Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	348158
Gene name	Acyl-CoA synthetase medium chain family member 2B
Gene symbol	ACSM2B
Synonyms (NCBI Gene)	ACSM2HXMAHYST1046
Chromosome	16
Chromosome location	16p12.3

148

Show/Hide all (148)

miRTarBase ID	miRNA	Experiments	Reference
MIRT619970	hsa-miR-4797-5p	HITS-CLIP	23313552
MIRT619969	hsa-miR-6847-5p	HITS-CLIP	23313552
MIRT619968	hsa-miR-3177-5p	HITS-CLIP	23313552
MIRT619967	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT684886	hsa-miR-3191-5p	HITS-CLIP	23313552
MIRT619966	hsa-let-7a-2-3p	HITS-CLIP	23313552
MIRT619965	hsa-let-7g-3p	HITS-CLIP	23313552
MIRT619964	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT619970	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT619969	hsa-miR-6847-5p	HITS-CLIP	23824327
MIRT619968	hsa-miR-3177-5p	HITS-CLIP	23824327
MIRT619966	hsa-let-7a-2-3p	HITS-CLIP	23824327
MIRT619965	hsa-let-7g-3p	HITS-CLIP	23824327
MIRT619964	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT619970	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT619969	hsa-miR-6847-5p	HITS-CLIP	23824327
MIRT619968	hsa-miR-3177-5p	HITS-CLIP	23824327
MIRT619967	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT619966	hsa-let-7a-2-3p	HITS-CLIP	23824327
MIRT619965	hsa-let-7g-3p	HITS-CLIP	23824327
MIRT619964	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT544828	hsa-miR-548a-5p	PAR-CLIP	21572407
MIRT544827	hsa-miR-548ab	PAR-CLIP	21572407
MIRT544826	hsa-miR-548ad-5p	PAR-CLIP	21572407
MIRT544825	hsa-miR-548ae-5p	PAR-CLIP	21572407
MIRT544824	hsa-miR-548ak	PAR-CLIP	21572407
MIRT544823	hsa-miR-548am-5p	PAR-CLIP	21572407
MIRT544822	hsa-miR-548ap-5p	PAR-CLIP	21572407
MIRT544821	hsa-miR-548aq-5p	PAR-CLIP	21572407
MIRT544820	hsa-miR-548ar-5p	PAR-CLIP	21572407
MIRT544819	hsa-miR-548as-5p	PAR-CLIP	21572407
MIRT544818	hsa-miR-548au-5p	PAR-CLIP	21572407
MIRT544817	hsa-miR-548ay-5p	PAR-CLIP	21572407
MIRT544816	hsa-miR-548b-5p	PAR-CLIP	21572407
MIRT544815	hsa-miR-548bb-5p	PAR-CLIP	21572407
MIRT544814	hsa-miR-548c-5p	PAR-CLIP	21572407
MIRT544813	hsa-miR-548d-5p	PAR-CLIP	21572407
MIRT544812	hsa-miR-548h-5p	PAR-CLIP	21572407
MIRT544811	hsa-miR-548i	PAR-CLIP	21572407
MIRT544810	hsa-miR-548j-5p	PAR-CLIP	21572407
MIRT544809	hsa-miR-548o-5p	PAR-CLIP	21572407
MIRT544808	hsa-miR-548w	PAR-CLIP	21572407
MIRT544807	hsa-miR-548y	PAR-CLIP	21572407
MIRT544806	hsa-miR-559	PAR-CLIP	21572407
MIRT544805	hsa-miR-548av-5p	PAR-CLIP	21572407
MIRT544804	hsa-miR-548k	PAR-CLIP	21572407
MIRT544802	hsa-miR-8054	PAR-CLIP	21572407
MIRT544803	hsa-miR-548l	PAR-CLIP	21572407
MIRT544801	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT544800	hsa-miR-5692b	PAR-CLIP	21572407
MIRT544799	hsa-miR-5692c	PAR-CLIP	21572407
MIRT544798	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT544797	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT619966	hsa-let-7a-2-3p	HITS-CLIP	27418678
MIRT619966	hsa-let-7a-2-3p	HITS-CLIP	27418678
MIRT619966	hsa-let-7a-2-3p	HITS-CLIP	27418678
MIRT619966	hsa-let-7a-2-3p	HITS-CLIP	27418678
MIRT619965	hsa-let-7g-3p	HITS-CLIP	27418678
MIRT619965	hsa-let-7g-3p	HITS-CLIP	27418678
MIRT619965	hsa-let-7g-3p	HITS-CLIP	27418678
MIRT619965	hsa-let-7g-3p	HITS-CLIP	27418678
MIRT619968	hsa-miR-3177-5p	HITS-CLIP	27418678
MIRT619968	hsa-miR-3177-5p	HITS-CLIP	27418678
MIRT619968	hsa-miR-3177-5p	HITS-CLIP	27418678
MIRT619968	hsa-miR-3177-5p	HITS-CLIP	27418678
MIRT619968	hsa-miR-3177-5p	HITS-CLIP	27418678
MIRT684886	hsa-miR-3191-5p	HITS-CLIP	27418678
MIRT684886	hsa-miR-3191-5p	HITS-CLIP	27418678
MIRT684886	hsa-miR-3191-5p	HITS-CLIP	27418678
MIRT684886	hsa-miR-3191-5p	HITS-CLIP	27418678
MIRT619970	hsa-miR-4797-5p	HITS-CLIP	27418678
MIRT619970	hsa-miR-4797-5p	HITS-CLIP	27418678
MIRT619970	hsa-miR-4797-5p	HITS-CLIP	27418678
MIRT619970	hsa-miR-4797-5p	HITS-CLIP	27418678
MIRT619964	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT619964	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT619964	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT619964	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT619964	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT619964	hsa-miR-574-5p	HITS-CLIP	27418678
MIRT753763	hsa-miR-6758-3p	HITS-CLIP	27418678
MIRT753763	hsa-miR-6758-3p	HITS-CLIP	27418678
MIRT753763	hsa-miR-6758-3p	HITS-CLIP	27418678
MIRT619969	hsa-miR-6847-5p	HITS-CLIP	27418678
MIRT619969	hsa-miR-6847-5p	HITS-CLIP	27418678
MIRT619969	hsa-miR-6847-5p	HITS-CLIP	27418678
MIRT619969	hsa-miR-6847-5p	HITS-CLIP	27418678
MIRT619967	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT619967	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT619967	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT619967	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT619967	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT619967	hsa-miR-6867-5p	HITS-CLIP	27418678
MIRT619970	hsa-miR-4797-5p	HITS-CLIP	23313552
MIRT619969	hsa-miR-6847-5p	HITS-CLIP	23313552
MIRT619968	hsa-miR-3177-5p	HITS-CLIP	23313552
MIRT619967	hsa-miR-6867-5p	HITS-CLIP	23313552
MIRT684886	hsa-miR-3191-5p	HITS-CLIP	23313552
MIRT619966	hsa-let-7a-2-3p	HITS-CLIP	23313552
MIRT619965	hsa-let-7g-3p	HITS-CLIP	23313552
MIRT619964	hsa-miR-574-5p	HITS-CLIP	23313552
MIRT619970	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT619969	hsa-miR-6847-5p	HITS-CLIP	23824327
MIRT619968	hsa-miR-3177-5p	HITS-CLIP	23824327
MIRT619966	hsa-let-7a-2-3p	HITS-CLIP	23824327
MIRT619965	hsa-let-7g-3p	HITS-CLIP	23824327
MIRT619964	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT619970	hsa-miR-4797-5p	HITS-CLIP	23824327
MIRT619969	hsa-miR-6847-5p	HITS-CLIP	23824327
MIRT619968	hsa-miR-3177-5p	HITS-CLIP	23824327
MIRT619967	hsa-miR-6867-5p	HITS-CLIP	23824327
MIRT619966	hsa-let-7a-2-3p	HITS-CLIP	23824327
MIRT619965	hsa-let-7g-3p	HITS-CLIP	23824327
MIRT619964	hsa-miR-574-5p	HITS-CLIP	23824327
MIRT544828	hsa-miR-548a-5p	PAR-CLIP	21572407
MIRT544827	hsa-miR-548ab	PAR-CLIP	21572407
MIRT544826	hsa-miR-548ad-5p	PAR-CLIP	21572407
MIRT544825	hsa-miR-548ae-5p	PAR-CLIP	21572407
MIRT544824	hsa-miR-548ak	PAR-CLIP	21572407
MIRT544823	hsa-miR-548am-5p	PAR-CLIP	21572407
MIRT544822	hsa-miR-548ap-5p	PAR-CLIP	21572407
MIRT544821	hsa-miR-548aq-5p	PAR-CLIP	21572407
MIRT544820	hsa-miR-548ar-5p	PAR-CLIP	21572407
MIRT544819	hsa-miR-548as-5p	PAR-CLIP	21572407
MIRT544818	hsa-miR-548au-5p	PAR-CLIP	21572407
MIRT544817	hsa-miR-548ay-5p	PAR-CLIP	21572407
MIRT544816	hsa-miR-548b-5p	PAR-CLIP	21572407
MIRT544815	hsa-miR-548bb-5p	PAR-CLIP	21572407
MIRT544814	hsa-miR-548c-5p	PAR-CLIP	21572407
MIRT544813	hsa-miR-548d-5p	PAR-CLIP	21572407
MIRT544812	hsa-miR-548h-5p	PAR-CLIP	21572407
MIRT544811	hsa-miR-548i	PAR-CLIP	21572407
MIRT544810	hsa-miR-548j-5p	PAR-CLIP	21572407
MIRT544809	hsa-miR-548o-5p	PAR-CLIP	21572407
MIRT544808	hsa-miR-548w	PAR-CLIP	21572407
MIRT544807	hsa-miR-548y	PAR-CLIP	21572407
MIRT544806	hsa-miR-559	PAR-CLIP	21572407
MIRT544805	hsa-miR-548av-5p	PAR-CLIP	21572407
MIRT544804	hsa-miR-548k	PAR-CLIP	21572407
MIRT544802	hsa-miR-8054	PAR-CLIP	21572407
MIRT544803	hsa-miR-548l	PAR-CLIP	21572407
MIRT544801	hsa-miR-369-3p	PAR-CLIP	21572407
MIRT544800	hsa-miR-5692b	PAR-CLIP	21572407
MIRT544799	hsa-miR-5692c	PAR-CLIP	21572407
MIRT544798	hsa-miR-374a-5p	PAR-CLIP	21572407
MIRT544797	hsa-miR-374b-5p	PAR-CLIP	21572407
MIRT763680	hsa-miR-3646	CLIP-seq
MIRT1925077	hsa-miR-4713-5p	CLIP-seq

Show/Hide all (25)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0004321	Function	Fatty-acyl-CoA synthase activity	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005524	Function	ATP binding	IEA
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA	12616642
GO:0005739	Component	Mitochondrion	IEA
GO:0005739	Component	Mitochondrion	NAS	19634011
GO:0005759	Component	Mitochondrial matrix	IBA
GO:0005759	Component	Mitochondrial matrix	TAS
GO:0006629	Process	Lipid metabolic process	IEA
GO:0006631	Process	Fatty acid metabolic process	IEA
GO:0006633	Process	Fatty acid biosynthetic process	IBA
GO:0006637	Process	Acyl-CoA metabolic process	IBA
GO:0006805	Process	Xenobiotic metabolic process	TAS
GO:0015645	Function	Fatty acid ligase activity	IBA
GO:0016405	Function	CoA-ligase activity	IEA
GO:0016405	Function	CoA-ligase activity	TAS
GO:0016874	Function	Ligase activity	IEA
GO:0016878	Function	Acid-thiol ligase activity	IEA
GO:0018858	Function	Benzoate-CoA ligase activity	IDA	10434065, 12616642
GO:0018858	Function	Benzoate-CoA ligase activity	IEA
GO:0031956	Function	Medium-chain fatty acid-CoA ligase activity	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0102391	Function	Decanoate-CoA ligase activity	IEA

MIM	HGNC	e!Ensembl
614359	30931	ENSG00000066813

Q68CK6

Protein name

Acyl-coenzyme A synthetase ACSM2B, mitochondrial (EC 6.2.1.2) (Acyl-CoA synthetase medium-chain family member 2B) (Benzoate--CoA ligase) (EC 6.2.1.25) (Butyrate--CoA ligase 2B) (Butyryl-coenzyme A synthetase 2B) (Middle-chain acyl-CoA synthetase 2B) (Xeno

Protein function

Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:10434065, PubMed:12616642). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and ce

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00501	AMP-binding	58 → 469	AMP-binding enzyme	Family
PF13193	AMP-binding_C	477 → 557	AMP-binding enzyme C-terminal domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Detected in liver. {ECO:0000269|PubMed:10434065, ECO:0000269|PubMed:19634011}.

Sequence

MHWLRKVQGLCTLWGTQMSSRTLYINSRQLVSLQWGHQEVPAKFNFASDVLDHWADMEKA
GKRLPSPALWWVNGKGKELMWNFRELSENSQQAANILSGACGLQRGDRVAVMLPRVPEWW
LVILGCIRAGLIFMPGTIQMKSTDILYRLQMSKAKAIVAGDEVIQEVDTVASECPSLRIK
LLVSEKSCDGWLNFKKLLNEASTTHHCVETGSQEASAIYFTSGTSGLPKMAEHSYSSLGL
KAKMDAGWTGLQASDIMWTISDTGWILNILGSLLESWTLGACTFVHLLPKFDPLVILKTL
SSYPIKSMMGAPIVYRMLLQQDLSSYKFPHLQNCLAGGESLLPETLENWRAQTGLDIREF
YGQTETGLTCMVSKTMKIKPGYMGTAASCYDVQVIDDKGNVLPPGTEGDIGIRVKPIRPI
GIFSGYVENPDKTAANIRGDFWLLGDRGIKDEDGYFQFMGRADDIINSSGYRIGPSEVEN
ALMKHPAVVETAVISSPDPVRGEVVKAFVILASQFLSHDPEQLTKELQQHVKSVTAPYKY
PRKIEFVLNLPKTVTGKIQRTKLRDKEWKMSGKARAQ

Sequence length

577

Interactions

View interactions

	KEGG		Reactome
	Butanoate metabolism Metabolic pathways		Conjugation of salicylate with glycine Conjugation of benzoate with glycine Conjugation of phenylacetate with glutamine

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (4)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
ASTROCYTOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CENTRAL NERVOUS SYSTEM CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GLIOMA	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
GOUT	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

ACSM2B (acyl-CoA synthetase medium chain family member 2B)