Gene Gene information from NCBI Gene database.
Entrez ID 3589
Gene name Interleukin 11
Gene symbol IL11
Synonyms (NCBI Gene)
AGIFIL-11
Chromosome 19
Chromosome location 19q13.42
Summary The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cy
miRNA miRNA information provided by mirtarbase database.
274
miRTarBase ID miRNA Experiments Reference
MIRT005829 hsa-miR-204-5p ELISAMicroarray 21282569
MIRT005829 hsa-miR-204-5p Luciferase reporter assay 22629385
MIRT007023 hsa-miR-211-5p Luciferase reporter assay 22629385
MIRT007025 hsa-miR-379-5p Luciferase reporter assay 22629385
MIRT022448 hsa-miR-124-3p Microarray 18668037
Transcription factors Transcription factors information provided by TRRUST V2 database.
2
Transcription factor Regulation Reference
HOXA10 Repression 20478621
STAT3 Unknown 23224145
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
32
GO ID Ontology Definition Evidence Reference
GO:0005125 Function Cytokine activity IBA
GO:0005125 Function Cytokine activity IDA 33397952
GO:0005125 Function Cytokine activity IEA
GO:0005142 Function Interleukin-11 receptor binding IEA
GO:0005142 Function Interleukin-11 receptor binding NAS 2145578
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
147681 5966 ENSG00000095752
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P20809
Protein name Interleukin-11 (IL-11) (Adipogenesis inhibitory factor) (AGIF) (Oprelvekin)
Protein function Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578). Also promotes the proliferation of hepato
PDB 4MHL , 6O4O , 8DPS , 8DPT , 8DPU , 8DPV , 8DPW , 8QY4
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF07400 IL11 26 199 Interleukin 11 Domain
Sequence
Sequence length 199
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
  KEGG  Reactome
  Cytokine-cytokine receptor interaction
JAK-STAT signaling pathway
Hematopoietic cell lineage
Rheumatoid arthritis
  IL-6-type cytokine receptor ligand interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
10
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Evidence Score
CYSTITIS CTD, Disgenet
CTD, Disgenet
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
DIFFUSE IDIOPATHIC SKELETAL HYPEROSTOSIS GWAS catalog
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
EDEMA CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
HEMORRHAGE CTD
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Abetalipoproteinemia Abetalipoproteinemia BEFREE 30817088
★☆☆☆☆
Found in Text Mining only
Acute Erythroblastic Leukemia Erythroblastic Leukemia BEFREE 7670098
★☆☆☆☆
Found in Text Mining only
Acute leukemia Leukemia BEFREE 31222870
★☆☆☆☆
Found in Text Mining only
Acute lymphocytic leukemia Lymphocytic Leukemia BEFREE 28861713
★☆☆☆☆
Found in Text Mining only
Acute Megakaryocytic Leukemias Megakaryocytic Leukemia BEFREE 15307108, 7670098
★☆☆☆☆
Found in Text Mining only
Acute Megakaryocytic Leukemias Megakaryocytic Leukemia LHGDN 15307108
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma LHGDN 16964382
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma Adenocarcinoma BEFREE 17724739, 20008143, 27524264
★☆☆☆☆
Found in Text Mining only
Adenocarcinoma of lung (disorder) Lung adenocarcinoma BEFREE 16002475, 27524264, 27922075
★☆☆☆☆
Found in Text Mining only
Anaplastic thyroid carcinoma Anaplastic thyroid cancer BEFREE 27487122
★☆☆☆☆
Found in Text Mining only