Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	3632
Gene name	Inositol polyphosphate-5-phosphatase A
Gene symbol	INPP5A
Synonyms (NCBI Gene)	5PTASE
Chromosome	10
Chromosome location	10q26.3
Summary	The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses

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miRTarBase ID	miRNA	Experiments	Reference
MIRT029103	hsa-miR-26b-5p	Microarray	19088304
MIRT042796	hsa-miR-339-5p	CLASH	23622248
MIRT054208	hsa-miR-210-3p	Luciferase reporter assayMicroarrayqRT-PCRWestern blot	23028679
MIRT177101	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT440454	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT177101	hsa-miR-142-3p	HITS-CLIP	22473208
MIRT440454	hsa-miR-155-5p	HITS-CLIP	22473208
MIRT1067202	hsa-let-7a	CLIP-seq
MIRT1067203	hsa-let-7b	CLIP-seq
MIRT1067204	hsa-let-7c	CLIP-seq
MIRT1067205	hsa-let-7d	CLIP-seq
MIRT1067206	hsa-let-7e	CLIP-seq
MIRT1067207	hsa-let-7f	CLIP-seq
MIRT1067208	hsa-let-7g	CLIP-seq
MIRT1067209	hsa-let-7i	CLIP-seq
MIRT1067210	hsa-miR-1203	CLIP-seq
MIRT1067211	hsa-miR-1224-3p	CLIP-seq
MIRT1067212	hsa-miR-1231	CLIP-seq
MIRT1067213	hsa-miR-1236	CLIP-seq
MIRT1067214	hsa-miR-1260	CLIP-seq
MIRT1067215	hsa-miR-1260b	CLIP-seq
MIRT1067216	hsa-miR-1266	CLIP-seq
MIRT1067217	hsa-miR-1271	CLIP-seq
MIRT1067218	hsa-miR-1280	CLIP-seq
MIRT1067219	hsa-miR-1294	CLIP-seq
MIRT1067220	hsa-miR-148a	CLIP-seq
MIRT1067221	hsa-miR-148b	CLIP-seq
MIRT1067222	hsa-miR-150	CLIP-seq
MIRT1067223	hsa-miR-152	CLIP-seq
MIRT1067224	hsa-miR-154	CLIP-seq
MIRT1067225	hsa-miR-188-3p	CLIP-seq
MIRT1067226	hsa-miR-202	CLIP-seq
MIRT1067227	hsa-miR-2467-5p	CLIP-seq
MIRT1067228	hsa-miR-3127-5p	CLIP-seq
MIRT1067229	hsa-miR-3137	CLIP-seq
MIRT1067230	hsa-miR-3145-3p	CLIP-seq
MIRT1067231	hsa-miR-3151	CLIP-seq
MIRT1067232	hsa-miR-3156-3p	CLIP-seq
MIRT1067233	hsa-miR-3188	CLIP-seq
MIRT1067234	hsa-miR-323b-5p	CLIP-seq
MIRT1067235	hsa-miR-3607-5p	CLIP-seq
MIRT1067236	hsa-miR-3613-5p	CLIP-seq
MIRT1067237	hsa-miR-3648	CLIP-seq
MIRT1067238	hsa-miR-3665	CLIP-seq
MIRT1067239	hsa-miR-371-3p	CLIP-seq
MIRT1067240	hsa-miR-376c	CLIP-seq
MIRT1067241	hsa-miR-3908	CLIP-seq
MIRT1067242	hsa-miR-3915	CLIP-seq
MIRT1067243	hsa-miR-3918	CLIP-seq
MIRT1067244	hsa-miR-3928	CLIP-seq
MIRT1067245	hsa-miR-3929	CLIP-seq
MIRT1067246	hsa-miR-3940-5p	CLIP-seq
MIRT1067247	hsa-miR-3975	CLIP-seq
MIRT1067248	hsa-miR-425	CLIP-seq
MIRT1067249	hsa-miR-4283	CLIP-seq
MIRT1067250	hsa-miR-4288	CLIP-seq
MIRT1067251	hsa-miR-4316	CLIP-seq
MIRT1067252	hsa-miR-4328	CLIP-seq
MIRT1067253	hsa-miR-4419b	CLIP-seq
MIRT1067254	hsa-miR-4447	CLIP-seq
MIRT1067255	hsa-miR-4458	CLIP-seq
MIRT1067256	hsa-miR-4462	CLIP-seq
MIRT1067257	hsa-miR-4472	CLIP-seq
MIRT1067258	hsa-miR-4478	CLIP-seq
MIRT1067259	hsa-miR-4489	CLIP-seq
MIRT1067260	hsa-miR-4492	CLIP-seq
MIRT1067261	hsa-miR-4498	CLIP-seq
MIRT1067262	hsa-miR-4500	CLIP-seq
MIRT1067263	hsa-miR-4501	CLIP-seq
MIRT1067264	hsa-miR-4504	CLIP-seq
MIRT1067265	hsa-miR-4507	CLIP-seq
MIRT1067266	hsa-miR-4518	CLIP-seq
MIRT1067267	hsa-miR-4533	CLIP-seq
MIRT1067268	hsa-miR-4640-3p	CLIP-seq
MIRT1067269	hsa-miR-4642	CLIP-seq
MIRT1067270	hsa-miR-4659a-5p	CLIP-seq
MIRT1067271	hsa-miR-4659b-5p	CLIP-seq
MIRT1067272	hsa-miR-4690-5p	CLIP-seq
MIRT1067273	hsa-miR-4697-3p	CLIP-seq
MIRT1067274	hsa-miR-4713-5p	CLIP-seq
MIRT1067275	hsa-miR-4720-5p	CLIP-seq
MIRT1067276	hsa-miR-4776-3p	CLIP-seq
MIRT1067277	hsa-miR-4790-3p	CLIP-seq
MIRT1067278	hsa-miR-4795-3p	CLIP-seq
MIRT1067279	hsa-miR-4799-3p	CLIP-seq
MIRT1067280	hsa-miR-485-5p	CLIP-seq
MIRT1067281	hsa-miR-491-5p	CLIP-seq
MIRT1067282	hsa-miR-516a-5p	CLIP-seq
MIRT1067283	hsa-miR-532-3p	CLIP-seq
MIRT1067284	hsa-miR-542-3p	CLIP-seq
MIRT1067285	hsa-miR-548aa	CLIP-seq
MIRT1067286	hsa-miR-582-5p	CLIP-seq
MIRT1067287	hsa-miR-595	CLIP-seq
MIRT1067288	hsa-miR-632	CLIP-seq
MIRT1067289	hsa-miR-635	CLIP-seq
MIRT1067290	hsa-miR-645	CLIP-seq
MIRT1067291	hsa-miR-656	CLIP-seq
MIRT1067292	hsa-miR-762	CLIP-seq
MIRT1067293	hsa-miR-767-5p	CLIP-seq
MIRT1067294	hsa-miR-890	CLIP-seq
MIRT1067295	hsa-miR-96	CLIP-seq
MIRT1067296	hsa-miR-98	CLIP-seq
MIRT1067202	hsa-let-7a	CLIP-seq
MIRT1067203	hsa-let-7b	CLIP-seq
MIRT1067204	hsa-let-7c	CLIP-seq
MIRT1067205	hsa-let-7d	CLIP-seq
MIRT1067206	hsa-let-7e	CLIP-seq
MIRT1067207	hsa-let-7f	CLIP-seq
MIRT1067208	hsa-let-7g	CLIP-seq
MIRT1067209	hsa-let-7i	CLIP-seq
MIRT1067219	hsa-miR-1294	CLIP-seq
MIRT1067220	hsa-miR-148a	CLIP-seq
MIRT1067221	hsa-miR-148b	CLIP-seq
MIRT1067223	hsa-miR-152	CLIP-seq
MIRT1067226	hsa-miR-202	CLIP-seq
MIRT1067227	hsa-miR-2467-5p	CLIP-seq
MIRT1067229	hsa-miR-3137	CLIP-seq
MIRT2016287	hsa-miR-3614-5p	CLIP-seq
MIRT1067237	hsa-miR-3648	CLIP-seq
MIRT2016288	hsa-miR-3664-5p	CLIP-seq
MIRT1067239	hsa-miR-371-3p	CLIP-seq
MIRT1067240	hsa-miR-376c	CLIP-seq
MIRT2016289	hsa-miR-3978	CLIP-seq
MIRT1067255	hsa-miR-4458	CLIP-seq
MIRT1067256	hsa-miR-4462	CLIP-seq
MIRT1067262	hsa-miR-4500	CLIP-seq
MIRT2016290	hsa-miR-450b-5p	CLIP-seq
MIRT1067267	hsa-miR-4533	CLIP-seq
MIRT2016291	hsa-miR-4536	CLIP-seq
MIRT1067273	hsa-miR-4697-3p	CLIP-seq
MIRT2016292	hsa-miR-4704-3p	CLIP-seq
MIRT2016293	hsa-miR-495	CLIP-seq
MIRT2016294	hsa-miR-548l	CLIP-seq
MIRT2016295	hsa-miR-553	CLIP-seq
MIRT1067293	hsa-miR-767-5p	CLIP-seq
MIRT2016296	hsa-miR-802	CLIP-seq
MIRT1067296	hsa-miR-98	CLIP-seq
MIRT1067202	hsa-let-7a	CLIP-seq
MIRT1067203	hsa-let-7b	CLIP-seq
MIRT1067204	hsa-let-7c	CLIP-seq
MIRT1067205	hsa-let-7d	CLIP-seq
MIRT1067206	hsa-let-7e	CLIP-seq
MIRT1067207	hsa-let-7f	CLIP-seq
MIRT1067208	hsa-let-7g	CLIP-seq
MIRT1067209	hsa-let-7i	CLIP-seq
MIRT1067217	hsa-miR-1271	CLIP-seq
MIRT1067219	hsa-miR-1294	CLIP-seq
MIRT2248586	hsa-miR-140-3p	CLIP-seq
MIRT1067222	hsa-miR-150	CLIP-seq
MIRT2248587	hsa-miR-181a	CLIP-seq
MIRT2248588	hsa-miR-181b	CLIP-seq
MIRT2248589	hsa-miR-181c	CLIP-seq
MIRT2248590	hsa-miR-181d	CLIP-seq
MIRT1067225	hsa-miR-188-3p	CLIP-seq
MIRT1067226	hsa-miR-202	CLIP-seq
MIRT2248591	hsa-miR-2052	CLIP-seq
MIRT2248592	hsa-miR-2116	CLIP-seq
MIRT2248593	hsa-miR-2277-3p	CLIP-seq
MIRT2248594	hsa-miR-23a	CLIP-seq
MIRT2248595	hsa-miR-23b	CLIP-seq
MIRT2248596	hsa-miR-23c	CLIP-seq
MIRT1067227	hsa-miR-2467-5p	CLIP-seq
MIRT1067229	hsa-miR-3137	CLIP-seq
MIRT1067230	hsa-miR-3145-3p	CLIP-seq
MIRT1067231	hsa-miR-3151	CLIP-seq
MIRT1067233	hsa-miR-3188	CLIP-seq
MIRT1067236	hsa-miR-3613-5p	CLIP-seq
MIRT2016287	hsa-miR-3614-5p	CLIP-seq
MIRT1067238	hsa-miR-3665	CLIP-seq
MIRT1067240	hsa-miR-376c	CLIP-seq
MIRT1067245	hsa-miR-3929	CLIP-seq
MIRT2248597	hsa-miR-3941	CLIP-seq
MIRT1067247	hsa-miR-3975	CLIP-seq
MIRT2248598	hsa-miR-4262	CLIP-seq
MIRT2248599	hsa-miR-4274	CLIP-seq
MIRT2248600	hsa-miR-4277	CLIP-seq
MIRT1067249	hsa-miR-4283	CLIP-seq
MIRT1067251	hsa-miR-4316	CLIP-seq
MIRT1067253	hsa-miR-4419b	CLIP-seq
MIRT1067254	hsa-miR-4447	CLIP-seq
MIRT1067255	hsa-miR-4458	CLIP-seq
MIRT1067256	hsa-miR-4462	CLIP-seq
MIRT1067257	hsa-miR-4472	CLIP-seq
MIRT1067258	hsa-miR-4478	CLIP-seq
MIRT1067259	hsa-miR-4489	CLIP-seq
MIRT1067260	hsa-miR-4492	CLIP-seq
MIRT1067261	hsa-miR-4498	CLIP-seq
MIRT1067262	hsa-miR-4500	CLIP-seq
MIRT1067263	hsa-miR-4501	CLIP-seq
MIRT2016290	hsa-miR-450b-5p	CLIP-seq
MIRT2016291	hsa-miR-4536	CLIP-seq
MIRT2248601	hsa-miR-466	CLIP-seq
MIRT2248602	hsa-miR-4672	CLIP-seq
MIRT1067272	hsa-miR-4690-5p	CLIP-seq
MIRT2016292	hsa-miR-4704-3p	CLIP-seq
MIRT1067274	hsa-miR-4713-5p	CLIP-seq
MIRT2248603	hsa-miR-4733-5p	CLIP-seq
MIRT1067277	hsa-miR-4790-3p	CLIP-seq
MIRT1067278	hsa-miR-4795-3p	CLIP-seq
MIRT1067280	hsa-miR-485-5p	CLIP-seq
MIRT1067281	hsa-miR-491-5p	CLIP-seq
MIRT2248604	hsa-miR-492	CLIP-seq
MIRT2016293	hsa-miR-495	CLIP-seq
MIRT2248605	hsa-miR-503	CLIP-seq
MIRT2248606	hsa-miR-514	CLIP-seq
MIRT2248607	hsa-miR-514b-3p	CLIP-seq
MIRT1067283	hsa-miR-532-3p	CLIP-seq
MIRT2248608	hsa-miR-549	CLIP-seq
MIRT1067287	hsa-miR-595	CLIP-seq
MIRT2248609	hsa-miR-624	CLIP-seq
MIRT1067289	hsa-miR-635	CLIP-seq
MIRT1067290	hsa-miR-645	CLIP-seq
MIRT2248610	hsa-miR-653	CLIP-seq
MIRT1067291	hsa-miR-656	CLIP-seq
MIRT1067292	hsa-miR-762	CLIP-seq
MIRT1067293	hsa-miR-767-5p	CLIP-seq
MIRT2016296	hsa-miR-802	CLIP-seq
MIRT2248611	hsa-miR-889	CLIP-seq
MIRT1067294	hsa-miR-890	CLIP-seq
MIRT1067295	hsa-miR-96	CLIP-seq
MIRT1067296	hsa-miR-98	CLIP-seq
MIRT1067227	hsa-miR-2467-5p	CLIP-seq
MIRT1067229	hsa-miR-3137	CLIP-seq
MIRT1067241	hsa-miR-3908	CLIP-seq
MIRT1067242	hsa-miR-3915	CLIP-seq
MIRT1067244	hsa-miR-3928	CLIP-seq
MIRT1067252	hsa-miR-4328	CLIP-seq
MIRT1067286	hsa-miR-582-5p	CLIP-seq
MIRT1067202	hsa-let-7a	CLIP-seq
MIRT1067203	hsa-let-7b	CLIP-seq
MIRT1067204	hsa-let-7c	CLIP-seq
MIRT1067205	hsa-let-7d	CLIP-seq
MIRT1067206	hsa-let-7e	CLIP-seq
MIRT1067207	hsa-let-7f	CLIP-seq
MIRT1067208	hsa-let-7g	CLIP-seq
MIRT1067209	hsa-let-7i	CLIP-seq
MIRT1067219	hsa-miR-1294	CLIP-seq
MIRT1067226	hsa-miR-202	CLIP-seq
MIRT1067227	hsa-miR-2467-5p	CLIP-seq
MIRT2430068	hsa-miR-299-5p	CLIP-seq
MIRT1067233	hsa-miR-3188	CLIP-seq
MIRT1067240	hsa-miR-376c	CLIP-seq
MIRT1067247	hsa-miR-3975	CLIP-seq
MIRT1067251	hsa-miR-4316	CLIP-seq
MIRT1067255	hsa-miR-4458	CLIP-seq
MIRT1067262	hsa-miR-4500	CLIP-seq
MIRT1067263	hsa-miR-4501	CLIP-seq
MIRT1067277	hsa-miR-4790-3p	CLIP-seq
MIRT1067280	hsa-miR-485-5p	CLIP-seq
MIRT2430069	hsa-miR-520d-5p	CLIP-seq
MIRT2430070	hsa-miR-524-5p	CLIP-seq
MIRT2016295	hsa-miR-553	CLIP-seq
MIRT1067296	hsa-miR-98	CLIP-seq
MIRT1067212	hsa-miR-1231	CLIP-seq
MIRT2552073	hsa-miR-1243	CLIP-seq
MIRT2552074	hsa-miR-138	CLIP-seq
MIRT2248587	hsa-miR-181a	CLIP-seq
MIRT2248588	hsa-miR-181b	CLIP-seq
MIRT2248589	hsa-miR-181c	CLIP-seq
MIRT2248590	hsa-miR-181d	CLIP-seq
MIRT2552075	hsa-miR-1914	CLIP-seq
MIRT2552076	hsa-miR-1976	CLIP-seq
MIRT2552077	hsa-miR-210	CLIP-seq
MIRT2248592	hsa-miR-2116	CLIP-seq
MIRT2248594	hsa-miR-23a	CLIP-seq
MIRT2248595	hsa-miR-23b	CLIP-seq
MIRT2248596	hsa-miR-23c	CLIP-seq
MIRT2430068	hsa-miR-299-5p	CLIP-seq
MIRT1067229	hsa-miR-3137	CLIP-seq
MIRT2552078	hsa-miR-3145-5p	CLIP-seq
MIRT2552079	hsa-miR-3166	CLIP-seq
MIRT2552080	hsa-miR-3199	CLIP-seq
MIRT1067234	hsa-miR-323b-5p	CLIP-seq
MIRT2552081	hsa-miR-337-5p	CLIP-seq
MIRT2552082	hsa-miR-340	CLIP-seq
MIRT2552083	hsa-miR-3622b-5p	CLIP-seq
MIRT2552084	hsa-miR-3654	CLIP-seq
MIRT2552085	hsa-miR-3670	CLIP-seq
MIRT2552086	hsa-miR-370	CLIP-seq
MIRT1067241	hsa-miR-3908	CLIP-seq
MIRT1067242	hsa-miR-3915	CLIP-seq
MIRT1067244	hsa-miR-3928	CLIP-seq
MIRT1067246	hsa-miR-3940-5p	CLIP-seq
MIRT2248597	hsa-miR-3941	CLIP-seq
MIRT2016289	hsa-miR-3978	CLIP-seq
MIRT2248598	hsa-miR-4262	CLIP-seq
MIRT2248600	hsa-miR-4277	CLIP-seq
MIRT1067250	hsa-miR-4288	CLIP-seq
MIRT2552087	hsa-miR-4304	CLIP-seq
MIRT1067252	hsa-miR-4328	CLIP-seq
MIRT2552088	hsa-miR-4485	CLIP-seq
MIRT1067265	hsa-miR-4507	CLIP-seq
MIRT2552089	hsa-miR-4632	CLIP-seq
MIRT2552090	hsa-miR-4641	CLIP-seq
MIRT2248601	hsa-miR-466	CLIP-seq
MIRT2552091	hsa-miR-4663	CLIP-seq
MIRT2248602	hsa-miR-4672	CLIP-seq
MIRT2552092	hsa-miR-4690-3p	CLIP-seq
MIRT2552093	hsa-miR-4716-5p	CLIP-seq
MIRT2552094	hsa-miR-4753-3p	CLIP-seq
MIRT2552095	hsa-miR-4768-5p	CLIP-seq
MIRT2552096	hsa-miR-4771	CLIP-seq
MIRT2552097	hsa-miR-485-3p	CLIP-seq
MIRT2430069	hsa-miR-520d-5p	CLIP-seq
MIRT2430070	hsa-miR-524-5p	CLIP-seq
MIRT2016294	hsa-miR-548l	CLIP-seq
MIRT2552098	hsa-miR-548m	CLIP-seq
MIRT2552099	hsa-miR-548q	CLIP-seq
MIRT2016295	hsa-miR-553	CLIP-seq
MIRT1067286	hsa-miR-582-5p	CLIP-seq
MIRT1067288	hsa-miR-632	CLIP-seq
MIRT2552100	hsa-miR-671-5p	CLIP-seq
MIRT2552101	hsa-miR-875-3p	CLIP-seq
MIRT2248611	hsa-miR-889	CLIP-seq
MIRT2552102	hsa-miR-944	CLIP-seq
MIRT1067212	hsa-miR-1231	CLIP-seq
MIRT2552073	hsa-miR-1243	CLIP-seq
MIRT2248587	hsa-miR-181a	CLIP-seq
MIRT2248588	hsa-miR-181b	CLIP-seq
MIRT2248589	hsa-miR-181c	CLIP-seq
MIRT2248590	hsa-miR-181d	CLIP-seq
MIRT2552075	hsa-miR-1914	CLIP-seq
MIRT2552076	hsa-miR-1976	CLIP-seq
MIRT2552077	hsa-miR-210	CLIP-seq
MIRT2248592	hsa-miR-2116	CLIP-seq
MIRT2248594	hsa-miR-23a	CLIP-seq
MIRT2248595	hsa-miR-23b	CLIP-seq
MIRT2248596	hsa-miR-23c	CLIP-seq
MIRT2430068	hsa-miR-299-5p	CLIP-seq
MIRT1067229	hsa-miR-3137	CLIP-seq
MIRT2552078	hsa-miR-3145-5p	CLIP-seq
MIRT2552080	hsa-miR-3199	CLIP-seq
MIRT1067234	hsa-miR-323b-5p	CLIP-seq
MIRT2552083	hsa-miR-3622b-5p	CLIP-seq
MIRT2552084	hsa-miR-3654	CLIP-seq
MIRT2552085	hsa-miR-3670	CLIP-seq
MIRT2552086	hsa-miR-370	CLIP-seq
MIRT1067241	hsa-miR-3908	CLIP-seq
MIRT1067242	hsa-miR-3915	CLIP-seq
MIRT1067244	hsa-miR-3928	CLIP-seq
MIRT1067246	hsa-miR-3940-5p	CLIP-seq
MIRT2248597	hsa-miR-3941	CLIP-seq
MIRT2016289	hsa-miR-3978	CLIP-seq
MIRT2248598	hsa-miR-4262	CLIP-seq
MIRT2248600	hsa-miR-4277	CLIP-seq
MIRT1067250	hsa-miR-4288	CLIP-seq
MIRT2552087	hsa-miR-4304	CLIP-seq
MIRT1067252	hsa-miR-4328	CLIP-seq
MIRT1067265	hsa-miR-4507	CLIP-seq
MIRT2552089	hsa-miR-4632	CLIP-seq
MIRT2248601	hsa-miR-466	CLIP-seq
MIRT2552091	hsa-miR-4663	CLIP-seq
MIRT2248602	hsa-miR-4672	CLIP-seq
MIRT2552094	hsa-miR-4753-3p	CLIP-seq
MIRT2552095	hsa-miR-4768-5p	CLIP-seq
MIRT2552097	hsa-miR-485-3p	CLIP-seq
MIRT2430069	hsa-miR-520d-5p	CLIP-seq
MIRT2430070	hsa-miR-524-5p	CLIP-seq
MIRT2016294	hsa-miR-548l	CLIP-seq
MIRT2552098	hsa-miR-548m	CLIP-seq
MIRT2016295	hsa-miR-553	CLIP-seq
MIRT1067286	hsa-miR-582-5p	CLIP-seq
MIRT1067288	hsa-miR-632	CLIP-seq
MIRT2552101	hsa-miR-875-3p	CLIP-seq
MIRT2248611	hsa-miR-889	CLIP-seq

Show/Hide all (30)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004445	Function	Inositol-polyphosphate 5-phosphatase activity	IBA
GO:0004445	Function	Inositol-polyphosphate 5-phosphatase activity	IDA	8006039, 8013665, 8626616
GO:0004445	Function	Inositol-polyphosphate 5-phosphatase activity	IEA
GO:0004445	Function	Inositol-polyphosphate 5-phosphatase activity	NAS	8006039
GO:0005515	Function	Protein binding	IPI	8999861, 32296183, 33961781
GO:0005886	Component	Plasma membrane	IDA	8626616
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006796	Process	Phosphate-containing compound metabolic process	IEA
GO:0016020	Component	Membrane	IDA	8006039
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	NAS	8006039
GO:0016787	Function	Hydrolase activity	IEA
GO:0016791	Function	Phosphatase activity	IEA
GO:0019637	Process	Organophosphate metabolic process	IEA
GO:0030425	Component	Dendrite	IEA
GO:0030425	Component	Dendrite	ISS
GO:0042731	Function	PH domain binding	IPI	8999861
GO:0042995	Component	Cell projection	IEA
GO:0043647	Process	Inositol phosphate metabolic process	IDA	8999861
GO:0043647	Process	Inositol phosphate metabolic process	TAS
GO:0046856	Process	Phosphatidylinositol dephosphorylation	IEA
GO:0050849	Process	Negative regulation of calcium-mediated signaling	IDA	8999861
GO:0052658	Function	Inositol-1,4,5-trisphosphate 5-phosphatase activity	IDA	8999861
GO:0052658	Function	Inositol-1,4,5-trisphosphate 5-phosphatase activity	IEA
GO:0052658	Function	Inositol-1,4,5-trisphosphate 5-phosphatase activity	TAS
GO:0052659	Function	Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	IDA	8999861
GO:0052659	Function	Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	IEA
GO:1900737	Process	Negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway	IEA
GO:1900737	Process	Negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway	ISS

MIM	HGNC	e!Ensembl
600106	6076	ENSG00000068383

Q14642

Protein name

Inositol polyphosphate-5-phosphatase A (EC 3.1.3.56) (43 kDa inositol polyphosphate 5-phosphatase) (Type I inositol 1,4,5-trisphosphate 5-phosphatase) (5PTase)

Protein function

Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate (PubMed:8013665, PubMed:8626616, PubMed:8769125). Plays a

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF03372	Exo_endo_phos	15 → 385	Endonuclease/Exonuclease/phosphatase family	Domain

Tissue specificity

TISSUE SPECIFICITY: Predominantly expressed in heart, brain, and skeletal muscle (PubMed:8006039). In brain; high level in Purkinje cells (PubMed:8013665). {ECO:0000269|PubMed:8006039, ECO:0000269|PubMed:8013665}.

Sequence

MAGKAAAPGTAVLLVTANVGSLFDDPENLQKNWLREFYQVVHTHKPHFMALHCQEFGGKN
YEASMSHVDKFVKELLSSDAMKEYNRARVYLDENYKSQEHFTALGSFYFLHESLKNIYQF
DFKAKKYRKVAGKEIYSDTLESTPMLEKEKFPQDYFPECKWSRKGFIRTRWCIADCAFDL
VNIHLFHDASNLVAWETSPSVYSGIRHKALGYVLDRIIDQRFEKVSYFVFGDFNFRLDSK
SVVETLCTKATMQTVRAADTNEVVKLIFRESDNDRKVMLQLEKKLFDYFNQEVFRDNNGT
ALLEFDKELSVFKDRLYELDISFPPSYPYSEDARQGEQYMNTRCPAWCDRILMSPSAKEL
VLRSESEEKVVTYDHIGPNVCMGDHKPVFLAFRIMPGAGKPHAHVHKCCVVQ

Sequence length

412

Interactions

View interactions

	KEGG		Reactome
	Inositol phosphate metabolism Metabolic pathways Phosphatidylinositol signaling system Insulin signaling pathway		Synthesis of IP2, IP, and Ins in the cytosol

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (17)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ALZHEIMER DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ATYPICAL FEMORAL FRACTURE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, SQUAMOUS CELL	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARDIOVASCULAR DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
DERMATOLOGIC DISORDERS	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYPERTENSION	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
INSOMNIA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
METABOLIC SYNDROME	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIPROSTHETIC OSTEOLYSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	CTD, Disgenet CTD, Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCLEROSING CHOLANGITIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SKIN DISEASE	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SKIN DISEASES	—	CTD	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SKIN DISEASES, GENETIC	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (27)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Actinic keratosis	Actinic keratosis	BEFREE	20876729, 31437542		★★★★★ ★☆☆☆☆ Found in Text Mining only
Arsenic Encephalopathy	Arsenic Encephalopathy	CTD_human_DG	25759212		★★★★★ ★☆☆☆☆ Found in Text Mining only
Astrocytoma	Astrocytoma	Pubtator	24358143	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	19875416, 20876729	Inhibit	★★★★★ ★☆☆☆☆ Found in Text Mining only
Carcinoma Squamous Cell	Squamous cell carcinoma	Pubtator	31437542	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Cardiovascular Diseases	Cardiovascular Diseases	GWASCAT_DG	30595370		★★★★★ ★☆☆☆☆ Found in Text Mining only
cervical cancer	Cervical Cancer	BEFREE	28653606		★★★★★ ★☆☆☆☆ Found in Text Mining only
Cholangitis, Sclerosing	Cholangitis	GWASCAT_DG	27992413		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colitis Ulcerative	Ulcerative colitis	Pubtator	33132321	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	34311674	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Dermatologic disorders	Dermatologic Disorders	CTD_human_DG	25759212		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Esophageal Squamous Cell Carcinoma	Esophageal squamous cell carcinoma	Pubtator	36437782	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	Pubtator	24358143	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of skin	Skin cancer	BEFREE	25759212		★★★★★ ★☆☆☆☆ Found in Text Mining only
Migraine Disorders	Migraine	GWASCAT_DG	27182965		★★★★★ ★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	20876729, 31437542		★★★★★ ★☆☆☆☆ Found in Text Mining only
Oculocerebrorenal Syndrome	Oculocerebrorenal Syndrome	BEFREE	19272022		★★★★★ ★☆☆☆☆ Found in Text Mining only
Sarcoma	Sarcoma	Pubtator	36619306	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	CTD_human_DG	21822266		★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Skin Diseases	Skin disease	Pubtator	25759212	Associate	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Skin lesion	Skin Lesion	BEFREE	25759212		★★★★★ ★☆☆☆☆ Found in Text Mining only
Skin Neoplasms	Skin neoplasm	Pubtator	25759212	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	BEFREE	19875416		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma	Carcinoma	CTD_human_DG	25759212		★★★★★ ★☆☆☆☆ Found in Text Mining only
Squamous cell carcinoma of skin	Skin carcinoma	BEFREE	20876729, 30359624, 31437542		★★★★★ ★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	28653606	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Xeroderma Pigmentosum Complementation Group C	Xeroderma pigmentosum	Pubtator	25759212	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

INPP5A (inositol polyphosphate-5-phosphatase A)