ARPIN (actin related protein 2/3 complex inhibitor)

Gene

• Entrez ID: 348110
• Gene name: Actin related protein 2/3 complex inhibitor
• Gene symbol: ARPIN
• Synonyms (NCBI Gene): C15orf38
• Chromosome: 15
• Chromosome location: 15q26.1

miRNA

miRTarBase ID	miRNA	Experiments	Reference
MIRT728134	hsa-miR-19a-3p	HITS-CLIP	22473208
MIRT728132	hsa-miR-19b-3p	HITS-CLIP	22473208
MIRT741273	hsa-miR-1247-3p	PAR-CLIP	26701625
MIRT741273	hsa-miR-1247-3p	PAR-CLIP	26701625
MIRT741274	hsa-miR-1827	PAR-CLIP	26701625
MIRT741274	hsa-miR-1827	PAR-CLIP	26701625
MIRT741269	hsa-miR-1910-3p	PAR-CLIP	26701625
MIRT741269	hsa-miR-1910-3p	PAR-CLIP	26701625
MIRT741272	hsa-miR-194-3p	PAR-CLIP	26701625
MIRT741272	hsa-miR-194-3p	PAR-CLIP	26701625
MIRT741277	hsa-miR-2467-3p	PAR-CLIP	26701625
MIRT741277	hsa-miR-2467-3p	PAR-CLIP	26701625
MIRT741279	hsa-miR-3612	PAR-CLIP	26701625
MIRT741279	hsa-miR-3612	PAR-CLIP	26701625
MIRT741275	hsa-miR-377-5p	PAR-CLIP	26701625
MIRT741275	hsa-miR-377-5p	PAR-CLIP	26701625
MIRT741271	hsa-miR-4257	PAR-CLIP	26701625
MIRT741271	hsa-miR-4257	PAR-CLIP	26701625
MIRT741284	hsa-miR-455-3p	PAR-CLIP	26701625
MIRT741284	hsa-miR-455-3p	PAR-CLIP	26701625
MIRT741281	hsa-miR-4640-5p	PAR-CLIP	26701625
MIRT741281	hsa-miR-4640-5p	PAR-CLIP	26701625
MIRT741282	hsa-miR-4726-5p	PAR-CLIP	26701625
MIRT741282	hsa-miR-4726-5p	PAR-CLIP	26701625
MIRT741276	hsa-miR-6086	PAR-CLIP	26701625
MIRT741276	hsa-miR-6086	PAR-CLIP	26701625
MIRT741278	hsa-miR-6499-3p	PAR-CLIP	26701625
MIRT741278	hsa-miR-6499-3p	PAR-CLIP	26701625
MIRT741283	hsa-miR-6508-3p	PAR-CLIP	26701625
MIRT741283	hsa-miR-6508-3p	PAR-CLIP	26701625
MIRT741280	hsa-miR-650	PAR-CLIP	26701625
MIRT741280	hsa-miR-650	PAR-CLIP	26701625
MIRT741270	hsa-miR-6511a-5p	PAR-CLIP	26701625
MIRT741270	hsa-miR-6511a-5p	PAR-CLIP	26701625
MIRT741285	hsa-miR-6516-5p	PAR-CLIP	26701625
MIRT741285	hsa-miR-6516-5p	PAR-CLIP	26701625
MIRT741273	hsa-miR-1247-3p	PAR-CLIP	27292025
MIRT741273	hsa-miR-1247-3p	PAR-CLIP	27292025
MIRT741273	hsa-miR-1247-3p	PAR-CLIP	27292025
MIRT741273	hsa-miR-1247-3p	PAR-CLIP	27292025
MIRT741274	hsa-miR-1827	PAR-CLIP	27292025
MIRT741274	hsa-miR-1827	PAR-CLIP	27292025
MIRT741274	hsa-miR-1827	PAR-CLIP	27292025
MIRT741274	hsa-miR-1827	PAR-CLIP	27292025
MIRT741269	hsa-miR-1910-3p	PAR-CLIP	27292025
MIRT741269	hsa-miR-1910-3p	PAR-CLIP	27292025
MIRT741269	hsa-miR-1910-3p	PAR-CLIP	27292025
MIRT741269	hsa-miR-1910-3p	PAR-CLIP	27292025
MIRT741272	hsa-miR-194-3p	PAR-CLIP	27292025
MIRT741272	hsa-miR-194-3p	PAR-CLIP	27292025
MIRT741272	hsa-miR-194-3p	PAR-CLIP	27292025
MIRT741272	hsa-miR-194-3p	PAR-CLIP	27292025
MIRT741277	hsa-miR-2467-3p	PAR-CLIP	27292025
MIRT741277	hsa-miR-2467-3p	PAR-CLIP	27292025
MIRT741277	hsa-miR-2467-3p	PAR-CLIP	27292025
MIRT741277	hsa-miR-2467-3p	PAR-CLIP	27292025
MIRT741279	hsa-miR-3612	PAR-CLIP	27292025
MIRT741279	hsa-miR-3612	PAR-CLIP	27292025
MIRT741279	hsa-miR-3612	PAR-CLIP	27292025
MIRT741279	hsa-miR-3612	PAR-CLIP	27292025
MIRT741275	hsa-miR-377-5p	PAR-CLIP	27292025
MIRT741275	hsa-miR-377-5p	PAR-CLIP	27292025
MIRT741275	hsa-miR-377-5p	PAR-CLIP	27292025
MIRT741275	hsa-miR-377-5p	PAR-CLIP	27292025
MIRT741271	hsa-miR-4257	PAR-CLIP	27292025
MIRT741271	hsa-miR-4257	PAR-CLIP	27292025
MIRT741271	hsa-miR-4257	PAR-CLIP	27292025
MIRT741271	hsa-miR-4257	PAR-CLIP	27292025
MIRT741284	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT741284	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT741284	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT741284	hsa-miR-455-3p	PAR-CLIP	27292025
MIRT741281	hsa-miR-4640-5p	PAR-CLIP	27292025
MIRT741281	hsa-miR-4640-5p	PAR-CLIP	27292025
MIRT741281	hsa-miR-4640-5p	PAR-CLIP	27292025
MIRT741281	hsa-miR-4640-5p	PAR-CLIP	27292025
MIRT741282	hsa-miR-4726-5p	PAR-CLIP	27292025
MIRT741282	hsa-miR-4726-5p	PAR-CLIP	27292025
MIRT741282	hsa-miR-4726-5p	PAR-CLIP	27292025
MIRT741282	hsa-miR-4726-5p	PAR-CLIP	27292025
MIRT741263	hsa-miR-5186	PAR-CLIP	27292025
MIRT741276	hsa-miR-6086	PAR-CLIP	27292025
MIRT741276	hsa-miR-6086	PAR-CLIP	27292025
MIRT741276	hsa-miR-6086	PAR-CLIP	27292025
MIRT741276	hsa-miR-6086	PAR-CLIP	27292025
MIRT741278	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT741278	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT741278	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT741278	hsa-miR-6499-3p	PAR-CLIP	27292025
MIRT741283	hsa-miR-6508-3p	PAR-CLIP	27292025
MIRT741283	hsa-miR-6508-3p	PAR-CLIP	27292025
MIRT741283	hsa-miR-6508-3p	PAR-CLIP	27292025
MIRT741283	hsa-miR-6508-3p	PAR-CLIP	27292025
MIRT741280	hsa-miR-650	PAR-CLIP	27292025
MIRT741280	hsa-miR-650	PAR-CLIP	27292025
MIRT741280	hsa-miR-650	PAR-CLIP	27292025
MIRT741280	hsa-miR-650	PAR-CLIP	27292025
MIRT741270	hsa-miR-6511a-5p	PAR-CLIP	27292025
MIRT741270	hsa-miR-6511a-5p	PAR-CLIP	27292025
MIRT741270	hsa-miR-6511a-5p	PAR-CLIP	27292025
MIRT741270	hsa-miR-6511a-5p	PAR-CLIP	27292025
MIRT741285	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT741285	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT741285	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT741285	hsa-miR-6516-5p	PAR-CLIP	27292025
MIRT741266	hsa-miR-6807-5p	PAR-CLIP	27292025
MIRT740292	hsa-miR-1179	HITS-CLIP	19536157
MIRT740293	hsa-miR-2681-3p	HITS-CLIP	19536157
MIRT740294	hsa-miR-96-3p	HITS-CLIP	19536157
MIRT740295	hsa-miR-3688-3p	HITS-CLIP	19536157
MIRT740296	hsa-miR-490-5p	HITS-CLIP	19536157
MIRT740297	hsa-miR-5093	HITS-CLIP	19536157
MIRT740298	hsa-miR-4795-3p	HITS-CLIP	19536157
MIRT740459	hsa-miR-4438	HITS-CLIP	19536157
MIRT740460	hsa-miR-449b-3p	HITS-CLIP	19536157
MIRT740461	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT740462	hsa-miR-370-3p	HITS-CLIP	19536157
MIRT740463	hsa-miR-6893-3p	HITS-CLIP	19536157
MIRT740464	hsa-miR-1976	HITS-CLIP	19536157
MIRT740465	hsa-miR-378g	HITS-CLIP	19536157
MIRT740466	hsa-miR-4505	HITS-CLIP	19536157
MIRT740467	hsa-miR-5787	HITS-CLIP	19536157
MIRT740468	hsa-miR-4437	HITS-CLIP	19536157
MIRT740469	hsa-miR-4674	HITS-CLIP	19536157
MIRT741248	hsa-miR-508-5p	HITS-CLIP	23706177
MIRT741249	hsa-miR-25-3p	HITS-CLIP	23706177
MIRT741250	hsa-miR-32-5p	HITS-CLIP	23706177
MIRT741251	hsa-miR-363-3p	HITS-CLIP	23706177
MIRT741252	hsa-miR-367-3p	HITS-CLIP	23706177
MIRT741253	hsa-miR-92a-3p	HITS-CLIP	23706177
MIRT741254	hsa-miR-92b-3p	HITS-CLIP	23706177
MIRT741255	hsa-miR-6849-3p	HITS-CLIP	23706177
MIRT741256	hsa-miR-939-3p	HITS-CLIP	23706177
MIRT741257	hsa-miR-766-3p	HITS-CLIP	23706177
MIRT741258	hsa-miR-1285-3p	HITS-CLIP	23706177
MIRT741259	hsa-miR-3187-5p	HITS-CLIP	23706177
MIRT741260	hsa-miR-5189-5p	HITS-CLIP	23706177
MIRT741261	hsa-miR-612	HITS-CLIP	23706177
MIRT741262	hsa-miR-6860	HITS-CLIP	23706177
MIRT741263	hsa-miR-5186	HITS-CLIP	23706177
MIRT741264	hsa-miR-6512-3p	HITS-CLIP	23706177
MIRT741265	hsa-miR-6720-5p	HITS-CLIP	23706177
MIRT741266	hsa-miR-6807-5p	HITS-CLIP	23706177
MIRT741267	hsa-miR-7703	HITS-CLIP	23706177
MIRT741268	hsa-miR-4325	HITS-CLIP	23706177
MIRT741269	hsa-miR-1910-3p	HITS-CLIP	23706177
MIRT741270	hsa-miR-6511a-5p	HITS-CLIP	23706177
MIRT741271	hsa-miR-4257	HITS-CLIP	23706177
MIRT741272	hsa-miR-194-3p	HITS-CLIP	23706177
MIRT741273	hsa-miR-1247-3p	HITS-CLIP	23706177
MIRT741274	hsa-miR-1827	HITS-CLIP	23706177
MIRT741275	hsa-miR-377-5p	HITS-CLIP	23706177
MIRT741276	hsa-miR-6086	HITS-CLIP	23706177
MIRT741277	hsa-miR-2467-3p	HITS-CLIP	23706177
MIRT741278	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT741279	hsa-miR-3612	HITS-CLIP	23706177
MIRT741280	hsa-miR-650	HITS-CLIP	23706177
MIRT741281	hsa-miR-4640-5p	HITS-CLIP	23706177
MIRT741282	hsa-miR-4726-5p	HITS-CLIP	23706177
MIRT741283	hsa-miR-6508-3p	HITS-CLIP	23706177
MIRT741284	hsa-miR-455-3p	HITS-CLIP	23706177
MIRT741285	hsa-miR-6516-5p	HITS-CLIP	23706177
MIRT741784	hsa-miR-5000-5p	HITS-CLIP	23824327
MIRT741785	hsa-miR-6865-3p	HITS-CLIP	23824327
MIRT741786	hsa-miR-6814-5p	HITS-CLIP	23824327
MIRT741787	hsa-miR-6892-3p	HITS-CLIP	23824327
MIRT741788	hsa-miR-3183	HITS-CLIP	23824327
MIRT741789	hsa-miR-4723-3p	HITS-CLIP	23824327
MIRT741790	hsa-miR-6769b-3p	HITS-CLIP	23824327
MIRT741791	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT741792	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT741793	hsa-miR-197-3p	HITS-CLIP	23824327
MIRT741794	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT741795	hsa-miR-6736-3p	HITS-CLIP	23824327
MIRT741796	hsa-miR-5693	HITS-CLIP	23824327
MIRT741797	hsa-miR-6787-3p	HITS-CLIP	23824327
MIRT741278	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT741798	hsa-miR-3135b	HITS-CLIP	23824327
MIRT741799	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT741800	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT741801	hsa-miR-3652	HITS-CLIP	23824327
MIRT741802	hsa-miR-4430	HITS-CLIP	23824327
MIRT741803	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT741804	hsa-miR-3688-5p	HITS-CLIP	23824327
MIRT741805	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT741806	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT741807	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT741808	hsa-miR-5698	HITS-CLIP	23824327
MIRT742274	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT742275	hsa-miR-4733-5p	HITS-CLIP	23824327
MIRT742276	hsa-miR-3189-3p	HITS-CLIP	23824327
MIRT742277	hsa-miR-7106-5p	HITS-CLIP	23824327
MIRT742278	hsa-miR-149-3p	HITS-CLIP	23824327
MIRT742279	hsa-miR-4728-5p	HITS-CLIP	23824327
MIRT742280	hsa-miR-6785-5p	HITS-CLIP	23824327
MIRT742281	hsa-miR-6883-5p	HITS-CLIP	23824327
MIRT742282	hsa-miR-6799-5p	HITS-CLIP	23824327
MIRT742283	hsa-miR-30c-1-3p	HITS-CLIP	23824327
MIRT742284	hsa-miR-30c-2-3p	HITS-CLIP	23824327
MIRT742285	hsa-miR-6788-5p	HITS-CLIP	23824327
MIRT742286	hsa-miR-1273h-5p	HITS-CLIP	23824327
MIRT742287	hsa-miR-30b-3p	HITS-CLIP	23824327
MIRT742288	hsa-miR-3689a-3p	HITS-CLIP	23824327
MIRT742289	hsa-miR-3689b-3p	HITS-CLIP	23824327
MIRT742290	hsa-miR-3689c	HITS-CLIP	23824327
MIRT742291	hsa-miR-6779-5p	HITS-CLIP	23824327
MIRT742292	hsa-miR-6780a-5p	HITS-CLIP	23824327
MIRT742293	hsa-miR-887-5p	HITS-CLIP	23824327
MIRT741794	hsa-miR-216a-5p	HITS-CLIP	23824327
MIRT742355	hsa-miR-892a	HITS-CLIP	23824327
MIRT741796	hsa-miR-5693	HITS-CLIP	23824327
MIRT741278	hsa-miR-6499-3p	HITS-CLIP	23824327
MIRT741798	hsa-miR-3135b	HITS-CLIP	23824327
MIRT741799	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT741800	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT741801	hsa-miR-3652	HITS-CLIP	23824327
MIRT741802	hsa-miR-4430	HITS-CLIP	23824327
MIRT741803	hsa-miR-143-5p	HITS-CLIP	23824327
MIRT741804	hsa-miR-3688-5p	HITS-CLIP	23824327
MIRT741805	hsa-miR-6501-5p	HITS-CLIP	23824327
MIRT741806	hsa-miR-4423-5p	HITS-CLIP	23824327
MIRT741807	hsa-miR-744-3p	HITS-CLIP	23824327
MIRT741808	hsa-miR-5698	HITS-CLIP	23824327
MIRT754074	hsa-miR-548c-3p	PAR-CLIP	20371350
MIRT754075	hsa-miR-186-5p	PAR-CLIP	20371350
MIRT754076	hsa-miR-3163	PAR-CLIP	20371350
MIRT740295	hsa-miR-3688-3p	PAR-CLIP	20371350
MIRT754077	hsa-miR-3148	PAR-CLIP	20371350
MIRT754078	hsa-miR-6124	PAR-CLIP	20371350
MIRT754079	hsa-miR-340-5p	PAR-CLIP	20371350
MIRT741269	hsa-miR-1910-3p	PAR-CLIP	23446348
MIRT741270	hsa-miR-6511a-5p	PAR-CLIP	23446348
MIRT741271	hsa-miR-4257	PAR-CLIP	23446348
MIRT741272	hsa-miR-194-3p	PAR-CLIP	23446348
MIRT741274	hsa-miR-1827	PAR-CLIP	23446348
MIRT741275	hsa-miR-377-5p	PAR-CLIP	23446348
MIRT741276	hsa-miR-6086	PAR-CLIP	23446348
MIRT741277	hsa-miR-2467-3p	PAR-CLIP	23446348
MIRT741278	hsa-miR-6499-3p	PAR-CLIP	23446348
MIRT741279	hsa-miR-3612	PAR-CLIP	23446348
MIRT741280	hsa-miR-650	PAR-CLIP	23446348
MIRT741281	hsa-miR-4640-5p	PAR-CLIP	23446348
MIRT741282	hsa-miR-4726-5p	PAR-CLIP	23446348
MIRT741283	hsa-miR-6508-3p	PAR-CLIP	23446348
MIRT741284	hsa-miR-455-3p	PAR-CLIP	23446348
MIRT741285	hsa-miR-6516-5p	PAR-CLIP	23446348

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	24132237, 25416956, 26774128, 32296183
GO:0030027	Component	Lamellipodium	IEA
GO:0030027	Component	Lamellipodium	ISS
GO:0030336	Process	Negative regulation of cell migration	IMP	24132237
GO:0033058	Process	Directional locomotion	IMP	24132237
GO:0042995	Component	Cell projection	IEA
GO:0051126	Process	Negative regulation of actin nucleation	IBA
GO:0051126	Process	Negative regulation of actin nucleation	IDA	24132237
GO:0051126	Process	Negative regulation of actin nucleation	IEA
GO:2000393	Process	Negative regulation of lamellipodium morphogenesis	IMP	24132237

Other IDs

• MIM: 615543
• HGNC: 28782
• e!Ensembl: ENSG00000242498

Protein

• UniProt ID: Q7Z6K5
• Protein name: Arpin (Arp2/3 inhibition protein)
• Protein function: Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors. Participates in an incoherent feedforward loop at the lamellipodium tip where it inh
• PDB: 4Z68, 7JPN
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10574	UPF0552	1 → 224	Arp2/3-interacting proteins Arpin	Family

• Sequence:

  MSRIYHDGALRNKAVQSVRLPGAWDPAAHQGGNGVLLEGELIDVSRHSILDTHGRKERYY
  VLYIRPSHIHRRKFDAKGNEIEPNFSATRKVNTGFLMSSYKVEAKGDTDRLTPEALKGLV
  NKPELLALTESLTPDHTVAFWMPESEMEVMELELGAGVRLKTRGDGPFLDSLAKLEAGTV
  TKCNFTGDGKTGASWTDNIMAQKCSKGAAAEIREQGDGAEDEEWDD

• Sequence length: 226

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Evidence Score
DIABETIC NEUROPATHY	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
OLIGODENDROGLIOMA	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★☆☆☆ Found in Text Mining + Unknown/Other Associations