Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases
Entrez ID	347240
Gene name	Kinesin family member 24
Gene symbol	KIF24
Synonyms (NCBI Gene)	C9orf48bA571F15.4
Chromosome	9
Chromosome location	9p13.3
Summary	This gene encodes a member of the kinesin superfamily of microtubule-based motor proteins which are involved in the intracellular transport of membranous organelles, protein complexes, and mRNAs. They also play critical roles in mitosis, morphogenesis, an

Show/Hide all (94)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024387	hsa-miR-215-5p	Microarray	19074876
MIRT025887	hsa-miR-7-5p	Microarray	19073608
MIRT026144	hsa-miR-192-5p	Microarray	19074876
MIRT045890	hsa-miR-125b-5p	CLASH	23622248
MIRT036329	hsa-miR-1229-3p	CLASH	23622248
MIRT1094356	hsa-miR-1200	CLIP-seq
MIRT1094357	hsa-miR-1294	CLIP-seq
MIRT1094358	hsa-miR-2115	CLIP-seq
MIRT1094359	hsa-miR-22	CLIP-seq
MIRT1094360	hsa-miR-28-5p	CLIP-seq
MIRT1094361	hsa-miR-3074-5p	CLIP-seq
MIRT1094362	hsa-miR-3129-3p	CLIP-seq
MIRT1094363	hsa-miR-3132	CLIP-seq
MIRT1094364	hsa-miR-3139	CLIP-seq
MIRT1094365	hsa-miR-3160-3p	CLIP-seq
MIRT1094366	hsa-miR-3174	CLIP-seq
MIRT1094367	hsa-miR-3184	CLIP-seq
MIRT1094368	hsa-miR-370	CLIP-seq
MIRT1094369	hsa-miR-423-5p	CLIP-seq
MIRT1094370	hsa-miR-4324	CLIP-seq
MIRT1094371	hsa-miR-4487	CLIP-seq
MIRT1094372	hsa-miR-4492	CLIP-seq
MIRT1094373	hsa-miR-4498	CLIP-seq
MIRT1094374	hsa-miR-4505	CLIP-seq
MIRT1094375	hsa-miR-4637	CLIP-seq
MIRT1094376	hsa-miR-4639-5p	CLIP-seq
MIRT1094377	hsa-miR-4659a-5p	CLIP-seq
MIRT1094378	hsa-miR-4659b-5p	CLIP-seq
MIRT1094379	hsa-miR-4769-3p	CLIP-seq
MIRT1094380	hsa-miR-516a-3p	CLIP-seq
MIRT1094381	hsa-miR-544b	CLIP-seq
MIRT1094382	hsa-miR-558	CLIP-seq
MIRT1094383	hsa-miR-665	CLIP-seq
MIRT1094384	hsa-miR-708	CLIP-seq
MIRT1094385	hsa-miR-762	CLIP-seq
MIRT1094386	hsa-miR-921	CLIP-seq
MIRT2025255	hsa-miR-1257	CLIP-seq
MIRT2025256	hsa-miR-147	CLIP-seq
MIRT1094358	hsa-miR-2115	CLIP-seq
MIRT2025257	hsa-miR-3146	CLIP-seq
MIRT1094365	hsa-miR-3160-3p	CLIP-seq
MIRT2025258	hsa-miR-339-5p	CLIP-seq
MIRT2025259	hsa-miR-3612	CLIP-seq
MIRT2025260	hsa-miR-3942-3p	CLIP-seq
MIRT2025261	hsa-miR-3975	CLIP-seq
MIRT2025262	hsa-miR-4254	CLIP-seq
MIRT2025263	hsa-miR-4257	CLIP-seq
MIRT2025264	hsa-miR-4443	CLIP-seq
MIRT2025265	hsa-miR-4452	CLIP-seq
MIRT1094371	hsa-miR-4487	CLIP-seq
MIRT2025266	hsa-miR-4652-3p	CLIP-seq
MIRT2025267	hsa-miR-4699-3p	CLIP-seq
MIRT2025268	hsa-miR-4761-5p	CLIP-seq
MIRT2025269	hsa-miR-4778-5p	CLIP-seq
MIRT2025270	hsa-miR-491-3p	CLIP-seq
MIRT2025271	hsa-miR-511	CLIP-seq
MIRT1094380	hsa-miR-516a-3p	CLIP-seq
MIRT1094382	hsa-miR-558	CLIP-seq
MIRT2025272	hsa-miR-605	CLIP-seq
MIRT2025273	hsa-miR-619	CLIP-seq
MIRT2025274	hsa-miR-642b	CLIP-seq
MIRT2025275	hsa-miR-650	CLIP-seq
MIRT2025276	hsa-miR-670	CLIP-seq
MIRT2256537	hsa-miR-1207-5p	CLIP-seq
MIRT2256538	hsa-miR-1243	CLIP-seq
MIRT2256539	hsa-miR-1255a	CLIP-seq
MIRT2256540	hsa-miR-1255b	CLIP-seq
MIRT2256541	hsa-miR-214	CLIP-seq
MIRT2256542	hsa-miR-223	CLIP-seq
MIRT2256543	hsa-miR-29a	CLIP-seq
MIRT2256544	hsa-miR-29b	CLIP-seq
MIRT2256545	hsa-miR-29c	CLIP-seq
MIRT2025258	hsa-miR-339-5p	CLIP-seq
MIRT2256546	hsa-miR-3545-3p	CLIP-seq
MIRT2025259	hsa-miR-3612	CLIP-seq
MIRT2256547	hsa-miR-3619-5p	CLIP-seq
MIRT2256548	hsa-miR-3670	CLIP-seq
MIRT2256549	hsa-miR-3675-5p	CLIP-seq
MIRT2256550	hsa-miR-4276	CLIP-seq
MIRT2025264	hsa-miR-4443	CLIP-seq
MIRT2256551	hsa-miR-4446-3p	CLIP-seq
MIRT2256552	hsa-miR-4493	CLIP-seq
MIRT2256553	hsa-miR-4514	CLIP-seq
MIRT2256554	hsa-miR-4656	CLIP-seq
MIRT2256555	hsa-miR-4672	CLIP-seq
MIRT2256556	hsa-miR-4690-5p	CLIP-seq
MIRT2256557	hsa-miR-4692	CLIP-seq
MIRT2256558	hsa-miR-4697-3p	CLIP-seq
MIRT2256559	hsa-miR-4753-5p	CLIP-seq
MIRT2256560	hsa-miR-4763-3p	CLIP-seq
MIRT2256561	hsa-miR-486-3p	CLIP-seq
MIRT2025274	hsa-miR-642b	CLIP-seq
MIRT2025275	hsa-miR-650	CLIP-seq
MIRT2256562	hsa-miR-761	CLIP-seq

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0003777	Function	Microtubule motor activity	IBA
GO:0003777	Function	Microtubule motor activity	IDA	21620453
GO:0003777	Function	Microtubule motor activity	IEA
GO:0005515	Function	Protein binding	IPI	21620453, 24421332, 25416956, 26290419, 26496610, 30375385, 32296183, 33961781, 35709258
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005813	Component	Centrosome	IDA	30375385
GO:0005813	Component	Centrosome	IEA
GO:0005814	Component	Centriole	IDA	21620453, 30375385
GO:0005814	Component	Centriole	IEA
GO:0005829	Component	Cytosol	TAS
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IBA
GO:0005874	Component	Microtubule	IEA
GO:0007018	Process	Microtubule-based movement	IEA
GO:0007019	Process	Microtubule depolymerization	IBA
GO:0007019	Process	Microtubule depolymerization	IDA	21620453
GO:0007019	Process	Microtubule depolymerization	IEA
GO:0008017	Function	Microtubule binding	IEA
GO:0030030	Process	Cell projection organization	IEA
GO:0032991	Component	Protein-containing complex	IDA	24421332
GO:0042802	Function	Identical protein binding	IPI	26290419
GO:0060271	Process	Cilium assembly	IMP	21620453
GO:1902018	Process	Negative regulation of cilium assembly	IMP	30375385

MIM	HGNC	e!Ensembl
613747	19916	ENSG00000186638

Q5T7B8

Protein name

Kinesin-like protein KIF24

Protein function

Microtubule-dependent motor protein that acts as a negative regulator of ciliogenesis by mediating recruitment of CCP110 to mother centriole in cycling cells, leading to restrict nucleation of cilia at centrioles. Mediates depolymerization of mi

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00536	SAM_1	2 → 62	SAM domain (Sterile alpha motif)	Domain
PF00225	Kinesin	229 → 546	Kinesin motor domain	Domain

Sequence

MASWLYECLCEAELAQYYSHFTALGLQKIDELAKITMKDYSKLGVHDMNDRKRLFQLIKI
IKIMQEEDKAVSIPERHLQTSSLRIKSQELRSGPRRQLNFDSPADNKDRNASNDGFEMCS
LSDFSANEQKSTYLKVLEHMLPDDSQYHTKTGILNATAGDSYVQTEISTSLFSPNYLSAI
LGDCDIPIIQRISHVSGYNYGIPHSCIRQNTSEKQNPWTEMEKIRVCVRKRPLGMREVRR
GEINIITVEDKETLLVHEKKEAVDLTQYILQHVFYFDEVFGEACTNQDVYMKTTHPLIQH
IFNGGNATCFAYGQTGAGKTYTMIGTHENPGLYALAAKDIFRQLEVSQPRKHLFVWISFY
EIYCGQLYDLLNRRKRLFAREDSKHMVQIVGLQELQVDSVELLLEVILKGSKERSTGATG
VNADSSRSHAVIQIQIKDSAKRTFGRISFIDLAGSERAADARDSDRQTKMEGAEINQSLL
ALKECIRALDQEHTHTPFRQSKLTQVLKDSFIGNAKTCMIANISPSHVATEHTLNTLRYA
DRVKELKKGIKCCTSVTSRNRTSGNSSPKRIQSSPGALSEDKCSPKKVKLGFQQSLTVAA
PGSTRGKVHPLTSHPPNIPFTSAPKVSGKRGGSRGSPSQEWVIHASPVKGTVRSGHVAKK
KPEESAPLCSEKNRMGNKTVLGWESRASGPGEGLVRGKLSTKCKKVQTVQPVQKQLVSRV
ELSFGNAHHRAEYSQDSQRGTPARPASEAWTNIPPHQKEREEHLRFYHQQFQQPPLLQQK
LKYQPLKRSLRQYRPPEGQLTNETPPLFHSYSENHDGAQVEELDDSDFSEDSFSHISSQR
ATKQRNTLENSEDSFFLHQTWGQGPEKQVAERQQSLFSSPRTGDKKDLTKSWVDSRDPIN
HRRAALDHSCSPSKGPVDWSRENSTSSGPSPRDSLAEKPYCSQVDFIYRQERGGGSSFDL
RKDASQSEVSGENEGNLPSPEEDGFTISLSHVAVPGSPDQRDTVTTPLREVSADGPIQVT
STVKNGHAVPGEDPRGQLGTHAEYASGLMSPLTMSLLENPDNEGSPPSEQLVQDGATHSL
VAESTGGPVVSHTVPSGDQEAALPVSSATRHLWLSSSPPDNKPGGDLPALSPSPIRQHPA
DKLPSREADLGEACQSRETVLFSHEHMGSEQYDADAEETGLDGSWGFPGKPFTTIHMGVP
HSGPTLTPRTGSSDVADQLWAQERKHPTRLGWQEFGLSTDPIKLPCNSENVTWLKPRPIS
RCLARPSSPLVPSCSPKTAGTLRQPTLEQAQQVVIRAHQEQLDEMAELGFKEETLMSQLA
SNDFEDFVTQLDEIMVLKSKCIQSLRSQLQLYLTCHGPTAAPEGTVPS

Sequence length

1368

Interactions

View interactions

	KEGG		Reactome
	Motor proteins		Anchoring of the basal body to the plasma membrane

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Causal Diseases (1)

Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Causal Diseases associated with Pathogenic or Likely Pathogenic variants in ClinVar
Asphyxiating thoracic dystrophy 3	Pathogenic	rs535585536	RCV001581093	★★★★★ ★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Show/Hide Unknown Diseases (5)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
PERIPHERAL NEUROPATHY	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SALDINO-NOONAN SYNDROME	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCHIZOPHRENIA	—	Disgenet	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (5)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Aphasia, Progressive	Aphasia	BEFREE	20670673		★★★★★ ★☆☆☆☆ Found in Text Mining only
Basal Cell Nevus Syndrome	Basal cell nevus syndrome	Pubtator	29081410	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	26290419	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Frontotemporal Lobar Degeneration	Frontotemporal dementia	BEFREE	20670673		★★★★★ ★☆☆☆☆ Found in Text Mining only
Parkinson Disease	Parkinson disease	Pubtator	34148545	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

KIF24 (kinesin family member 24)