CLIP-seq
MIRT1074207	hsa-miR-4644	CLIP-seq
MIRT1074210	hsa-miR-4690-3p	CLIP-seq
MIRT2018332	hsa-miR-4709-5p	CLIP-seq
MIRT2250208	hsa-miR-4719	CLIP-seq
MIRT2250209	hsa-miR-4724-3p	CLIP-seq
MIRT1074220	hsa-miR-4797-3p	CLIP-seq
MIRT2018333	hsa-miR-518a-5p	CLIP-seq
MIRT2018334	hsa-miR-527	CLIP-seq
MIRT2250210	hsa-miR-548n	CLIP-seq
MIRT2250211	hsa-miR-548t	CLIP-seq
MIRT2452007	hsa-miR-3176	CLIP-seq
MIRT2452008	hsa-miR-3622b-5p	CLIP-seq
MIRT2452009	hsa-miR-3922-3p	CLIP-seq
MIRT2452010	hsa-miR-4720-5p	CLIP-seq
MIRT2452011	hsa-miR-4799-3p	CLIP-seq
MIRT2452012	hsa-miR-760	CLIP-seq
MIRT2250200	hsa-miR-103b	CLIP-seq
MIRT1074167	hsa-miR-1179	CLIP-seq
MIRT1074168	hsa-miR-1207-5p	CLIP-seq
MIRT2553731	hsa-miR-1231	CLIP-seq
MIRT2553732	hsa-miR-125a-3p	CLIP-seq
MIRT2250201	hsa-miR-1266	CLIP-seq
MIRT2553733	hsa-miR-1286	CLIP-seq
MIRT1074169	hsa-miR-1287	CLIP-seq
MIRT1074170	hsa-miR-1302	CLIP-seq
MIRT1074171	hsa-miR-1321	CLIP-seq
MIRT1074172	hsa-miR-1343	CLIP-seq
MIRT2553734	hsa-miR-15a	CLIP-seq
MIRT2553735	hsa-miR-15b	CLIP-seq
MIRT2553736	hsa-miR-16	CLIP-seq
MIRT1074173	hsa-miR-185	CLIP-seq
MIRT2553737	hsa-miR-195	CLIP-seq
MIRT1074174	hsa-miR-1973	CLIP-seq
MIRT2553738	hsa-miR-19a	CLIP-seq
MIRT2553739	hsa-miR-19b	CLIP-seq
MIRT1074175	hsa-miR-3122	CLIP-seq
MIRT2553740	hsa-miR-3126-5p	CLIP-seq
MIRT2018327	hsa-miR-3127-3p	CLIP-seq
MIRT1074176	hsa-miR-3136-3p	CLIP-seq
MIRT1074177	hsa-miR-3153	CLIP-seq
MIRT1074178	hsa-miR-3154	CLIP-seq
MIRT1074179	hsa-miR-3155	CLIP-seq
MIRT1074180	hsa-miR-3155b	CLIP-seq
MIRT1074181	hsa-miR-3162-5p	CLIP-seq
MIRT2452007	hsa-miR-3176	CLIP-seq
MIRT2018328	hsa-miR-3189-5p	CLIP-seq
MIRT1074182	hsa-miR-3202	CLIP-seq
MIRT1074183	hsa-miR-320a	CLIP-seq
MIRT1074184	hsa-miR-320b	CLIP-seq
MIRT1074185	hsa-miR-320c	CLIP-seq
MIRT1074186	hsa-miR-320d	CLIP-seq
MIRT1074187	hsa-miR-320e	CLIP-seq
MIRT1074188	hsa-miR-338-3p	CLIP-seq
MIRT1074189	hsa-miR-339-3p	CLIP-seq
MIRT2452008	hsa-miR-3622b-5p	CLIP-seq
MIRT2553741	hsa-miR-3655	CLIP-seq
MIRT2250204	hsa-miR-3664-3p	CLIP-seq
MIRT1074190	hsa-miR-3682-5p	CLIP-seq
MIRT1074191	hsa-miR-3688-5p	CLIP-seq
MIRT1074192	hsa-miR-3690	CLIP-seq
MIRT2553742	hsa-miR-3910	CLIP-seq
MIRT1074193	hsa-miR-3913-5p	CLIP-seq
MIRT2452009	hsa-miR-3922-3p	CLIP-seq
MIRT2018329	hsa-miR-421	CLIP-seq
MIRT2553743	hsa-miR-424	CLIP-seq
MIRT1074194	hsa-miR-4254	CLIP-seq
MIRT1074195	hsa-miR-4256	CLIP-seq
MIRT1074196	hsa-miR-4264	CLIP-seq
MIRT2553744	hsa-miR-4265	CLIP-seq
MIRT1074197	hsa-miR-4284	CLIP-seq
MIRT2553745	hsa-miR-4288	CLIP-seq
MIRT2553746	hsa-miR-4296	CLIP-seq
MIRT1074198	hsa-miR-4298	CLIP-seq
MIRT1074199	hsa-miR-4300	CLIP-seq
MIRT1074200	hsa-miR-4306	CLIP-seq
MIRT1074201	hsa-miR-4310	CLIP-seq
MIRT2553747	hsa-miR-4318	CLIP-seq
MIRT2553748	hsa-miR-4322	CLIP-seq
MIRT2018330	hsa-miR-4323	CLIP-seq
MIRT2553749	hsa-miR-4417	CLIP-seq
MIRT1074202	hsa-miR-4429	CLIP-seq
MIRT2553750	hsa-miR-4435	CLIP-seq
MIRT2250205	hsa-miR-4436a	CLIP-seq
MIRT1074203	hsa-miR-4437	CLIP-seq
MIRT1074204	hsa-miR-4488	CLIP-seq
MIRT1074205	hsa-miR-4505	CLIP-seq
MIRT2018331	hsa-miR-450b-5p	CLIP-seq
MIRT2250206	hsa-miR-4518	CLIP-seq
MIRT2553751	hsa-miR-4524	CLIP-seq
MIRT1074206	hsa-miR-4533	CLIP-seq
MIRT1074207	hsa-miR-4644	CLIP-seq
MIRT2553752	hsa-miR-4645-3p	CLIP-seq
MIRT1074208	hsa-miR-4674	CLIP-seq
MIRT1074209	hsa-miR-4679	CLIP-seq
MIRT1074210	hsa-miR-4690-3p	CLIP-seq
MIRT1074211	hsa-miR-4697-5p	CLIP-seq
MIRT1074212	hsa-miR-4708-3p	CLIP-seq
MIRT2018332	hsa-miR-4709-5p	CLIP-seq
MIRT2250208	hsa-miR-4719	CLIP-seq
MIRT2452010	hsa-miR-4720-5p	CLIP-seq
MIRT2553753	hsa-miR-4722-5p	CLIP-seq
MIRT2250209	hsa-miR-4724-3p	CLIP-seq
MIRT1074213	hsa-miR-4731-5p	CLIP-seq
MIRT1074214	hsa-miR-4733-5p	CLIP-seq
MIRT1074215	hsa-miR-4736	CLIP-seq
MIRT1074216	hsa-miR-4739	CLIP-seq
MIRT2553754	hsa-miR-4755-3p	CLIP-seq
MIRT1074217	hsa-miR-4756-5p	CLIP-seq
MIRT1074218	hsa-miR-4763-3p	CLIP-seq
MIRT1074219	hsa-miR-4764-5p	CLIP-seq
MIRT2553755	hsa-miR-4778-3p	CLIP-seq
MIRT1074220	hsa-miR-4797-3p	CLIP-seq
MIRT2452011	hsa-miR-4799-3p	CLIP-seq
MIRT1074221	hsa-miR-484	CLIP-seq
MIRT1074222	hsa-miR-493	CLIP-seq
MIRT2553756	hsa-miR-497	CLIP-seq
MIRT2553757	hsa-miR-503	CLIP-seq
MIRT2018333	hsa-miR-518a-5p	CLIP-seq
MIRT2018334	hsa-miR-527	CLIP-seq
MIRT2553758	hsa-miR-578	CLIP-seq
MIRT1074223	hsa-miR-622	CLIP-seq
MIRT2553759	hsa-miR-632	CLIP-seq
MIRT1074224	hsa-miR-637	CLIP-seq
MIRT2553760	hsa-miR-646	CLIP-seq
MIRT1074225	hsa-miR-659	CLIP-seq
MIRT2452012	hsa-miR-760	CLIP-seq
MIRT1074226	hsa-miR-920	CLIP-seq
MIRT1074227	hsa-miR-942	CLIP-seq
MIRT2250200	hsa-miR-103b	CLIP-seq
MIRT1074167	hsa-miR-1179	CLIP-seq
MIRT1074168	hsa-miR-1207-5p	CLIP-seq
MIRT2553731	hsa-miR-1231	CLIP-seq
MIRT2250201	hsa-miR-1266	CLIP-seq
MIRT2553733	hsa-miR-1286	CLIP-seq
MIRT1074169	hsa-miR-1287	CLIP-seq
MIRT1074170	hsa-miR-1302	CLIP-seq
MIRT1074171	hsa-miR-1321	CLIP-seq
MIRT1074172	hsa-miR-1343	CLIP-seq
MIRT2553734	hsa-miR-15a	CLIP-seq
MIRT2553735	hsa-miR-15b	CLIP-seq
MIRT2553736	hsa-miR-16	CLIP-seq
MIRT2553737	hsa-miR-195	CLIP-seq
MIRT1074174	hsa-miR-1973	CLIP-seq
MIRT2553738	hsa-miR-19a	CLIP-seq
MIRT2553739	hsa-miR-19b	CLIP-seq
MIRT1074175	hsa-miR-3122	CLIP-seq
MIRT2553740	hsa-miR-3126-5p	CLIP-seq
MIRT2018327	hsa-miR-3127-3p	CLIP-seq
MIRT1074176	hsa-miR-3136-3p	CLIP-seq
MIRT1074177	hsa-miR-3153	CLIP-seq
MIRT1074178	hsa-miR-3154	CLIP-seq
MIRT1074179	hsa-miR-3155	CLIP-seq
MIRT1074180	hsa-miR-3155b	CLIP-seq
MIRT1074181	hsa-miR-3162-5p	CLIP-seq
MIRT2452007	hsa-miR-3176	CLIP-seq
MIRT2018328	hsa-miR-3189-5p	CLIP-seq
MIRT1074182	hsa-miR-3202	CLIP-seq
MIRT1074183	hsa-miR-320a	CLIP-seq
MIRT1074184	hsa-miR-320b	CLIP-seq
MIRT1074185	hsa-miR-320c	CLIP-seq
MIRT1074186	hsa-miR-320d	CLIP-seq
MIRT1074187	hsa-miR-320e	CLIP-seq
MIRT1074188	hsa-miR-338-3p	CLIP-seq
MIRT1074189	hsa-miR-339-3p	CLIP-seq
MIRT2452008	hsa-miR-3622b-5p	CLIP-seq
MIRT2553741	hsa-miR-3655	CLIP-seq
MIRT2250204	hsa-miR-3664-3p	CLIP-seq
MIRT1074191	hsa-miR-3688-5p	CLIP-seq
MIRT1074192	hsa-miR-3690	CLIP-seq
MIRT2553742	hsa-miR-3910	CLIP-seq
MIRT1074193	hsa-miR-3913-5p	CLIP-seq
MIRT2452009	hsa-miR-3922-3p	CLIP-seq
MIRT2018329	hsa-miR-421	CLIP-seq
MIRT2553743	hsa-miR-424	CLIP-seq
MIRT1074194	hsa-miR-4254	CLIP-seq
MIRT1074195	hsa-miR-4256	CLIP-seq
MIRT1074196	hsa-miR-4264	CLIP-seq
MIRT2553744	hsa-miR-4265	CLIP-seq
MIRT1074197	hsa-miR-4284	CLIP-seq
MIRT2553745	hsa-miR-4288	CLIP-seq
MIRT2553746	hsa-miR-4296	CLIP-seq
MIRT1074198	hsa-miR-4298	CLIP-seq
MIRT1074199	hsa-miR-4300	CLIP-seq
MIRT1074201	hsa-miR-4310	CLIP-seq
MIRT2553747	hsa-miR-4318	CLIP-seq
MIRT2553748	hsa-miR-4322	CLIP-seq
MIRT2018330	hsa-miR-4323	CLIP-seq
MIRT2553749	hsa-miR-4417	CLIP-seq
MIRT1074202	hsa-miR-4429	CLIP-seq
MIRT2553750	hsa-miR-4435	CLIP-seq
MIRT2250205	hsa-miR-4436a	CLIP-seq
MIRT1074203	hsa-miR-4437	CLIP-seq
MIRT1074204	hsa-miR-4488	CLIP-seq
MIRT1074205	hsa-miR-4505	CLIP-seq
MIRT2018331	hsa-miR-450b-5p	CLIP-seq
MIRT2250206	hsa-miR-4518	CLIP-seq
MIRT2553751	hsa-miR-4524	CLIP-seq
MIRT1074206	hsa-miR-4533	CLIP-seq
MIRT2553752	hsa-miR-4645-3p	CLIP-seq
MIRT1074208	hsa-miR-4674	CLIP-seq
MIRT1074209	hsa-miR-4679	CLIP-seq
MIRT1074210	hsa-miR-4690-3p	CLIP-seq
MIRT1074211	hsa-miR-4697-5p	CLIP-seq
MIRT1074212	hsa-miR-4708-3p	CLIP-seq
MIRT2018332	hsa-miR-4709-5p	CLIP-seq
MIRT2452010	hsa-miR-4720-5p	CLIP-seq
MIRT2553753	hsa-miR-4722-5p	CLIP-seq
MIRT2250209	hsa-miR-4724-3p	CLIP-seq
MIRT1074213	hsa-miR-4731-5p	CLIP-seq
MIRT1074214	hsa-miR-4733-5p	CLIP-seq
MIRT1074215	hsa-miR-4736	CLIP-seq
MIRT1074216	hsa-miR-4739	CLIP-seq
MIRT2553754	hsa-miR-4755-3p	CLIP-seq
MIRT1074217	hsa-miR-4756-5p	CLIP-seq
MIRT1074218	hsa-miR-4763-3p	CLIP-seq
MIRT1074219	hsa-miR-4764-5p	CLIP-seq
MIRT2553755	hsa-miR-4778-3p	CLIP-seq
MIRT1074220	hsa-miR-4797-3p	CLIP-seq
MIRT2452011	hsa-miR-4799-3p	CLIP-seq
MIRT1074221	hsa-miR-484	CLIP-seq
MIRT1074222	hsa-miR-493	CLIP-seq
MIRT2553756	hsa-miR-497	CLIP-seq
MIRT2553757	hsa-miR-503	CLIP-seq
MIRT2018333	hsa-miR-518a-5p	CLIP-seq
MIRT2018334	hsa-miR-527	CLIP-seq
MIRT2553758	hsa-miR-578	CLIP-seq
MIRT1074223	hsa-miR-622	CLIP-seq
MIRT2553759	hsa-miR-632	CLIP-seq
MIRT1074224	hsa-miR-637	CLIP-seq
MIRT2553760	hsa-miR-646	CLIP-seq
MIRT2452012	hsa-miR-760	CLIP-seq
MIRT1074226	hsa-miR-920	CLIP-seq
MIRT1074227	hsa-miR-942	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001618	Function	Virus receptor activity	IEA
GO:0001704	Process	Formation of primary germ layer	IEA
GO:0005102	Function	Signaling receptor binding	IEA
GO:0005178	Function	Integrin binding	IBA
GO:0005515	Function	Protein binding	IPI	1694173, 15611078, 19910644, 21397862, 21642953, 24997346, 25448675, 32296183
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0005925	Component	Focal adhesion	HDA	21423176
GO:0005925	Component	Focal adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007160	Process	Cell-matrix adhesion	IBA
GO:0007160	Process	Cell-matrix adhesion	IEA
GO:0007160	Process	Cell-matrix adhesion	IMP	24036928
GO:0007160	Process	Cell-matrix adhesion	NAS	19693543
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	IBA
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	IEA
GO:0007179	Process	Transforming growth factor beta receptor signaling pathway	IMP	24036928
GO:0007229	Process	Integrin-mediated signaling pathway	IBA
GO:0007229	Process	Integrin-mediated signaling pathway	IEA
GO:0007229	Process	Integrin-mediated signaling pathway	IMP	24036928
GO:0007229	Process	Integrin-mediated signaling pathway	NAS	19693543
GO:0008305	Component	Integrin complex	IBA
GO:0009986	Component	Cell surface	HDA	23658023
GO:0009986	Component	Cell surface	IBA
GO:0009986	Component	Cell surface	IDA	7525578, 23154389, 24036928, 25063885
GO:0016020	Component	Membrane	IEA
GO:0016477	Process	Cell migration	IBA
GO:0016477	Process	Cell migration	IMP	26934001
GO:0033627	Process	Cell adhesion mediated by integrin	IBA
GO:0034684	Component	Integrin alphav-beta5 complex	IDA	25063885
GO:0034684	Component	Integrin alphav-beta5 complex	IEA
GO:0034684	Component	Integrin alphav-beta5 complex	IPI	1694173
GO:0035313	Process	Wound healing, spreading of epidermal cells	NAS	19693543
GO:0035987	Process	Endodermal cell differentiation	IEP	23154389
GO:0043149	Process	Stress fiber assembly	IBA
GO:0043149	Process	Stress fiber assembly	IEA
GO:0043149	Process	Stress fiber assembly	IMP	24036928
GO:0043235	Component	Receptor complex	IDA	23382219
GO:0045335	Component	Phagocytic vesicle	TAS
GO:0046718	Process	Symbiont entry into host cell	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0070062	Component	Extracellular exosome	HDA	23533145
GO:0090136	Process	Epithelial cell-cell adhesion	IMP	24036928
GO:0098609	Process	Cell-cell adhesion	IBA

Other IDs

• MIM: 147561
• HGNC: 6160
• e!Ensembl: ENSG00000082781

Protein

• UniProt ID: P18084
• Protein name: Integrin beta-5
• Protein function: Integrin alpha-V/beta-5 (ITGAV:ITGB5) is a receptor for fibronectin. It recognizes the sequence R-G-D in its ligand.; (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for adenovirus type C.
• PDB: 7S46, 7S47, 7S48
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF17205	PSI_integrin	26 → 76	Integrin plexin domain	Domain
  PF00362	Integrin_beta	133 → 382	Integrin beta chain VWA domain	Domain
  PF18372	I-EGF_1	465 → 493	Integrin beta epidermal growth factor like domain 1	Domain
  PF07965	Integrin_B_tail	635 → 719	Integrin beta tail domain	Domain
  PF08725	Integrin_b_cyt	743 → 788	Integrin beta cytoplasmic domain	Domain

• Sequence:

  MPRAPAPLYACLLGLCALLPRLAGLNICTSGSATSCEECLLIHPKCAWCSKEDFGSPRSI
  TSRCDLRANLVKNGCGGEIESPASSFHVLRSLPLSSKGSGSAGWDVIQMTPQEIAVNLRP
  GDKTTFQLQVRQVEDYPVDLYYLMDLSLSMKDDLDNIRSLGTKLAEEMRKLTSNFRLGFG
  SFVDKDISPFSYTAPRYQTNPCIGYKLFPNCVPSFGFRHLLPLTDRVDSFNEEVRKQRVS
  RNRDAPEGGFDAVLQAAVCKEKIGWRKDALHLLVFTTDDVPHIALDGKLGGLVQPHDGQC
  HLNEANEYTASNQMDYPSLALLGEKLAENNINLIFAVTKNHYMLYKNFTALIPGTTVEIL
  DGDSKNIIQLIINAYNSIRSKVELSVWDQPEDLNLFFTATCQDGVSYPGQRKCEGLKIGD
  TASFEVSLEARSCPSRHTEHVFALRPVGFRDSLEVGVTYNCTCGCSVGLEPNSARCNGSG
  TYVCGLCECSPGYLGTRCECQDGENQSVYQNLCREAEGKPLCSGRGDCSCNQCSCFESEF
  GKIYGPFCECDNFSCARNKGVLCSGHGECHCGECKCHAGYIGDNCNCSTDISTCRGRDGQ
  ICSERGHCLCGQCQCTEPGAFGEMCEKCPTCPDACSTKRDCVECLLLHSGKPDNQTCHSL
  CRDEVITWVDTIVKDDQEAVLCFYKTAKDCVMMFTYVELPSGKSNLTVLREPECGNTPNA
  MTILLAVVGSILLVGLALLAIWKLLVTIHDRREFAKFQSERSRARYEMASNPLYRKPIST
  HTVDFTFNKFNKSYNGTVD

• Sequence length: 799

Pathways

KEGG:

Phagosome
Efferocytosis
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Regulation of actin cytoskeleton
Cytoskeleton in muscle cells
Human papillomavirus infection
Proteoglycans in cancer
Hypertrophic cardiomyopathy
Arrhythmogenic right ventricular cardiomyopathy
Dilated cardiomyopathy

Reactome:

Cross-presentation of particulate exogenous antigens (phagosomes)
Molecules associated with elastic fibres
Integrin cell surface interactions
Syndecan interactions
ECM proteoglycans
Smooth Muscle Contraction

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ARTHRITIS, JUVENILE	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARPAL TUNNEL SYNDROME	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
JUVENILE CHRONIC POLYARTHRITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MONOARTICULAR JUVENILE RHEUMATOID ARTHRITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PAUCIARTICULAR JUVENILE RHEUMATOID ARTHRITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
THYROID DISEASES	—	CTD, Disgenet CTD, Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Androgen Insensitivity Syndrome	Androgen insensitivity syndrome	Pubtator	25313366	Associate	★☆☆☆☆ Found in Text Mining only
Arrhythmogenic Right Ventricular Dysplasia	Arrhythmogenic right ventricular cardiomyopathy	Pubtator	27613243	Associate	★☆☆☆☆ Found in Text Mining only
Atherosclerosis	Atherosclerosis	LHGDN	16672769		★☆☆☆☆ Found in Text Mining only
Biliary Atresia	Biliary Atresia	BEFREE	25079481		★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar Disorder	BEFREE	31695175		★☆☆☆☆ Found in Text Mining only
Bipolar Disorder	Bipolar disorder	Pubtator	31695175	Stimulate	★☆☆☆☆ Found in Text Mining only
Breast Carcinoma	Breast Carcinoma	BEFREE	18550570, 22824793		★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	32951492, 36212176, 37149115	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	37603520	Stimulate	★☆☆☆☆ Found in Text Mining only
Carcinoma Pancreatic Ductal	Pancreatic ductal carcinoma	Pubtator	40520021	Associate	★☆☆☆☆ Found in Text Mining only
Cardiomyopathies	Cardiomyopathy	Pubtator	27613243	Associate	★☆☆☆☆ Found in Text Mining only
Cartilage Diseases	Cartilage disease	Pubtator	9741315	Associate	★☆☆☆☆ Found in Text Mining only
Chronic Obstructive Airway Disease	Chronic Obstructive Pulmonary Disease	BEFREE	19502044		★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	24737953	Associate	★☆☆☆☆ Found in Text Mining only
Congenital atresia of extrahepatic bile duct	Extrahepatic Biliary Atresia	BEFREE	25079481		★☆☆☆☆ Found in Text Mining only
Fuchs' Endothelial Dystrophy	Fuchs endothelial dystrophy	Pubtator	28726551	Stimulate	★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	31616629		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	32634050	Associate	★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	31616629		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	31616629		★☆☆☆☆ Found in Text Mining only
Intracranial Arteriovenous Malformation	Intracranial Arteriovenous Malformation	LHGDN	16385340		★☆☆☆☆ Found in Text Mining only
Juvenile arthritis	Arthritis	CTD_human_DG	19565504		★☆☆☆☆ Found in Text Mining only
Juvenile psoriatic arthritis	Juvenile arthritis	CTD_human_DG	19565504		★☆☆☆☆ Found in Text Mining only
Juvenile-Onset Still Disease	Still Disease	CTD_human_DG	19565504		★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	29386044		★☆☆☆☆ Found in Text Mining only
Localized scleroderma	Scleroderma	LHGDN	16675963		★☆☆☆☆ Found in Text Mining only
Lymphatic Metastasis	Lymphatic metastasis	Pubtator	18224668, 25472585	Associate	★☆☆☆☆ Found in Text Mining only
Major Depressive Disorder	Mental Depression	GWASDB_DG	22915352		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of breast	Breast Cancer	BEFREE	18550570, 22824793		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of stomach	Stomach Neoplasms	BEFREE	21931799		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29386044		★☆☆☆☆ Found in Text Mining only
Melanoma	Melanoma	Pubtator	10684289	Associate	★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	16838325, 22824793		★☆☆☆☆ Found in Text Mining only
Neurodegenerative Diseases	Neurodegenerative disorder	Pubtator	40106490	Associate	★☆☆☆☆ Found in Text Mining only
Obesity	Obesity	Pubtator	26213922, 34248836	Associate	★☆☆☆☆ Found in Text Mining only
Pancreatic Neoplasms	Pancreatic neoplasm	Pubtator	33073486, 33591944	Associate	★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	33021140	Associate	★☆☆☆☆ Found in Text Mining only
Polyarthritis, Juvenile, Rheumatoid Factor Negative	Seronegative polyarthritis	CTD_human_DG	19565504		★☆☆☆☆ Found in Text Mining only
Polyarthritis, Juvenile, Rheumatoid Factor Positive	Polyarthritis, Rheumatoid Factor Positive	CTD_human_DG	19565504		★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic Ovary Syndrome	BEFREE	24279306		★☆☆☆☆ Found in Text Mining only
Polycystic Ovary Syndrome	Polycystic ovary syndrome	Pubtator	24279306	Associate	★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	Pubtator	38478639	Associate	★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	BEFREE	31695175		★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	Pubtator	31695175	Stimulate	★☆☆☆☆ Found in Text Mining only
Septicemia	Septicemia	BEFREE	30445996		★☆☆☆☆ Found in Text Mining only
Squamous Cell Carcinoma of Head and Neck	Squamous cell carcinoma	Pubtator	18224668, 24769516	Associate	★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of tongue	Tongue carcinoma	BEFREE	18224668		★☆☆☆☆ Found in Text Mining only
Stomach Carcinoma	Stomach Carcinoma	BEFREE	21931799		★☆☆☆☆ Found in Text Mining only
Stomach Neoplasms	Stomach neoplasms	Pubtator	21931799, 25472585, 33178362, 39394072	Associate	★☆☆☆☆ Found in Text Mining only
Systemic Scleroderma	Scleroderma	BEFREE	30426551		★☆☆☆☆ Found in Text Mining only
Thyroid Diseases	Thyroid Diseases	CTD_human_DG	23397585		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Triple Negative Breast Neoplasms	Triple negative breast cancer	Pubtator	31882647	Associate	★☆☆☆☆ Found in Text Mining only