Gene Details | GeDiPNet - Complete Gene Info, Disease Associations & Pathways

Gene Gene information from NCBI Gene database. Gene miRNA Gene ontology Other IDs Protein Associated diseases
Entrez ID	345930
Gene name	Epithelial cell transforming 2 like
Gene symbol	ECT2L
Synonyms (NCBI Gene)	ARHGEF32C6orf91FBXO49LFDHdJ509I19.2dJ509I19.3dJ509I19.5
Chromosome	6
Chromosome location	6q24.1

156

Show/Hide all (156)

miRTarBase ID	miRNA	Experiments
MIRT951858	hsa-miR-1297	CLIP-seq
MIRT951859	hsa-miR-1305	CLIP-seq
MIRT951860	hsa-miR-26a	CLIP-seq
MIRT951861	hsa-miR-26b	CLIP-seq
MIRT951862	hsa-miR-4465	CLIP-seq
MIRT951863	hsa-miR-4670-3p	CLIP-seq
MIRT951864	hsa-miR-498	CLIP-seq
MIRT951865	hsa-miR-1227	CLIP-seq
MIRT951866	hsa-miR-1254	CLIP-seq
MIRT951867	hsa-miR-136	CLIP-seq
MIRT951868	hsa-miR-2467-5p	CLIP-seq
MIRT951869	hsa-miR-3116	CLIP-seq
MIRT951870	hsa-miR-3149	CLIP-seq
MIRT951871	hsa-miR-3188	CLIP-seq
MIRT951872	hsa-miR-3663-5p	CLIP-seq
MIRT951873	hsa-miR-3975	CLIP-seq
MIRT951874	hsa-miR-411	CLIP-seq
MIRT951875	hsa-miR-4316	CLIP-seq
MIRT951876	hsa-miR-4438	CLIP-seq
MIRT951877	hsa-miR-4690-5p	CLIP-seq
MIRT951878	hsa-miR-4710	CLIP-seq
MIRT951879	hsa-miR-4715-3p	CLIP-seq
MIRT951880	hsa-miR-4716-5p	CLIP-seq
MIRT951881	hsa-miR-4735-5p	CLIP-seq
MIRT951882	hsa-miR-4775	CLIP-seq
MIRT951883	hsa-miR-4781-3p	CLIP-seq
MIRT951884	hsa-miR-4792	CLIP-seq
MIRT951885	hsa-miR-4794	CLIP-seq
MIRT951886	hsa-miR-483-5p	CLIP-seq
MIRT951887	hsa-miR-485-5p	CLIP-seq
MIRT951888	hsa-miR-5095	CLIP-seq
MIRT951889	hsa-miR-515-5p	CLIP-seq
MIRT951890	hsa-miR-590-3p	CLIP-seq
MIRT951891	hsa-miR-661	CLIP-seq
MIRT1981878	hsa-miR-130a	CLIP-seq
MIRT1981879	hsa-miR-130b	CLIP-seq
MIRT1981880	hsa-miR-301a	CLIP-seq
MIRT1981881	hsa-miR-301b	CLIP-seq
MIRT1981882	hsa-miR-3616-5p	CLIP-seq
MIRT1981883	hsa-miR-3647-5p	CLIP-seq
MIRT1981884	hsa-miR-3666	CLIP-seq
MIRT1981885	hsa-miR-3929	CLIP-seq
MIRT1981886	hsa-miR-4295	CLIP-seq
MIRT1981887	hsa-miR-4419b	CLIP-seq
MIRT1981888	hsa-miR-4478	CLIP-seq
MIRT1981889	hsa-miR-454	CLIP-seq
MIRT1981890	hsa-miR-4795-5p	CLIP-seq
MIRT1981891	hsa-miR-494	CLIP-seq
MIRT1981892	hsa-miR-519a	CLIP-seq
MIRT1981893	hsa-miR-519b-3p	CLIP-seq
MIRT1981894	hsa-miR-519c-3p	CLIP-seq
MIRT1981895	hsa-miR-573	CLIP-seq
MIRT2216776	hsa-miR-106a	CLIP-seq
MIRT2216777	hsa-miR-106b	CLIP-seq
MIRT1981878	hsa-miR-130a	CLIP-seq
MIRT1981879	hsa-miR-130b	CLIP-seq
MIRT2216778	hsa-miR-150	CLIP-seq
MIRT2216779	hsa-miR-17	CLIP-seq
MIRT2216780	hsa-miR-20a	CLIP-seq
MIRT2216781	hsa-miR-20b	CLIP-seq
MIRT951868	hsa-miR-2467-5p	CLIP-seq
MIRT1981880	hsa-miR-301a	CLIP-seq
MIRT1981881	hsa-miR-301b	CLIP-seq
MIRT951871	hsa-miR-3188	CLIP-seq
MIRT1981882	hsa-miR-3616-5p	CLIP-seq
MIRT1981883	hsa-miR-3647-5p	CLIP-seq
MIRT951872	hsa-miR-3663-5p	CLIP-seq
MIRT1981884	hsa-miR-3666	CLIP-seq
MIRT2216782	hsa-miR-371-5p	CLIP-seq
MIRT2216783	hsa-miR-371b-5p	CLIP-seq
MIRT1981885	hsa-miR-3929	CLIP-seq
MIRT951873	hsa-miR-3975	CLIP-seq
MIRT1981886	hsa-miR-4295	CLIP-seq
MIRT951875	hsa-miR-4316	CLIP-seq
MIRT1981887	hsa-miR-4419b	CLIP-seq
MIRT2216784	hsa-miR-4464	CLIP-seq
MIRT1981888	hsa-miR-4478	CLIP-seq
MIRT1981889	hsa-miR-454	CLIP-seq
MIRT951878	hsa-miR-4710	CLIP-seq
MIRT951880	hsa-miR-4716-5p	CLIP-seq
MIRT2216785	hsa-miR-4748	CLIP-seq
MIRT951883	hsa-miR-4781-3p	CLIP-seq
MIRT951884	hsa-miR-4792	CLIP-seq
MIRT1981890	hsa-miR-4795-5p	CLIP-seq
MIRT951887	hsa-miR-485-5p	CLIP-seq
MIRT1981892	hsa-miR-519a	CLIP-seq
MIRT1981893	hsa-miR-519b-3p	CLIP-seq
MIRT1981894	hsa-miR-519c-3p	CLIP-seq
MIRT2216786	hsa-miR-519d	CLIP-seq
MIRT2216787	hsa-miR-520g	CLIP-seq
MIRT2216788	hsa-miR-520h	CLIP-seq
MIRT1981895	hsa-miR-573	CLIP-seq
MIRT2216789	hsa-miR-93	CLIP-seq
MIRT951866	hsa-miR-1254	CLIP-seq
MIRT951869	hsa-miR-3116	CLIP-seq
MIRT951870	hsa-miR-3149	CLIP-seq
MIRT951874	hsa-miR-411	CLIP-seq
MIRT951879	hsa-miR-4715-3p	CLIP-seq
MIRT951881	hsa-miR-4735-5p	CLIP-seq
MIRT951882	hsa-miR-4775	CLIP-seq
MIRT951885	hsa-miR-4794	CLIP-seq
MIRT951886	hsa-miR-483-5p	CLIP-seq
MIRT951890	hsa-miR-590-3p	CLIP-seq
MIRT951891	hsa-miR-661	CLIP-seq
MIRT951866	hsa-miR-1254	CLIP-seq
MIRT951869	hsa-miR-3116	CLIP-seq
MIRT951870	hsa-miR-3149	CLIP-seq
MIRT951874	hsa-miR-411	CLIP-seq
MIRT951879	hsa-miR-4715-3p	CLIP-seq
MIRT951881	hsa-miR-4735-5p	CLIP-seq
MIRT951882	hsa-miR-4775	CLIP-seq
MIRT951885	hsa-miR-4794	CLIP-seq
MIRT951886	hsa-miR-483-5p	CLIP-seq
MIRT951890	hsa-miR-590-3p	CLIP-seq
MIRT951891	hsa-miR-661	CLIP-seq
MIRT951865	hsa-miR-1227	CLIP-seq
MIRT951866	hsa-miR-1254	CLIP-seq
MIRT951867	hsa-miR-136	CLIP-seq
MIRT951869	hsa-miR-3116	CLIP-seq
MIRT951870	hsa-miR-3149	CLIP-seq
MIRT951874	hsa-miR-411	CLIP-seq
MIRT951876	hsa-miR-4438	CLIP-seq
MIRT951878	hsa-miR-4710	CLIP-seq
MIRT951879	hsa-miR-4715-3p	CLIP-seq
MIRT951880	hsa-miR-4716-5p	CLIP-seq
MIRT951881	hsa-miR-4735-5p	CLIP-seq
MIRT951882	hsa-miR-4775	CLIP-seq
MIRT951883	hsa-miR-4781-3p	CLIP-seq
MIRT951884	hsa-miR-4792	CLIP-seq
MIRT951885	hsa-miR-4794	CLIP-seq
MIRT951886	hsa-miR-483-5p	CLIP-seq
MIRT951888	hsa-miR-5095	CLIP-seq
MIRT951889	hsa-miR-515-5p	CLIP-seq
MIRT951890	hsa-miR-590-3p	CLIP-seq
MIRT951891	hsa-miR-661	CLIP-seq
MIRT951865	hsa-miR-1227	CLIP-seq
MIRT951866	hsa-miR-1254	CLIP-seq
MIRT951867	hsa-miR-136	CLIP-seq
MIRT951869	hsa-miR-3116	CLIP-seq
MIRT951870	hsa-miR-3149	CLIP-seq
MIRT951874	hsa-miR-411	CLIP-seq
MIRT951875	hsa-miR-4316	CLIP-seq
MIRT951876	hsa-miR-4438	CLIP-seq
MIRT951878	hsa-miR-4710	CLIP-seq
MIRT951879	hsa-miR-4715-3p	CLIP-seq
MIRT951880	hsa-miR-4716-5p	CLIP-seq
MIRT951881	hsa-miR-4735-5p	CLIP-seq
MIRT951882	hsa-miR-4775	CLIP-seq
MIRT951883	hsa-miR-4781-3p	CLIP-seq
MIRT951884	hsa-miR-4792	CLIP-seq
MIRT951885	hsa-miR-4794	CLIP-seq
MIRT951886	hsa-miR-483-5p	CLIP-seq
MIRT951888	hsa-miR-5095	CLIP-seq
MIRT951889	hsa-miR-515-5p	CLIP-seq
MIRT951890	hsa-miR-590-3p	CLIP-seq
MIRT951891	hsa-miR-661	CLIP-seq

Show/Hide all (1)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005085	Function	Guanyl-nucleotide exchange factor activity	IEA

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Q008S8

Protein name

Epithelial cell-transforming sequence 2 oncogene-like (Lung-specific F-box and DH domain-containing protein) (Putative guanine nucleotide exchange factor LFDH)

Protein function

May act as a guanine nucleotide exchange factor (GEF).

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF12937	F-box-like	79 → 124	F-box-like	Domain
PF14252	DUF4347	290 → 460	Domain of unknown function (DUF4347)	Family
PF00621	RhoGEF	570 → 752	RhoGEF domain	Domain

Sequence

MESFHTRFSAWTPFSNKSLNRQLFQERVALISHWFDLWTNKQRQEFLFAIFLRCTKSQLR
FVQDWFSERMQVAKVDFSTVLPRFISLYIFSFLSPKDLCAAAQVSWPWKFLTEQDCLWMP
KCVKFGWFLPYTPTDNEYGAWKRHYIACVSHLDWLTPREAAATYGTLNEPKTEDEELLER
QREKCLRKRIWEKIALRKKELFKVRPPWVSGTCCSSVLKPRCQPRLSQTVRERVGLHEAL
EKQLVLTSLETLPKRSNISGSHSYPLLSKKNWHGVHKNDDRSSYALRPHFMLISSRIPAY
EMVMESVKAGVVSVVYEHSVTLESLLYLIEKALDGQKAQSIGIFSDGDSREINLLQGYKI
GVKNLLRPEVRDFWEKLGSYVATEEEGGHVDFFVPLGASEAGIEVLSQLSQLTGTFFTAP
TGIATGSYQHILSDWLGSQWGKAPSSIYFCESKLQTWSSFTDFLEETLKTVRKQLYPFFK
ELQKSISGRMIGQFMFDTMGMTNILNNQDTAQALADGLMELSKEDSERNVVEDNSWDTKS
RLSKNDLNFEALINLERILQKDSAEKRARVVRELLQSERKYVQILEIVRDVYVAPLKAAL
SSNRAILSAANIQIIFCDILQILSLNRQFLDNLRDRLQEWGPAHCVGEIVTKFGSQLNTY
TNFFNNYPVILKTIEKCREMIPAFRTFLKRHDKTIVTKMLSLPELLLYPSRRFEEYLNLL
YAVRLHTPAEHVDRGDLTTAIDQIKKYKGYIDQMKQNITMKDHLSDIQRIIWGCPTLSEV
NRYLIRVQDVAQLHCCDEEISFSLRLYEHIHDLSLFLFNDALLVSSRGTSHTPFERTSKT
TYQFIASVALHRLLIENIPDSKYVKNAFILQGPKYKWICATEIEDDKFLWLSVLRNAIKS
SMEK

Sequence length

904

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Show/Hide Unknown Diseases (10)

Phenotype Name	Clinical Significance	Source	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Cholangiocarcinoma	not provided	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	not provided	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ENDOMETRIAL NEOPLASM	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	not provided	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	not provided	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	not provided	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thymoma	not provided	ClinVar	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Show/Hide Text Mining Associations (9)

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Adenocarcinoma of large intestine	Colorectal Cancer	GWASCAT_DG	26621817		★★★★★ ★☆☆☆☆ Found in Text Mining only
Breast Neoplasms	Breast neoplasm	Pubtator	36344993	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	GWASCAT_DG	26621817		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	GWASCAT_DG	26621817		★★★★★ ★☆☆☆☆ Found in Text Mining only
Endometrial Neoplasms	Endometrial Neoplasms	GWASCAT_DG	26621817		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of large intestine	Colorectal Neoplasms	GWASCAT_DG	26621817		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	GWASCAT_DG	26621817		★★★★★ ★☆☆☆☆ Found in Text Mining only
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Lymphoblastic Leukemia	CGI_DG			★★★★★ ★☆☆☆☆ Found in Text Mining only
Spastic Paraplegia Hereditary	Hereditary spastic paraplegia	Pubtator	36344993	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

ECT2L (epithelial cell transforming 2 like)