TICAM2 (TIR domain containing adaptor molecule 2)

Gene

• Entrez ID: 353376
• Gene name: TIR domain containing adaptor molecule 2
• Gene symbol: TICAM2
• Synonyms (NCBI Gene): MyD88-4, TICAM-2, TIRAP3, TIRP, TRAM
• Chromosome: 5
• Chromosome location: 5q22.3
• Summary: TIRP is a Toll/interleukin-1 receptor (IL1R; MIM 147810) (TIR) domain-containing adaptor protein involved in Toll receptor signaling (see TLR4; MIM 603030).[supplied by OMIM, Apr 2004]

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT020664	hsa-miR-155-5p	Proteomics	18668040
MIRT024278	hsa-miR-215-5p	Microarray	19074876
MIRT026317	hsa-miR-192-5p	Microarray	19074876
MIRT028516	hsa-miR-30a-5p	Proteomics	18668040
MIRT1424567	hsa-miR-1262	CLIP-seq
MIRT1424568	hsa-miR-1272	CLIP-seq
MIRT1424569	hsa-miR-1279	CLIP-seq
MIRT1424570	hsa-miR-1343	CLIP-seq
MIRT1424571	hsa-miR-137	CLIP-seq
MIRT1424572	hsa-miR-18a	CLIP-seq
MIRT1424573	hsa-miR-18b	CLIP-seq
MIRT1424574	hsa-miR-1976	CLIP-seq
MIRT1424575	hsa-miR-23a	CLIP-seq
MIRT1424576	hsa-miR-23b	CLIP-seq
MIRT1424577	hsa-miR-23c	CLIP-seq
MIRT1424578	hsa-miR-25	CLIP-seq
MIRT1424579	hsa-miR-3123	CLIP-seq
MIRT1424580	hsa-miR-3128	CLIP-seq
MIRT1424581	hsa-miR-3153	CLIP-seq
MIRT1424582	hsa-miR-32	CLIP-seq
MIRT1424583	hsa-miR-363	CLIP-seq
MIRT1424584	hsa-miR-3660	CLIP-seq
MIRT1424585	hsa-miR-367	CLIP-seq
MIRT1424586	hsa-miR-3919	CLIP-seq
MIRT1424587	hsa-miR-3944-5p	CLIP-seq
MIRT1424588	hsa-miR-4314	CLIP-seq
MIRT1424589	hsa-miR-4432	CLIP-seq
MIRT1424590	hsa-miR-4464	CLIP-seq
MIRT1424591	hsa-miR-4477b	CLIP-seq
MIRT1424592	hsa-miR-4517	CLIP-seq
MIRT1424593	hsa-miR-4526	CLIP-seq
MIRT1424594	hsa-miR-4652-3p	CLIP-seq
MIRT1424595	hsa-miR-4668-5p	CLIP-seq
MIRT1424596	hsa-miR-4701-3p	CLIP-seq
MIRT1424597	hsa-miR-4709-3p	CLIP-seq
MIRT1424598	hsa-miR-4712-3p	CLIP-seq
MIRT1424599	hsa-miR-4714-5p	CLIP-seq
MIRT1424600	hsa-miR-4720-5p	CLIP-seq
MIRT1424601	hsa-miR-4728-3p	CLIP-seq
MIRT1424602	hsa-miR-4735-3p	CLIP-seq
MIRT1424603	hsa-miR-4738-3p	CLIP-seq
MIRT1424604	hsa-miR-4748	CLIP-seq
MIRT1424605	hsa-miR-4756-3p	CLIP-seq
MIRT1424606	hsa-miR-4760-3p	CLIP-seq
MIRT1424607	hsa-miR-4783-3p	CLIP-seq
MIRT1424608	hsa-miR-4799-3p	CLIP-seq
MIRT1424609	hsa-miR-520d-5p	CLIP-seq
MIRT1424610	hsa-miR-524-5p	CLIP-seq
MIRT1424611	hsa-miR-541	CLIP-seq
MIRT1424612	hsa-miR-548n	CLIP-seq
MIRT1424613	hsa-miR-548t	CLIP-seq
MIRT1424614	hsa-miR-576-3p	CLIP-seq
MIRT1424615	hsa-miR-626	CLIP-seq
MIRT1424616	hsa-miR-654-5p	CLIP-seq
MIRT1424617	hsa-miR-92a	CLIP-seq
MIRT1424618	hsa-miR-92b	CLIP-seq
MIRT2127229	hsa-miR-298	CLIP-seq
MIRT2127230	hsa-miR-3154	CLIP-seq
MIRT2127231	hsa-miR-4446-3p	CLIP-seq
MIRT2127232	hsa-miR-4675	CLIP-seq
MIRT1424597	hsa-miR-4709-3p	CLIP-seq
MIRT2127233	hsa-miR-4741	CLIP-seq
MIRT2127234	hsa-miR-765	CLIP-seq
MIRT2349060	hsa-miR-214	CLIP-seq
MIRT1424575	hsa-miR-23a	CLIP-seq
MIRT1424576	hsa-miR-23b	CLIP-seq
MIRT1424577	hsa-miR-23c	CLIP-seq
MIRT2349061	hsa-miR-3619-5p	CLIP-seq
MIRT2349062	hsa-miR-3653	CLIP-seq
MIRT2349063	hsa-miR-3658	CLIP-seq
MIRT2349064	hsa-miR-3675-5p	CLIP-seq
MIRT2349065	hsa-miR-4266	CLIP-seq
MIRT2349066	hsa-miR-4283	CLIP-seq
MIRT2349067	hsa-miR-4291	CLIP-seq
MIRT2349068	hsa-miR-4293	CLIP-seq
MIRT2349069	hsa-miR-4489	CLIP-seq
MIRT2349070	hsa-miR-4695-5p	CLIP-seq
MIRT2349071	hsa-miR-4779	CLIP-seq
MIRT2349072	hsa-miR-761	CLIP-seq
MIRT2349073	hsa-miR-922	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001891	Component	Phagocytic cup	IDA	30883606
GO:0001891	Component	Phagocytic cup	IEA
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	17258210, 21829704, 21903422, 25416956, 25736436, 26592460, 30883606, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005768	Component	Endosome	IBA
GO:0005768	Component	Endosome	IDA	28630139
GO:0005768	Component	Endosome	IEA
GO:0005769	Component	Early endosome	IDA	19412184
GO:0005770	Component	Late endosome	IDA	19412184
GO:0005783	Component	Endoplasmic reticulum	IDA	19412184
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0005886	Component	Plasma membrane	IDA	19412184
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006909	Process	Phagocytosis	IEA
GO:0006909	Process	Phagocytosis	IMP	30883606
GO:0006954	Process	Inflammatory response	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0010008	Component	Endosome membrane	IDA	28630139
GO:0010008	Component	Endosome membrane	TAS
GO:0016020	Component	Membrane	IEA
GO:0030667	Component	Secretory granule membrane	TAS
GO:0031901	Component	Early endosome membrane	IEA
GO:0031902	Component	Late endosome membrane	IEA
GO:0032481	Process	Positive regulation of type I interferon production	IBA
GO:0032481	Process	Positive regulation of type I interferon production	IDA	25385819
GO:0034142	Process	Toll-like receptor 4 signaling pathway	IDA	12471095, 18222170, 25636800, 28747347
GO:0034142	Process	Toll-like receptor 4 signaling pathway	IDA	28630139
GO:0034144	Process	Negative regulation of toll-like receptor 4 signaling pathway	IDA	19412184
GO:0034145	Process	Positive regulation of toll-like receptor 4 signaling pathway	IDA	19412184
GO:0034145	Process	Positive regulation of toll-like receptor 4 signaling pathway	IMP	22685567
GO:0035591	Function	Signaling adaptor activity	IBA
GO:0035666	Process	TRIF-dependent toll-like receptor signaling pathway	IBA
GO:0035666	Process	TRIF-dependent toll-like receptor signaling pathway	IEA
GO:0035669	Process	TRAM-dependent toll-like receptor 4 signaling pathway	IDA	19412184
GO:0035669	Process	TRAM-dependent toll-like receptor 4 signaling pathway	IMP	22685567
GO:0042995	Component	Cell projection	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	HMP	12761501
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IBA
GO:0045087	Process	Innate immune response	IEA
GO:0051707	Process	Response to other organism	IEA
GO:0060090	Function	Molecular adaptor activity	IDA	28630139
GO:0071222	Process	Cellular response to lipopolysaccharide	IDA	19412184
GO:0071222	Process	Cellular response to lipopolysaccharide	IMP	22685567
GO:0071650	Process	Negative regulation of chemokine (C-C motif) ligand 5 production	IMP	19412184
GO:0071651	Process	Positive regulation of chemokine (C-C motif) ligand 5 production	IEA
GO:0071651	Process	Positive regulation of chemokine (C-C motif) ligand 5 production	IMP	19412184
GO:2000494	Process	Positive regulation of interleukin-18-mediated signaling pathway	IEA
GO:2000494	Process	Positive regulation of interleukin-18-mediated signaling pathway	IMP	22685567

Other IDs

• MIM: 608321
• HGNC: 21354
• e!Ensembl: ENSG00000243414

Interactions View interactions

Pathways

KEGG:

NF-kappa B signaling pathway
Necroptosis
Toll-like receptor signaling pathway
Pertussis
Hepatitis B
PD-L1 expression and PD-1 checkpoint pathway in cancer
Lipid and atherosclerosis

Reactome:

Caspase activation via Death Receptors in the presence of ligand
Toll Like Receptor 4 (TLR4) Cascade
MyD88-independent TLR4 cascade
TRIF-mediated programmed cell death
Neutrophil degranulation
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6-mediated induction of TAK1 complex within TLR4 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
BRAIN INJURIES	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONOTRUNCAL HEART MALFORMATIONS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations