Gene Gene information from NCBI Gene database.
Entrez ID 3624
Gene name Inhibin subunit beta A
Gene symbol INHBA
Synonyms (NCBI Gene)
EDFFRP
Chromosome 7
Chromosome location 7p14.1
Summary This gene encodes a member of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate a subunit of the dimeric activin and inhibin protein complexes. These complexes activa
miRNA miRNA information provided by mirtarbase database.
1116
miRTarBase ID miRNA Experiments Reference
MIRT019457 hsa-miR-148b-3p Microarray 17612493
MIRT047412 hsa-miR-10b-5p CLASH 23622248
MIRT038928 hsa-miR-31-3p CLASH 23622248
MIRT484725 hsa-miR-548ac HITS-CLIP 21572407
MIRT484724 hsa-miR-548bb-3p HITS-CLIP 21572407
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
98
GO ID Ontology Definition Evidence Reference
GO:0001541 Process Ovarian follicle development IGI 10932194
GO:0001541 Process Ovarian follicle development NAS 9166111
GO:0001707 Process Mesoderm formation IEA
GO:0001942 Process Hair follicle development IGI 10932194
GO:0002244 Process Hematopoietic progenitor cell differentiation IDA 15451575
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
147290 6066 ENSG00000122641
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P08476
Protein name Inhibin beta A chain (Activin beta-A chain) (Erythroid differentiation protein) (EDF)
Protein function Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve
PDB 1NYS , 1NYU , 1S4Y , 2ARP , 2ARV , 2B0U , 2P6A , 3B4V , 4MID , 5HLY , 5HLZ , 6Y6N , 6Y6O , 7OLY , 7U5P , 9I5W
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00688 TGFb_propeptide 46 295 TGF-beta propeptide Family
PF00019 TGF_beta 320 425 Transforming growth factor beta like domain Domain
Sequence
Sequence length 426
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cytokine-cytokine receptor interaction
TGF-beta signaling pathway
Signaling pathways regulating pluripotency of stem cells
  Signaling by Activin
Glycoprotein hormones
Antagonism of Activin by Follistatin
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
10
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
GENERALISED EPILEPSY GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LEIOMYOMA CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
LIVER FAILURE, ACUTE CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Acute Erythroblastic Leukemia Erythroblastic Leukemia BEFREE 1673636
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 12088879
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 19308293, 28766011
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of ovary Adenocarcinoma Of Ovary Orphanet
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma, Clear Cell Adenocarcinoma LHGDN 16820918
★☆☆☆☆
Found in Text Mining only
Adrenocortical Carcinoma Adrenocortical carcinoma Pubtator 36039643 Associate
★☆☆☆☆
Found in Text Mining only
Asthma Asthma BEFREE 29694255
★☆☆☆☆
Found in Text Mining only
Bone Diseases Bone disease Pubtator 17900349 Associate
★☆☆☆☆
Found in Text Mining only
Brain Neoplasms Brain neoplasms Pubtator 7670558 Associate
★☆☆☆☆
Found in Text Mining only
Breast Neoplasms Breast neoplasm Pubtator 33378021, 33819300, 34889158, 35248133, 35999846 Associate
★☆☆☆☆
Found in Text Mining only