INPP5B (inositol polyphosphate-5-phosphatase B)

Gene

• Entrez ID: 3633
• Gene name: Inositol polyphosphate-5-phosphatase B
• Gene symbol: INPP5B
• Synonyms (NCBI Gene): 5PTase
• Chromosome: 1
• Chromosome location: 1p34.3
• Summary: This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and assoc

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT030250	hsa-miR-26b-5p	Microarray	19088304
MIRT692726	hsa-miR-1537-3p	HITS-CLIP	23313552
MIRT692725	hsa-miR-187-3p	HITS-CLIP	23313552
MIRT692724	hsa-miR-1284	HITS-CLIP	23313552
MIRT692723	hsa-miR-4796-5p	HITS-CLIP	23313552
MIRT441793	hsa-miR-521	PAR-CLIP	22291592
MIRT441792	hsa-miR-6807-5p	PAR-CLIP	22291592
MIRT441793	hsa-miR-521	PAR-CLIP	23708386
MIRT441792	hsa-miR-6807-5p	PAR-CLIP	23708386
MIRT441793	hsa-miR-521	PAR-CLIP	22100165
MIRT441792	hsa-miR-6807-5p	PAR-CLIP	22100165
MIRT441793	hsa-miR-521	PAR-CLIP	22100165
MIRT441792	hsa-miR-6807-5p	PAR-CLIP	22100165
MIRT732922	hsa-miR-223-3p	Luciferase reporter assay, Microarray, qRT-PCR, Western blotting	31712567
MIRT692726	hsa-miR-1537-3p	HITS-CLIP	23313552
MIRT692725	hsa-miR-187-3p	HITS-CLIP	23313552
MIRT692724	hsa-miR-1284	HITS-CLIP	23313552
MIRT692723	hsa-miR-4796-5p	HITS-CLIP	23313552
MIRT441793	hsa-miR-521	PAR-CLIP	22291592
MIRT441792	hsa-miR-6807-5p	PAR-CLIP	22291592
MIRT441793	hsa-miR-521	PAR-CLIP	23708386
MIRT441792	hsa-miR-6807-5p	PAR-CLIP	23708386
MIRT441793	hsa-miR-521	PAR-CLIP	22100165
MIRT441792	hsa-miR-6807-5p	PAR-CLIP	22100165
MIRT441793	hsa-miR-521	PAR-CLIP	22100165
MIRT441792	hsa-miR-6807-5p	PAR-CLIP	22100165
MIRT1067297	hsa-miR-1206	CLIP-seq
MIRT1067298	hsa-miR-1268	CLIP-seq
MIRT1067299	hsa-miR-1268b	CLIP-seq
MIRT1067300	hsa-miR-1273e	CLIP-seq
MIRT1067301	hsa-miR-1295	CLIP-seq
MIRT1067302	hsa-miR-140-3p	CLIP-seq
MIRT1067303	hsa-miR-1827	CLIP-seq
MIRT1067304	hsa-miR-197	CLIP-seq
MIRT1067305	hsa-miR-24	CLIP-seq
MIRT1067306	hsa-miR-2467-3p	CLIP-seq
MIRT1067307	hsa-miR-2964a-3p	CLIP-seq
MIRT1067308	hsa-miR-302f	CLIP-seq
MIRT1067309	hsa-miR-3122	CLIP-seq
MIRT1067310	hsa-miR-3151	CLIP-seq
MIRT1067311	hsa-miR-3165	CLIP-seq
MIRT1067312	hsa-miR-3173-3p	CLIP-seq
MIRT1067313	hsa-miR-323-5p	CLIP-seq
MIRT1067314	hsa-miR-339-5p	CLIP-seq
MIRT1067315	hsa-miR-3607-3p	CLIP-seq
MIRT1067316	hsa-miR-3612	CLIP-seq
MIRT1067317	hsa-miR-3622a-3p	CLIP-seq
MIRT1067318	hsa-miR-3622b-3p	CLIP-seq
MIRT1067319	hsa-miR-3663-5p	CLIP-seq
MIRT1067320	hsa-miR-3665	CLIP-seq
MIRT1067321	hsa-miR-3674	CLIP-seq
MIRT1067322	hsa-miR-3686	CLIP-seq
MIRT1067323	hsa-miR-3689a-3p	CLIP-seq
MIRT1067324	hsa-miR-3689c	CLIP-seq
MIRT1067325	hsa-miR-3714	CLIP-seq
MIRT1067326	hsa-miR-3913-5p	CLIP-seq
MIRT1067327	hsa-miR-3929	CLIP-seq
MIRT1067328	hsa-miR-4257	CLIP-seq
MIRT1067329	hsa-miR-4281	CLIP-seq
MIRT1067330	hsa-miR-4283	CLIP-seq
MIRT1067331	hsa-miR-4284	CLIP-seq
MIRT1067332	hsa-miR-4287	CLIP-seq
MIRT1067333	hsa-miR-4327	CLIP-seq
MIRT1067334	hsa-miR-4419b	CLIP-seq
MIRT1067335	hsa-miR-4459	CLIP-seq
MIRT1067336	hsa-miR-4469	CLIP-seq
MIRT1067337	hsa-miR-4478	CLIP-seq
MIRT1067338	hsa-miR-4489	CLIP-seq
MIRT1067339	hsa-miR-4490	CLIP-seq
MIRT1067340	hsa-miR-4492	CLIP-seq
MIRT1067341	hsa-miR-4498	CLIP-seq
MIRT1067342	hsa-miR-4537	CLIP-seq
MIRT1067343	hsa-miR-4649-3p	CLIP-seq
MIRT1067344	hsa-miR-4685-3p	CLIP-seq
MIRT1067345	hsa-miR-4695-5p	CLIP-seq
MIRT1067346	hsa-miR-4711-5p	CLIP-seq
MIRT1067347	hsa-miR-4717-5p	CLIP-seq
MIRT1067348	hsa-miR-4722-5p	CLIP-seq
MIRT1067349	hsa-miR-4728-5p	CLIP-seq
MIRT1067350	hsa-miR-4732-5p	CLIP-seq
MIRT1067351	hsa-miR-4736	CLIP-seq
MIRT1067352	hsa-miR-4755-3p	CLIP-seq
MIRT1067353	hsa-miR-4768-3p	CLIP-seq
MIRT1067354	hsa-miR-485-5p	CLIP-seq
MIRT1067355	hsa-miR-494	CLIP-seq
MIRT1067356	hsa-miR-500a	CLIP-seq
MIRT1067357	hsa-miR-544b	CLIP-seq
MIRT1067358	hsa-miR-552	CLIP-seq
MIRT1067359	hsa-miR-650	CLIP-seq
MIRT1067360	hsa-miR-665	CLIP-seq
MIRT1067361	hsa-miR-762	CLIP-seq
MIRT1067362	hsa-miR-876-3p	CLIP-seq
MIRT1067363	hsa-miR-940	CLIP-seq
MIRT1550157	hsa-miR-1297	CLIP-seq
MIRT1550158	hsa-miR-185	CLIP-seq
MIRT1550159	hsa-miR-26a	CLIP-seq
MIRT1550160	hsa-miR-26b	CLIP-seq
MIRT1550161	hsa-miR-3150b-3p	CLIP-seq
MIRT1550162	hsa-miR-4266	CLIP-seq
MIRT1550163	hsa-miR-4306	CLIP-seq
MIRT1550164	hsa-miR-4465	CLIP-seq
MIRT1550165	hsa-miR-4644	CLIP-seq
MIRT1067345	hsa-miR-4695-5p	CLIP-seq
MIRT1550166	hsa-miR-4779	CLIP-seq
MIRT1550167	hsa-miR-4784	CLIP-seq
MIRT1550168	hsa-miR-765	CLIP-seq
MIRT1550169	hsa-miR-885-3p	CLIP-seq
MIRT1067297	hsa-miR-1206	CLIP-seq
MIRT1067300	hsa-miR-1273e	CLIP-seq
MIRT1067302	hsa-miR-140-3p	CLIP-seq
MIRT1067303	hsa-miR-1827	CLIP-seq
MIRT1067304	hsa-miR-197	CLIP-seq
MIRT2016297	hsa-miR-2110	CLIP-seq
MIRT1067306	hsa-miR-2467-3p	CLIP-seq
MIRT1067307	hsa-miR-2964a-3p	CLIP-seq
MIRT1067308	hsa-miR-302f	CLIP-seq
MIRT1067309	hsa-miR-3122	CLIP-seq
MIRT2016298	hsa-miR-3150a-3p	CLIP-seq
MIRT1067311	hsa-miR-3165	CLIP-seq
MIRT1067312	hsa-miR-3173-3p	CLIP-seq
MIRT2016299	hsa-miR-3175	CLIP-seq
MIRT1067313	hsa-miR-323-5p	CLIP-seq
MIRT1067315	hsa-miR-3607-3p	CLIP-seq
MIRT1067316	hsa-miR-3612	CLIP-seq
MIRT2016300	hsa-miR-3614-5p	CLIP-seq
MIRT1067317	hsa-miR-3622a-3p	CLIP-seq
MIRT1067318	hsa-miR-3622b-3p	CLIP-seq
MIRT2016301	hsa-miR-3622b-5p	CLIP-seq
MIRT2016302	hsa-miR-3649	CLIP-seq
MIRT1067320	hsa-miR-3665	CLIP-seq
MIRT1067322	hsa-miR-3686	CLIP-seq
MIRT1067323	hsa-miR-3689a-3p	CLIP-seq
MIRT1067324	hsa-miR-3689c	CLIP-seq
MIRT1067325	hsa-miR-3714	CLIP-seq
MIRT1067326	hsa-miR-3913-5p	CLIP-seq
MIRT1067327	hsa-miR-3929	CLIP-seq
MIRT1067328	hsa-miR-4257	CLIP-seq
MIRT2016303	hsa-miR-4302	CLIP-seq
MIRT1067334	hsa-miR-4419b	CLIP-seq
MIRT1067337	hsa-miR-4478	CLIP-seq
MIRT2016304	hsa-miR-4645-5p	CLIP-seq
MIRT1067343	hsa-miR-4649-3p	CLIP-seq
MIRT2016305	hsa-miR-4662a-5p	CLIP-seq
MIRT2016306	hsa-miR-4673	CLIP-seq
MIRT2016307	hsa-miR-4676-5p	CLIP-seq
MIRT1067345	hsa-miR-4695-5p	CLIP-seq
MIRT1067346	hsa-miR-4711-5p	CLIP-seq
MIRT1067348	hsa-miR-4722-5p	CLIP-seq
MIRT1067349	hsa-miR-4728-5p	CLIP-seq
MIRT2016308	hsa-miR-4730	CLIP-seq
MIRT1067351	hsa-miR-4736	CLIP-seq
MIRT1067352	hsa-miR-4755-3p	CLIP-seq
MIRT2016309	hsa-miR-4763-5p	CLIP-seq
MIRT1067353	hsa-miR-4768-3p	CLIP-seq
MIRT1067354	hsa-miR-485-5p	CLIP-seq
MIRT1067356	hsa-miR-500a	CLIP-seq
MIRT1067357	hsa-miR-544b	CLIP-seq
MIRT2016310	hsa-miR-550a	CLIP-seq
MIRT2016311	hsa-miR-575	CLIP-seq
MIRT1067359	hsa-miR-650	CLIP-seq
MIRT2016312	hsa-miR-874	CLIP-seq
MIRT1067362	hsa-miR-876-3p	CLIP-seq
MIRT2016313	hsa-miR-939	CLIP-seq
MIRT1067363	hsa-miR-940	CLIP-seq
MIRT2248612	hsa-miR-1184	CLIP-seq
MIRT1067297	hsa-miR-1206	CLIP-seq
MIRT1067298	hsa-miR-1268	CLIP-seq
MIRT1067299	hsa-miR-1268b	CLIP-seq
MIRT1067300	hsa-miR-1273e	CLIP-seq
MIRT1067302	hsa-miR-140-3p	CLIP-seq
MIRT2248613	hsa-miR-150	CLIP-seq
MIRT1067303	hsa-miR-1827	CLIP-seq
MIRT1067304	hsa-miR-197	CLIP-seq
MIRT1067305	hsa-miR-24	CLIP-seq
MIRT1067306	hsa-miR-2467-3p	CLIP-seq
MIRT1067308	hsa-miR-302f	CLIP-seq
MIRT1067309	hsa-miR-3122	CLIP-seq
MIRT1067311	hsa-miR-3165	CLIP-seq
MIRT1067313	hsa-miR-323-5p	CLIP-seq
MIRT1067315	hsa-miR-3607-3p	CLIP-seq
MIRT1067316	hsa-miR-3612	CLIP-seq
MIRT1067317	hsa-miR-3622a-3p	CLIP-seq
MIRT1067318	hsa-miR-3622b-3p	CLIP-seq
MIRT2016302	hsa-miR-3649	CLIP-seq
MIRT1067320	hsa-miR-3665	CLIP-seq
MIRT1067322	hsa-miR-3686	CLIP-seq
MIRT1067323	hsa-miR-3689a-3p	CLIP-seq
MIRT1067324	hsa-miR-3689c	CLIP-seq
MIRT1067325	hsa-miR-3714	CLIP-seq
MIRT2248614	hsa-miR-371-5p	CLIP-seq
MIRT1067326	hsa-miR-3913-5p	CLIP-seq
MIRT1067327	hsa-miR-3929	CLIP-seq
MIRT1067328	hsa-miR-4257	CLIP-seq
MIRT1067331	hsa-miR-4284	CLIP-seq
MIRT2016303	hsa-miR-4302	CLIP-seq
MIRT1067333	hsa-miR-4327	CLIP-seq
MIRT2248615	hsa-miR-4418	CLIP-seq
MIRT1067334	hsa-miR-4419b	CLIP-seq
MIRT1067335	hsa-miR-4459	CLIP-seq
MIRT1067337	hsa-miR-4478	CLIP-seq
MIRT1067340	hsa-miR-4492	CLIP-seq
MIRT1067341	hsa-miR-4498	CLIP-seq
MIRT1067342	hsa-miR-4537	CLIP-seq
MIRT1067343	hsa-miR-4649-3p	CLIP-seq
MIRT1067345	hsa-miR-4695-5p	CLIP-seq
MIRT1067346	hsa-miR-4711-5p	CLIP-seq
MIRT1067349	hsa-miR-4728-5p	CLIP-seq
MIRT1067351	hsa-miR-4736	CLIP-seq
MIRT2016309	hsa-miR-4763-5p	CLIP-seq
MIRT1067354	hsa-miR-485-5p	CLIP-seq
MIRT2248616	hsa-miR-509-3-5p	CLIP-seq
MIRT2248617	hsa-miR-509-5p	CLIP-seq
MIRT1067357	hsa-miR-544b	CLIP-seq
MIRT2016310	hsa-miR-550a	CLIP-seq
MIRT1067359	hsa-miR-650	CLIP-seq
MIRT1067360	hsa-miR-665	CLIP-seq
MIRT1067361	hsa-miR-762	CLIP-seq
MIRT1067362	hsa-miR-876-3p	CLIP-seq
MIRT1067363	hsa-miR-940	CLIP-seq
MIRT1067300	hsa-miR-1273e	CLIP-seq
MIRT1067303	hsa-miR-1827	CLIP-seq
MIRT1067305	hsa-miR-24	CLIP-seq
MIRT1067309	hsa-miR-3122	CLIP-seq
MIRT1067311	hsa-miR-3165	CLIP-seq
MIRT1067317	hsa-miR-3622a-3p	CLIP-seq
MIRT1067318	hsa-miR-3622b-3p	CLIP-seq
MIRT1067320	hsa-miR-3665	CLIP-seq
MIRT1067323	hsa-miR-3689a-3p	CLIP-seq
MIRT1067324	hsa-miR-3689c	CLIP-seq
MIRT1067325	hsa-miR-3714	CLIP-seq
MIRT1067326	hsa-miR-3913-5p	CLIP-seq
MIRT1067327	hsa-miR-3929	CLIP-seq
MIRT1067334	hsa-miR-4419b	CLIP-seq
MIRT1067337	hsa-miR-4478	CLIP-seq
MIRT1067343	hsa-miR-4649-3p	CLIP-seq
MIRT1067349	hsa-miR-4728-5p	CLIP-seq
MIRT1067351	hsa-miR-4736	CLIP-seq
MIRT2016309	hsa-miR-4763-5p	CLIP-seq
MIRT1067354	hsa-miR-485-5p	CLIP-seq
MIRT2016310	hsa-miR-550a	CLIP-seq
MIRT1067363	hsa-miR-940	CLIP-seq
MIRT1067298	hsa-miR-1268	CLIP-seq
MIRT1067299	hsa-miR-1268b	CLIP-seq
MIRT2016297	hsa-miR-2110	CLIP-seq
MIRT1067309	hsa-miR-3122	CLIP-seq
MIRT2016298	hsa-miR-3150a-3p	CLIP-seq
MIRT1067311	hsa-miR-3165	CLIP-seq
MIRT2016299	hsa-miR-3175	CLIP-seq
MIRT1067315	hsa-miR-3607-3p	CLIP-seq
MIRT2451876	hsa-miR-3613-3p	CLIP-seq
MIRT2016300	hsa-miR-3614-5p	CLIP-seq
MIRT1067317	hsa-miR-3622a-3p	CLIP-seq
MIRT1067318	hsa-miR-3622b-3p	CLIP-seq
MIRT2451877	hsa-miR-3662	CLIP-seq
MIRT1067320	hsa-miR-3665	CLIP-seq
MIRT1067322	hsa-miR-3686	CLIP-seq
MIRT1067323	hsa-miR-3689a-3p	CLIP-seq
MIRT1067324	hsa-miR-3689c	CLIP-seq
MIRT1067325	hsa-miR-3714	CLIP-seq
MIRT2248614	hsa-miR-371-5p	CLIP-seq
MIRT2451878	hsa-miR-371b-5p	CLIP-seq
MIRT1067326	hsa-miR-3913-5p	CLIP-seq
MIRT2451879	hsa-miR-4486	CLIP-seq
MIRT1067343	hsa-miR-4649-3p	CLIP-seq
MIRT2451880	hsa-miR-4684-5p	CLIP-seq
MIRT1067349	hsa-miR-4728-5p	CLIP-seq
MIRT1067351	hsa-miR-4736	CLIP-seq
MIRT2451881	hsa-miR-4738-3p	CLIP-seq
MIRT1067356	hsa-miR-500a	CLIP-seq
MIRT1067357	hsa-miR-544b	CLIP-seq
MIRT2451882	hsa-miR-585	CLIP-seq
MIRT2016313	hsa-miR-939	CLIP-seq
MIRT1067363	hsa-miR-940	CLIP-seq
MIRT2016297	hsa-miR-2110	CLIP-seq
MIRT2016298	hsa-miR-3150a-3p	CLIP-seq
MIRT2016299	hsa-miR-3175	CLIP-seq
MIRT1067315	hsa-miR-3607-3p	CLIP-seq
MIRT2016300	hsa-miR-3614-5p	CLIP-seq
MIRT1067322	hsa-miR-3686	CLIP-seq
MIRT1067356	hsa-miR-500a	CLIP-seq
MIRT2016313	hsa-miR-939	CLIP-seq
MIRT2552103	hsa-let-7a	CLIP-seq
MIRT2552104	hsa-let-7b	CLIP-seq
MIRT2552105	hsa-let-7c	CLIP-seq
MIRT2552106	hsa-let-7d	CLIP-seq
MIRT2552107	hsa-let-7e	CLIP-seq
MIRT2552108	hsa-let-7f	CLIP-seq
MIRT2552109	hsa-let-7g	CLIP-seq
MIRT2552110	hsa-let-7i	CLIP-seq
MIRT1067297	hsa-miR-1206	CLIP-seq
MIRT1067298	hsa-miR-1268	CLIP-seq
MIRT1067299	hsa-miR-1268b	CLIP-seq
MIRT2552111	hsa-miR-1285	CLIP-seq
MIRT1067301	hsa-miR-1295	CLIP-seq
MIRT2552112	hsa-miR-1323	CLIP-seq
MIRT1067302	hsa-miR-140-3p	CLIP-seq
MIRT2552113	hsa-miR-146b-3p	CLIP-seq
MIRT2552114	hsa-miR-1911	CLIP-seq
MIRT1067304	hsa-miR-197	CLIP-seq
MIRT2016297	hsa-miR-2110	CLIP-seq
MIRT1067309	hsa-miR-3122	CLIP-seq
MIRT2016298	hsa-miR-3150a-3p	CLIP-seq
MIRT1067311	hsa-miR-3165	CLIP-seq
MIRT2552115	hsa-miR-3173-5p	CLIP-seq
MIRT2552116	hsa-miR-3174	CLIP-seq
MIRT2016299	hsa-miR-3175	CLIP-seq
MIRT2552117	hsa-miR-3187-5p	CLIP-seq
MIRT1067313	hsa-miR-323-5p	CLIP-seq
MIRT1067314	hsa-miR-339-5p	CLIP-seq
MIRT1067315	hsa-miR-3607-3p	CLIP-seq
MIRT2451876	hsa-miR-3613-3p	CLIP-seq
MIRT2016300	hsa-miR-3614-5p	CLIP-seq
MIRT1067317	hsa-miR-3622a-3p	CLIP-seq
MIRT1067318	hsa-miR-3622b-3p	CLIP-seq
MIRT2016302	hsa-miR-3649	CLIP-seq
MIRT2451877	hsa-miR-3662	CLIP-seq
MIRT1067320	hsa-miR-3665	CLIP-seq
MIRT1067321	hsa-miR-3674	CLIP-seq
MIRT1067322	hsa-miR-3686	CLIP-seq
MIRT1067323	hsa-miR-3689a-3p	CLIP-seq
MIRT1067324	hsa-miR-3689c	CLIP-seq
MIRT2552118	hsa-miR-3689d	CLIP-seq
MIRT1067325	hsa-miR-3714	CLIP-seq
MIRT2248614	hsa-miR-371-5p	CLIP-seq
MIRT2451878	hsa-miR-371b-5p	CLIP-seq
MIRT1067326	hsa-miR-3913-5p	CLIP-seq
MIRT2552119	hsa-miR-4254	CLIP-seq
MIRT1067332	hsa-miR-4287	CLIP-seq
MIRT2016303	hsa-miR-4302	CLIP-seq
MIRT2552120	hsa-miR-4307	CLIP-seq
MIRT2552121	hsa-miR-4308	CLIP-seq
MIRT2552122	hsa-miR-4423-5p	CLIP-seq
MIRT2552123	hsa-miR-4458	CLIP-seq
MIRT1067336	hsa-miR-4469	CLIP-seq
MIRT2451879	hsa-miR-4486	CLIP-seq
MIRT2552124	hsa-miR-4500	CLIP-seq
MIRT2016304	hsa-miR-4645-5p	CLIP-seq
MIRT1067343	hsa-miR-4649-3p	CLIP-seq
MIRT2016306	hsa-miR-4673	CLIP-seq
MIRT2451880	hsa-miR-4684-5p	CLIP-seq
MIRT1067344	hsa-miR-4685-3p	CLIP-seq
MIRT2552125	hsa-miR-4698	CLIP-seq
MIRT1067346	hsa-miR-4711-5p	CLIP-seq
MIRT1067347	hsa-miR-4717-5p	CLIP-seq
MIRT1067349	hsa-miR-4728-5p	CLIP-seq
MIRT1067350	hsa-miR-4732-5p	CLIP-seq
MIRT2552126	hsa-miR-4735-5p	CLIP-seq
MIRT1067351	hsa-miR-4736	CLIP-seq
MIRT2451881	hsa-miR-4738-3p	CLIP-seq
MIRT1067352	hsa-miR-4755-3p	CLIP-seq
MIRT2016309	hsa-miR-4763-5p	CLIP-seq
MIRT2552127	hsa-miR-4765	CLIP-seq
MIRT2552128	hsa-miR-4773	CLIP-seq
MIRT2552129	hsa-miR-4775	CLIP-seq
MIRT1067356	hsa-miR-500a	CLIP-seq
MIRT1067357	hsa-miR-544b	CLIP-seq
MIRT2552130	hsa-miR-548ac	CLIP-seq
MIRT2552131	hsa-miR-548ae	CLIP-seq
MIRT2552132	hsa-miR-548aj	CLIP-seq
MIRT2552133	hsa-miR-548am	CLIP-seq
MIRT2552134	hsa-miR-548c-3p	CLIP-seq
MIRT2552135	hsa-miR-548d-3p	CLIP-seq
MIRT2552136	hsa-miR-548o	CLIP-seq
MIRT2552137	hsa-miR-548p	CLIP-seq
MIRT2552138	hsa-miR-548x	CLIP-seq
MIRT2552139	hsa-miR-548z	CLIP-seq
MIRT2016310	hsa-miR-550a	CLIP-seq
MIRT2552140	hsa-miR-582-5p	CLIP-seq
MIRT2451882	hsa-miR-585	CLIP-seq
MIRT2552141	hsa-miR-590-3p	CLIP-seq
MIRT2552142	hsa-miR-612	CLIP-seq
MIRT2552143	hsa-miR-661	CLIP-seq
MIRT2016312	hsa-miR-874	CLIP-seq
MIRT1067362	hsa-miR-876-3p	CLIP-seq
MIRT2016313	hsa-miR-939	CLIP-seq
MIRT1067363	hsa-miR-940	CLIP-seq
MIRT2552144	hsa-miR-98	CLIP-seq
MIRT2552103	hsa-let-7a	CLIP-seq
MIRT2552104	hsa-let-7b	CLIP-seq
MIRT2552105	hsa-let-7c	CLIP-seq
MIRT2552106	hsa-let-7d	CLIP-seq
MIRT2552107	hsa-let-7e	CLIP-seq
MIRT2552108	hsa-let-7f	CLIP-seq
MIRT2552109	hsa-let-7g	CLIP-seq
MIRT2552110	hsa-let-7i	CLIP-seq
MIRT1067297	hsa-miR-1206	CLIP-seq
MIRT1067301	hsa-miR-1295	CLIP-seq
MIRT2552112	hsa-miR-1323	CLIP-seq
MIRT1067302	hsa-miR-140-3p	CLIP-seq
MIRT2552113	hsa-miR-146b-3p	CLIP-seq
MIRT2552114	hsa-miR-1911	CLIP-seq
MIRT1067304	hsa-miR-197	CLIP-seq
MIRT2016297	hsa-miR-2110	CLIP-seq
MIRT1067309	hsa-miR-3122	CLIP-seq
MIRT2016298	hsa-miR-3150a-3p	CLIP-seq
MIRT1067311	hsa-miR-3165	CLIP-seq
MIRT2552115	hsa-miR-3173-5p	CLIP-seq
MIRT2552116	hsa-miR-3174	CLIP-seq
MIRT2016299	hsa-miR-3175	CLIP-seq
MIRT1067313	hsa-miR-323-5p	CLIP-seq
MIRT1067314	hsa-miR-339-5p	CLIP-seq
MIRT1067315	hsa-miR-3607-3p	CLIP-seq
MIRT2451876	hsa-miR-3613-3p	CLIP-seq
MIRT2016300	hsa-miR-3614-5p	CLIP-seq
MIRT1067317	hsa-miR-3622a-3p	CLIP-seq
MIRT1067318	hsa-miR-3622b-3p	CLIP-seq
MIRT2016302	hsa-miR-3649	CLIP-seq
MIRT2451877	hsa-miR-3662	CLIP-seq
MIRT1067320	hsa-miR-3665	CLIP-seq
MIRT1067321	hsa-miR-3674	CLIP-seq
MIRT1067322	hsa-miR-3686	CLIP-seq
MIRT1067323	hsa-miR-3689a-3p	CLIP-seq
MIRT1067324	hsa-miR-3689c	CLIP-seq
MIRT2552118	hsa-miR-3689d	CLIP-seq
MIRT1067325	hsa-miR-3714	CLIP-seq
MIRT2248614	hsa-miR-371-5p	CLIP-seq
MIRT2451878	hsa-miR-371b-5p	CLIP-seq
MIRT1067326	hsa-miR-3913-5p	CLIP-seq
MIRT2552119	hsa-miR-4254	CLIP-seq
MIRT1067329	hsa-miR-4281	CLIP-seq
MIRT1067332	hsa-miR-4287	CLIP-seq
MIRT2552120	hsa-miR-4307	CLIP-seq
MIRT2552121	hsa-miR-4308	CLIP-seq
MIRT2552122	hsa-miR-4423-5p	CLIP-seq
MIRT2552123	hsa-miR-4458	CLIP-seq
MIRT1067336	hsa-miR-4469	CLIP-seq
MIRT2552124	hsa-miR-4500	CLIP-seq
MIRT2016304	hsa-miR-4645-5p	CLIP-seq
MIRT1067343	hsa-miR-4649-3p	CLIP-seq
MIRT2016306	hsa-miR-4673	CLIP-seq
MIRT2451880	hsa-miR-4684-5p	CLIP-seq
MIRT1067344	hsa-miR-4685-3p	CLIP-seq
MIRT2552125	hsa-miR-4698	CLIP-seq
MIRT1067346	hsa-miR-4711-5p	CLIP-seq
MIRT1067347	hsa-miR-4717-5p	CLIP-seq
MIRT1067349	hsa-miR-4728-5p	CLIP-seq
MIRT1067350	hsa-miR-4732-5p	CLIP-seq
MIRT2552126	hsa-miR-4735-5p	CLIP-seq
MIRT1067351	hsa-miR-4736	CLIP-seq
MIRT2451881	hsa-miR-4738-3p	CLIP-seq
MIRT1067352	hsa-miR-4755-3p	CLIP-seq
MIRT2016309	hsa-miR-4763-5p	CLIP-seq
MIRT2552127	hsa-miR-4765	CLIP-seq
MIRT2552129	hsa-miR-4775	CLIP-seq
MIRT1067356	hsa-miR-500a	CLIP-seq
MIRT1067357	hsa-miR-544b	CLIP-seq
MIRT2552130	hsa-miR-548ac	CLIP-seq
MIRT2552131	hsa-miR-548ae	CLIP-seq
MIRT2552132	hsa-miR-548aj	CLIP-seq
MIRT2552133	hsa-miR-548am	CLIP-seq
MIRT2552134	hsa-miR-548c-3p	CLIP-seq
MIRT2552135	hsa-miR-548d-3p	CLIP-seq
MIRT2552136	hsa-miR-548o	CLIP-seq
MIRT2552137	hsa-miR-548p	CLIP-seq
MIRT2552138	hsa-miR-548x	CLIP-seq
MIRT2552139	hsa-miR-548z	CLIP-seq
MIRT2016310	hsa-miR-550a	CLIP-seq
MIRT2552140	hsa-miR-582-5p	CLIP-seq
MIRT2552141	hsa-miR-590-3p	CLIP-seq
MIRT2016312	hsa-miR-874	CLIP-seq
MIRT1067362	hsa-miR-876-3p	CLIP-seq
MIRT2016313	hsa-miR-939	CLIP-seq
MIRT1067363	hsa-miR-940	CLIP-seq
MIRT2552144	hsa-miR-98	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001701	Process	In utero embryonic development	IEA
GO:0004439	Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IBA
GO:0004439	Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IDA	7721860
GO:0004439	Function	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	IEA
GO:0005515	Function	Protein binding	IPI	21233288, 25869668
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IEA
GO:0005793	Component	Endoplasmic reticulum-Golgi intermediate compartment	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA	7721860
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007283	Process	Spermatogenesis	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IDA	7721860
GO:0016020	Component	Membrane	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IEA
GO:0030317	Process	Flagellated sperm motility	IEA
GO:0030670	Component	Phagocytic vesicle membrane	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031901	Component	Early endosome membrane	IEA
GO:0043005	Component	Neuron projection	IBA
GO:0043647	Process	Inositol phosphate metabolic process	IEA
GO:0043647	Process	Inositol phosphate metabolic process	TAS
GO:0046856	Process	Phosphatidylinositol dephosphorylation	IDA	7721860
GO:0046856	Process	Phosphatidylinositol dephosphorylation	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0052658	Function	Inositol-1,4,5-trisphosphate 5-phosphatase activity	IBA
GO:0052658	Function	Inositol-1,4,5-trisphosphate 5-phosphatase activity	IDA	7721860
GO:0052658	Function	Inositol-1,4,5-trisphosphate 5-phosphatase activity	IEA
GO:0052658	Function	Inositol-1,4,5-trisphosphate 5-phosphatase activity	TAS
GO:0052659	Function	Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	TAS
GO:0052745	Function	Inositol phosphate phosphatase activity	IEA
GO:0070613	Process	Regulation of protein processing	IEA

Other IDs

• MIM: 147264
• HGNC: 6077
• e!Ensembl: ENSG00000204084

Protein

• UniProt ID: P32019
• Protein name: Type II inositol 1,4,5-trisphosphate 5-phosphatase (EC 3.1.3.36) (75 kDa inositol polyphosphate-5-phosphatase) (Phosphoinositide 5-phosphatase) (5PTase)
• Protein function: Hydrolyzes phosphatidylinositol 4,5-bisphosphate (PtIns(4,5)P2) and the signaling molecule phosphatidylinositol 1,4,5-trisphosphate (PtIns(1,4,5)P3), and thereby modulates cellular signaling events.
• PDB: 3MTC, 3N9V, 4CML, 5A7I, 5A7J
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF16776	INPP5B_PH	1 → 149	Type II inositol 1,4,5-trisphosphate 5-phosphatase PH domain	Domain
  PF03372	Exo_endo_phos	350 → 629	Endonuclease/Exonuclease/phosphatase family	Domain
  PF00620	RhoGAP	830 → 972	RhoGAP domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Platelets.
• Sequence:

  MDQSVAIQETLAEGEYCVIAVQGVLCEGDSRQSRLLGLVRYRLEHGGQEHALFLYTHRRM
  AITGDDVSLDQIVPVSRDFTLEEVSPDGELYILGSDVTVQLDTAELSLVFQLPFGSQTRM
  FLHEVARACPGFDSATRDPEFLWLSRYRCAELELEMPTPRGCNSALVTWPGYATIGGGRY
  PSRKKRWGLEEARPQGAGSVLFWGGAMEKTGFRLMERAHGGGFVWGRSARDGRRDEELEE
  AGREMSAAAGSRERNTAGGSNFDGLRPNGKGVPMDQSSRGQDKPESLQPRQNKSKSEITD
  MVRSSTITVSDKAHILSMQKFGLRDTIVKSHLLQKEEDYTYIQNFRFFAGTYNVNGQSPK
  ECLRLWLSNGIQAPDVYCVGFQELDLSKEAFFFHDTPKEEEWFKAVSEGLHPDAKYAKVK
  LIRLVGIMLLLYVKQEHAAYISEVEAETVGTGIMGRMGNKGGVAIRFQFHNTSICVVNSH
  LAAHIEEYERRNQDYKDICSRMQFCQPDPSLPPLTISNHDVILWLGDLNYRIEELDVEKV
  KKLIEEKDFQMLYAYDQLKIQVAAKTVFEGFTEGELTFQPTYKYDTGSDDWDTSEKCRAP
  AWCDRILWKGKNITQLSYQSHMALKTSDHKPVSSVFDIGVRVVNDELYRKTLEEIVRSLD
  KMENANIPSVSLSKREFCFQNVKYMQLKVESFTIHNGQVPCHFEFINKPDEESYCKQWLN
  ANPSRGFLLPDSDVEIDLELFVNKMTATKLNSGEDKIEDILVLHLDRGKDYFLSVSGNYL
  PSCFGSPIHTLCYMREPILDLPLETISELTLMPVWTGDDGSQLDSPMEIPKELWMMVDYL
  YRNAVQQEDLFQQPGLRSEFEHIRDCLDTGMIDNLSASNHSVAEALLLFLESLPEPVICY
  STYHNCLECSGNYTASKQVISTLPIFHKNVFHYLMAFLRELLKNSAKNHLDENILASIFG
  SLLLRNPAGHQKLDMTEKKKAQEFIHQFLCNPL

• Sequence length: 993

Pathways

KEGG:

Inositol phosphate metabolism
Metabolic pathways
Phosphatidylinositol signaling system

Reactome:

Synthesis of IP2, IP, and Ins in the cytosol
Synthesis of IP3 and IP4 in the cytosol
Rho GTPase cycle

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Dent disease type 2	Likely pathogenic	rs773387490	RCV000662295	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ALZHEIMER DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
AUTOIMMUNE THYROID DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
BASAL CELL CARCINOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CORONARY ARTERY DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DENT DISEASE 2	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPOTHYROIDISM	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
IGA GLOMERULONEPHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INPP5B-related disorder	Likely benign; Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MYOCARDIAL INFARCTION	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC LUPUS ERYTHEMATOSUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
THYROID DISEASE	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 1 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	28051077		★☆☆☆☆ Found in Text Mining only
Atrophy of testis	Testicular atrophy	BEFREE	9593760		★☆☆☆☆ Found in Text Mining only
Cataract	Cataract	BEFREE	23805271		★☆☆☆☆ Found in Text Mining only
Dent Disease 2	Dent`s Disease	CLINVAR_DG	28018608		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial aplasia of the vermis	Cerebellar vermis agenesis	BEFREE	27927754		★☆☆☆☆ Found in Text Mining only
Glaucoma	Glaucoma	BEFREE	23805271		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	30695232		★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	30695232		★☆☆☆☆ Found in Text Mining only
Hypothyroidism	Hypothyroidism	GWASCAT_DG	30595370		★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Mild cognitive disorder	Cognitive disorder	BEFREE	28190456		★☆☆☆☆ Found in Text Mining only
Muscular Dystrophy	Muscular dystrophy	BEFREE	28190456		★☆☆☆☆ Found in Text Mining only
Oculocerebrorenal Syndrome	Oculocerebrorenal Syndrome	BEFREE	19272022, 20872266, 23805271, 25305077, 27895154, 9593760		★☆☆☆☆ Found in Text Mining only