CCN1 (cellular communication network factor 1)

Gene

• Entrez ID: 3491
• Gene name: Cellular communication network factor 1
• Gene symbol: CCN1
• Synonyms (NCBI Gene): CYR61, GIG1, IGFBP10
• Chromosome: 1
• Chromosome location: 1p22.3
• Summary: The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell prolife

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001649	Process	Osteoblast differentiation	IEA
GO:0002041	Process	Intussusceptive angiogenesis	IEA
GO:0003181	Process	Atrioventricular valve morphogenesis	IEA
GO:0003278	Process	Apoptotic process involved in heart morphogenesis	IEA
GO:0003281	Process	Ventricular septum development	IEA
GO:0005178	Function	Integrin binding	IBA
GO:0005178	Function	Integrin binding	IEA
GO:0005201	Function	Extracellular matrix structural constituent	RCA	28327460
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0005615	Component	Extracellular space	IBA
GO:0005788	Component	Endoplasmic reticulum lumen	TAS
GO:0006915	Process	Apoptotic process	IEA
GO:0006935	Process	Chemotaxis	IEA
GO:0007155	Process	Cell adhesion	IBA
GO:0007155	Process	Cell adhesion	IEA
GO:0007155	Process	Cell adhesion	IEA
GO:0007165	Process	Signal transduction	IBA
GO:0007165	Process	Signal transduction	IEA
GO:0007229	Process	Integrin-mediated signaling pathway	IDA	20675382
GO:0008201	Function	Heparin binding	IBA
GO:0008201	Function	Heparin binding	IEA
GO:0009891	Process	Positive regulation of biosynthetic process	IEA
GO:0010556	Process	Regulation of macromolecule biosynthetic process	IEA
GO:0010811	Process	Positive regulation of cell-substrate adhesion	IEA
GO:0019838	Function	Growth factor binding	IEA
GO:0030198	Process	Extracellular matrix organization	IEA
GO:0030335	Process	Positive regulation of cell migration	IBA
GO:0030335	Process	Positive regulation of cell migration	IDA	20675382
GO:0030335	Process	Positive regulation of cell migration	IEA
GO:0030501	Process	Positive regulation of bone mineralization	IDA	20675382
GO:0030513	Process	Positive regulation of BMP signaling pathway	IGI	20675382
GO:0031012	Component	Extracellular matrix	HDA	23658023, 28327460
GO:0031012	Component	Extracellular matrix	IBA
GO:0033690	Process	Positive regulation of osteoblast proliferation	IDA	20675382
GO:0043065	Process	Positive regulation of apoptotic process	IEA
GO:0043066	Process	Negative regulation of apoptotic process	IEA
GO:0045597	Process	Positive regulation of cell differentiation	IBA
GO:0045597	Process	Positive regulation of cell differentiation	IEA
GO:0045669	Process	Positive regulation of osteoblast differentiation	IDA	20675382
GO:0045778	Process	Positive regulation of ossification	IEA
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	20675382
GO:0050840	Function	Extracellular matrix binding	IEA
GO:0051094	Process	Positive regulation of developmental process	IEA
GO:0060413	Process	Atrial septum morphogenesis	IEA
GO:0060591	Process	Chondroblast differentiation	IEA
GO:0060710	Process	Chorio-allantoic fusion	IEA
GO:0060716	Process	Labyrinthine layer blood vessel development	IEA
GO:0061036	Process	Positive regulation of cartilage development	IEA
GO:0070372	Process	Regulation of ERK1 and ERK2 cascade	IDA	20675382
GO:0072593	Process	Reactive oxygen species metabolic process	IEA
GO:0098609	Process	Cell-cell adhesion	IEA
GO:2000026	Process	Regulation of multicellular organismal development	IEA
GO:2000304	Process	Positive regulation of ceramide biosynthetic process	IEA

Other IDs

• MIM: 602369
• HGNC: 2654
• e!Ensembl: ENSG00000142871

Protein

• UniProt ID: O00622
• Protein name: CCN family member 1 (Cellular communication network factor 1) (Cysteine-rich angiogenic inducer 61) (Insulin-like growth factor-binding protein 10) (IBP-10) (IGF-binding protein 10) (IGFBP-10) (Protein CYR61) (Protein GIG1)
• Protein function: Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodel
• PDB: 4D0Z, 4D11
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00219	IGFBP	26 → 78	Insulin-like growth factor binding protein	Domain
  PF00093	VWC	100 → 163	von Willebrand factor type C domain	Family
  PF19035	TSP1_CCN	229 → 272	CCN3 Nov like TSP1 domain	Domain
  PF00007	Cys_knot	283 → 375	Cystine-knot domain	Domain

• Sequence:

  MSSRIARALALVVTLLHLTRLALSTCPAACHCPLEAPKCAPGVGLVRDGCGCCKVCAKQL
  NEDCSKTQPCDHTKGLECNFGASSTALKGICRAQSEGRPCEYNSRIYQNGESFQPNCKHQ
  CTCIDGAVGCIPLCPQELSLPNLGCPNPRLVKVTGQCCEEWVCDEDSIKDPMEDQDGLLG
  KELGFDASEVELTRNNELIAVGKGSSLKRLPVFGMEPRILYNPLQGQKCIVQTTSWSQCS
  KTCGTGISTRVTNDNPECRLVKETRICEVRPCGQPVYSSLKKGKKCSKTKKSPEPVRFTY
  AGCLSVKKYRPKYCGSCVDGRCCTPQLTRTVKMRFRCEDGETFSKNVMMIQSCKCNYNCP
  HANEAAFPFYRLFNDIHKFRD

• Sequence length: 381

Pathways

Reactome:

Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
ARTHRITIS, RHEUMATOID	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CARCINOMA, HEPATOCELLULAR	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG NEOPLASMS	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCLERODERMA, SYSTEMIC	—	CTD	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SYSTEMIC SCLERODERMA	—	Disgenet	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	★★☆☆☆ Found in Text Mining + Unknown/Other Associations